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Patent code US9145391

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182052
PNG
(US9145391, 1-20)
Show SMILES COC1CC(Cc2ccc(cn2)-c2cc(C)cc(Nc3cc(ccn3)C(F)(F)F)n2)CCC1C(O)=O
Show InChI InChI=1S/C26H27F3N4O3/c1-15-9-21(32-24(10-15)33-23-13-18(7-8-30-23)26(27,28)29)17-4-5-19(31-14-17)11-16-3-6-20(25(34)35)22(12-16)36-2/h4-5,7-10,13-14,16,20,22H,3,6,11-12H2,1-2H3,(H,34,35)(H,30,32,33)
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US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182098
PNG
(US9145391, 3-2 | US9145391, 3-3)
Show SMILES CC1CC(CCC1C(O)=O)Nc1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H26F3N5O2/c1-14-9-20(32-23(10-14)33-22-12-17(7-8-29-22)25(26,27)28)16-3-6-21(30-13-16)31-18-4-5-19(24(34)35)15(2)11-18/h3,6-10,12-13,15,18-19H,4-5,11H2,1-2H3,(H,30,31)(H,34,35)(H,29,32,33)
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US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182063
PNG
(US9145391, 1-31)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C(O)(C1CC1)C1CCC(CC1)C(O)=O |(.43,-10.27,;-.9,-9.5,;-2.23,-10.27,;-3.57,-9.5,;-4.9,-10.27,;-6.23,-9.5,;-6.23,-7.96,;-7.57,-7.19,;-8.9,-7.96,;-8.9,-9.5,;-7.57,-10.27,;-7.57,-5.65,;-8.9,-4.88,;-7.17,-4.16,;-6.08,-6.05,;-3.57,-7.96,;-2.23,-7.19,;-.9,-7.96,;-2.23,-5.65,;-.9,-4.88,;-.9,-3.34,;-2.23,-2.57,;-3.57,-3.34,;-3.57,-4.88,;-2.23,-1.03,;-1.46,.31,;-3.36,1.03,;-3.36,2.57,;-4.7,1.8,;-.69,-1.03,;.08,.31,;1.62,.31,;2.44,-1.03,;1.62,-2.36,;.08,-2.36,;3.98,-1.03,;4.75,-2.36,;4.75,.31,)|
Show InChI InChI=1S/C28H29F3N4O3/c1-16-12-22(34-25(13-16)35-24-14-21(10-11-32-24)28(29,30)31)18-4-9-23(33-15-18)27(38,20-7-8-20)19-5-2-17(3-6-19)26(36)37/h4,9-15,17,19-20,38H,2-3,5-8H2,1H3,(H,36,37)(H,32,34,35)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182065
PNG
(US9145391, 1-33)
Show SMILES CC(O)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(cc(Nc2cc(ccn2)C(F)F)n1)C1CC1 |(-3.1,1.33,;-2.33,,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,;-2.33,-1.54,;-1,-2.31,;-1,-3.85,;-2.33,-4.62,;-3.67,-3.85,;-3.67,-2.31,;-2.33,-6.16,;-1,-6.93,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-9,-3.85,;-6.67,-3.68,;-3.67,-6.93,;.33,-9.24,;.33,-10.78,;1.87,-9.24,)|
Show InChI InChI=1S/C28H30F2N4O3/c1-28(37,21-7-4-17(5-8-21)27(35)36)23-9-6-19(15-32-23)22-12-20(16-2-3-16)14-25(33-22)34-24-13-18(26(29)30)10-11-31-24/h6,9-17,21,26,37H,2-5,7-8H2,1H3,(H,35,36)(H,31,33,34)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182240
PNG
(US9145391, 12)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(2.67,-6.93,;1.33,-6.16,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.79,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.25,;-6.67,-1.48,;-4,-1.48,;-1.33,-4.62,;,-3.85,;1.33,-4.62,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;1.33,,;1.33,-1.54,;,2.31,;-1.33,1.54,;-1.33,3.08,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,)|
Show InChI InChI=1S/C26H28F2N4O3/c1-15-11-20(31-23(12-15)32-22-13-17(24(27)28)9-10-29-22)18-5-8-21(30-14-18)26(2,35)19-6-3-16(4-7-19)25(33)34/h5,8-14,16,19,24,35H,3-4,6-7H2,1-2H3,(H,33,34)(H,29,31,32)/t16-,19-,26?
