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Patent code US9102637

Compile Data Set for Download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174187
PNG
(US9102637, 222)
Show SMILES NC1CCN(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)CC1
Show InChI InChI=1S/C27H28N6O2S/c28-21-11-13-33(14-12-21)16-17-5-7-19(8-6-17)25(35)32-26-23(24(29)34)31-27(36-26)30-22-10-9-18-3-1-2-4-20(18)15-22/h1-10,15,21H,11-14,16,28H2,(H2,29,34)(H,30,31)(H,32,35)
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US Patent
n/an/a 1.30n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174104
PNG
(US9102637, 139)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-c1sc(-[#7]-c2ccc3cc(-[#6]-[#8])ccc3c2)nc1-[#6](-[#7])=O
Show InChI InChI=1S/C20H20N4O3S/c1-11(2)7-16(26)23-19-17(18(21)27)24-20(28-19)22-15-6-5-13-8-12(10-25)3-4-14(13)9-15/h3-9,25H,10H2,1-2H3,(H2,21,27)(H,22,24)(H,23,26)
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US Patent
n/an/a 1.60n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174202
PNG
(US9102637, 237)
Show SMILES Cc1nccn1Cc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C26H22N6O2S/c1-16-28-12-13-32(16)15-17-6-8-19(9-7-17)24(34)31-25-22(23(27)33)30-26(35-25)29-21-11-10-18-4-2-3-5-20(18)14-21/h2-14H,15H2,1H3,(H2,27,33)(H,29,30)(H,31,34)
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n/an/a 2.30n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174160
PNG
(US9102637, 195)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cncn2)cc1
Show InChI InChI=1S/C24H19N7O2S/c25-21(32)20-23(30-22(33)17-7-5-15(6-8-17)12-31-14-26-13-27-31)34-24(29-20)28-19-10-9-16-3-1-2-4-18(16)11-19/h1-11,13-14H,12H2,(H2,25,32)(H,28,29)(H,30,33)
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n/an/a 2.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174186
PNG
(US9102637, 221)
Show SMILES CN(C)[C@H]1CCN(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)C1 |r|
Show InChI InChI=1S/C28H30N6O2S/c1-33(2)23-13-14-34(17-23)16-18-7-9-20(10-8-18)26(36)32-27-24(25(29)35)31-28(37-27)30-22-12-11-19-5-3-4-6-21(19)15-22/h3-12,15,23H,13-14,16-17H2,1-2H3,(H2,29,35)(H,30,31)(H,32,36)/t23-/m0/s1
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n/an/a 2.60n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174150
PNG
(US9102637, 185)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCN(CCO)CC2)cc1
Show InChI InChI=1S/C28H30N6O3S/c29-25(36)24-27(38-28(31-24)30-23-10-9-20-3-1-2-4-22(20)17-23)32-26(37)21-7-5-19(6-8-21)18-34-13-11-33(12-14-34)15-16-35/h1-10,17,35H,11-16,18H2,(H2,29,36)(H,30,31)(H,32,37)
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n/an/a 2.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174196
PNG
(US9102637, 231)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cc2nn[nH]n2)cc1
Show InChI InChI=1S/C23H18N8O2S/c24-20(32)19-22(27-21(33)15-7-5-13(6-8-15)11-18-28-30-31-29-18)34-23(26-19)25-17-10-9-14-3-1-2-4-16(14)12-17/h1-10,12H,11H2,(H2,24,32)(H,25,26)(H,27,33)(H,28,29,30,31)
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n/an/a 2.90n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174173
PNG
(US9102637, 208)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C25H20N6O2S/c26-22(32)21-24(30-23(33)18-7-5-16(6-8-18)14-31-12-11-27-15-31)34-25(29-21)28-20-10-9-17-3-1-2-4-19(17)13-20/h1-13,15H,14H2,(H2,26,32)(H,28,29)(H,30,33)
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n/an/a 3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174215
PNG
(US9102637, 250)
Show SMILES NC(=O)c1nc(Nc2ccc3ncccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C24H19N7O2S/c25-21(32)20-23(30-22(33)16-5-3-15(4-6-16)13-31-11-10-26-14-31)34-24(29-20)28-18-7-8-19-17(12-18)2-1-9-27-19/h1-12,14H,13H2,(H2,25,32)(H,28,29)(H,30,33)
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n/an/a 3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174185
PNG
(US9102637, 220)
Show SMILES N[C@H]1CCN(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)C1 |r|
Show InChI InChI=1S/C26H26N6O2S/c27-20-11-12-32(15-20)14-16-5-7-18(8-6-16)24(34)31-25-22(23(28)33)30-26(35-25)29-21-10-9-17-3-1-2-4-19(17)13-21/h1-10,13,20H,11-12,14-15,27H2,(H2,28,33)(H,29,30)(H,31,34)/t20-/m0/s1
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n/an/a 3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174203
PNG
(US9102637, 238)
Show SMILES Cc1cn(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)cn1
Show InChI InChI=1S/C26H22N6O2S/c1-16-13-32(15-28-16)14-17-6-8-19(9-7-17)24(34)31-25-22(23(27)33)30-26(35-25)29-21-11-10-18-4-2-3-5-20(18)12-21/h2-13,15H,14H2,1H3,(H2,27,33)(H,29,30)(H,31,34)
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n/an/a 3.10n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174155
