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Patent code US9139529

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181203
PNG
(US9139529, 46 | US9783501, Compound 46)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-20-12-14(24)10-11-19(20)32-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-15-6-5-7-16(13-15)33(2,29)30/h3-13H,1-2H3,(H,25,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181223
PNG
(US9139529, 66 | US9783501, Compound 66)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C22H15ClFN3O4S/c23-18-11-14(24)8-9-20(18)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181163
PNG
(US9139529, 6 | US9783501, Compound 6)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C21H14ClFN4O4S/c22-15-10-12(23)8-9-18(15)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181161
PNG
(US9139529, 4 | US9783501, Compound 4)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181168
PNG
(US9139529, 11 | US9783501, Compound 11)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181165
PNG
(US9139529, 8 | US9783501, Compound 8)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(OC)c1
Show InChI InChI=1S/C23H20N4O6S/c1-31-15-10-11-19(20(13-15)32-2)33-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-14-6-5-7-16(12-14)34(24,29)30/h3-13H,1-2H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181159
PNG
(US9139529, 2 | US9783501, Compound 2)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181171
PNG
(US9139529, 14 | US9783501, Compound 14)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181190
PNG
(US9139529, 33 | US9783501, Compound 33)
Show SMILES OC(=O)c1cc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-7-5-13(6-8-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-9-10-26-17(11-12)21(31)32/h1-11H,(H,31,32)(H,26,27,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181220
PNG
(US9139529, 63 | US9783501, Compound 63)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181222
PNG
(US9139529, 65 | US9783501, Compound 65)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C22H15F2N3O4S/c23-14-8-9-20(18(24)11-14)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181218
PNG
(US9139529, 61 | US9783501, Compound 61)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181225
PNG
(US9139529, 68 | US9783501, Compound 68)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H16F3N3O5S/c24-23(25,26)34-17-10-8-16(9-11-17)33-22-19(12-14-4-1-2-7-20(14)29-22)21(30)28-15-5-3-6-18(13-15)35(27,31)32/h1-13H,(H,28,30)(H2,27,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181162
PNG
(US9139529, 5 | US9783501, Compound 5)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C21H14F2N4O4S/c22-12-8-9-18(15(23)10-12)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181228
PNG
(US9139529, 71 | US9783501, Compound 71)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181166
PNG
(US9139529, 9 | US9783501, Compound 9)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181160
PNG
(US9139529, 3 | US9783501, Compound 3)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C22H15F3N4O5S/c23-22(24,25)34-15-10-8-14(9-11-15)33-21-19(28-17-6-1-2-7-18(17)29-21)20(30)27-13-4-3-5-16(12-13)35(26,31)32/h1-12H,(H,27,30)(H2,26,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181226
PNG
(US9139529, 69 | US9783501, Compound 69)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181188
PNG
(US9139529, 31 | US9783501, Compound 31)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-8-6-13(7-9-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-5-10-17(21(31)32)26-11-12/h1-11H,(H,27,30)(H,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181191
PNG
(US9139529, 34 | US9783501, Compound 34)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-7-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-8-9-24-16(11-13)22(29)30/h2-11H,1H3,(H,29,30)(H,24,25,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181217
PNG
(US9139529, 60 | US9783501, Compound 60)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c23-15-8-10-17(11-9-15)30-22-19(12-14-4-1-2-7-20(14)26-22)21(27)25-16-5-3-6-18(13-16)31(24,28)29/h1-13H,(H,25,27)(H2,24,28,29)
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n/an/a 17n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181214
PNG
(US9139529, 57 | US9783501, Compound 57)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C23H16FN5O4/c1-32-19-10-12(24)6-9-18(19)33-22-20(26-14-4-2-3-5-15(14)27-22)21(30)25-13-7-8-16-17(11-13)29-23(31)28-16/h2-11H,1H3,(H,25,30)(H2,28,29,31)
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n/an/a 19n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181180
PNG