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182298
PNG
(US9145391, 12-2)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(C[C@H](O)C2CCC(CC2)C(O)=O)nc1 |wD:22.24,(11.91,-5,;10.58,-4.23,;9.25,-5,;7.91,-4.23,;6.58,-5,;6.58,-6.54,;7.91,-7.31,;7.91,-8.85,;6.58,-9.62,;5.25,-8.85,;5.25,-7.31,;9.25,-9.62,;10.58,-8.85,;9.25,-11.16,;7.91,-2.69,;9.25,-1.92,;10.58,-2.69,;9.25,-.38,;7.91,.39,;7.91,1.93,;9.25,2.7,;9.25,4.24,;7.91,5.01,;6.58,4.24,;7.91,6.55,;9.25,7.32,;9.25,8.86,;7.91,9.63,;6.58,8.86,;6.58,7.32,;7.91,11.17,;6.58,11.94,;9.25,11.94,;10.58,1.93,;10.58,.39,)|
Show InChI InChI=1S/C26H28F2N4O3/c1-15-10-21(31-24(11-15)32-23-12-18(25(27)28)8-9-29-23)19-6-7-20(30-14-19)13-22(33)16-2-4-17(5-3-16)26(34)35/h6-12,14,16-17,22,25,33H,2-5,13H2,1H3,(H,34,35)(H,29,31,32)/t16?,17?,22-/m0/s1
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US Patent
n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182067
PNG
(US9145391, 1-35)
Show SMILES CC1CC(CCC1C(O)=O)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1
Show InChI InChI=1S/C27H30F2N4O3/c1-15-10-21(32-24(11-15)33-23-13-17(25(28)29)8-9-30-23)18-4-7-22(31-14-18)27(3,36)19-5-6-20(26(34)35)16(2)12-19/h4,7-11,13-14,16,19-20,25,36H,5-6,12H2,1-3H3,(H,34,35)(H,30,32,33)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182242
PNG
(US9145391, 14)
Show SMILES CC([C@H]1CC[C@@H](CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |r,wU:5.8,wD:2.1,(-1.33,3.08,;,2.31,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,;,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,-3.85,;1.33,-4.62,;1.33,-6.16,;2.67,-6.93,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.85,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.31,;-4,-1.54,;-6.67,-1.54,;-5.33,-.77,;-1.33,-4.62,)|
Show InChI InChI=1S/C26H27F3N4O2/c1-15-11-22(32-24(12-15)33-23-13-20(9-10-30-23)26(27,28)29)19-7-8-21(31-14-19)16(2)17-3-5-18(6-4-17)25(34)35/h7-14,16-18H,3-6H2,1-2H3,(H,34,35)(H,30,32,33)/t16?,17-,18-
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182100
PNG
(US9145391, 3-4 | US9145391, 3-5)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCC(C(O)=O)C(C)(C)C2)nc1
Show InChI InChI=1S/C26H28F3N5O2/c1-15-10-20(33-23(11-15)34-22-12-17(8-9-30-22)26(27,28)29)16-4-7-21(31-14-16)32-18-5-6-19(24(35)36)25(2,3)13-18/h4,7-12,14,18-19H,5-6,13H2,1-3H3,(H,31,32)(H,35,36)(H,30,33,34)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182147
PNG
(US9145391, 4-44)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2ccc3cccnc3n2)nc1
Show InChI InChI=1S/C31H27F3N8O/c1-19-15-25(39-28(16-19)41-27-17-22(8-12-35-27)31(32,33)34)21-5-7-26(37-18-21)38-23-9-13-42(14-10-23)30(43)24-6-4-20-3-2-11-36-29(20)40-24/h2-8,11-12,15-18,23H,9-10,13-14H2,1H3,(H,37,38)(H,35,39,41)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182244
PNG
(US9145391, 16)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(O)[C@H]1CC[C@@H](CC1)C([O-])=O |r,wU:29.35,wD:26.28,(4.71,-1.94,;3.38,-1.17,;3.38,.37,;2.04,1.14,;2.04,2.68,;3.38,3.45,;3.38,4.99,;4.71,5.76,;6.05,4.99,;6.05,3.45,;4.71,2.68,;4.71,7.3,;3.38,8.07,;6.05,8.07,;.71,.37,;.71,-1.17,;2.04,-1.94,;-.62,-1.94,;-1.96,-1.17,;-3.29,-1.94,;-3.29,-3.48,;-1.96,-4.25,;-.62,-3.48,;-4.62,-4.25,;-5.39,-2.91,;-3.85,-5.58,;-5.96,-5.02,;-7.29,-4.25,;-8.63,-5.02,;-8.63,-6.56,;-7.29,-7.33,;-5.96,-6.56,;-9.96,-7.33,;-9.96,-8.87,;-11.29,-6.56,)|
Show InChI InChI=1S/C26H28F2N4O3/c1-15-11-20(31-23(12-15)32-22-13-17(24(27)28)9-10-29-22)18-5-8-21(30-14-18)26(2,35)19-6-3-16(4-7-19)25(33)34/h5,8-14,16,19,24,35H,3-4,6-7H2,1-2H3,(H,33,34)(H,29,31,32)/p-1/t16-,19-,26?
