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Patent code US9139578

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))		BDBM181685
PNG
(US9139578, 3)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(NC(=O)c1cccnc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C22H17FN8O4S2/c23-17-6-4-13(10-26-17)12-3-5-15-16(8-12)36-22(28-15)19(29-20(32)14-2-1-7-25-9-14)21-31-30-18(35-21)11-27-37(24,33)34/h1-10,19,27H,11H2,(H,29,32)(H2,24,33,34)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181694
PNG
(US9139578, 13)
Show SMILES CC(C)C(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H22N6O4S2/c1-12(2)19(28)25-18(20-27-26-17(31-20)11-23-33(22,29)30)21-24-15-9-8-14(10-16(15)32-21)13-6-4-3-5-7-13/h3-10,12,18,23H,11H2,1-2H3,(H,25,28)(H2,22,29,30)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181700
PNG
(US9139578, 19)
Show SMILES OS(=O)(=O)Cc1nnc(o1)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C25H17F3N4O5S2/c26-25(27,28)17-9-6-15(7-10-17)22(33)30-21(23-32-31-20(37-23)13-39(34,35)36)24-29-18-11-8-16(12-19(18)38-24)14-4-2-1-3-5-14/h1-12,21H,13H2,(H,30,33)(H,34,35,36)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181698
PNG
(US9139578, 17)
Show SMILES CC(=O)NC(c1nnc(CNC(=O)OC(C)(C)C)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C24H25N5O4S/c1-14(30)26-20(21-29-28-19(32-21)13-25-23(31)33-24(2,3)4)22-27-17-11-10-16(12-18(17)34-22)15-8-6-5-7-9-15/h5-12,20H,13H2,1-4H3,(H,25,31)(H,26,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181690
PNG
(US9139578, 8)
Show SMILES Cc1noc(C)c1NC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C22H20FN9O5S2/c1-10-18(11(2)37-32-10)28-22(33)29-19(20-31-30-17(36-20)9-26-39(24,34)35)21-27-14-5-3-12(7-15(14)38-21)13-4-6-16(23)25-8-13/h3-8,19,26H,9H2,1-2H3,(H2,24,34,35)(H2,28,29,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181697
PNG
(US9139578, 16)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C25H19F3N6O4S2/c26-25(27,28)17-9-6-15(7-10-17)22(35)32-21(23-34-33-20(38-23)13-30-40(29,36)37)24-31-18-11-8-16(12-19(18)39-24)14-4-2-1-3-5-14/h1-12,21,30H,13H2,(H,32,35)(H2,29,36,37)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181699
PNG
(US9139578, 18)
Show SMILES OS(=O)(=O)Cc1nnc(o1)C(NC(=O)C1CC1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H18N4O5S2/c26-19(13-6-7-13)23-18(20-25-24-17(30-20)11-32(27,28)29)21-22-15-9-8-14(10-16(15)31-21)12-4-2-1-3-5-12/h1-5,8-10,13,18H,6-7,11H2,(H,23,26)(H,27,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181691
PNG
(US9139578, 9)
Show SMILES CC(=O)NC(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2o1)-c1ccc(F)nc1
Show InChI InChI=1S/C21H15FN6O5S/c1-9(29)24-17(20-28-27-16(33-20)7-14-18(30)26-21(31)34-14)19-25-12-4-2-10(6-13(12)32-19)11-3-5-15(22)23-8-11/h2-6,8,14,17H,7H2,1H3,(H,24,29)(H,26,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181695
PNG
(US9139578, 14)
Show SMILES CC(C)(C)OC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C22H24N6O5S2/c1-22(2,3)33-21(29)26-18(19-28-27-17(32-19)12-24-35(23,30)31)20-25-15-10-9-14(11-16(15)34-20)13-7-5-4-6-8-13/h4-11,18,24H,12H2,1-3H3,(H,26,29)(H2,23,30,31)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181703
PNG
(US9139578, 22)
