BindingDB logo
myBDB logout

Patent code US9126980

Compile Data Set for Download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179558
PNG
(US9126980, 3)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)(=O)C(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C33H45N5O5S/c1-6-8-16-36(17-9-7-2)33(41)30-18-24(5)38(34-30)31-15-14-27(35-44(42,43)23(3)4)20-29(31)32(40)37-21-26-13-11-10-12-25(26)19-28(37)22-39/h10-15,18,20,23,28,35,39H,6-9,16-17,19,21-22H2,1-5H3/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 90.4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179558
PNG
(US9126980, 3)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)(=O)C(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C33H45N5O5S/c1-6-8-16-36(17-9-7-2)33(41)30-18-24(5)38(34-30)31-15-14-27(35-44(42,43)23(3)4)20-29(31)32(40)37-21-26-13-11-10-12-25(26)19-28(37)22-39/h10-15,18,20,23,28,35,39H,6-9,16-17,19,21-22H2,1-5H3/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 127n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179566
PNG
(US9126980, 11)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)CCN2C(=O)c3ccccc3C2=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H46N6O6S/c1-4-6-18-43(19-7-5-2)40(51)35-22-27(3)46(41-35)36-17-16-30(42-53(52)21-20-44-37(48)32-14-10-11-15-33(32)38(44)49)24-34(36)39(50)45-25-29-13-9-8-12-28(29)23-31(45)26-47/h8-17,22,24,31,42,47H,4-7,18-21,23,25-26H2,1-3H3/t31-,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 253n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179580
PNG
(US9126980, 25)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(NC(C)=O)c(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45ClN6O5S/c1-5-7-17-43(18-8-6-2)38(49)35-19-25(3)45(41-35)36-16-13-29(42-51(50)31-14-15-34(33(39)22-31)40-26(4)47)21-32(36)37(48)44-23-28-12-10-9-11-27(28)20-30(44)24-46/h9-16,19,21-22,30,42,46H,5-8,17-18,20,23-24H2,1-4H3,(H,40,47)/t30-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 255n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179597
PNG
(US9126980, 42)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2[NH3+])cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H44N6O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24,37H2,1-3H3/p+1/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 255n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179590
PNG
(US9126980, 35)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc3nonc23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41N7O5S/c1-4-6-17-41(18-7-5-2)36(46)31-19-24(3)43(37-31)32-16-15-27(40-49(47)33-14-10-13-30-34(33)39-48-38-30)21-29(32)35(45)42-22-26-12-9-8-11-25(26)20-28(42)23-44/h8-16,19,21,28,40,44H,4-7,17-18,20,22-23H2,1-3H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 257n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179593
PNG
(US9126980, 38)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(F)c(Br)cc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H40BrF2N5O4S/c1-4-6-14-42(15-7-5-2)36(47)32-16-23(3)44(40-32)33-13-12-26(41-49(48)34-20-30(38)29(37)19-31(34)39)18-28(33)35(46)43-21-25-11-9-8-10-24(25)17-27(43)22-45/h8-13,16,18-20,27,41,45H,4-7,14-15,17,21-22H2,1-3H3/t27-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 269n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179597
PNG
(US9126980, 42)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2[NH3+])cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H44N6O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24,37H2,1-3H3/p+1/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 270n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179590
PNG
(US9126980, 35)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc3nonc23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41N7O5S/c1-4-6-17-41(18-7-5-2)36(46)31-19-24(3)43(37-31)32-16-15-27(40-49(47)33-14-10-13-30-34(33)39-48-38-30)21-29(32)35(45)42-22-26-12-9-8-11-25(26)20-28(42)23-44/h8-16,19,21,28,40,44H,4-7,17-18,20,22-23H2,1-3H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 272n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179600
PNG
(US9126980, 45)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccsc2C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O6S2/c1-5-7-16-39(17-8-6-2)35(44)30-19-24(3)41(37-30)31-14-13-27(38-49(46)32-15-18-48-33(32)36(45)47-4)21-29(31)34(43)40-22-26-12-10-9-11-25(26)20-28(40)23-42/h9-15,18-19,21,28,38,42H,5-8,16-17,20,22-23H2,1-4H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 293n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179557
PNG
(US9126980, 2)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(C)(=O)=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C31H41N5O5S/c1-5-7-15-34(16-8-6-2)31(39)28-17-22(3)36(32-28)29-14-13-25(33-42(4,40)41)19-27(29)30(38)35-20-24-12-10-9-11-23(24)18-26(35)21-37/h9-14,17,19,26,33,37H,5-8,15-16,18,20-21H2,1-4H3/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 295n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179566
PNG
(US9126980, 11)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)CCN2C(=O)c3ccccc3C2=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H46N6O6S/c1-4-6-18-43(19-7-5-2)40(51)35-22-27(3)46(41-35)36-17-16-30(42-53(52)21-20-44-37(48)32-14-10-11-15-33(32)38(44)49)24-34(36)39(50)45-25-29-13-9-8-12-28(29)23-31(45)26-47/h8-17,22,24,31,42,47H,4-7,18-21,23,25-26H2,1-3H3/t31-,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 296n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179583