PNG
(US9102637, 190)
Show SMILES CN1CCCN(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)CC1
Show InChI InChI=1S/C28H30N6O2S/c1-33-13-4-14-34(16-15-33)18-19-7-9-21(10-8-19)26(36)32-27-24(25(29)35)31-28(37-27)30-23-12-11-20-5-2-3-6-22(20)17-23/h2-3,5-12,17H,4,13-16,18H2,1H3,(H2,29,35)(H,30,31)(H,32,36)
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n/an/a 3.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174138
PNG
(US9102637, 173)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCC(O)CC2)cc1
Show InChI InChI=1S/C27H27N5O3S/c28-24(34)23-26(36-27(30-23)29-21-10-9-18-3-1-2-4-20(18)15-21)31-25(35)19-7-5-17(6-8-19)16-32-13-11-22(33)12-14-32/h1-10,15,22,33H,11-14,16H2,(H2,28,34)(H,29,30)(H,31,35)
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n/an/a 3.40n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174211
PNG
(US9102637, 246)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc(CO)c2)cc1
Show InChI InChI=1S/C26H22N6O3S/c27-23(34)22-25(36-26(30-22)29-20-10-9-17-3-1-2-4-19(17)11-20)31-24(35)18-7-5-16(6-8-18)12-32-13-21(14-33)28-15-32/h1-11,13,15,33H,12,14H2,(H2,27,34)(H,29,30)(H,31,35)
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n/an/a 3.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174128
PNG
(US9102637, 163)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CNCCO)cc1
Show InChI InChI=1S/C24H23N5O3S/c25-21(31)20-23(29-22(32)17-7-5-15(6-8-17)14-26-11-12-30)33-24(28-20)27-19-10-9-16-3-1-2-4-18(16)13-19/h1-10,13,26,30H,11-12,14H2,(H2,25,31)(H,27,28)(H,29,32)
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US Patent
n/an/a 3.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174190
PNG
(US9102637, 225)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCO
Show InChI InChI=1S/C19H16N4O3S/c20-17(26)16-18(22-15(25)7-3-4-10-24)27-19(23-16)21-14-9-8-12-5-1-2-6-13(12)11-14/h1-2,5-6,8-9,11,24H,4,10H2,(H2,20,26)(H,21,23)(H,22,25)
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n/an/a 4n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173989
PNG
(US9102637, 24)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ncccc3c2)nc1C(N)=O
Show InChI InChI=1S/C25H25N7O2S/c1-31-11-13-32(14-12-31)19-7-4-16(5-8-19)23(34)30-24-21(22(26)33)29-25(35-24)28-18-6-9-20-17(15-18)3-2-10-27-20/h2-10,15H,11-14H2,1H3,(H2,26,33)(H,28,29)(H,30,34)
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n/an/a 4.10n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174145
PNG
(US9102637, 180)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCNC(=O)C2)cc1
Show InChI InChI=1S/C26H24N6O3S/c27-23(34)22-25(36-26(30-22)29-20-10-9-17-3-1-2-4-19(17)13-20)31-24(35)18-7-5-16(6-8-18)14-32-12-11-28-21(33)15-32/h1-10,13H,11-12,14-15H2,(H2,27,34)(H,28,33)(H,29,30)(H,31,35)
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n/an/a 4.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174130
PNG
(US9102637, 165)
Show SMILES CC#CC(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C18H14N4O2S/c1-2-5-14(23)21-17-15(16(19)24)22-18(25-17)20-13-9-8-11-6-3-4-7-12(11)10-13/h3-4,6-10H,1H3,(H2,19,24)(H,20,22)(H,21,23)
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US Patent
n/an/a 4.40n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174183
PNG
(US9102637, 218)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCO
Show InChI InChI=1S/C18H14N4O3S/c19-16(25)15-17(21-14(24)6-3-9-23)26-18(22-15)20-13-8-7-11-4-1-2-5-12(11)10-13/h1-2,4-5,7-8,10,23H,9H2,(H2,19,25)(H,20,22)(H,21,24)
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n/an/a 4.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174219
PNG
(US9102637, 254)
Show SMILES NC(=O)c1nc(Nc2cccc3ncccc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C24H19N7O2S/c25-21(32)20-23(30-22(33)16-8-6-15(7-9-16)13-31-12-11-26-14-31)34-24(29-20)28-19-5-1-4-18-17(19)3-2-10-27-18/h1-12,14H,13H2,(H2,25,32)(H,28,29)(H,30,33)
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n/an/a 4.80n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174168
PNG
(US9102637, 203)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC[C@H](O)C2)cc1 |r|
Show InChI InChI=1S/C26H25N5O3S/c27-23(33)22-25(35-26(29-22)28-20-10-9-17-3-1-2-4-19(17)13-20)30-24(34)18-7-5-16(6-8-18)14-31-12-11-21(32)15-31/h1-10,13,21,32H,11-12,14-15H2,(H2,27,33)(H,28,29)(H,30,34)/t21-/m0/s1
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n/an/a 5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173982
PNG
(US9102637, 17)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)CC1
Show InChI InChI=1S/C27H28N6O2S/c1-32-12-14-33(15-13-32)17-18-6-8-20(9-7-18)25(35)31-26-23(24(28)34)30-27(36-26)29-22-11-10-19-4-2-3-5-21(19)16-22/h2-11,16H,12-15,17H2,1H3,(H2,28,34)(H,29,30)(H,31,35)
