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Patent code US9096606

Compile Data Set for Download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173484
PNG
(US9096606, 21)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1Cl)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39ClNO4/c1-34(17-20-7-8-20)14-13-31-27-21-9-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-21)16-23(32)19-37-18-22-5-3-4-6-24(22)33/h3-6,9-10,20,23,26,29,35H,7-8,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.190 -51.6n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173479
PNG
(US9096606, 16)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1F)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-7-8-20)14-13-31-27-21-9-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-21)16-23(32)19-37-18-22-5-3-4-6-24(22)33/h3-6,9-10,20,23,26,29,35H,7-8,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.200 -51.5n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173478
PNG
(US9096606, 15)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccsc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO4S/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)35-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)17-34-16-20-7-12-36-18-20/h5-7,12,18-19,22,24,27,32H,3-4,8-11,13-17H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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US Patent
 0.200 -51.5n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173482
PNG
(US9096606, 19)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(F)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-6-7-20)13-12-31-27-22-8-9-25(35)28(27)38-29(31)32(36-2)11-10-30(31,26(34)15-22)16-23(32)19-37-18-21-4-3-5-24(33)14-21/h3-5,8-9,14,20,23,26,29,35H,6-7,10-13,15-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.25 -50.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173467
PNG
(US9096606, 4)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(F)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-3-4-20)14-13-31-27-22-7-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-22)16-23(32)19-37-18-21-5-8-24(33)9-6-21/h5-10,20,23,26,29,35H,3-4,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.260 -50.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173483
PNG
(US9096606, 20)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(Cl)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39ClNO4/c1-34(17-20-6-7-20)13-12-31-27-22-8-9-25(35)28(27)38-29(31)32(36-2)11-10-30(31,26(34)15-22)16-23(32)19-37-18-21-4-3-5-24(33)14-21/h3-5,8-9,14,20,23,26,29,35H,6-7,10-13,15-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.270 -50.8n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173474
PNG
(US9096606, 11)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccoc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO5/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)36-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)18-35-17-20-7-12-34-16-20/h5-7,12,16,19,22,24,27,32H,3-4,8-11,13-15,17-18H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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US Patent
 0.290 -50.6n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173480
PNG
(US9096606, 17)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(C)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-5-4-6-23(15-21)19-37-20-25-17-31-11-12-33(25,36-3)30-32(31)13-14-34(2,18-22-7-8-22)27(31)16-24-9-10-26(35)29(38-30)28(24)32/h4-6,9-10,15,22,25,27,30,35H,7-8,11-14,16-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 0.290 -50.6n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173485
PNG
(US9096606, 22)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-6-4-5-7-24(21)19-37-20-25-17-31-12-13-33(25,36-3)30-32(31)14-15-34(2,18-22-8-9-22)27(31)16-23-10-11-26(35)29(38-30)28(23)32/h4-7,10-11,22,25,27,30,35H,8-9,12-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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 0.470 -49.5n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173470
PNG
(US9096606, 7)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:27.26:3.4|
Show InChI InChI=1S/C32H40NO4/c1-33(18-21-8-9-21)15-14-31-27-23-10-11-25(34)28(27)37-29(31)32(35-2)13-12-30(31,26(33)16-23)17-24(32)20-36-19-22-6-4-3-5-7-22/h3-7,10-11,21,24,26,29,34H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 0.550 -49.1n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173477
PNG
(US9096606, 14)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(Cl)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39ClNO4/c1-34(17-20-3-4-20)14-13-31-27-22-7-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-22)16-23(32)19-37-18-21-5-8-24(33)9-6-21/h5-10,20,23,26,29,35H,3-4,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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 0.590 -49.0n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173468