PNG
(US9126980, 28)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O6S/c1-5-7-19-41(20-8-6-2)37(46)33-21-26(3)43(39-33)34-18-17-29(40-50(48)35-16-12-11-15-31(35)38(47)49-4)23-32(34)36(45)42-24-28-14-10-9-13-27(28)22-30(42)25-44/h9-18,21,23,30,40,44H,5-8,19-20,22,24-25H2,1-4H3/t30-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 311n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179582
PNG
(US9126980, 27)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H42FN5O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24H2,1-3H3/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 315n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179593
PNG
(US9126980, 38)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(F)c(Br)cc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H40BrF2N5O4S/c1-4-6-14-42(15-7-5-2)36(47)32-16-23(3)44(40-32)33-13-12-26(41-49(48)34-20-30(38)29(37)19-31(34)39)18-28(33)35(46)43-21-25-11-9-8-10-24(25)17-27(43)22-45/h8-13,16,18-20,27,41,45H,4-7,14-15,17,21-22H2,1-3H3/t27-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 328n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179581
PNG
(US9126980, 26)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(Cl)c2Cl)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41Cl2N5O4S/c1-4-6-17-41(18-7-5-2)36(46)31-19-24(3)43(39-31)32-16-15-27(40-48(47)33-14-10-13-30(37)34(33)38)21-29(32)35(45)42-22-26-12-9-8-11-25(26)20-28(42)23-44/h8-16,19,21,28,40,44H,4-7,17-18,20,22-23H2,1-3H3/t28-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 370n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179557
PNG
(US9126980, 2)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(C)(=O)=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C31H41N5O5S/c1-5-7-15-34(16-8-6-2)31(39)28-17-22(3)36(32-28)29-14-13-25(33-42(4,40)41)19-27(29)30(38)35-20-24-12-10-9-11-23(24)18-26(35)21-37/h9-14,17,19,26,33,37H,5-8,15-16,18,20-21H2,1-4H3/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 377n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179560
PNG
(US9126980, 5)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)C(C)=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O5S/c1-5-7-19-41(20-8-6-2)38(47)35-21-26(3)43(39-35)36-18-15-31(40-49(48)33-16-13-28(14-17-33)27(4)45)23-34(36)37(46)42-24-30-12-10-9-11-29(30)22-32(42)25-44/h9-18,21,23,32,40,44H,5-8,19-20,22,24-25H2,1-4H3/t32-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 412n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179580
PNG
(US9126980, 25)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(NC(C)=O)c(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45ClN6O5S/c1-5-7-17-43(18-8-6-2)38(49)35-19-25(3)45(41-35)36-16-13-29(42-51(50)31-14-15-34(33(39)22-31)40-26(4)47)21-32(36)37(48)44-23-28-12-10-9-11-27(28)20-30(44)24-46/h9-16,19,21-22,30,42,46H,5-8,17-18,20,23-24H2,1-4H3,(H,40,47)/t30-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 427n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179583
PNG
(US9126980, 28)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O6S/c1-5-7-19-41(20-8-6-2)37(46)33-21-26(3)43(39-33)34-18-17-29(40-50(48)35-16-12-11-15-31(35)38(47)49-4)23-32(34)36(45)42-24-28-14-10-9-13-27(28)22-30(42)25-44/h9-18,21,23,30,40,44H,5-8,19-20,22,24-25H2,1-4H3/t30-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 448n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179582
PNG
(US9126980, 27)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H42FN5O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24H2,1-3H3/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 454n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179573
PNG
(US9126980, 18)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(o2)C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O7S/c1-5-7-17-39(18-8-6-2)35(44)30-19-24(3)41(37-30)31-14-13-27(38-49(46)33-16-15-32(48-33)36(45)47-4)21-29(31)34(43)40-22-26-12-10-9-11-25(26)20-28(40)23-42/h9-16,19,21,28,38,42H,5-8,17-18,20,22-23H2,1-4H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 457n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179561
PNG
(US9126980, 6)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2sc(Cl)cc2Br)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C34H39BrClN5O4S2/c1-4-6-14-39(15-7-5-2)33(44)29-16-22(3)41(37-29)30-13-12-25(38-47(45)34-28(35)19-31(36)46-34)18-27(30)32(43)40-20-24-11-9-8-10-23(24)17-26(40)21-42/h8-13,16,18-19,26,38,42H,4-7,14-15,17,20-21H2,1-3H3/t26-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 465n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179579
PNG
(US9126980, 24)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2c(C)nn(C)c2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H47N7O4S/c1-7-9-17-41(18-10-8-2)36(46)32-19-24(3)43(38-32)33-16-15-29(39-48(47)34-25(4)37-40(6)26(34)5)21-31(33)35(45)42-22-28-14-12-11-13-27(28)20-30(42)23-44/h11-16,19,21,30,39,44H,7-10,17-18,20,22-23H2,1-6H3/t30-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 466n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179562