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n/an/a 5.10n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174225
PNG
(US9102637, 260)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cc(CO)nn2)cc1
Show InChI InChI=1S/C25H21N7O3S/c26-22(34)21-24(36-25(28-21)27-19-10-9-16-3-1-2-4-18(16)11-19)29-23(35)17-7-5-15(6-8-17)12-32-13-20(14-33)30-31-32/h1-11,13,33H,12,14H2,(H2,26,34)(H,27,28)(H,29,35)
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n/an/a 5.30n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173988
PNG
(US9102637, 23)
Show SMILES NCc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C22H19N5O2S/c23-12-13-5-7-15(8-6-13)20(29)27-21-18(19(24)28)26-22(30-21)25-17-10-9-14-3-1-2-4-16(14)11-17/h1-11H,12,23H2,(H2,24,28)(H,25,26)(H,27,29)
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n/an/a 5.30n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174035
PNG
(US9102637, 70)
Show SMILES NC(=O)c1nc(Nc2ccc3cc(CO)ccc3c2)sc1NC(=O)c1ccsc1
Show InChI InChI=1S/C20H16N4O3S2/c21-17(26)16-19(24-18(27)14-5-6-28-10-14)29-20(23-16)22-15-4-3-12-7-11(9-25)1-2-13(12)8-15/h1-8,10,25H,9H2,(H2,21,26)(H,22,23)(H,24,27)
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n/an/a 5.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174224
PNG
(US9102637, 259)
Show SMILES NC(=O)c1nc(Nc2cccc3cccnc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C24H19N7O2S/c25-21(32)20-23(30-22(33)17-8-6-15(7-9-17)13-31-12-11-26-14-31)34-24(29-20)28-18-5-1-3-16-4-2-10-27-19(16)18/h1-12,14H,13H2,(H2,25,32)(H,28,29)(H,30,33)
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n/an/a 5.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174167
PNG
(US9102637, 202)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC[C@@H](O)C2)cc1 |r|
Show InChI InChI=1S/C26H25N5O3S/c27-23(33)22-25(35-26(29-22)28-20-10-9-17-3-1-2-4-19(17)13-20)30-24(34)18-7-5-16(6-8-18)14-31-12-11-21(32)15-31/h1-10,13,21,32H,11-12,14-15H2,(H2,27,33)(H,28,29)(H,30,34)/t21-/m1/s1
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n/an/a 5.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174166
PNG
(US9102637, 201)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CC(O)C2)cc1
Show InChI InChI=1S/C25H23N5O3S/c26-22(32)21-24(29-23(33)17-7-5-15(6-8-17)12-30-13-20(31)14-30)34-25(28-21)27-19-10-9-16-3-1-2-4-18(16)11-19/h1-11,20,31H,12-14H2,(H2,26,32)(H,27,28)(H,29,33)
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n/an/a 5.60n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174016
PNG
(US9102637, 51)
Show SMILES CN(c1nc(C(N)=O)c(NC(=O)c2csc(CN3CCOCC3)c2)s1)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H24N6O3S2/c1-29(17-4-5-19-15(11-17)3-2-6-26-19)24-27-20(21(25)31)23(35-24)28-22(32)16-12-18(34-14-16)13-30-7-9-33-10-8-30/h2-6,11-12,14H,7-10,13H2,1H3,(H2,25,31)(H,28,32)
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n/an/a 5.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174103
PNG
(US9102637, 138)
Show SMILES NC(=O)c1nc(Nc2ccc3cc(CO)ccc3c2)sc1NC(=O)C1CC1
Show InChI InChI=1S/C19H18N4O3S/c20-16(25)15-18(23-17(26)11-3-4-11)27-19(22-15)21-14-6-5-12-7-10(9-24)1-2-13(12)8-14/h1-2,5-8,11,24H,3-4,9H2,(H2,20,25)(H,21,22)(H,23,26)
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n/an/a 5.80n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174081
PNG
(US9102637, 116)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CCO)cc1
Show InChI InChI=1S/C23H20N4O3S/c24-20(29)19-22(27-21(30)16-7-5-14(6-8-16)11-12-28)31-23(26-19)25-18-10-9-15-3-1-2-4-17(15)13-18/h1-10,13,28H,11-12H2,(H2,24,29)(H,25,26)(H,27,30)
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n/an/a 5.80n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174170
PNG
(US9102637, 205)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnnn2)cc1
Show InChI InChI=1S/C23H18N8O2S/c24-20(32)19-22(28-21(33)16-7-5-14(6-8-16)12-31-13-25-29-30-31)34-23(27-19)26-18-10-9-15-3-1-2-4-17(15)11-18/h1-11,13H,12H2,(H2,24,32)(H,26,27)(H,28,33)
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n/an/a 5.90n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174204
PNG
(US9102637, 239)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C25H19N7O4S/c26-22(33)21-24(37-25(29-21)28-19-10-9-16-3-1-2-4-18(16)11-19)30-23(34)17-7-5-15(6-8-17)12-31-13-20(27-14-31)32(35)36/h1-11,13-14H,12H2,(H2,26,33)(H,28,29)(H,30,34)
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n/an/a 5.90n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174169
PNG
(US9102637, 204)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#C
Show InChI InChI=1S/C17H12N4O2S/c1-2-13(22)20-16-14(15(18)23)21-17(24-16)19-12-8-7-10-5-3-4-6-11(10)9-12/h1,3-9H,(H2,18,23)(H,19,21)(H,20,22)