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182038
PNG
(US9145391, 1)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C(C)(O)C1CC[C@@H](CC1)C(O)=O |r,wD:30.36,(2.03,-5.98,;.7,-5.21,;-.64,-5.98,;-1.97,-5.21,;-3.3,-5.98,;-3.3,-7.52,;-4.64,-8.29,;-4.64,-9.83,;-3.3,-10.6,;-1.97,-9.83,;-1.97,-8.29,;-5.97,-10.6,;-7.3,-11.37,;-6.74,-9.26,;-5.2,-11.93,;-1.97,-3.67,;-.64,-2.9,;.7,-3.67,;-.64,-1.36,;-1.97,-.59,;-1.97,.95,;-.64,1.72,;.7,.95,;.7,-.59,;-.64,3.26,;.9,3.26,;-2.18,3.26,;-.64,4.8,;-1.97,5.57,;-1.97,7.11,;-.64,7.88,;.7,7.11,;.7,5.57,;-.64,9.42,;.7,10.19,;-1.97,10.19,)|
Show InChI InChI=1S/C26H27F3N4O3/c1-15-11-20(32-23(12-15)33-22-13-19(9-10-30-22)26(27,28)29)17-5-8-21(31-14-17)25(2,36)18-6-3-16(4-7-18)24(34)35/h5,8-14,16,18,36H,3-4,6-7H2,1-2H3,(H,34,35)(H,30,32,33)/t16-,18?,25?
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182062
PNG
(US9145391, 1-30)
Show SMILES CCC(O)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |(-4.98,1.8,;-3.08,1.8,;-1.95,-.26,;-1.18,1.08,;-.41,-.26,;.36,1.08,;1.9,1.08,;2.73,-.26,;1.9,-1.59,;.36,-1.59,;4.27,-.26,;5.04,-1.59,;5.04,1.08,;-1.95,-1.8,;-.62,-2.57,;-.62,-4.11,;-1.95,-4.88,;-3.28,-4.11,;-3.28,-2.57,;-1.95,-6.42,;-.62,-7.19,;-.62,-8.73,;.72,-9.5,;-1.95,-9.5,;-3.28,-8.73,;-4.62,-9.5,;-5.95,-8.73,;-5.95,-7.19,;-7.28,-6.42,;-8.62,-7.19,;-8.62,-8.73,;-7.28,-9.5,;-7.28,-4.88,;-8.62,-4.11,;-6.89,-3.39,;-5.8,-5.28,;-3.28,-7.19,)|
Show InChI InChI=1S/C27H29F3N4O3/c1-3-26(37,19-7-4-17(5-8-19)25(35)36)22-9-6-18(15-32-22)21-12-16(2)13-24(33-21)34-23-14-20(10-11-31-23)27(28,29)30/h6,9-15,17,19,37H,3-5,7-8H2,1-2H3,(H,35,36)(H,31,33,34)
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182241
PNG
(US9145391, 13)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(F)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(2.67,-6.93,;1.33,-6.16,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.79,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.25,;-6.67,-1.48,;-4,-1.48,;-1.33,-4.62,;,-3.85,;1.33,-4.62,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;1.33,,;1.33,-1.54,;,2.31,;-1.33,1.54,;-1.33,3.08,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,)|
Show InChI InChI=1S/C26H27F3N4O2/c1-15-11-20(32-23(12-15)33-22-13-17(24(27)28)9-10-30-22)18-5-8-21(31-14-18)26(2,29)19-6-3-16(4-7-19)25(34)35/h5,8-14,16,19,24H,3-4,6-7H2,1-2H3,(H,34,35)(H,30,32,33)/t16-,19-,26?
