Affinity Data by Patent

Patent code US9115082

Found 9 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-1 adrenergic receptor (Homo sapiens (Human))	BDBM175238 (US9115082, 7) Show SMILES OC(CNCC(=O)N1CCCC1C#N)COc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.83E+3	n/a	1.70E+4	n/a	n/a	n/a	n/a	7.4	n/a
TBA US Patent					Assay Description Human recombinant adrenergic β1 receptors expressed in CHO-K1 cells are used in modified Tris-HCl buffer pH 7.4. A 25 aliquot is incubated with ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM175238 (US9115082, 7) Show SMILES OC(CNCC(=O)N1CCCC1C#N)COc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20E+4	n/a	3.20E+4	n/a	n/a	n/a	n/a	7.4	n/a
TBA US Patent					Assay Description Human recombinant adrenergic β2 receptors expressed in CHO cells are used in modified Tris-HCl buffer pH 7.4. A 50 aliquot is incubated with 0.2...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM175238 (US9115082, 7) Show SMILES OC(CNCC(=O)N1CCCC1C#N)COc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50265160 (1-(2-amino-2-cyclohexylacetyl)pyrrolidine-2-carbon...) Show SMILES NC(C1CCCCC1)C(=O)N1CCCC1C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50118952 (2-Amino-3-methyl-1-pyrrolidin-1-yl-butan-1-one \| C...) Show SMILES CC(C)C(N)C(=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	548	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50135065 (2-Amino-3-methyl-1-pyrrolidin-1-yl-pentan-1-one \| ...) Show SMILES CCC(C)C(N)C(=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM175240 (US9115082, 12) Show SMILES CC(C)C(NCC(O)COc1ccccc1)C(=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM175239 (US9115082, 11) Show SMILES OC(CNCC(=O)N1CCCC1)COc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM175241 (US9115082, 13) Show SMILES CCC(C)C(NCC(O)COc1ccccc1)C(=O)N1CCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	4.0	n/a
TBA US Patent					Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ...				US Patent US9115082 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P7B
TBA US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%