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n/an/a 6n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174213
PNG
(US9102637, 248)
Show SMILES COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(Cn5ccnc5)cc4)s3)ccc2c1
Show InChI InChI=1S/C26H22N6O3S/c1-35-21-9-7-18-12-20(8-6-19(18)13-21)29-26-30-22(23(27)33)25(36-26)31-24(34)17-4-2-16(3-5-17)14-32-11-10-28-15-32/h2-13,15H,14H2,1H3,(H2,27,33)(H,29,30)(H,31,34)
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n/an/a 6.10n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174222
PNG
(US9102637, 257)
Show SMILES Cc1nnc(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)o1
Show InChI InChI=1S/C25H20N6O3S/c1-14-30-31-20(34-14)12-15-6-8-17(9-7-15)23(33)29-24-21(22(26)32)28-25(35-24)27-19-11-10-16-4-2-3-5-18(16)13-19/h2-11,13H,12H2,1H3,(H2,26,32)(H,27,28)(H,29,33)
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n/an/a 6.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174154
PNG
(US9102637, 189)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCCCC2CO)cc1
Show InChI InChI=1S/C28H29N5O3S/c29-25(35)24-27(37-28(31-24)30-22-13-12-19-5-1-2-6-21(19)15-22)32-26(36)20-10-8-18(9-11-20)16-33-14-4-3-7-23(33)17-34/h1-2,5-6,8-13,15,23,34H,3-4,7,14,16-17H2,(H2,29,35)(H,30,31)(H,32,36)
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n/an/a 6.80n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174209
PNG
(US9102637, 244)
Show SMILES Cc1nnnn1Cc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C24H20N8O2S/c1-14-29-30-31-32(14)13-15-6-8-17(9-7-15)22(34)28-23-20(21(25)33)27-24(35-23)26-19-11-10-16-4-2-3-5-18(16)12-19/h2-12H,13H2,1H3,(H2,25,33)(H,26,27)(H,28,34)
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n/an/a 7.10n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174093
PNG
(US9102637, 128)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-c1sc(-[#7]-c2ccc3ccc(F)cc3c2)nc1-[#6](-[#7])=O
Show InChI InChI=1S/C19H17FN4O2S/c1-10(2)7-15(25)23-18-16(17(21)26)24-19(27-18)22-14-6-4-11-3-5-13(20)8-12(11)9-14/h3-9H,1-2H3,(H2,21,26)(H,22,24)(H,23,25)
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n/an/a 7.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174152
PNG
(US9102637, 187)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(cc1)N1CCN(CCO)CC1
Show InChI InChI=1S/C27H28N6O3S/c28-24(35)23-26(37-27(30-23)29-21-8-5-18-3-1-2-4-20(18)17-21)31-25(36)19-6-9-22(10-7-19)33-13-11-32(12-14-33)15-16-34/h1-10,17,34H,11-16H2,(H2,28,35)(H,29,30)(H,31,36)
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n/an/a 7.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173998
PNG
(US9102637, 33)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc[nH]1
Show InChI InChI=1S/C19H15N5O2S/c20-16(25)15-18(24-17(26)14-6-3-9-21-14)27-19(23-15)22-13-8-7-11-4-1-2-5-12(11)10-13/h1-10,21H,(H2,20,25)(H,22,23)(H,24,26)
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n/an/a 7.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174216
PNG
(US9102637, 251)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)s1
Show InChI InChI=1S/C23H18N6O2S2/c24-20(30)19-22(28-21(31)18-8-7-17(32-18)12-29-10-9-25-13-29)33-23(27-19)26-16-6-5-14-3-1-2-4-15(14)11-16/h1-11,13H,12H2,(H2,24,30)(H,26,27)(H,28,31)
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n/an/a 7.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173978
PNG
(US9102637, 13)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCN2CCCCC2)cc1
Show InChI InChI=1S/C28H30N6O2S/c29-25(35)24-27(37-28(32-24)31-23-13-8-19-6-2-3-7-21(19)18-23)33-26(36)20-9-11-22(12-10-20)30-14-17-34-15-4-1-5-16-34/h2-3,6-13,18,30H,1,4-5,14-17H2,(H2,29,35)(H,31,32)(H,33,36)
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n/an/a 8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174021
PNG
(US9102637, 56)
Show SMILES CN1CCN(Cc2cc(cs2)C(=O)Nc2sc(Nc3cccc4ncccc34)nc2C(N)=O)CC1
Show InChI InChI=1S/C24H25N7O2S2/c1-30-8-10-31(11-9-30)13-16-12-15(14-34-16)22(33)29-23-20(21(25)32)28-24(35-23)27-19-6-2-5-18-17(19)4-3-7-26-18/h2-7,12,14H,8-11,13H2,1H3,(H2,25,32)(H,27,28)(H,29,33)
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n/an/a 8.20n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174153
PNG
(US9102637, 188)
Show SMILES NCCNc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C23H22N6O2S/c24-11-12-26-17-8-6-15(7-9-17)21(31)29-22-19(20(25)30)28-23(32-22)27-18-10-5-14-3-1-2-4-16(14)13-18/h1-10,13,26H,11-12,24H2,(H2,25,30)(H,27,28)(H,29,31)
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n/an/a 8.40n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174227
PNG
(US9102637, 262)
Show SMILES NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C25H19FN6O2S/c26-19-7-5-16-6-8-20(12-18(16)11-19)29-25-30-21(22(27)33)24(35-25)31-23(34)17-3-1-15(2-4-17)13-32-10-9-28-14-32/h1-12,14H,13H2,(H2,27,33)(H,29,30)(H,31,34)