PNG
(US9126980, 7)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Br)c(Br)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41Br2N5O4S/c1-4-6-16-41(17-7-5-2)36(46)33-18-24(3)43(39-33)34-15-12-27(40-48(47)29-13-14-31(37)32(38)21-29)20-30(34)35(45)42-22-26-11-9-8-10-25(26)19-28(42)23-44/h8-15,18,20-21,28,40,44H,4-7,16-17,19,22-23H2,1-3H3/t28-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 474n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179601
PNG
(US9126980, 46)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)Cc2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H45N5O4S/c1-4-6-19-40(20-7-5-2)37(45)34-21-27(3)42(38-34)35-18-17-31(39-47(46)26-28-13-9-8-10-14-28)23-33(35)36(44)41-24-30-16-12-11-15-29(30)22-32(41)25-43/h8-18,21,23,32,39,43H,4-7,19-20,22,24-26H2,1-3H3/t32-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 475n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179571
PNG
(US9126980, 16)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cn(C)cn2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C34H43N7O4S/c1-5-7-15-39(16-8-6-2)34(44)30-17-24(3)41(36-30)31-14-13-27(37-46(45)32-21-38(4)23-35-32)19-29(31)33(43)40-20-26-12-10-9-11-25(26)18-28(40)22-42/h9-14,17,19,21,23,28,37,42H,5-8,15-16,18,20,22H2,1-4H3/t28-,46?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 475n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179600
PNG
(US9126980, 45)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccsc2C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O6S2/c1-5-7-16-39(17-8-6-2)35(44)30-19-24(3)41(37-30)31-14-13-27(38-49(46)32-15-18-48-33(32)36(45)47-4)21-29(31)34(43)40-22-26-12-10-9-11-25(26)20-28(40)23-42/h9-15,18-19,21,28,38,42H,5-8,16-17,20,22-23H2,1-4H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 480n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179581
PNG
(US9126980, 26)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(Cl)c2Cl)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41Cl2N5O4S/c1-4-6-17-41(18-7-5-2)36(46)31-19-24(3)43(39-31)32-16-15-27(40-48(47)33-14-10-13-30(37)34(33)38)21-29(32)35(45)42-22-26-12-9-8-11-25(26)20-28(42)23-44/h8-16,19,21,28,40,44H,4-7,17-18,20,22-23H2,1-3H3/t28-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 494n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179587
PNG
(US9126980, 32)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc3OCCOc3c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O6S/c1-4-6-16-41(17-7-5-2)38(46)33-20-26(3)43(39-33)34-14-12-29(40-50(47)31-13-15-35-36(23-31)49-19-18-48-35)22-32(34)37(45)42-24-28-11-9-8-10-27(28)21-30(42)25-44/h8-15,20,22-23,30,40,44H,4-7,16-19,21,24-25H2,1-3H3/t30-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 512n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179556
PNG
(US9126980, 1)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)(=O)c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O5S/c1-4-6-19-39(20-7-5-2)36(44)33-21-26(3)41(37-33)34-18-17-29(38-47(45,46)31-15-9-8-10-16-31)23-32(34)35(43)40-24-28-14-12-11-13-27(28)22-30(40)25-42/h8-18,21,23,30,38,42H,4-7,19-20,22,24-25H2,1-3H3/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 519n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179599
PNG
(US9126980, 44)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2cnco2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H44N6O5S/c1-4-6-18-43(19-7-5-2)39(48)35-20-27(3)45(41-35)36-17-14-31(42-51(49)33-15-12-28(13-16-33)37-23-40-26-50-37)22-34(36)38(47)44-24-30-11-9-8-10-29(30)21-32(44)25-46/h8-17,20,22-23,26,32,42,46H,4-7,18-19,21,24-25H2,1-3H3/t32-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 522n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179584
PNG
(US9126980, 29)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)CCc2cccc3ccccc23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H49N5O4S/c1-4-6-22-45(23-7-5-2)42(50)39-25-30(3)47(43-39)40-20-19-35(44-52(51)24-21-32-17-12-16-31-13-10-11-18-37(31)32)27-38(40)41(49)46-28-34-15-9-8-14-33(34)26-36(46)29-48/h8-20,25,27,36,44,48H,4-7,21-24,26,28-29H2,1-3H3/t36-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 529n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179596
PNG
(US9126980, 41)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc([NH3+])ccc2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H46N6O4S/c1-5-7-17-41(18-8-6-2)37(46)33-19-26(4)43(39-33)34-16-15-30(40-48(47)35-21-29(38)14-13-25(35)3)22-32(34)36(45)42-23-28-12-10-9-11-27(28)20-31(42)24-44/h9-16,19,21-22,31,40,44H,5-8,17-18,20,23-24,38H2,1-4H3/p+1/t31-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 531n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179569
PNG
(US9126980, 14)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2Cl)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H42ClN5O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24H2,1-3H3/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 559n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179595
PNG
