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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM181157 (US9138494, Example 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM181154 (US9138494, Example 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50419436 (CHEMBL1915747 | US9138494, JNJ-41510417) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50357701 (CHEMBL1915725 | US9138494, Janssen B-3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM181153 (US9138494, Example 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.05 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM31592 (PF-2545920 | US9138494, MP-10 | substituted pyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB US Patent | n/a | n/a | 1.68 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM181156 (US9138494, Example 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM181155 (US9138494, Example 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG US Patent | Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst... | US Patent US9138494 (2015) BindingDB Entry DOI: 10.7270/Q23777GS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