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n/an/a 8.40n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173983
PNG
(US9102637, 18)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C26H25N5O3S/c27-23(32)22-25(35-26(29-22)28-21-10-9-18-3-1-2-4-20(18)15-21)30-24(33)19-7-5-17(6-8-19)16-31-11-13-34-14-12-31/h1-10,15H,11-14,16H2,(H2,27,32)(H,28,29)(H,30,33)
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n/an/a 8.60n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173976
PNG
(US9102637, 11)
Show SMILES CN(C)CCNc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C25H26N6O2S/c1-31(2)14-13-27-19-10-8-17(9-11-19)23(33)30-24-21(22(26)32)29-25(34-24)28-20-12-7-16-5-3-4-6-18(16)15-20/h3-12,15,27H,13-14H2,1-2H3,(H2,26,32)(H,28,29)(H,30,33)
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n/an/a 8.60n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174223
PNG
(US9102637, 258)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1csc(Cn2ccnc2)c1
Show InChI InChI=1S/C23H18N6O2S2/c24-20(30)19-22(28-21(31)16-10-18(32-12-16)11-29-8-7-25-13-29)33-23(27-19)26-17-6-5-14-3-1-2-4-15(14)9-17/h1-10,12-13H,11H2,(H2,24,30)(H,26,27)(H,28,31)
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n/an/a 8.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174005
PNG
(US9102637, 40)
Show SMILES NC(=O)c1nc(Nc2cccc3ncccc23)sc1NC(=O)c1ccsc1
Show InChI InChI=1S/C18H13N5O2S2/c19-15(24)14-17(23-16(25)10-6-8-26-9-10)27-18(22-14)21-13-5-1-4-12-11(13)3-2-7-20-12/h1-9H,(H2,19,24)(H,21,22)(H,23,25)
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n/an/a 9.40n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174200
PNG
(US9102637, 235)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2[N+]([O-])=O)cc1
Show InChI InChI=1S/C25H19N7O4S/c26-21(33)20-23(37-24(29-20)28-19-10-9-16-3-1-2-4-18(16)13-19)30-22(34)17-7-5-15(6-8-17)14-31-12-11-27-25(31)32(35)36/h1-13H,14H2,(H2,26,33)(H,28,29)(H,30,34)
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n/an/a 9.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174101
PNG
(US9102637, 136)
Show SMILES COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(N)cc4)s3)ccc2c1
Show InChI InChI=1S/C22H19N5O3S/c1-30-17-9-5-13-10-16(8-4-14(13)11-17)25-22-26-18(19(24)28)21(31-22)27-20(29)12-2-6-15(23)7-3-12/h2-11H,23H2,1H3,(H2,24,28)(H,25,26)(H,27,29)
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n/an/a 9.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174199
PNG
(US9102637, 234)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCCn1ccnc1
Show InChI InChI=1S/C23H20N6O2S/c24-21(31)20-22(27-19(30)8-2-1-5-12-29-13-11-25-15-29)32-23(28-20)26-18-10-9-16-6-3-4-7-17(16)14-18/h3-4,6-7,9-11,13-15H,1,5,12H2,(H2,24,31)(H,26,28)(H,27,30)
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n/an/a 9.70n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174214
PNG
(US9102637, 249)
Show SMILES NC(=O)c1nc(Nc2ccc3cc(F)ccc3c2)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C25H19FN6O2S/c26-19-7-5-18-12-20(8-6-17(18)11-19)29-25-30-21(22(27)33)24(35-25)31-23(34)16-3-1-15(2-4-16)13-32-10-9-28-14-32/h1-12,14H,13H2,(H2,27,33)(H,29,30)(H,31,34)
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n/an/a 10.1n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173977
PNG
(US9102637, 12)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C26H26N6O2S/c1-31-12-14-32(15-13-31)21-10-7-18(8-11-21)24(34)30-25-22(23(27)33)29-26(35-25)28-20-9-6-17-4-2-3-5-19(17)16-20/h2-11,16H,12-15H2,1H3,(H2,27,33)(H,28,29)(H,30,34)
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n/an/a 10.2n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174197
PNG
(US9102637, 232)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cccn2)cc1
Show InChI InChI=1S/C25H20N6O2S/c26-22(32)21-24(30-23(33)18-8-6-16(7-9-18)15-31-13-3-12-27-31)34-25(29-21)28-20-11-10-17-4-1-2-5-19(17)14-20/h1-14H,15H2,(H2,26,32)(H,28,29)(H,30,33)
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n/an/a 10.3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173975
PNG
(US9102637, 10)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCO)cc1
Show InChI InChI=1S/C23H21N5O3S/c24-20(30)19-22(28-21(31)15-6-8-17(9-7-15)25-11-12-29)32-23(27-19)26-18-10-5-14-3-1-2-4-16(14)13-18/h1-10,13,25,29H,11-12H2,(H2,24,30)(H,26,27)(H,28,31)
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n/an/a 10.6n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174198
PNG
(US9102637, 233)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C#CCCCn1cncn1
Show InChI InChI=1S/C22H19N7O2S/c23-20(31)19-21(27-18(30)8-2-1-5-11-29-14-24-13-25-29)32-22(28-19)26-17-10-9-15-6-3-4-7-16(15)12-17/h3-4,6-7,9-10,12-14H,1,5,11H2,(H2,23,31)(H,26,28)(H,27,30)