(US9126980, 40)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(c2)C#N)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H42N6O4S/c1-4-6-17-41(18-7-5-2)37(46)34-19-26(3)43(39-34)35-16-15-30(40-48(47)32-14-10-11-27(20-32)23-38)22-33(35)36(45)42-24-29-13-9-8-12-28(29)21-31(42)25-44/h8-16,19-20,22,31,40,44H,4-7,17-18,21,24-25H2,1-3H3/t31-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 562n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179561
PNG
(US9126980, 6)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2sc(Cl)cc2Br)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C34H39BrClN5O4S2/c1-4-6-14-39(15-7-5-2)33(44)29-16-22(3)41(37-29)30-13-12-25(38-47(45)34-28(35)19-31(36)46-34)18-27(30)32(43)40-20-24-11-9-8-10-23(24)17-26(40)21-42/h8-13,16,18-19,26,38,42H,4-7,14-15,17,20-21H2,1-3H3/t26-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 563n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179594
PNG
(US9126980, 39)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2scc(C(=O)OC)c2OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H45N5O7S2/c1-6-8-16-40(17-9-7-2)35(45)31-18-24(3)42(38-31)32-15-14-27(39-51(47)37-33(48-4)30(23-50-37)36(46)49-5)20-29(32)34(44)41-21-26-13-11-10-12-25(26)19-28(41)22-43/h10-15,18,20,23,28,39,43H,6-9,16-17,19,21-22H2,1-5H3/t28-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 566n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179573
PNG
(US9126980, 18)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(o2)C(=O)OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O7S/c1-5-7-17-39(18-8-6-2)35(44)30-19-24(3)41(37-30)31-14-13-27(38-49(46)33-16-15-32(48-33)36(45)47-4)21-29(31)34(43)40-22-26-12-10-9-11-25(26)20-28(40)23-42/h9-16,19,21,28,38,42H,5-8,17-18,20,22-23H2,1-4H3/t28-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 585n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179560
PNG
(US9126980, 5)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)C(C)=O)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O5S/c1-5-7-19-41(20-8-6-2)38(47)35-21-26(3)43(39-35)36-18-15-31(40-49(48)33-16-13-28(14-17-33)27(4)45)23-34(36)37(46)42-24-30-12-10-9-11-29(30)22-32(42)25-44/h9-18,21,23,32,40,44H,5-8,19-20,22,24-25H2,1-4H3/t32-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 609n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179587
PNG
(US9126980, 32)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc3OCCOc3c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H45N5O6S/c1-4-6-16-41(17-7-5-2)38(46)33-20-26(3)43(39-33)34-14-12-29(40-50(47)31-13-15-35-36(23-31)49-19-18-48-35)22-32(34)37(45)42-24-28-11-9-8-10-27(28)21-30(42)25-44/h8-15,20,22-23,30,40,44H,4-7,16-19,21,24-25H2,1-3H3/t30-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 631n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179594
PNG
(US9126980, 39)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2scc(C(=O)OC)c2OC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H45N5O7S2/c1-6-8-16-40(17-9-7-2)35(45)31-18-24(3)42(38-31)32-15-14-27(39-51(47)37-33(48-4)30(23-50-37)36(46)49-5)20-29(32)34(44)41-21-26-13-11-10-12-25(26)19-28(41)22-43/h10-15,18,20,23,28,39,43H,6-9,16-17,19,21-22H2,1-5H3/t28-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 632n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179562
PNG
(US9126980, 7)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Br)c(Br)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41Br2N5O4S/c1-4-6-16-41(17-7-5-2)36(46)33-18-24(3)43(39-33)34-15-12-27(40-48(47)29-13-14-31(37)32(38)21-29)20-30(34)35(45)42-22-26-11-9-8-10-25(26)19-28(42)23-44/h8-15,18,20-21,28,40,44H,4-7,16-17,19,22-23H2,1-3H3/t28-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 638n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179571
PNG
(US9126980, 16)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cn(C)cn2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C34H43N7O4S/c1-5-7-15-39(16-8-6-2)34(44)30-17-24(3)41(36-30)31-14-13-27(37-46(45)32-21-38(4)23-35-32)19-29(31)33(43)40-20-26-12-10-9-11-25(26)18-28(40)22-42/h9-14,17,19,21,23,28,37,42H,5-8,15-16,18,20,22H2,1-4H3/t28-,46?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 640n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179589
PNG
(US9126980, 34)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2noc(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H45N7O5S/c1-5-7-19-44(20-8-6-2)39(49)35-21-26(3)46(41-35)36-18-15-31(43-52(50)33-16-13-28(14-17-33)37-40-27(4)51-42-37)23-34(36)38(48)45-24-30-12-10-9-11-29(30)22-32(45)25-47/h9-18,21,23,32,43,47H,5-8,19-20,22,24-25H2,1-4H3/t32-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 641n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179579
PNG
(US9126980, 24)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2c(C)nn(C)c2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H47N7O4S/c1-7-9-17-41(18-10-8-2)36(46)32-19-24(3)43(38-32)33-16-15-29(39-48(47)34-25(4)37-40(6)26(34)5)21-31(33)35(45)42-22-28-14-12-11-13-27(28)20-30(42)23-44/h11-16,19,21,30,39,44H,7-10,17-18,20,22-23H2,1-6H3/t30-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 652n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179596
PNG
(US9126980, 41)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc([NH3+])ccc2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H46N6O4S/c1-5-7-17-41(18-8-6-2)37(46)33-19-26(4)43(39-33)34-16-15-30(40-48(47)35-21-29(38)14-13-25(35)3)22-32(34)36(45)42-23-28-12-10-9-11-27(28)20-31(42)24-44/h9-16,19,21-22,31,40,44H,5-8,17-18,20,23-24,38H2,1-4H3/p+1/t31-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 660n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179563