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n/an/a<0.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182089
PNG
(US9145391, 2-24)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCC(CC2)C(O)=O)nc1 |(-11.08,-4.01,;-10.31,-2.67,;-11.08,-1.34,;-10.31,-.01,;-11.08,1.33,;-10.31,2.66,;-8.76,2.66,;-7.99,3.99,;-8.76,5.33,;-10.31,5.33,;-11.08,3.99,;-6.45,3.99,;-5.68,5.33,;-5.64,2.62,;-4.91,3.99,;-8.76,-.01,;-7.99,-1.34,;-8.76,-2.67,;-6.45,-1.34,;-5.68,-2.67,;-4.14,-2.67,;-3.37,-1.34,;-2.41,.38,;-.87,.38,;-.1,1.72,;1.44,1.72,;2.26,.39,;1.44,-.95,;-.1,-.95,;3.8,.39,;4.57,-.95,;4.57,1.72,;-4.14,-.01,;-5.68,-.01,)|
Show InChI InChI=1S/C24H24F3N5O2/c1-14-10-19(31-22(11-14)32-21-12-17(8-9-28-21)24(25,26)27)16-4-7-20(29-13-16)30-18-5-2-15(3-6-18)23(33)34/h4,7-13,15,18H,2-3,5-6H2,1H3,(H,29,30)(H,33,34)(H,28,31,32)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM60638
PNG
(BDBM182292 | US9145391, 2-19)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC(C)(C)C(O)=O)nc1
Show InChI InChI=1S/C21H20F3N5O2/c1-12-8-15(13-4-5-16(26-11-13)29-20(2,3)19(30)31)27-18(9-12)28-17-10-14(6-7-25-17)21(22,23)24/h4-11H,1-3H3,(H,26,29)(H,30,31)(H,25,27,28)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182107
PNG
(US9145391, 4-4)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2ccc3CNC(=O)c3c2)nc1
Show InChI InChI=1S/C31H28F3N7O2/c1-18-12-25(39-28(13-18)40-27-15-22(6-9-35-27)31(32,33)34)21-4-5-26(36-17-21)38-23-7-10-41(11-8-23)30(43)19-2-3-20-16-37-29(42)24(20)14-19/h2-6,9,12-15,17,23H,7-8,10-11,16H2,1H3,(H,36,38)(H,37,42)(H,35,39,40)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182299
PNG
(US9145391, 12-3)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(C[C@@H](O)C2CCC(CC2)C(O)=O)nc1 |wU:22.24,(11.91,-5,;10.58,-4.23,;9.25,-5,;7.91,-4.23,;6.58,-5,;6.58,-6.54,;7.91,-7.31,;7.91,-8.85,;6.58,-9.62,;5.25,-8.85,;5.25,-7.31,;9.25,-9.62,;10.58,-8.85,;9.25,-11.16,;7.91,-2.69,;9.25,-1.92,;10.58,-2.69,;9.25,-.38,;7.91,.39,;7.91,1.93,;9.25,2.7,;9.25,4.24,;7.91,5.01,;6.58,4.24,;7.91,6.55,;9.25,7.32,;9.25,8.86,;7.91,9.63,;6.58,8.86,;6.58,7.32,;7.91,11.17,;6.58,11.94,;9.25,11.94,;10.58,1.93,;10.58,.39,)|
Show InChI InChI=1S/C26H28F2N4O3/c1-15-10-21(31-24(11-15)32-23-12-18(25(27)28)8-9-29-23)19-6-7-20(30-14-19)13-22(33)16-2-4-17(5-3-16)26(34)35/h6-12,14,16-17,22,25,33H,2-5,13H2,1H3,(H,34,35)(H,29,31,32)/t16?,17?,22-/m1/s1
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182094
PNG
(US9145391, 2-31)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)N1CC(CC1=O)C(O)=O
Show InChI InChI=1S/C22H18F3N5O3/c1-12-6-16(28-18(7-12)29-17-9-15(4-5-26-17)22(23,24)25)13-2-3-19(27-10-13)30-11-14(21(32)33)8-20(30)31/h2-7,9-10,14H,8,11H2,1H3,(H,32,33)(H,26,28,29)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182050
PNG
(US9145391, 1-18)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCC(CC1)C(O)=O |(-1.28,-9.05,;-2.37,-7.96,;-3.85,-8.36,;-4.94,-7.27,;-6.43,-7.67,;-7.52,-6.58,;-7.12,-5.09,;-8.21,-4,;-9.7,-4.4,;-10.1,-5.89,;-9.01,-6.98,;-7.81,-2.52,;-8.9,-1.43,;-7.04,-1.18,;-6.48,-3.29,;-4.54,-5.78,;-3.06,-5.38,;-1.97,-6.47,;-2.66,-3.9,;-1.17,-3.5,;-.77,-2.01,;-1.86,-.92,;-3.35,-1.32,;-3.75,-2.81,;-1.46,.57,;-3.16,1.7,;-.69,1.9,;.85,1.9,;1.67,.57,;.85,-.77,;-.69,-.77,;3.21,.57,;3.98,-.77,;3.98,1.9,)|