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n/an/a 10.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173995
PNG
(US9102637, 30)
Show SMILES CC(O)CNc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C24H23N5O3S/c1-14(30)13-26-18-9-7-16(8-10-18)22(32)29-23-20(21(25)31)28-24(33-23)27-19-11-6-15-4-2-3-5-17(15)12-19/h2-12,14,26,30H,13H2,1H3,(H2,25,31)(H,27,28)(H,29,32)
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n/an/a 10.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174116
PNG
(US9102637, 151)
Show SMILES Cc1ccc(s1)C(=O)Nc1sc(Nc2ccc3cc(CO)ccc3c2)nc1C(N)=O
Show InChI InChI=1S/C21H18N4O3S2/c1-11-2-7-16(29-11)19(28)25-20-17(18(22)27)24-21(30-20)23-15-6-5-13-8-12(10-26)3-4-14(13)9-15/h2-9,26H,10H2,1H3,(H2,22,27)(H,23,24)(H,25,28)
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n/an/a 11.1n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174011
PNG
(US9102637, 46)
Show SMILES NC(=O)c1nc(Nc2ccc3cnccc3c2)sc1NC(=O)c1ccsc1
Show InChI InChI=1S/C18H13N5O2S2/c19-15(24)14-17(23-16(25)12-4-6-26-9-12)27-18(22-14)21-13-2-1-11-8-20-5-3-10(11)7-13/h1-9H,(H2,19,24)(H,21,22)(H,23,25)
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n/an/a 12n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174048
PNG
(US9102637, 83)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-c1sc(-[#7]-c2ccc3ccccc3c2)nc1-[#6](-[#7])=O
Show InChI InChI=1S/C19H18N4O2S/c1-11(2)9-15(24)22-18-16(17(20)25)23-19(26-18)21-14-8-7-12-5-3-4-6-13(12)10-14/h3-10H,1-2H3,(H2,20,25)(H,21,23)(H,22,24)
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n/an/a 12.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174062
PNG
(US9102637, 97)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(cc1)N1CCC(O)CC1
Show InChI InChI=1S/C26H25N5O3S/c27-23(33)22-25(35-26(29-22)28-19-8-5-16-3-1-2-4-18(16)15-19)30-24(34)17-6-9-20(10-7-17)31-13-11-21(32)12-14-31/h1-10,15,21,32H,11-14H2,(H2,27,33)(H,28,29)(H,30,34)
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n/an/a 12.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174087
PNG
(US9102637, 122)
Show SMILES NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)C1CC1
Show InChI InChI=1S/C18H15FN4O2S/c19-12-5-3-9-4-6-13(8-11(9)7-12)21-18-22-14(15(20)24)17(26-18)23-16(25)10-1-2-10/h3-8,10H,1-2H2,(H2,20,24)(H,21,22)(H,23,25)
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n/an/a 12.8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174089
PNG
(US9102637, 124)
Show SMILES NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccc(NCCO)cc1
Show InChI InChI=1S/C23H20FN5O3S/c24-16-5-1-13-2-8-18(12-15(13)11-16)27-23-28-19(20(25)31)22(33-23)29-21(32)14-3-6-17(7-4-14)26-9-10-30/h1-8,11-12,26,30H,9-10H2,(H2,25,31)(H,27,28)(H,29,32)
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n/an/a 12.9n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174208
PNG
(US9102637, 243)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(Cn2cnc(n2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C24H18N8O4S/c25-20(33)19-22(37-24(28-19)27-18-10-9-15-3-1-2-4-17(15)11-18)29-21(34)16-7-5-14(6-8-16)12-31-13-26-23(30-31)32(35)36/h1-11,13H,12H2,(H2,25,33)(H,27,28)(H,29,34)
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n/an/a 14.8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174078
PNG
(US9102637, 113)
Show SMILES COc1ccc2cc(Nc3nc(C(N)=O)c(NC(=O)c4ccc(NCCO)cc4)s3)ccc2c1
Show InChI InChI=1S/C24H23N5O4S/c1-33-19-9-5-15-12-18(8-4-16(15)13-19)27-24-28-20(21(25)31)23(34-24)29-22(32)14-2-6-17(7-3-14)26-10-11-30/h2-9,12-13,26,30H,10-11H2,1H3,(H2,25,31)(H,27,28)(H,29,32)
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n/an/a 14.8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174058
PNG
(US9102637, 93)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)C1CC1
Show InChI InChI=1S/C18H16N4O2S/c19-15(23)14-17(22-16(24)11-5-6-11)25-18(21-14)20-13-8-7-10-3-1-2-4-12(10)9-13/h1-4,7-9,11H,5-6H2,(H2,19,23)(H,20,21)(H,22,24)
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n/an/a 15n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174111
PNG
(US9102637, 146)
Show SMILES C[C@H](O)CNc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O |r|
Show InChI InChI=1S/C24H23N5O3S/c1-14(30)13-26-18-9-7-16(8-10-18)22(32)29-23-20(21(25)31)28-24(33-23)27-19-11-6-15-4-2-3-5-17(15)12-19/h2-12,14,26,30H,13H2,1H3,(H2,25,31)(H,27,28)(H,29,32)/t14-/m0/s1
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n/an/a 15.1n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174102
PNG
(US9102637, 137)
Show SMILES [#6]-[#8]-c1ccc2cc(-[#7]-c3nc(-[#6](-[#7])=O)c(-[#7]-[#6](=O)\[#6]=[#6](\[#6])-[#6])s3)ccc2c1