PNG
(US9126980, 8)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2c(C)onc2-c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H46N6O5S/c1-5-7-20-44(21-8-6-2)40(49)35-22-27(3)46(41-35)36-19-18-32(43-52(50)38-28(4)51-42-37(38)29-14-10-9-11-15-29)24-34(36)39(48)45-25-31-17-13-12-16-30(31)23-33(45)26-47/h9-19,22,24,33,43,47H,5-8,20-21,23,25-26H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 664n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179601
PNG
(US9126980, 46)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)Cc2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H45N5O4S/c1-4-6-19-40(20-7-5-2)37(45)34-21-27(3)42(38-34)35-18-17-31(39-47(46)26-28-13-9-8-10-14-28)23-33(35)36(44)41-24-30-16-12-11-15-29(30)22-32(41)25-43/h8-18,21,23,32,39,43H,4-7,19-20,22,24-26H2,1-3H3/t32-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 666n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179595
PNG
(US9126980, 40)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(c2)C#N)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H42N6O4S/c1-4-6-17-41(18-7-5-2)37(46)34-19-26(3)43(39-34)35-16-15-30(40-48(47)32-14-10-11-27(20-32)23-38)22-33(35)36(45)42-24-29-13-9-8-12-28(29)21-31(42)25-44/h8-16,19-20,22,31,40,44H,4-7,17-18,21,24-25H2,1-3H3/t31-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 673n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179559
PNG
(US9126980, 4)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(cs2)S(=O)c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H45N5O5S3/c1-4-6-19-43(20-7-5-2)40(48)36-21-28(3)45(41-36)37-18-17-31(42-53(50)38-24-34(27-51-38)52(49)33-15-9-8-10-16-33)23-35(37)39(47)44-25-30-14-12-11-13-29(30)22-32(44)26-46/h8-18,21,23-24,27,32,42,46H,4-7,19-20,22,25-26H2,1-3H3/t32-,52?,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 675n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179556
PNG
(US9126980, 1)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)(=O)c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H43N5O5S/c1-4-6-19-39(20-7-5-2)36(44)33-21-26(3)41(37-33)34-18-17-29(38-47(45,46)31-15-9-8-10-16-31)23-32(34)35(43)40-24-28-14-12-11-13-27(28)22-30(40)25-42/h8-18,21,23,30,38,42H,4-7,19-20,22,24-25H2,1-3H3/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 692n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179584
PNG
(US9126980, 29)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)CCc2cccc3ccccc23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H49N5O4S/c1-4-6-22-45(23-7-5-2)42(50)39-25-30(3)47(43-39)40-20-19-35(44-52(51)24-21-32-17-12-16-31-13-10-11-18-37(31)32)27-38(40)41(49)46-28-34-15-9-8-14-33(34)26-36(46)29-48/h8-20,25,27,36,44,48H,4-7,21-24,26,28-29H2,1-3H3/t36-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 709n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179569
PNG
(US9126980, 14)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccccc2Cl)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H42ClN5O4S/c1-4-6-18-40(19-7-5-2)36(45)32-20-25(3)42(38-32)33-17-16-28(39-47(46)34-15-11-10-14-31(34)37)22-30(33)35(44)41-23-27-13-9-8-12-26(27)21-29(41)24-43/h8-17,20,22,29,39,43H,4-7,18-19,21,23-24H2,1-3H3/t29-,47?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 715n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179598
PNG
(US9126980, 43)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)C[C@]23CC[C@H](CC2=O)C3(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r,THB:31:30:27.26:32|
Show InChI InChI=1S/C40H53N5O5S/c1-6-8-18-43(19-9-7-2)38(49)34-20-27(3)45(41-34)35-15-14-31(42-51(50)26-40-17-16-30(22-36(40)47)39(40,4)5)23-33(35)37(48)44-24-29-13-11-10-12-28(29)21-32(44)25-46/h10-15,20,23,30,32,42,46H,6-9,16-19,21-22,24-26H2,1-5H3/t30-,32+,40-,51?/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 726n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179575
PNG
(US9126980, 20)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2ccn(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H47N7O4S/c1-5-7-20-45(21-8-6-2)40(50)37-23-28(3)47(42-37)38-18-15-32(43-52(51)34-16-13-29(14-17-34)36-19-22-44(4)41-36)25-35(38)39(49)46-26-31-12-10-9-11-30(31)24-33(46)27-48/h9-19,22-23,25,33,43,48H,5-8,20-21,24,26-27H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 757n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179559
PNG
(US9126980, 4)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(cs2)S(=O)c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H45N5O5S3/c1-4-6-19-43(20-7-5-2)40(48)36-21-28(3)45(41-36)37-18-17-31(42-53(50)38-24-34(27-51-38)52(49)33-15-9-8-10-16-33)23-35(37)39(47)44-25-30-14-12-11-13-29(30)22-32(44)26-46/h8-18,21,23-24,27,32,42,46H,4-7,19-20,22,25-26H2,1-3H3/t32-,52?,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 799n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179598
PNG
(US9126980, 43)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)C[C@]23CC[C@H](CC2=O)C3(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r,THB:31:30:27.26:32|