Show SMILES Fc1cc(cc2sc(nc12)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1nnc(CC2SC(=O)NC2=O)o1)-c1ccccc1
Show InChI InChI=1S/C28H17F4N5O4S2/c29-17-10-15(13-4-2-1-3-5-13)11-18-21(17)34-26(42-18)22(33-23(38)14-6-8-16(9-7-14)28(30,31)32)25-37-36-20(41-25)12-19-24(39)35-27(40)43-19/h1-11,19,22H,12H2,(H,33,38)(H,35,39,40)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181702
PNG
(US9139578, 21)
Show SMILES Fc1cc(cc2sc(nc12)C(NC(=O)C1CC1)c1nnc(CC2SC(=O)NC2=O)o1)-c1ccccc1
Show InChI InChI=1S/C24H18FN5O4S2/c25-14-8-13(11-4-2-1-3-5-11)9-15-18(14)27-23(35-15)19(26-20(31)12-6-7-12)22-30-29-17(34-22)10-16-21(32)28-24(33)36-16/h1-5,8-9,12,16,19H,6-7,10H2,(H,26,31)(H,28,32,33)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181693
PNG
(US9139578, 11)
Show SMILES CC(=O)NC(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccnn1C
Show InChI InChI=1S/C20H17N7O4S2/c1-9(28)22-16(18-26-25-15(31-18)8-14-17(29)24-20(30)33-14)19-23-11-4-3-10(7-13(11)32-19)12-5-6-21-27(12)2/h3-7,14,16H,8H2,1-2H3,(H,22,28)(H,24,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181684
PNG
(US9139578, 2)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C24H17F4N7O4S2/c25-18-8-4-14(10-30-18)13-3-7-16-17(9-13)40-23(32-16)20(22-35-34-19(39-22)11-31-41(29,37)38)33-21(36)12-1-5-15(6-2-12)24(26,27)28/h1-10,20,31H,11H2,(H,33,36)(H2,29,37,38)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181686
PNG
(US9139578, 4)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(NC(=O)NCc1ccccc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C24H21FN8O4S2/c25-19-9-7-16(12-27-19)15-6-8-17-18(10-15)38-23(30-17)21(22-33-32-20(37-22)13-29-39(26,35)36)31-24(34)28-11-14-4-2-1-3-5-14/h1-10,12,21,29H,11,13H2,(H2,26,35,36)(H2,28,31,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181687
PNG
(US9139578, 5)
Show SMILES CCC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C19H18FN7O4S2/c1-2-15(28)25-17(18-27-26-16(31-18)9-23-33(21,29)30)19-24-12-5-3-10(7-13(12)32-19)11-4-6-14(20)22-8-11/h3-8,17,23H,2,9H2,1H3,(H,25,28)(H2,21,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181688
PNG
(US9139578, 6)
Show SMILES CCOC(=O)CNC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C21H21FN8O6S2/c1-2-35-17(31)10-25-21(32)28-18(19-30-29-16(36-19)9-26-38(23,33)34)20-27-13-5-3-11(7-14(13)37-20)12-4-6-15(22)24-8-12/h3-8,18,26H,2,9-10H2,1H3,(H2,23,33,34)(H2,25,28,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181689
PNG
(US9139578, 7)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(NC(=O)Nc1ccc(F)cc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C23H18F2N8O4S2/c24-14-3-5-15(6-4-14)29-23(34)31-20(21-33-32-19(37-21)11-28-39(26,35)36)22-30-16-7-1-12(9-17(16)38-22)13-2-8-18(25)27-10-13/h1-10,20,28H,11H2,(H2,26,35,36)(H2,29,31,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181692
PNG
(US9139578, 10)
Show SMILES CC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C18H16FN7O4S2/c1-9(27)23-16(17-26-25-15(30-17)8-22-32(20,28)29)18-24-12-4-2-10(6-13(12)31-18)11-3-5-14(19)21-7-11/h2-7,16,22H,8H2,1H3,(H,23,27)(H2,20,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181701
PNG
(US9139578, 20)