(US9139529, 23 | US9783501, Compound 23)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 19n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181169
PNG
(US9139529, 12 | US9783501, Compound 12)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C22H17FN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181173
PNG
(US9139529, 16 | US9783501, Compound 16)
Show SMILES CNS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2OC)c1
Show InChI InChI=1S/C23H19FN4O5S/c1-25-34(30,31)16-7-5-6-15(13-16)26-22(29)21-23(28-18-9-4-3-8-17(18)27-21)33-19-11-10-14(24)12-20(19)32-2/h3-13,25H,1-2H3,(H,26,29)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181210
PNG
(US9139529, 53 | US9783501, Compound 53)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C21H15FN4O3/c1-28-18-12-13(22)6-7-17(18)29-21-19(20(27)24-14-8-10-23-11-9-14)25-15-4-2-3-5-16(15)26-21/h2-12H,1H3,(H,23,24,27)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181231
PNG
(US9139529, 74 | US9783501, Compound 74)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C23H17F2N3O5S/c24-23(25)33-20-11-4-3-10-19(20)32-22-17(12-14-6-1-2-9-18(14)28-22)21(29)27-15-7-5-8-16(13-15)34(26,30)31/h1-13,23H,(H,27,29)(H2,26,30,31)
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n/an/a 24n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181229
PNG
(US9139529, 72 | US9783501, Compound 72)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(OC)c1
Show InChI InChI=1S/C24H21N3O6S/c1-31-17-10-11-21(22(14-17)32-2)33-24-19(12-15-6-3-4-9-20(15)27-24)23(28)26-16-7-5-8-18(13-16)34(25,29)30/h3-14H,1-2H3,(H,26,28)(H2,25,29,30)
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n/an/a 26n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181158
PNG
(US9139529, 1 | US9783501, Compound 1)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H15FN4O4S/c22-13-8-10-15(11-9-13)30-21-19(25-17-6-1-2-7-18(17)26-21)20(27)24-14-4-3-5-16(12-14)31(23,28)29/h1-12H,(H,24,27)(H2,23,28,29)
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n/an/a 27n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181213
PNG
(US9139529, 56 | US9783501, Compound 56)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C23H15FN4O3/c1-30-20-12-15(24)9-10-19(20)31-23-21(27-17-7-2-3-8-18(17)28-23)22(29)26-16-6-4-5-14(11-16)13-25/h2-12H,1H3,(H,26,29)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181219
PNG
(US9139529, 62 | US9783501, Compound 62)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-10-9-16(13-19(21)24)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181215
PNG
(US9139529, 58 | US9783501, Compound 58)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(cc1)C(N)=O
Show InChI InChI=1S/C23H17FN4O4/c1-31-19-12-14(24)8-11-18(19)32-23-20(27-16-4-2-3-5-17(16)28-23)22(30)26-15-9-6-13(7-10-15)21(25)29/h2-12H,1H3,(H2,25,29)(H,26,30)
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n/an/a 31n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181230
PNG
(US9139529, 73 | US9783501, Compound 73)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 31n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181227
PNG
(US9139529, 70 | US9783501, Compound 70)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C23H18FN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 34n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181167
PNG
(US9139529, 10 | US9783501, Compound 10)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C22H16F2N4O5S/c23-22(24)33-18-11-4-3-10-17(18)32-21-19(27-15-8-1-2-9-16(15)28-21)20(29)26-13-6-5-7-14(12-13)34(25,30)31/h1-12,22H,(H,26,29)(H2,25,30,31)
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n/an/a 36n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181208
PNG
(US9139529, 51 | US9783501, Compound 51)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-19-10-13(23)6-9-18(19)31-22-20(27-16-4-2-3-5-17(16)28-22)21(29)26-15-8-7-14(11-24)25-12-15/h2-10,12H,1H3,(H,26,29)
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n/an/a 37n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181164
PNG
(US9139529, 7 | US9783501, Compound 7)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-10-9-14(12-16(19)23)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 42n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181174
PNG
(US9139529, 17 | US9783501, Compound 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H14F3N3O5/c24-23(25,26)34-16-11-9-15(10-12-16)33-21-19(28-17-3-1-2-4-18(17)29-21)20(30)27-14-7-5-13(6-8-14)22(31)32/h1-12H,(H,27,30)(H,31,32)
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n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181212
PNG