Show InChI InChI=1S/C40H53N5O5S/c1-6-8-18-43(19-9-7-2)38(49)34-20-27(3)45(41-34)35-15-14-31(42-51(50)26-40-17-16-30(22-36(40)47)39(40,4)5)23-33(35)37(48)44-24-29-13-11-10-12-28(29)21-32(44)25-46/h10-15,20,23,30,32,42,46H,6-9,16-19,21-22,24-26H2,1-5H3/t30-,32+,40-,51?/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 807n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179591
PNG
(US9126980, 36)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2sc3ccc(F)cc3c2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H44FN5O4S2/c1-5-7-17-43(18-8-6-2)38(48)34-19-25(3)45(41-34)35-15-14-30(42-51(49)39-26(4)32-21-29(40)13-16-36(32)50-39)22-33(35)37(47)44-23-28-12-10-9-11-27(28)20-31(44)24-46/h9-16,19,21-22,31,42,46H,5-8,17-18,20,23-24H2,1-4H3/t31-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 834n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179563
PNG
(US9126980, 8)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2c(C)onc2-c2ccccc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H46N6O5S/c1-5-7-20-44(21-8-6-2)40(49)35-22-27(3)46(41-35)36-19-18-32(43-52(50)38-28(4)51-42-37(38)29-14-10-9-11-15-29)24-34(36)39(48)45-25-31-17-13-12-16-30(31)23-33(45)26-47/h9-19,22,24,33,43,47H,5-8,20-21,23,25-26H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 836n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179589
PNG
(US9126980, 34)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2noc(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H45N7O5S/c1-5-7-19-44(20-8-6-2)39(49)35-21-26(3)46(41-35)36-18-15-31(43-52(50)33-16-13-28(14-17-33)37-40-27(4)51-42-37)23-34(36)38(48)45-24-30-12-10-9-11-29(30)22-32(45)25-47/h9-18,21,23,32,43,47H,5-8,19-20,22,24-25H2,1-4H3/t32-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 843n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179572
PNG
(US9126980, 17)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(Cl)ccc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41ClFN5O4S/c1-4-6-16-41(17-7-5-2)36(46)32-18-24(3)43(39-32)33-15-13-28(40-48(47)34-20-27(37)12-14-31(34)38)21-30(33)35(45)42-22-26-11-9-8-10-25(26)19-29(42)23-44/h8-15,18,20-21,29,40,44H,4-7,16-17,19,22-23H2,1-3H3/t29-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 850n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179575
PNG
(US9126980, 20)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2ccn(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H47N7O4S/c1-5-7-20-45(21-8-6-2)40(50)37-23-28(3)47(42-37)38-18-15-32(43-52(51)34-16-13-29(14-17-34)36-19-22-44(4)41-36)25-35(38)39(49)46-26-31-12-10-9-11-30(31)24-33(46)27-48/h9-19,22-23,25,33,43,48H,5-8,20-21,24,26-27H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 855n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179599
PNG
(US9126980, 44)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2cnco2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H44N6O5S/c1-4-6-18-43(19-7-5-2)39(48)35-20-27(3)45(41-35)36-17-14-31(42-51(49)33-15-12-28(13-16-33)37-23-40-26-50-37)22-34(36)38(47)44-24-30-11-9-8-10-29(30)21-32(44)25-46/h8-17,20,22-23,26,32,42,46H,4-7,18-19,21,24-25H2,1-3H3/t32-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 885n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179572
PNG
(US9126980, 17)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cc(Cl)ccc2F)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C36H41ClFN5O4S/c1-4-6-16-41(17-7-5-2)36(46)32-18-24(3)43(39-32)33-15-13-28(40-48(47)34-20-27(37)12-14-31(34)38)21-30(33)35(45)42-22-26-11-9-8-10-25(26)19-29(42)23-44/h8-15,18,20-21,29,40,44H,4-7,16-17,19,22-23H2,1-3H3/t29-,48?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 957n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179576
PNG
(US9126980, 21)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc3ccn(C)c23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H46N6O4S/c1-5-7-19-43(20-8-6-2)39(48)34-22-27(3)45(40-34)35-17-16-31(41-50(49)36-15-11-14-28-18-21-42(4)37(28)36)24-33(35)38(47)44-25-30-13-10-9-12-29(30)23-32(44)26-46/h9-18,21-22,24,32,41,46H,5-8,19-20,23,25-26H2,1-4H3/t32-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.05E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179591
PNG
(US9126980, 36)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2sc3ccc(F)cc3c2C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H44FN5O4S2/c1-5-7-17-43(18-8-6-2)38(48)34-19-25(3)45(41-34)35-15-14-30(42-51(49)39-26(4)32-21-29(40)13-16-36(32)50-39)22-33(35)37(47)44-23-28-12-10-9-11-27(28)20-31(44)24-46/h9-16,19,21-22,31,42,46H,5-8,17-18,20,23-24H2,1-4H3/t31-,51?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.08E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179576
PNG
(US9126980, 21)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc3ccn(C)c23)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C39H46N6O4S/c1-5-7-19-43(20-8-6-2)39(48)34-22-27(3)45(40-34)35-17-16-31(41-50(49)36-15-11-14-28-18-21-42(4)37(28)36)24-33(35)38(47)44-25-30-13-10-9-12-29(30)23-32(44)26-46/h9-18,21-22,24,32,41,46H,5-8,19-20,23,25-26H2,1-4H3/t32-,50?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.36E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179577
PNG