PNG
(US9096606, 5)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cc4ccccc4s1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:30.29:3.4|
Show InChI InChI=1S/C34H40NO4S/c1-35(18-21-7-8-21)14-13-33-29-23-9-10-26(36)30(29)39-31(33)34(37-2)12-11-32(33,28(35)16-23)17-24(34)19-38-20-25-15-22-5-3-4-6-27(22)40-25/h3-6,9-10,15,21,24,28,31,36H,7-8,11-14,16-20H2,1-2H3/t24-,28-,31-,32-,33+,34-/m1/s1
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 0.780 -48.3n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173469
PNG
(US9096606, 6)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(C)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-4-6-23(7-5-21)19-37-20-25-17-31-12-13-33(25,36-3)30-32(31)14-15-34(2,18-22-8-9-22)27(31)16-24-10-11-26(35)29(38-30)28(24)32/h4-7,10-11,22,25,27,30,35H,8-9,12-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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 1.06 -47.6n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173469
PNG
(US9096606, 6)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(C)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-4-6-23(7-5-21)19-37-20-25-17-31-12-13-33(25,36-3)30-32(31)14-15-34(2,18-22-8-9-22)27(31)16-24-10-11-26(35)29(38-30)28(24)32/h4-7,10-11,22,25,27,30,35H,8-9,12-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 1.36 -54.9n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173470
PNG
(US9096606, 7)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:27.26:3.4|
Show InChI InChI=1S/C32H40NO4/c1-33(18-21-8-9-21)15-14-31-27-23-10-11-25(34)28(27)37-29(31)32(35-2)13-12-30(31,26(33)16-23)17-24(32)20-36-19-22-6-4-3-5-7-22/h3-7,10-11,21,24,26,29,34H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 2.11 -53.7n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173468
PNG
(US9096606, 5)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cc4ccccc4s1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:30.29:3.4|
Show InChI InChI=1S/C34H40NO4S/c1-35(18-21-7-8-21)14-13-33-29-23-9-10-26(36)30(29)39-31(33)34(37-2)12-11-32(33,28(35)16-23)17-24(34)19-38-20-25-15-22-5-3-4-6-27(22)40-25/h3-6,9-10,15,21,24,28,31,36H,7-8,11-14,16-20H2,1-2H3/t24-,28-,31-,32-,33+,34-/m1/s1
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US Patent
 2.29 -53.5n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173480
PNG
(US9096606, 17)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(C)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-5-4-6-23(15-21)19-37-20-25-17-31-11-12-33(25,36-3)30-32(31)13-14-34(2,18-22-7-8-22)27(31)16-24-9-10-26(35)29(38-30)28(24)32/h4-6,9-10,15,22,25,27,30,35H,7-8,11-14,16-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 4.30 -51.8n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173479
PNG
(US9096606, 16)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1F)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-7-8-20)14-13-31-27-21-9-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-21)16-23(32)19-37-18-22-5-3-4-6-24(22)33/h3-6,9-10,20,23,26,29,35H,7-8,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 4.51 -51.6n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173464
PNG
(US9096606, 1)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(Cl)c(Cl)c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C33H40Cl2NO4/c1-36(17-20-4-5-20)13-12-32-28-22-7-9-26(37-2)29(28)40-30(32)33(38-3)11-10-31(32,27(36)15-22)16-23(33)19-39-18-21-6-8-24(34)25(35)14-21/h6-9,14,20,23,27,30H,4-5,10-13,15-19H2,1-3H3/t23-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 5.02 -44.0n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173482
PNG
(US9096606, 19)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(F)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-6-7-20)13-12-31-27-22-8-9-25(35)28(27)38-29(31)32(36-2)11-10-30(31,26(34)15-22)16-23(32)19-37-18-21-4-3-5-24(33)14-21/h3-5,8-9,14,20,23,26,29,35H,6-7,10-13,15-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 5.35 -51.2n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173483
PNG
(US9096606, 20)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cccc(Cl)c1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39ClNO4/c1-34(17-20-6-7-20)13-12-31-27-22-8-9-25(35)28(27)38-29(31)32(36-2)11-10-30(31,26(34)15-22)16-23(32)19-37-18-21-4-3-5-24(33)14-21/h3-5,8-9,14,20,23,26,29,35H,6-7,10-13,15-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 6.26 -50.7n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173467
PNG
(US9096606, 4)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(F)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-3-4-20)14-13-31-27-22-7-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-22)16-23(32)19-37-18-21-5-8-24(33)9-6-21/h5-10,20,23,26,29,35H,3-4,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 9.55 -49.6n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173487