Show InChI InChI=1S/C24H23F3N4O3/c1-14-10-18(30-21(11-14)31-20-12-17(6-9-28-20)24(25,26)27)16-2-3-19(29-13-16)23(34)7-4-15(5-8-23)22(32)33/h2-3,6,9-13,15,34H,4-5,7-8H2,1H3,(H,32,33)(H,28,30,31)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182098
PNG
(US9145391, 3-2 | US9145391, 3-3)
Show SMILES CC1CC(CCC1C(O)=O)Nc1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H26F3N5O2/c1-14-9-20(32-23(10-14)33-22-12-17(7-8-29-22)25(26,27)28)16-3-6-21(30-13-16)31-18-4-5-19(24(34)35)15(2)11-18/h3,6-10,12-13,15,18-19H,4-5,11H2,1-2H3,(H,30,31)(H,34,35)(H,29,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182055
PNG
(US9145391, 1-23 | US9145391, 1-24 | US9145391, 1-2...)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCC(C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H27F3N4O3/c1-15-10-19(32-22(11-15)33-21-12-17(7-9-30-21)26(27,28)29)16-4-5-20(31-13-16)25(36)8-6-18(23(34)35)24(2,3)14-25/h4-5,7,9-13,18,36H,6,8,14H2,1-3H3,(H,34,35)(H,30,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182180
PNG
(US9145391, 4-77)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)Cc2cccnc2)nc1
Show InChI InChI=1S/C29H28F3N7O/c1-19-13-24(37-27(14-19)38-26-16-22(6-10-34-26)29(30,31)32)21-4-5-25(35-18-21)36-23-7-11-39(12-8-23)28(40)15-20-3-2-9-33-17-20/h2-6,9-10,13-14,16-18,23H,7-8,11-12,15H2,1H3,(H,35,36)(H,34,37,38)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182140
PNG
(US9145391, 4-37)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2cnn3cccnc23)nc1
Show InChI InChI=1S/C29H26F3N9O/c1-18-13-23(38-26(14-18)39-25-15-20(5-9-33-25)29(30,31)32)19-3-4-24(35-16-19)37-21-6-11-40(12-7-21)28(42)22-17-36-41-10-2-8-34-27(22)41/h2-5,8-10,13-17,21H,6-7,11-12H2,1H3,(H,35,37)(H,33,38,39)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182105
PNG
(US9145391, 4-2)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)Cc2ccc3ccn(C)c3c2)nc1
Show InChI InChI=1S/C33H32F3N7O/c1-21-15-27(40-31(16-21)41-30-19-25(7-11-37-30)33(34,35)36)24-5-6-29(38-20-24)39-26-9-13-43(14-10-26)32(44)18-22-3-4-23-8-12-42(2)28(23)17-22/h3-8,11-12,15-17,19-20,26H,9-10,13-14,18H2,1-2H3,(H,38,39)(H,37,40,41)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182064
PNG
(US9145391, 1-32)
Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(.33,-9.24,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-8.89,-3.68,;-6.61,-3.63,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)|
Show InChI InChI=1S/C28H32N4O3/c1-17-13-23(31-26(14-17)32-25-15-20(11-12-29-25)18-3-4-18)21-7-10-24(30-16-21)28(2,35)22-8-5-19(6-9-22)27(33)34/h7,10-16,18-19,22,35H,3-6,8-9H2,1-2H3,(H,33,34)(H,29,31,32)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182061
PNG
(US9145391, 1-29)
Show SMILES Cc1cc(Nc2cc(OC(C)(C)C)ccn2)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(.33,-9.24,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-7.67,-4.62,;-6.34,-3.85,;-5.94,-2.36,;-5.11,-4.79,;-7.56,-2.91,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)|