Show InChI InChI=1S/C20H20N4O3S/c1-11(2)8-16(25)23-19-17(18(21)26)24-20(28-19)22-14-6-4-13-10-15(27-3)7-5-12(13)9-14/h4-10H,1-3H3,(H2,21,26)(H,22,24)(H,23,25)
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n/an/a 15.2n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173991
PNG
(US9102637, 26)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1sc(Nc2cccc3ncccc23)nc1C(N)=O
Show InChI InChI=1S/C25H25N7O2S/c1-31-12-14-32(15-13-31)17-9-7-16(8-10-17)23(34)30-24-21(22(26)33)29-25(35-24)28-20-6-2-5-19-18(20)4-3-11-27-19/h2-11H,12-15H2,1H3,(H2,26,33)(H,28,29)(H,30,34)
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n/an/a 15.6n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174217
PNG
(US9102637, 252)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(CN2C(=O)CSC2=O)cc1
Show InChI InChI=1S/C25H19N5O4S2/c26-21(32)20-23(36-24(28-20)27-18-10-9-15-3-1-2-4-17(15)11-18)29-22(33)16-7-5-14(6-8-16)12-30-19(31)13-35-25(30)34/h1-11H,12-13H2,(H2,26,32)(H,27,28)(H,29,33)
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n/an/a 15.9n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174139
PNG
(US9102637, 174)
Show SMILES CN1CCN(C\C=C\C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)CC1
Show InChI InChI=1S/C23H26N6O2S/c1-28-11-13-29(14-12-28)10-4-7-19(30)26-22-20(21(24)31)27-23(32-22)25-18-9-8-16-5-2-3-6-17(16)15-18/h2-9,15H,10-14H2,1H3,(H2,24,31)(H,25,27)(H,26,30)/b7-4+
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n/an/a 16n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174112
PNG
(US9102637, 147)
Show SMILES C[C@@H](O)CNc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O |r|
Show InChI InChI=1S/C24H23N5O3S/c1-14(30)13-26-18-9-7-16(8-10-18)22(32)29-23-20(21(25)31)28-24(33-23)27-19-11-6-15-4-2-3-5-17(15)12-19/h2-12,14,26,30H,13H2,1H3,(H2,25,31)(H,27,28)(H,29,32)/t14-/m1/s1
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n/an/a 16.8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174045
PNG
(US9102637, 80)
Show SMILES NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)c1ccsc1
Show InChI InChI=1S/C19H13FN4O2S2/c20-13-3-1-10-2-4-14(8-12(10)7-13)22-19-23-15(16(21)25)18(28-19)24-17(26)11-5-6-27-9-11/h1-9H,(H2,21,25)(H,22,23)(H,24,26)
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n/an/a 16.9n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173993
PNG
(US9102637, 28)
Show SMILES CN(c1nc(C(N)=O)c(NC(=O)c2ccc(cc2)N2CCN(C)CC2)s1)c1ccc2ncccc2c1
Show InChI InChI=1S/C26H27N7O2S/c1-31-12-14-33(15-13-31)19-7-5-17(6-8-19)24(35)30-25-22(23(27)34)29-26(36-25)32(2)20-9-10-21-18(16-20)4-3-11-28-21/h3-11,16H,12-15H2,1-2H3,(H2,27,34)(H,30,35)
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n/an/a 17n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174221
PNG
(US9102637, 256)
Show SMILES Cc1noc(Cc2ccc(cc2)C(=O)Nc2sc(Nc3ccc4ccccc4c3)nc2C(N)=O)n1
Show InChI InChI=1S/C25H20N6O3S/c1-14-27-20(34-31-14)12-15-6-8-17(9-7-15)23(33)30-24-21(22(26)32)29-25(35-24)28-19-11-10-16-4-2-3-5-18(16)13-19/h2-11,13H,12H2,1H3,(H2,26,32)(H,28,29)(H,30,33)
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n/an/a 18.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173992
PNG
(US9102637, 27)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1sc(Nc2cccc3cccnc23)nc1C(N)=O
Show InChI InChI=1S/C25H25N7O2S/c1-31-12-14-32(15-13-31)18-9-7-17(8-10-18)23(34)30-24-21(22(26)33)29-25(35-24)28-19-6-2-4-16-5-3-11-27-20(16)19/h2-11H,12-15H2,1H3,(H2,26,33)(H,28,29)(H,30,34)
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n/an/a 19.1n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174095
PNG
(US9102637, 130)
Show SMILES NC(=O)c1nc(Nc2ccc3ccc(F)cc3c2)sc1NC(=O)CCCCCN1CCOCC1
Show InChI InChI=1S/C24H28FN5O3S/c25-18-7-5-16-6-8-19(15-17(16)14-18)27-24-29-21(22(26)32)23(34-24)28-20(31)4-2-1-3-9-30-10-12-33-13-11-30/h5-8,14-15H,1-4,9-13H2,(H2,26,32)(H,27,29)(H,28,31)
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n/an/a 19.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173967
PNG
(US9102637, 2)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C23H19N5O3S/c1-13(29)25-17-9-7-15(8-10-17)21(31)28-22-19(20(24)30)27-23(32-22)26-18-11-6-14-4-2-3-5-16(14)12-18/h2-12H,1H3,(H2,24,30)(H,25,29)(H,26,27)(H,28,31)
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n/an/a 19.8n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174057
PNG
(US9102637, 92)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)CCCCCN1CCOCC1
Show InChI InChI=1S/C24H29N5O3S/c25-22(31)21-23(27-20(30)8-2-1-5-11-29-12-14-32-15-13-29)33-24(28-21)26-19-10-9-17-6-3-4-7-18(17)16-19/h3-4,6-7,9-10,16H,1-2,5,8,11-15H2,(H2,25,31)(H,26,28)(H,27,30)
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n/an/a 20.2n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173981
PNG