PNG
(US9096606, 24)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccco1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C31H40NO5/c1-32(17-20-6-7-20)13-12-30-26-21-8-9-24(33-2)27(26)37-28(30)31(34-3)11-10-29(30,25(32)15-21)16-22(31)18-35-19-23-5-4-14-36-23/h4-5,8-9,14,20,22,25,28H,6-7,10-13,15-19H2,1-3H3/t22-,25-,28-,29-,30+,31-/m1/s1
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US Patent
 10.6 -42.3n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173475
PNG
(US9096606, 12)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2ccccc2o1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H42NO5/c1-36(19-22-8-9-22)15-14-34-30-24-10-11-28(37-2)31(30)41-32(34)35(38-3)13-12-33(34,29(36)17-24)18-25(35)20-39-21-26-16-23-6-4-5-7-27(23)40-26/h4-7,10-11,16,22,25,29,32H,8-9,12-15,17-21H2,1-3H3/t25-,29-,32-,33-,34+,35-/m1/s1
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US Patent
 17.3 -41.2n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173470
PNG
(US9096606, 7)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:27.26:3.4|
Show InChI InChI=1S/C32H40NO4/c1-33(18-21-8-9-21)15-14-31-27-23-10-11-25(34)28(27)37-29(31)32(35-2)13-12-30(31,26(33)16-23)17-24(32)20-36-19-22-6-4-3-5-7-22/h3-7,10-11,21,24,26,29,34H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 18.8n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173478
PNG
(US9096606, 15)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccsc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO4S/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)35-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)17-34-16-20-7-12-36-18-20/h5-7,12,18-19,22,24,27,32H,3-4,8-11,13-17H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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US Patent
 24.3 -47.1n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173473
PNG
(US9096606, 10)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccoc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C31H40NO5/c1-32(16-20-4-5-20)12-11-30-26-22-6-7-24(33-2)27(26)37-28(30)31(34-3)10-9-29(30,25(32)14-22)15-23(31)19-36-18-21-8-13-35-17-21/h6-8,13,17,20,23,25,28H,4-5,9-12,14-16,18-19H2,1-3H3/t23-,25-,28-,29-,30+,31-/m1/s1
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US Patent
 35.0 -39.6n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173468
PNG
(US9096606, 5)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cc4ccccc4s1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:30.29:3.4|
Show InChI InChI=1S/C34H40NO4S/c1-35(18-21-7-8-21)14-13-33-29-23-9-10-26(36)30(29)39-31(33)34(37-2)12-11-32(33,28(35)16-23)17-24(34)19-38-20-25-15-22-5-3-4-6-27(22)40-25/h3-6,9-10,15,21,24,28,31,36H,7-8,11-14,16-20H2,1-2H3/t24-,28-,31-,32-,33+,34-/m1/s1
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US Patent
 45.3n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173474
PNG
(US9096606, 11)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccoc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO5/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)36-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)18-35-17-20-7-12-34-16-20/h5-7,12,16,19,22,24,27,32H,3-4,8-11,13-15,17-18H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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US Patent
 47.1 -45.3n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173471
PNG
(US9096606, 8)
Show SMILES COc1ccc(COC[C@H]2C[C@]34CC[C@]2(OC)[C@@H]2Oc5c6c(C[C@H]3[N](C)(CC3CC3)CC[C@@]426)ccc5OC)cc1 |r,TLB:8:9:32.17:13.12|
Show InChI InChI=1S/C34H44NO5/c1-35(19-22-5-6-22)16-15-33-29-24-9-12-27(37-3)30(29)40-31(33)34(38-4)14-13-32(33,28(35)17-24)18-25(34)21-39-20-23-7-10-26(36-2)11-8-23/h7-12,22,25,28,31H,5-6,13-21H2,1-4H3/t25-,28-,31-,32-,33+,34-/m1/s1
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 57.0 -38.4n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173465
PNG
(US9096606, 2)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2OCOc2cc1Cl)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H41ClNO6/c1-36(16-20-4-5-20)11-10-33-29-21-6-7-25(37-2)30(29)42-31(33)34(38-3)9-8-32(33,28(36)13-21)15-23(34)18-39-17-22-12-26-27(14-24(22)35)41-19-40-26/h6-7,12,14,20,23,28,31H,4-5,8-11,13,15-19H2,1-3H3/t23-,28-,31-,32-,33+,34-/m1/s1
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US Patent
 66.7 -38.1n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173464
PNG
(US9096606, 1)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(Cl)c(Cl)c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C33H40Cl2NO4/c1-36(17-20-4-5-20)13-12-32-28-22-7-9-26(37-2)29(28)40-30(32)33(38-3)11-10-31(32,27(36)15-22)16-23(33)19-39-18-21-6-8-24(34)25(35)14-21/h6-9,14,20,23,27,30H,4-5,10-13,15-19H2,1-3H3/t23-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 67.2 -44.4n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173469