(US9139529, 55 | US9783501, Compound 55)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C23H15FN4O3/c1-30-20-12-15(24)8-11-19(20)31-23-21(27-17-4-2-3-5-18(17)28-23)22(29)26-16-9-6-14(13-25)7-10-16/h2-12H,1H3,(H,26,29)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181183
PNG
(US9139529, 26 | US9783501, Compound 26)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(OC)c1
Show InChI InChI=1S/C23H18N4O6/c1-31-14-8-10-18(19(11-14)32-2)33-22-20(26-15-5-3-4-6-16(15)27-22)21(28)25-13-7-9-17(23(29)30)24-12-13/h3-12H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181185
PNG
(US9139529, 28 | US9783501, Compound 28)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C21H12ClFN4O4/c22-13-9-11(23)5-8-17(13)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 51n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181182
PNG
(US9139529, 25 | US9783501, Compound 25)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 56n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181224
PNG
(US9139529, 67 | US9783501, Compound 67)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H18F3N3O5S/c25-24(26,27)14-34-17-8-10-18(11-9-17)35-23-20(12-15-4-1-2-7-21(15)30-23)22(31)29-16-5-3-6-19(13-16)36(28,32)33/h1-13H,14H2,(H,29,31)(H2,28,32,33)
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n/an/a 61n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181172
PNG
(US9139529, 15 | US9783501, Compound 15)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H17F3N4O5S/c24-23(25,26)13-34-15-8-10-16(11-9-15)35-22-20(29-18-6-1-2-7-19(18)30-22)21(31)28-14-4-3-5-17(12-14)36(27,32)33/h1-12H,13H2,(H,28,31)(H2,27,32,33)
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n/an/a 66n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181187
PNG
(US9139529, 30 | US9783501, Compound 30)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C22H15ClN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181192
PNG
(US9139529, 35 | US9783501, Compound 35)
Show SMILES Fc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C20H13FN4O3/c21-12-5-7-14(8-6-12)28-20-18(24-15-3-1-2-4-16(15)25-20)19(27)23-13-9-10-22-17(26)11-13/h1-11H,(H2,22,23,26,27)
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n/an/a 74n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181211
PNG
(US9139529, 54 | US9783501, Compound 54)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C21H15FN4O3/c1-28-18-11-13(22)8-9-17(18)29-21-19(20(27)24-14-5-4-10-23-12-14)25-15-6-2-3-7-16(15)26-21/h2-12H,1H3,(H,24,27)
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n/an/a 80n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181221
PNG
(US9139529, 64 | US9783501, Compound 64)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2)c1
Show InChI InChI=1S/C22H17N3O4S/c23-30(27,28)18-11-6-8-16(14-18)24-21(26)19-13-15-7-4-5-12-20(15)25-22(19)29-17-9-2-1-3-10-17/h1-14H,(H,24,26)(H2,23,27,28)
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n/an/a 81n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181189
PNG
(US9139529, 32 | US9783501, Compound 32)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 83n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181176
PNG
(US9139529, 19 | US9783501, Compound 19)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181205
PNG
(US9139529, 48 | US9783501, Compound 48)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-11-14(24)6-9-19(20)32-23-21(27-17-4-2-3-5-18(17)28-23)22(30)26-15-7-8-16-13(10-15)12-25-29-16/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181170
PNG
(US9139529, 13 | US9783501, Compound 13)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)c1
Show InChI InChI=1S/C21H16N4O4S/c22-30(27,28)16-10-6-7-14(13-16)23-20(26)19-21(29-15-8-2-1-3-9-15)25-18-12-5-4-11-17(18)24-19/h1-13H,(H,23,26)(H2,22,27,28)
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n/an/a 92n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181199
PNG
(US9139529, 42 | US9783501, Compound 42)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]nnc2c1
Show InChI InChI=1S/C22H15FN6O3/c1-31-19-10-12(23)6-9-18(19)32-22-20(25-14-4-2-3-5-15(14)26-22)21(30)24-13-7-8-16-17(11-13)28-29-27-16/h2-11H,1H3,(H,24,30)(H,27,28,29)
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n/an/a 96n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181236
PNG
(US9139529, 79 | US9783501, Compound 79)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C22H13ClFN3O4/c23-16-10-13(24)5-8-19(16)31-21-15(9-12-3-1-2-4-17(12)27-21)20(28)26-14-6-7-18(22(29)30)25-11-14/h1-11H,(H,26,28)(H,29,30)
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n/an/a 96n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181204