(US9102637, 16)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(N)cc1
Show InChI InChI=1S/C21H17N5O2S/c22-15-8-5-13(6-9-15)19(28)26-20-17(18(23)27)25-21(29-20)24-16-10-7-12-3-1-2-4-14(12)11-16/h1-11H,22H2,(H2,23,27)(H,24,25)(H,26,28)
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n/an/a 20.3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173969
PNG
(US9102637, 4)
Show SMILES COc1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ncccc3c2)nc1C(N)=O
Show InChI InChI=1S/C21H17N5O3S/c1-29-15-7-4-12(5-8-15)19(28)26-20-17(18(22)27)25-21(30-20)24-14-6-9-16-13(11-14)3-2-10-23-16/h2-11H,1H3,(H2,22,27)(H,24,25)(H,26,28)
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n/an/a 21.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174077
PNG
(US9102637, 112)
Show SMILES NC(=O)c1nc(Nc2ccc3cc(F)ccc3c2)sc1NC(=O)c1ccc(NCCO)cc1
Show InChI InChI=1S/C23H20FN5O3S/c24-16-5-1-15-12-18(8-4-14(15)11-16)27-23-28-19(20(25)31)22(33-23)29-21(32)13-2-6-17(7-3-13)26-9-10-30/h1-8,11-12,26,30H,9-10H2,(H2,25,31)(H,27,28)(H,29,32)
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n/an/a 22.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174000
PNG
(US9102637, 35)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1cc2sccc2[nH]1
Show InChI InChI=1S/C21H15N5O2S2/c22-18(27)17-20(26-19(28)15-10-16-14(24-15)7-8-29-16)30-21(25-17)23-13-6-5-11-3-1-2-4-12(11)9-13/h1-10,24H,(H2,22,27)(H,23,25)(H,26,28)
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n/an/a 22.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174086
PNG
(US9102637, 121)
Show SMILES NC(=O)c1nc(Nc2ccc3ccccc3c2)sc1NC(=O)c1ccc(NCCO)c(N)c1
Show InChI InChI=1S/C23H22N6O3S/c24-17-12-15(6-8-18(17)26-9-10-30)21(32)29-22-19(20(25)31)28-23(33-22)27-16-7-5-13-3-1-2-4-14(13)11-16/h1-8,11-12,26,30H,9-10,24H2,(H2,25,31)(H,27,28)(H,29,32)
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n/an/a 24.4n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173966
PNG
(US9102637, 1)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1sc(Nc2cccc3ccccc23)nc1C(N)=O
Show InChI InChI=1S/C23H19N5O3S/c1-13(29)25-16-11-9-15(10-12-16)21(31)28-22-19(20(24)30)27-23(32-22)26-18-8-4-6-14-5-2-3-7-17(14)18/h2-12H,1H3,(H2,24,30)(H,25,29)(H,26,27)(H,28,31)
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n/an/a 24.7n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174220
PNG
(US9102637, 255)
Show SMILES NC(=O)c1nc(Nc2ccnc3ccccc23)sc1NC(=O)c1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C24H19N7O2S/c25-21(32)20-23(30-22(33)16-7-5-15(6-8-16)13-31-12-11-26-14-31)34-24(29-20)28-19-9-10-27-18-4-2-1-3-17(18)19/h1-12,14H,13H2,(H2,25,32)(H,30,33)(H,27,28,29)
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n/an/a 26.5n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173974
PNG
(US9102637, 9)
Show SMILES Cc1ccc(cc1N)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C22H19N5O2S/c1-12-6-7-15(11-17(12)23)20(29)27-21-18(19(24)28)26-22(30-21)25-16-9-8-13-4-2-3-5-14(13)10-16/h2-11H,23H2,1H3,(H2,24,28)(H,25,26)(H,27,29)
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n/an/a 27.2n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM173994
PNG
(US9102637, 29)
Show SMILES CN(CCO)c1ccc(cc1)C(=O)Nc1sc(Nc2ccc3ccccc3c2)nc1C(N)=O
Show InChI InChI=1S/C24H23N5O3S/c1-29(12-13-30)19-10-7-16(8-11-19)22(32)28-23-20(21(25)31)27-24(33-23)26-18-9-6-15-4-2-3-5-17(15)14-18/h2-11,14,30H,12-13H2,1H3,(H2,25,31)(H,26,27)(H,28,32)
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n/an/a 27.4n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174030
PNG
(US9102637, 65)
Show SMILES CN(c1nc(C(N)=O)c(NC(=O)c2ccc(cc2)N2CCN(C)CC2)s1)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H28N6O2S/c1-31-13-15-33(16-14-31)21-10-8-19(9-11-21)25(35)30-26-23(24(28)34)29-27(36-26)32(2)22-12-7-18-5-3-4-6-20(18)17-22/h3-12,17H,13-16H2,1-2H3,(H2,28,34)(H,30,35)
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n/an/a 36.3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
TRAF2 and NCK-interacting protein kinase


(Homo sapiens (Human))
BDBM174039
PNG
(US9102637, 74)
Show SMILES COc1cc(Nc2nc(C(N)=O)c(NC(=O)c3ccsc3)s2)cc2ccccc12
Show InChI InChI=1S/C20H16N4O3S2/c1-27-15-9-13(8-11-4-2-3-5-14(11)15)22-20-23-16(17(21)25)19(29-20)24-18(26)12-6-7-28-10-12/h2-10H,1H3,(H2,21,25)(H,22,23)(H,24,26)
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n/an/a 51.3n/an/an/an/a7.525



CARNA BIOSCIENCES, INC.; NATIONAL CANCER CENTER

US Patent


Assay Description
The kinase assays were conducted in a 20 μl volume using 384-well plates (Greiner). The reaction mixture consists of compound or vehicle (1% DMS...


US Patent US9102637 (2015)


BindingDB Entry DOI: 10.7270/Q2KS6Q9T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%