PNG
(US9096606, 6)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(C)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-4-6-23(7-5-21)19-37-20-25-17-31-12-13-33(25,36-3)30-32(31)14-15-34(2,18-22-8-9-22)27(31)16-24-10-11-26(35)29(38-30)28(24)32/h4-7,10-11,22,25,27,30,35H,8-9,12-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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 109n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173486
PNG
(US9096606, 23)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N+]3(C)CC1CC1)[C@@H](COCc1ccc(cc1)C(C)(F)F)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H44F2NO4/c1-32(36,37)25-10-7-23(8-11-25)20-41-21-26-18-33-13-14-35(26,40-4)31-34(33)15-16-38(2,19-22-5-6-22)28(33)17-24-9-12-27(39-3)30(42-31)29(24)34/h7-12,22,26,28,31H,5-6,13-21H2,1-4H3/q+1/t26-,28-,31-,33-,34+,35-,38?/m1/s1
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 112 -36.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173466
PNG
(US9096606, 3)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(C)cc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H44NO4/c1-22-5-7-24(8-6-22)20-38-21-26-18-32-13-14-34(26,37-4)31-33(32)15-16-35(2,19-23-9-10-23)28(32)17-25-11-12-27(36-3)30(39-31)29(25)33/h5-8,11-12,23,26,28,31H,9-10,13-21H2,1-4H3/t26-,28-,31-,32-,33+,34-/m1/s1
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 117 -36.8n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173465
PNG
(US9096606, 2)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2OCOc2cc1Cl)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H41ClNO6/c1-36(16-20-4-5-20)11-10-33-29-21-6-7-25(37-2)30(29)42-31(33)34(38-3)9-8-32(33,28(36)13-21)15-23(34)18-39-17-22-12-26-27(14-24(22)35)41-19-40-26/h6-7,12,14,20,23,28,31H,4-5,8-11,13,15-19H2,1-3H3/t23-,28-,31-,32-,33+,34-/m1/s1
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 163 -42.0n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173476
PNG
(US9096606, 13)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc2ccccc2c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C37H44NO4/c1-38(21-24-8-9-24)17-16-36-32-28-12-13-30(39-2)33(32)42-34(36)37(40-3)15-14-35(36,31(38)19-28)20-29(37)23-41-22-25-10-11-26-6-4-5-7-27(26)18-25/h4-7,10-13,18,24,29,31,34H,8-9,14-17,19-23H2,1-3H3/t29-,31-,34-,35-,36+,37-/m1/s1
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 165 -36.0n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173467
PNG
(US9096606, 4)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(F)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-3-4-20)14-13-31-27-22-7-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-22)16-23(32)19-37-18-21-5-8-24(33)9-6-21/h5-10,20,23,26,29,35H,3-4,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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 175n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173476
PNG
(US9096606, 13)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc2ccccc2c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C37H44NO4/c1-38(21-24-8-9-24)17-16-36-32-28-12-13-30(39-2)33(32)42-34(36)37(40-3)15-14-35(36,31(38)19-28)20-29(37)23-41-22-25-10-11-26-6-4-5-7-27(26)18-25/h4-7,10-13,18,24,29,31,34H,8-9,14-17,19-23H2,1-3H3/t29-,31-,34-,35-,36+,37-/m1/s1
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 182 -41.7n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173474
PNG
(US9096606, 11)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccoc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO5/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)36-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)18-35-17-20-7-12-34-16-20/h5-7,12,16,19,22,24,27,32H,3-4,8-11,13-15,17-18H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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 193n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173478
PNG
(US9096606, 15)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccsc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:26.25:3.4|
Show InChI InChI=1S/C30H38NO4S/c1-31(15-19-3-4-19)11-10-29-25-21-5-6-23(32)26(25)35-27(29)30(33-2)9-8-28(29,24(31)13-21)14-22(30)17-34-16-20-7-12-36-18-20/h5-7,12,18-19,22,24,27,32H,3-4,8-11,13-17H2,1-2H3/t22-,24-,27-,28-,29+,30-/m1/s1
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 202n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173466
PNG
(US9096606, 3)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(C)cc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H44NO4/c1-22-5-7-24(8-6-22)20-38-21-26-18-32-13-14-34(26,37-4)31-33(32)15-16-35(2,19-23-9-10-23)28(32)17-25-11-12-27(36-3)30(39-31)29(25)33/h5-8,11-12,23,26,28,31H,9-10,13-21H2,1-4H3/t26-,28-,31-,32-,33+,34-/m1/s1
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 242 -40.9n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173486