PNG
(US9139529, 47 | US9783501, Compound 47)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-14(24)7-9-19(20)32-23-21(27-16-4-2-3-5-17(16)28-23)22(30)26-15-8-6-13-12-25-29-18(13)11-15/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 130n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181216
PNG
(US9139529, 59 | US9783501, Compound 59)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)C(N)=O
Show InChI InChI=1S/C23H17FN4O4/c1-31-19-12-14(24)9-10-18(19)32-23-20(27-16-7-2-3-8-17(16)28-23)22(30)26-15-6-4-5-13(11-15)21(25)29/h2-12H,1H3,(H2,25,29)(H,26,30)
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n/an/a 180n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181179
PNG
(US9139529, 22 | US9783501, Compound 22)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C23H15F3N4O5/c24-23(25,26)12-34-14-6-8-15(9-7-14)35-21-19(29-16-3-1-2-4-17(16)30-21)20(31)28-13-5-10-18(22(32)33)27-11-13/h1-11H,12H2,(H,28,31)(H,32,33)
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n/an/a 180n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181186
PNG
(US9139529, 29 | US9783501, Compound 29)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)cn1
Show InChI InChI=1S/C21H12F2N4O4/c22-11-5-8-17(13(23)9-11)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181184
PNG
(US9139529, 27 | US9783501, Compound 27)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)cc1F
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-9-7-13(10-14(18)23)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181200
PNG
(US9139529, 43 | US9783501, Compound 43)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cn[nH]c1
Show InChI InChI=1S/C19H14FN5O3/c1-27-16-8-11(20)6-7-15(16)28-19-17(18(26)23-12-9-21-22-10-12)24-13-4-2-3-5-14(13)25-19/h2-10H,1H3,(H,21,22)(H,23,26)
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n/an/a 220n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181178
PNG
(US9139529, 21 | US9783501, Compound 21)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(F)c1
Show InChI InChI=1S/C22H15FN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 235n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181175
PNG
(US9139529, 18 | US9783501, Compound 18)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H13FN4O4/c22-12-5-8-14(9-6-12)30-20-18(25-15-3-1-2-4-16(15)26-20)19(27)24-13-7-10-17(21(28)29)23-11-13/h1-11H,(H,24,27)(H,28,29)
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n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181237
PNG
(US9139529, 80 | US9783501, Compound 80)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2F)cn1
Show InChI InChI=1S/C22H13F2N3O4/c23-13-5-8-19(16(24)10-13)31-21-15(9-12-3-1-2-4-17(12)27-21)20(28)26-14-6-7-18(22(29)30)25-11-14/h1-11H,(H,26,28)(H,29,30)
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n/an/a 255n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181232
PNG
(US9139529, 75 | US9783501, Compound 75)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C23H14F2N2O4/c24-15-7-10-20(18(25)12-15)31-22-17(11-14-3-1-2-4-19(14)27-22)21(28)26-16-8-5-13(6-9-16)23(29)30/h1-12H,(H,26,28)(H,29,30)
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n/an/a 275n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181233
PNG
(US9139529, 76 | US9783501, Compound 76)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17FN2O4/c1-14-12-17(25)8-11-21(14)31-23-19(13-16-4-2-3-5-20(16)27-23)22(28)26-18-9-6-15(7-10-18)24(29)30/h2-13H,1H3,(H,26,28)(H,29,30)
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n/an/a 315n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181181
PNG
(US9139529, 24 | US9783501, Compound 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C22H14F2N4O5/c23-22(24)33-17-8-4-3-7-16(17)32-20-18(27-13-5-1-2-6-14(13)28-20)19(29)26-12-9-10-15(21(30)31)25-11-12/h1-11,22H,(H,26,29)(H,30,31)
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n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181201
PNG
(US9139529, 44 | US9783501, Compound 44)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]c(CO)nc2c1
Show InChI InChI=1S/C24H18FN5O4/c1-33-20-10-13(25)6-9-19(20)34-24-22(29-15-4-2-3-5-16(15)30-24)23(32)26-14-7-8-17-18(11-14)28-21(12-31)27-17/h2-11,31H,12H2,1H3,(H,26,32)(H,27,28)
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n/an/a 425n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181194
PNG
(US9139529, 37 | US9783501, Compound 37)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H13FN4O5S/c1-29-15-8-10(21)6-7-14(15)30-18-16(22-11-4-2-3-5-12(11)23-18)17(26)25-20-24-13(9-31-20)19(27)28/h2-9H,1H3,(H,27,28)(H,24,25,26)
