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Patent code US9132129

Compile Data Set for Download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179822
PNG
(US9132129, Cpd003)
Show SMILES CCCC(C(O)=O)c1c(C)nc2ccc3CCCCc3c2c1-c1ccc(C)cc1
Show InChI InChI=1S/C26H29NO2/c1-4-7-21(26(28)29)23-17(3)27-22-15-14-18-8-5-6-9-20(18)25(22)24(23)19-12-10-16(2)11-13-19/h10-15,21H,4-9H2,1-3H3,(H,28,29)
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US Patent
n/an/a 470n/an/an/an/a7.44



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume i...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179820
PNG
(US9132129, Cpd001)
Show SMILES CCCC(C(O)=O)c1c(C)nc2cc3CCCCc3cc2c1-c1ccc(C)cc1
Show InChI InChI=1S/C26H29NO2/c1-4-7-21(26(28)29)24-17(3)27-23-15-20-9-6-5-8-19(20)14-22(23)25(24)18-12-10-16(2)11-13-18/h10-15,21H,4-9H2,1-3H3,(H,28,29)
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US Patent
n/an/a 470n/an/an/an/a7.44



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume i...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179821
PNG
(US9132129, Cpd002)
Show SMILES Cc1ccc(cc1)-c1c(C(OC(C)(C)C)C(O)=O)c(C)nc2cc3CCCCc3cc12
Show InChI InChI=1S/C27H31NO3/c1-16-10-12-18(13-11-16)24-21-14-19-8-6-7-9-20(19)15-22(21)28-17(2)23(24)25(26(29)30)31-27(3,4)5/h10-15,25H,6-9H2,1-5H3,(H,29,30)
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US Patent
n/an/a 550n/an/an/an/a7.025



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An Homogeneous Time Resolved Fluorescence (HTRF) assay was performed in a manner similar to previous reports on HTRF protein protein assays as review...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179831
PNG
(US9132129, Cpd012)
Show SMILES CCCC(C(O)=O)c1c(C)nc2cc3CCCc3cc2c1-c1ccc(C)cc1
Show InChI InChI=1S/C25H27NO2/c1-4-6-20(25(27)28)23-16(3)26-22-14-19-8-5-7-18(19)13-21(22)24(23)17-11-9-15(2)10-12-17/h9-14,20H,4-8H2,1-3H3,(H,27,28)
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US Patent
n/an/a 1.08E+3n/an/an/an/a7.44



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume i...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179866
PNG
(US9132129, Cpd047)
Show SMILES CCCC(C(O)=O)c1c(C)nc2c3ccccc3nn2c1-c1ccc(C)cc1
Show InChI InChI=1S/C23H23N3O2/c1-4-7-18(23(27)28)20-15(3)24-22-17-8-5-6-9-19(17)25-26(22)21(20)16-12-10-14(2)11-13-16/h5-6,8-13,18H,4,7H2,1-3H3,(H,27,28)
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US Patent
n/an/a 3.10E+3n/an/an/an/a7.025



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An Homogeneous Time Resolved Fluorescence (HTRF) assay was performed in a manner similar to previous reports on HTRF protein protein assays as review...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179831
PNG
(US9132129, Cpd012)
Show SMILES CCCC(C(O)=O)c1c(C)nc2cc3CCCc3cc2c1-c1ccc(C)cc1
Show InChI InChI=1S/C25H27NO2/c1-4-6-20(25(27)28)23-16(3)26-22-14-19-8-5-7-18(19)13-21(22)24(23)17-11-9-15(2)10-12-17/h9-14,20H,4-8H2,1-3H3,(H,27,28)
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US Patent
n/an/a 4.40E+3n/an/an/an/a7.025



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An Homogeneous Time Resolved Fluorescence (HTRF) assay was performed in a manner similar to previous reports on HTRF protein protein assays as review...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179842
PNG
(US9132129, Cpd023)
Show SMILES CCCC(C(O)=O)c1c(C)nc2ccc3CCCc3c2c1-c1ccc(C)cc1
Show InChI InChI=1S/C25H27NO2/c1-4-6-20(25(27)28)22-16(3)26-21-14-13-17-7-5-8-19(17)24(21)23(22)18-11-9-15(2)10-12-18/h9-14,20H,4-8H2,1-3H3,(H,27,28)
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US Patent
n/an/a 4.60E+3n/an/an/an/a7.44



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume i...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
PC4 and SFRS1-interacting protein


(Homo sapiens (Human))
BDBM179866
PNG
(US9132129, Cpd047)
Show SMILES CCCC(C(O)=O)c1c(C)nc2c3ccccc3nn2c1-c1ccc(C)cc1
Show InChI InChI=1S/C23H23N3O2/c1-4-7-18(23(27)28)20-15(3)24-22-17-8-5-6-9-19(17)25-26(22)21(20)16-12-10-14(2)11-13-16/h5-6,8-13,18H,4,7H2,1-3H3,(H,27,28)
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US Patent
n/an/a 7.85E+3n/an/an/an/a7.44



KATHOLIEKE UNIVERSITEIT LEUVEN

US Patent


Assay Description
An AlphaScreen assay was performed according to the manufacturer's protocol (Perkin Elmer, Benelux). Reactions were performed in 25 ul final volume i...


US Patent US9132129 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XSH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%