PNG
(US9096606, 23)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N+]3(C)CC1CC1)[C@@H](COCc1ccc(cc1)C(C)(F)F)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H44F2NO4/c1-32(36,37)25-10-7-23(8-11-25)20-41-21-26-18-33-13-14-35(26,40-4)31-34(33)15-16-38(2,19-22-5-6-22)28(33)17-24-9-12-27(39-3)30(42-31)29(24)34/h7-12,22,26,28,31H,5-6,13-21H2,1-4H3/q+1/t26-,28-,31-,33-,34+,35-,38?/m1/s1
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 262 -40.7n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173475
PNG
(US9096606, 12)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2ccccc2o1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H42NO5/c1-36(19-22-8-9-22)15-14-34-30-24-10-11-28(37-2)31(30)41-32(34)35(38-3)13-12-33(34,29(36)17-24)18-25(35)20-39-21-26-16-23-6-4-5-7-27(23)40-26/h4-7,10-11,16,22,25,29,32H,8-9,12-15,17-21H2,1-3H3/t25-,29-,32-,33-,34+,35-/m1/s1
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 275 -40.6n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173472
PNG
(US9096606, 9)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COc1ccccc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C32H40NO4/c1-33(19-21-9-10-21)16-15-31-27-22-11-12-25(34-2)28(27)37-29(31)32(35-3)14-13-30(31,26(33)17-22)18-23(32)20-36-24-7-5-4-6-8-24/h4-8,11-12,21,23,26,29H,9-10,13-20H2,1-3H3/t23-,26-,29-,30-,31+,32-/m1/s1
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 348 -34.3n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173471
PNG
(US9096606, 8)
Show SMILES COc1ccc(COC[C@H]2C[C@]34CC[C@]2(OC)[C@@H]2Oc5c6c(C[C@H]3[N](C)(CC3CC3)CC[C@@]426)ccc5OC)cc1 |r,TLB:8:9:32.17:13.12|
Show InChI InChI=1S/C34H44NO5/c1-35(19-22-5-6-22)16-15-33-29-24-9-12-27(37-3)30(29)40-31(33)34(38-4)14-13-32(33,28(35)17-24)18-25(34)21-39-20-23-7-10-26(36-2)11-8-23/h7-12,22,25,28,31H,5-6,13-21H2,1-4H3/t25-,28-,31-,32-,33+,34-/m1/s1
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 544 -38.8n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173487
PNG
(US9096606, 24)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccco1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C31H40NO5/c1-32(17-20-6-7-20)13-12-30-26-21-8-9-24(33-2)27(26)37-28(30)31(34-3)11-10-29(30,25(32)15-21)16-22(31)18-35-19-23-5-4-14-36-23/h4-5,8-9,14,20,22,25,28H,6-7,10-13,15-19H2,1-3H3/t22-,25-,28-,29-,30+,31-/m1/s1
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 571 -38.6n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))		BDBM173481
PNG
(US9096606, 18)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(cc1)C(N)=O)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H43N2O5/c1-36(18-21-4-5-21)15-14-33-28-24-10-11-26(38-2)29(28)41-31(33)34(39-3)13-12-32(33,27(36)16-24)17-25(34)20-40-19-22-6-8-23(9-7-22)30(35)37/h6-11,21,25,27,31H,4-5,12-20H2,1-3H3,(H2,35,37)/t25-,27-,31-,32-,33+,34-/m1/s1
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US Patent
 1.03E+3 -31.8n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173472
PNG
(US9096606, 9)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COc1ccccc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C32H40NO4/c1-33(19-21-9-10-21)16-15-31-27-22-11-12-25(34-2)28(27)37-29(31)32(35-3)14-13-30(31,26(33)17-22)18-23(32)20-36-24-7-5-4-6-8-24/h4-8,11-12,21,23,26,29H,9-10,13-20H2,1-3H3/t23-,26-,29-,30-,31+,32-/m1/s1
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US Patent
 1.49E+3 -36.0n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173464
PNG
(US9096606, 1)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(Cl)c(Cl)c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C33H40Cl2NO4/c1-36(17-20-4-5-20)13-12-32-28-22-7-9-26(37-2)29(28)40-30(32)33(38-3)11-10-31(32,27(36)15-22)16-23(33)19-39-18-21-6-8-24(34)25(35)14-21/h6-9,14,20,23,27,30H,4-5,10-13,15-19H2,1-3H3/t23-,27-,30-,31-,32+,33-/m1/s1
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US Patent
 4.41E+3n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173487
PNG
(US9096606, 24)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccco1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C31H40NO5/c1-32(17-20-6-7-20)13-12-30-26-21-8-9-24(33-2)27(26)37-28(30)31(34-3)11-10-29(30,25(32)15-21)16-22(31)18-35-19-23-5-4-14-36-23/h4-5,8-9,14,20,22,25,28H,6-7,10-13,15-19H2,1-3H3/t22-,25-,28-,29-,30+,31-/m1/s1
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 4.79E+3n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM173473
PNG
(US9096606, 10)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccoc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C31H40NO5/c1-32(16-20-4-5-20)12-11-30-26-22-6-7-24(33-2)27(26)37-28(30)31(34-3)10-9-29(30,25(32)14-22)15-23(31)19-36-18-21-8-13-35-17-21/h6-8,13,17,20,23,25,28H,4-5,9-12,14-16,18-19H2,1-3H3/t23-,25-,28-,29-,30+,31-/m1/s1
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 5.81E+3 -32.4n/an/an/an/an/a7.450



Purdue Pharma, L.P.