(US9126980, 22)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)Cc2ccc(Cl)c(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H43Cl2N5O4S/c1-4-6-16-42(17-7-5-2)37(47)34-18-25(3)44(40-34)35-15-13-29(41-49(48)24-26-12-14-32(38)33(39)19-26)21-31(35)36(46)43-22-28-11-9-8-10-27(28)20-30(43)23-45/h8-15,18-19,21,30,41,45H,4-7,16-17,20,22-24H2,1-3H3/t30-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.65E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179578
PNG
(US9126980, 23)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)N(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C32H44N6O4S/c1-6-8-16-36(17-9-7-2)32(41)29-18-23(3)38(33-29)30-15-14-26(34-43(42)35(4)5)20-28(30)31(40)37-21-25-13-11-10-12-24(25)19-27(37)22-39/h10-15,18,20,27,34,39H,6-9,16-17,19,21-22H2,1-5H3/t27-,43?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.74E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179570
PNG
(US9126980, 15)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Br)cc2CC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H46BrN5O4S/c1-5-8-18-42(19-9-6-2)38(47)34-20-26(4)44(40-34)35-16-15-31(41-49(48)36-17-14-30(39)21-27(36)7-3)23-33(35)37(46)43-24-29-13-11-10-12-28(29)22-32(43)25-45/h10-17,20-21,23,32,41,45H,5-9,18-19,22,24-25H2,1-4H3/t32-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.83E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179577
PNG
(US9126980, 22)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)Cc2ccc(Cl)c(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C37H43Cl2N5O4S/c1-4-6-16-42(17-7-5-2)37(47)34-18-25(3)44(40-34)35-15-13-29(41-49(48)24-26-12-14-32(38)33(39)19-26)21-31(35)36(46)43-22-28-11-9-8-10-27(28)20-30(43)23-45/h8-15,18-19,21,30,41,45H,4-7,16-17,20,22-24H2,1-3H3/t30-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.98E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179570
PNG
(US9126980, 15)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Br)cc2CC)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C38H46BrN5O4S/c1-5-8-18-42(19-9-6-2)38(47)34-20-26(4)44(40-34)35-16-15-31(41-49(48)36-17-14-30(39)21-27(36)7-3)23-33(35)37(46)43-24-29-13-11-10-12-28(29)22-32(43)25-45/h10-17,20-21,23,32,41,45H,5-9,18-19,22,24-25H2,1-4H3/t32-,49?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.17E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179578
PNG
(US9126980, 23)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)N(C)C)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C32H44N6O4S/c1-6-8-16-36(17-9-7-2)32(41)29-18-23(3)38(33-29)30-15-14-26(34-43(42)35(4)5)20-28(30)31(40)37-21-25-13-11-10-12-24(25)19-27(37)22-39/h10-15,18,20,27,34,39H,6-9,16-17,19,21-22H2,1-5H3/t27-,43?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.39E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179585
PNG
(US9126980, 30)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(CNC(=O)c3ccc(Cl)cc3)s2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H47ClN6O5S2/c1-4-6-20-47(21-7-5-2)42(53)37-22-28(3)49(45-37)38-18-16-33(24-36(38)41(52)48-26-31-11-9-8-10-30(31)23-34(48)27-50)46-56(54)39-19-17-35(55-39)25-44-40(51)29-12-14-32(43)15-13-29/h8-19,22,24,34,46,50H,4-7,20-21,23,25-27H2,1-3H3,(H,44,51)/t34-,56?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.39E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179585
PNG
(US9126980, 30)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(CNC(=O)c3ccc(Cl)cc3)s2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H47ClN6O5S2/c1-4-6-20-47(21-7-5-2)42(53)37-22-28(3)49(45-37)38-18-16-33(24-36(38)41(52)48-26-31-11-9-8-10-30(31)23-34(48)27-50)46-56(54)39-19-17-35(55-39)25-44-40(51)29-12-14-32(43)15-13-29/h8-19,22,24,34,46,50H,4-7,20-21,23,25-27H2,1-3H3,(H,44,51)/t34-,56?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.63E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179565
PNG
(US9126980, 10)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccccc3C)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-23-46(24-8-6-2)43(51)39-25-31(4)48(44-39)40-22-17-34(27-38(40)42(50)47-28-33-15-11-10-14-32(33)26-35(47)29-49)45-54(52)37-20-18-36(19-21-37)53-41-16-12-9-13-30(41)3/h9-22,25,27,35,45,49H,5-8,23-24,26,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.35E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179586
PNG
(US9126980, 31)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccc(F)cc3)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H46FN5O5S/c1-4-6-22-46(23-7-5-2)42(51)39-24-29(3)48(44-39)40-21-14-33(26-38(40)41(50)47-27-31-11-9-8-10-30(31)25-34(47)28-49)45-54(52)37-19-17-36(18-20-37)53-35-15-12-32(43)13-16-35/h8-21,24,26,34,45,49H,4-7,22-23,25,27-28H2,1-3H3/t34-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.53E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179588
PNG
(US9126980, 33)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(c2)-c2ccn(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H47N7O4S/c1-5-7-19-45(20-8-6-2)40(50)37-22-28(3)47(42-37)38-17-16-32(43-52(51)34-15-11-14-30(24-34)36-18-21-44(4)41-36)25-35(38)39(49)46-26-31-13-10-9-12-29(31)23-33(46)27-48/h9-18,21-22,24-25,33,43,48H,5-8,19-20,23,26-27H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.56E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179568
PNG