Show SMILES CC(=O)NC(c1nnc(o1)C1CN(C1)C(=O)OC(C)(C)C)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O4S/c1-15(32)27-21(23-30-29-22(34-23)18-13-31(14-18)25(33)35-26(2,3)4)24-28-19-11-10-17(12-20(19)36-24)16-8-6-5-7-9-16/h5-12,18,21H,13-14H2,1-4H3,(H,27,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181696
PNG
(US9139578, 15)
Show SMILES CC(C)NC(=O)NC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H23N7O4S2/c1-12(2)24-21(29)26-18(19-28-27-17(32-19)11-23-34(22,30)31)20-25-15-9-8-14(10-16(15)33-20)13-6-4-3-5-7-13/h3-10,12,18,23H,11H2,1-2H3,(H2,22,30,31)(H2,24,26,29)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181681
PNG
(US9139578, Reference 2, Isomer A | US9139578, Refe...)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C25H23N5O5S3/c1-25(37(31,32)16-17-8-4-2-5-9-17,23-30-29-22(35-23)15-27-38(26,33)34)24-28-20-13-12-19(14-21(20)36-24)18-10-6-3-7-11-18/h2-14,27H,15-16H2,1H3,(H2,26,33,34)
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n/an/a 713n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181680
PNG
(US9139578, Reference 1, Isomer A | US9139578, Refe...)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)(c1nc2ccc(cc2s1)-c1ccccc1)S(C)(=O)=O
Show InChI InChI=1S/C19H19N5O5S3/c1-19(31(2,25)26,17-24-23-16(29-17)11-21-32(20,27)28)18-22-14-9-8-13(10-15(14)30-18)12-6-4-3-5-7-12/h3-10,21H,11H2,1-2H3,(H2,20,27,28)
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n/an/a 3.75E+3n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181680
PNG
(US9139578, Reference 1, Isomer A | US9139578, Refe...)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)(c1nc2ccc(cc2s1)-c1ccccc1)S(C)(=O)=O
Show InChI InChI=1S/C19H19N5O5S3/c1-19(31(2,25)26,17-24-23-16(29-17)11-21-32(20,27)28)18-22-14-9-8-13(10-15(14)30-18)12-6-4-3-5-7-12/h3-10,21H,11H2,1-2H3,(H2,20,27,28)
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n/an/a 5.20E+3n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181682
PNG
(US9139578, Reference 3 | US9169240, Reference 1)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C17H15FN6O3S2/c1-9(16-24-23-15(27-16)8-21-29(19,25)26)17-22-12-4-2-10(6-13(12)28-17)11-3-5-14(18)20-7-11/h2-7,9,21H,8H2,1H3,(H2,19,25,26)
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n/an/a 6.52E+3n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181683
PNG
(US9139578, Reference 4 | US9169240, Reference 2)
Show SMILES CC(O)(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C17H15FN6O4S2/c1-17(25,15-24-23-14(28-15)8-21-30(19,26)27)16-22-11-4-2-9(6-12(11)29-16)10-3-5-13(18)20-7-10/h2-7,21,25H,8H2,1H3,(H2,19,26,27)
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n/an/a 1.49E+4n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))		BDBM181681
PNG
(US9139578, Reference 2, Isomer A | US9139578, Refe...)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)(c1nc2ccc(cc2s1)-c1ccccc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C25H23N5O5S3/c1-25(37(31,32)16-17-8-4-2-5-9-17,23-30-29-22(35-23)15-27-38(26,33)34)24-28-20-13-12-19(14-21(20)36-24)18-10-6-3-7-11-18/h2-14,27H,15-16H2,1H3,(H2,26,33,34)
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n/an/a>2.50E+4n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...

US Patent US9139578 (2015)


BindingDB Entry DOI: 10.7270/Q2FF3R45
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%