US Patent


Assay Description
Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173466
PNG
(US9096606, 3)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(C)cc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H44NO4/c1-22-5-7-24(8-6-22)20-38-21-26-18-32-13-14-34(26,37-4)31-33(32)15-16-35(2,19-23-9-10-23)28(32)17-25-11-12-27(36-3)30(39-31)29(25)33/h5-8,11-12,23,26,28,31H,9-10,13-21H2,1-4H3/t26-,28-,31-,32-,33+,34-/m1/s1
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 1.01E+4n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173468
PNG
(US9096606, 5)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1cc4ccccc4s1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:30.29:3.4|
Show InChI InChI=1S/C34H40NO4S/c1-35(18-21-7-8-21)14-13-33-29-23-9-10-26(36)30(29)39-31(33)34(37-2)12-11-32(33,28(35)16-23)17-24(34)19-38-20-25-15-22-5-3-4-6-27(22)40-25/h3-6,9-10,15,21,24,28,31,36H,7-8,11-14,16-20H2,1-2H3/t24-,28-,31-,32-,33+,34-/m1/s1
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US Patent
 1.82E+4 -25.2n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173465
PNG
(US9096606, 2)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2OCOc2cc1Cl)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H41ClNO6/c1-36(16-20-4-5-20)11-10-33-29-21-6-7-25(37-2)30(29)42-31(33)34(38-3)9-8-32(33,28(36)13-21)15-23(34)18-39-17-22-12-26-27(14-24(22)35)41-19-40-26/h6-7,12,14,20,23,28,31H,4-5,8-11,13,15-19H2,1-3H3/t23-,28-,31-,32-,33+,34-/m1/s1
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 1.84E+4n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173469
PNG
(US9096606, 6)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(C)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C33H42NO4/c1-21-4-6-23(7-5-21)19-37-20-25-17-31-12-13-33(25,36-3)30-32(31)14-15-34(2,18-22-8-9-22)27(31)16-24-10-11-26(35)29(38-30)28(24)32/h4-7,10-11,22,25,27,30,35H,8-9,12-20H2,1-3H3/t25-,27-,30-,31-,32+,33-/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173466
PNG
(US9096606, 3)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(C)cc1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H44NO4/c1-22-5-7-24(8-6-22)20-38-21-26-18-32-13-14-34(26,37-4)31-33(32)15-16-35(2,19-23-9-10-23)28(32)17-25-11-12-27(36-3)30(39-31)29(25)33/h5-8,11-12,23,26,28,31H,9-10,13-21H2,1-4H3/t26-,28-,31-,32-,33+,34-/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173471
PNG
(US9096606, 8)
Show SMILES COc1ccc(COC[C@H]2C[C@]34CC[C@]2(OC)[C@@H]2Oc5c6c(C[C@H]3[N](C)(CC3CC3)CC[C@@]426)ccc5OC)cc1 |r,TLB:8:9:32.17:13.12|
Show InChI InChI=1S/C34H44NO5/c1-35(19-22-5-6-22)16-15-33-29-24-9-12-27(37-3)30(29)40-31(33)34(38-4)14-13-32(33,28(35)17-24)18-25(34)21-39-20-23-7-10-26(36-2)11-8-23/h7-12,22,25,28,31H,5-6,13-21H2,1-4H3/t25-,28-,31-,32-,33+,34-/m1/s1
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>2.00E+4n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173486
PNG