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n/an/a 450n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181193
PNG
(US9139529, 36 | US9783501, Compound 36)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C23H16FN3O5/c1-31-19-12-14(24)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-15-6-4-5-13(11-15)23(29)30/h2-12H,1H3,(H,25,28)(H,29,30)
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n/an/a 460n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181235
PNG
(US9139529, 78 | US9783501, Compound 78)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2ccc(cc2)C(O)=O)c(OC)c1
Show InChI InChI=1S/C25H20N2O6/c1-31-18-11-12-21(22(14-18)32-2)33-24-19(13-16-5-3-4-6-20(16)27-24)23(28)26-17-9-7-15(8-10-17)25(29)30/h3-14H,1-2H3,(H,26,28)(H,29,30)
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n/an/a 550n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181206
PNG
(US9139529, 49 | US9783501, Compound 49)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2nc[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-13(24)6-9-19(20)32-23-21(28-16-4-2-3-5-17(16)29-23)22(30)27-14-7-8-15-18(11-14)26-12-25-15/h2-12H,1H3,(H,25,26)(H,27,30)
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n/an/a 585n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181234
PNG
(US9139529, 77 | US9783501, Compound 77)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2OC(F)F)cc1
Show InChI InChI=1S/C24H16F2N2O5/c25-24(26)33-20-8-4-3-7-19(20)32-22-17(13-15-5-1-2-6-18(15)28-22)21(29)27-16-11-9-14(10-12-16)23(30)31/h1-13,24H,(H,27,29)(H,30,31)
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n/an/a 975n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181177
PNG
(US9139529, 20 | US9783501, Compound 20)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)cn1
Show InChI InChI=1S/C21H14N4O4/c26-19(23-13-10-11-17(21(27)28)22-12-13)18-20(29-14-6-2-1-3-7-14)25-16-9-5-4-8-15(16)24-18/h1-12H,(H,23,26)(H,27,28)
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n/an/a 1.08E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181195
PNG
(US9139529, 38 | US9783501, Compound 38)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1nc[nH]n1
Show InChI InChI=1S/C18H13FN6O3/c1-27-14-8-10(19)6-7-13(14)28-17-15(16(26)24-18-20-9-21-25-18)22-11-4-2-3-5-12(11)23-17/h2-9H,1H3,(H2,20,21,24,25,26)
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n/an/a 1.22E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181207
PNG
(US9139529, 50 | US9783501, Compound 50)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cc(ccn1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-18-11-14(23)6-7-17(18)31-22-20(26-15-4-2-3-5-16(15)27-22)21(29)28-19-10-13(12-24)8-9-25-19/h2-11H,1H3,(H,25,28,29)
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n/an/a 1.25E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181202
PNG
(US9139529, 45 | US9783501, Compound 45)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C23H16FN7O3/c1-33-19-12-14(24)9-10-18(19)34-23-20(26-16-7-2-3-8-17(16)27-23)22(32)25-15-6-4-5-13(11-15)21-28-30-31-29-21/h2-12H,1H3,(H,25,32)(H,28,29,30,31)
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181197
PNG
(US9139529, 40 | US9783501, Compound 40)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cc[nH]n1
Show InChI InChI=1S/C19H14FN5O3/c1-27-15-10-11(20)6-7-14(15)28-19-17(18(26)24-16-8-9-21-25-16)22-12-4-2-3-5-13(12)23-19/h2-10H,1H3,(H2,21,24,25,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181198
PNG
(US9139529, 41 | US9783501, Compound 41)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C17H12FN7O3/c1-27-13-8-9(18)6-7-12(13)28-16-14(15(26)21-17-22-24-25-23-17)19-10-4-2-3-5-11(10)20-16/h2-8H,1H3,(H2,21,22,23,24,25,26)
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n/an/a 2.20E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181209
PNG
(US9139529, 52 | US9783501, Compound 52)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(cn1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-18-10-14(23)7-8-17(18)31-22-20(26-15-4-2-3-5-16(15)27-22)21(29)28-19-9-6-13(11-24)12-25-19/h2-10,12H,1H3,(H,25,28,29)
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n/an/a 2.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM181196
PNG
(US9139529, 39 | US9783501, Compound 39)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1nc(co1)C(O)=O
Show InChI InChI=1S/C20H13FN4O6/c1-29-15-8-10(21)6-7-14(15)31-18-16(22-11-4-2-3-5-12(11)23-18)17(26)25-20-24-13(9-30-20)19(27)28/h2-9H,1H3,(H,27,28)(H,24,25,26)
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n/an/a 2.60E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%