(US9126980, 13)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2cc(Cl)cc(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H45Cl2N5O4S/c1-4-6-18-47(19-7-5-2)42(52)39-20-28(3)49(45-39)40-17-14-35(25-38(40)41(51)48-26-31-11-9-8-10-30(31)23-36(48)27-50)46-54(53)37-15-12-29(13-16-37)32-21-33(43)24-34(44)22-32/h8-17,20-22,24-25,36,46,50H,4-7,18-19,23,26-27H2,1-3H3/t36-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.21E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179567
PNG
(US9126980, 12)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(Oc3ccc(C)cc3)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-22-46(23-8-6-2)43(51)40-24-31(4)48(44-40)41-21-18-34(26-39(41)42(50)47-28-33-13-10-9-12-32(33)25-35(47)29-49)45-54(52)38-15-11-14-37(27-38)53-36-19-16-30(3)17-20-36/h9-21,24,26-27,35,45,49H,5-8,22-23,25,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.86E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179588
PNG
(US9126980, 33)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(c2)-c2ccn(C)n2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C40H47N7O4S/c1-5-7-19-45(20-8-6-2)40(50)37-22-28(3)47(42-37)38-17-16-32(43-52(51)34-15-11-14-30(24-34)36-18-21-44(4)41-36)25-35(38)39(49)46-26-31-13-10-9-12-29(31)23-33(46)27-48/h9-18,21-22,24-25,33,43,48H,5-8,19-20,23,26-27H2,1-4H3/t33-,52?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179586
PNG
(US9126980, 31)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccc(F)cc3)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H46FN5O5S/c1-4-6-22-46(23-7-5-2)42(51)39-24-29(3)48(44-39)40-21-14-33(26-38(40)41(50)47-27-31-11-9-8-10-30(31)25-34(47)28-49)45-54(52)37-19-17-36(18-20-37)53-35-15-12-32(43)13-16-35/h8-21,24,26,34,45,49H,4-7,22-23,25,27-28H2,1-3H3/t34-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.41E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179567
PNG
(US9126980, 12)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2cccc(Oc3ccc(C)cc3)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-22-46(23-8-6-2)43(51)40-24-31(4)48(44-40)41-21-18-34(26-39(41)42(50)47-28-33-13-10-9-12-32(33)25-35(47)29-49)45-54(52)38-15-11-14-37(27-38)53-36-19-16-30(3)17-20-36/h9-21,24,26-27,35,45,49H,5-8,22-23,25,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.63E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179568
PNG
(US9126980, 13)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2cc(Cl)cc(Cl)c2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H45Cl2N5O4S/c1-4-6-18-47(19-7-5-2)42(52)39-20-28(3)49(45-39)40-17-14-35(25-38(40)41(51)48-26-31-11-9-8-10-30(31)23-36(48)27-50)46-54(53)37-15-12-29(13-16-37)32-21-33(43)24-34(44)22-32/h8-17,20-22,24-25,36,46,50H,4-7,18-19,23,26-27H2,1-3H3/t36-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7.28E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179564
PNG
(US9126980, 9)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H46ClN5O4S/c1-4-6-22-46(23-7-5-2)42(51)39-24-29(3)48(44-39)40-21-18-35(45-53(52)37-19-14-31(15-20-37)30-12-16-34(43)17-13-30)26-38(40)41(50)47-27-33-11-9-8-10-32(33)25-36(47)28-49/h8-21,24,26,36,45,49H,4-7,22-23,25,27-28H2,1-3H3/t36-,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7.94E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179565
PNG
(US9126980, 10)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccccc3C)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-23-46(24-8-6-2)43(51)39-25-31(4)48(44-39)40-22-17-34(27-38(40)42(50)47-28-33-15-11-10-14-32(33)26-35(47)29-49)45-54(52)37-20-18-36(19-21-37)53-41-16-12-9-13-30(41)3/h9-22,25,27,35,45,49H,5-8,23-24,26,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.60E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179564
PNG
(US9126980, 9)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C42H46ClN5O4S/c1-4-6-22-46(23-7-5-2)42(51)39-24-29(3)48(44-39)40-21-18-35(45-53(52)37-19-14-31(15-20-37)30-12-16-34(43)17-13-30)26-38(40)41(50)47-27-33-11-9-8-10-32(33)25-36(47)28-49/h8-21,24,26,36,45,49H,4-7,22-23,25,27-28H2,1-3H3/t36-,53?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.60E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179592
PNG
(US9126980, 37)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccc(C)cc3)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-23-46(24-8-6-2)43(51)40-25-31(4)48(44-40)41-22-15-34(27-39(41)42(50)47-28-33-12-10-9-11-32(33)26-35(47)29-49)45-54(52)38-20-18-37(19-21-38)53-36-16-13-30(3)14-17-36/h9-22,25,27,35,45,49H,5-8,23-24,26,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.60E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM179592
PNG
(US9126980, 37)
Show SMILES CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccc(NS(=O)c2ccc(Oc3ccc(C)cc3)cc2)cc1C(=O)N1Cc2ccccc2C[C@H]1CO |r|
Show InChI InChI=1S/C43H49N5O5S/c1-5-7-23-46(24-8-6-2)43(51)40-25-31(4)48(44-40)41-22-15-34(27-39(41)42(50)47-28-33-12-10-9-11-32(33)26-35(47)29-49)45-54(52)38-20-18-37(19-21-38)53-36-16-13-30(3)14-17-36/h9-22,25,27,35,45,49H,5-8,23-24,26,28-29H2,1-4H3/t35-,54?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a>1.60E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Methods for Determining IC50s.The present method includes utility of a Surface plasmon resonance (SPR)- based biosensor (Biacore GE Healthcare, Uppsa...

US Patent US9126980 (2015)


BindingDB Entry DOI: 10.7270/Q2S18184
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%