(US9096606, 23)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N+]3(C)CC1CC1)[C@@H](COCc1ccc(cc1)C(C)(F)F)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H44F2NO4/c1-32(36,37)25-10-7-23(8-11-25)20-41-21-26-18-33-13-14-35(26,40-4)31-34(33)15-16-38(2,19-22-5-6-22)28(33)17-24-9-12-27(39-3)30(42-31)29(24)34/h7-12,22,26,28,31H,5-6,13-21H2,1-4H3/q+1/t26-,28-,31-,33-,34+,35-,38?/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173465
PNG
(US9096606, 2)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1cc2OCOc2cc1Cl)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C34H41ClNO6/c1-36(16-20-4-5-20)11-10-33-29-21-6-7-25(37-2)30(29)42-31(33)34(38-3)9-8-32(33,28(36)13-21)15-23(34)18-39-17-22-12-26-27(14-24(22)35)41-19-40-26/h6-7,12,14,20,23,28,31H,4-5,8-11,13,15-19H2,1-3H3/t23-,28-,31-,32-,33+,34-/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173464
PNG
(US9096606, 1)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N]3(C)CC1CC1)[C@@H](COCc1ccc(Cl)c(Cl)c1)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C33H40Cl2NO4/c1-36(17-20-4-5-20)13-12-32-28-22-7-9-26(37-2)29(28)40-30(32)33(38-3)11-10-31(32,27(36)15-22)16-23(33)19-39-18-21-6-8-24(34)25(35)14-21/h6-9,14,20,23,27,30H,4-5,10-13,15-19H2,1-3H3/t23-,27-,30-,31-,32+,33-/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173467
PNG
(US9096606, 4)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(F)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45 |r,TLB:8:7:28.27:3.4|
Show InChI InChI=1S/C32H39FNO4/c1-34(17-20-3-4-20)14-13-31-27-22-7-10-25(35)28(27)38-29(31)32(36-2)12-11-30(31,26(34)15-22)16-23(32)19-37-18-21-5-8-24(33)9-6-21/h5-10,20,23,26,29,35H,3-4,11-19H2,1-2H3/t23-,26-,29-,30-,31+,32-/m1/s1
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>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM173486
PNG
(US9096606, 23)
Show SMILES COc1ccc2C[C@@H]3[C@]45CC[C@](OC)([C@@H]6Oc1c2[C@]46CC[N+]3(C)CC1CC1)[C@@H](COCc1ccc(cc1)C(C)(F)F)C5 |r,TLB:28:27:18.14:10.9|
Show InChI InChI=1S/C35H44F2NO4/c1-32(36,37)25-10-7-23(8-11-25)20-41-21-26-18-33-13-14-35(26,40-4)31-34(33)15-16-38(2,19-22-5-6-22)28(33)17-24-9-12-27(39-3)30(42-31)29(24)34/h7-12,22,26,28,31H,5-6,13-21H2,1-4H3/q+1/t26-,28-,31-,33-,34+,35-,38?/m1/s1
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US Patent
>2.00E+4n/an/an/an/an/an/a7.4n/a



Purdue Pharma, L.P.

US Patent


Assay Description
δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))		BDBM173471
PNG
(US9096606, 8)
Show SMILES COc1ccc(COC[C@H]2C[C@]34CC[C@]2(OC)[C@@H]2Oc5c6c(C[C@H]3[N](C)(CC3CC3)CC[C@@]426)ccc5OC)cc1 |r,TLB:8:9:32.17:13.12|
Show InChI InChI=1S/C34H44NO5/c1-35(19-22-5-6-22)16-15-33-29-24-9-12-27(37-3)30(29)40-31(33)34(38-4)14-13-32(33,28(35)17-24)18-25(34)21-39-20-23-7-10-26(36-2)11-8-23/h7-12,22,25,28,31H,5-6,13-21H2,1-4H3/t25-,28-,31-,32-,33+,34-/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
>2.00E+4>-24.9n/an/an/an/an/a7.44



Purdue Pharma, L.P.

US Patent


Assay Description
Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l...

US Patent US9096606 (2015)


BindingDB Entry DOI: 10.7270/Q2J101XF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%