Show InChI InChI=1S/C29H36N4O4/c1-18-14-23(32-26(15-18)33-25-16-22(12-13-30-25)37-28(2,3)4)20-8-11-24(31-17-20)29(5,36)21-9-6-19(7-10-21)27(34)35/h8,11-17,19,21,36H,6-7,9-10H2,1-5H3,(H,34,35)(H,30,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182059
PNG
(US9145391, 1-27)
Show SMILES Cc1cc(Nc2cc(c(F)cn2)C(C)(C)C)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(.33,-9.24,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-10.34,-6.16,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-9,-3.85,;-7.27,-3.13,;-6.18,-5.02,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)|
Show InChI InChI=1S/C29H35FN4O3/c1-17-12-23(33-26(13-17)34-25-14-21(28(2,3)4)22(30)16-32-25)19-8-11-24(31-15-19)29(5,37)20-9-6-18(7-10-20)27(35)36/h8,11-16,18,20,37H,6-7,9-10H2,1-5H3,(H,35,36)(H,32,33,34)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182055
PNG
(US9145391, 1-23 | US9145391, 1-24 | US9145391, 1-2...)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCC(C(O)=O)C(C)(C)C1
Show InChI InChI=1S/C26H27F3N4O3/c1-15-10-19(32-22(11-15)33-21-12-17(7-9-30-21)26(27,28)29)16-4-5-20(31-13-16)25(36)8-6-18(23(34)35)24(2,3)14-25/h4-5,7,9-13,18,36H,6,8,14H2,1-3H3,(H,34,35)(H,30,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182243
PNG
(US9145391, 15)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(-c2ccc(nc2)C(C)(O)[C@H]2CC[C@@H](CC2)C(O)=O)c1Br |r,wU:28.33,wD:25.26,(5.37,-1.95,;4.04,-1.18,;4.04,.36,;2.7,1.13,;2.7,2.67,;4.04,3.44,;4.04,4.98,;5.37,5.75,;6.71,4.98,;6.71,3.44,;5.37,2.67,;5.37,7.29,;4.04,8.06,;6.71,8.06,;1.37,.36,;1.37,-1.18,;.04,-1.95,;-1.3,-1.18,;-2.63,-1.95,;-2.63,-3.49,;-1.3,-4.26,;.04,-3.49,;-3.96,-4.26,;-4.73,-2.92,;-3.19,-5.59,;-5.3,-5.03,;-6.63,-4.26,;-7.97,-5.03,;-7.97,-6.57,;-6.63,-7.34,;-5.3,-6.57,;-9.3,-7.34,;-9.3,-8.88,;-10.63,-6.57,;2.7,-1.95,;2.7,-3.49,)|
Show InChI InChI=1S/C26H27BrF2N4O3/c1-14-11-21(32-20-12-16(24(28)29)9-10-30-20)33-23(22(14)27)17-5-8-19(31-13-17)26(2,36)18-6-3-15(4-7-18)25(34)35/h5,8-13,15,18,24,36H,3-4,6-7H2,1-2H3,(H,34,35)(H,30,32,33)/t15-,18-,26?
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182297
PNG
(US9145391, 12-1)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(C[C@@H](O)[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |wU:22.24,24.25,wD:27.32,(5.1,-6.89,;3.77,-6.12,;2.44,-6.89,;1.1,-6.12,;-.23,-6.89,;-.23,-8.43,;1.1,-9.2,;1.1,-10.74,;-.23,-11.51,;-1.57,-10.74,;-1.57,-9.2,;2.44,-11.51,;3.77,-10.74,;2.44,-13.05,;1.1,-4.58,;2.44,-3.81,;3.77,-4.58,;2.44,-2.27,;1.1,-1.5,;1.1,.04,;2.44,.81,;2.44,2.35,;1.1,3.12,;-.23,2.35,;1.1,4.66,;-.23,5.43,;-.23,6.97,;1.1,7.74,;2.44,6.97,;2.44,5.43,;1.1,9.28,;-.23,10.05,;2.44,10.05,;3.77,.04,;3.77,-1.5,)|
Show InChI InChI=1S/C26H28F2N4O3/c1-15-10-21(31-24(11-15)32-23-12-18(25(27)28)8-9-29-23)19-6-7-20(30-14-19)13-22(33)16-2-4-17(5-3-16)26(34)35/h6-12,14,16-17,22,25,33H,2-5,13H2,1H3,(H,34,35)(H,29,31,32)/t16-,17-,22-/m1/s1
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182053
PNG
(US9145391, 1-21 | US9145391, 1-22)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C28H23F3N4O3/c1-16-11-22(34-25(12-16)35-24-14-20(8-10-32-24)28(29,30)31)19-5-7-23(33-15-19)27(38)9-2-3-17-13-18(26(36)37)4-6-21(17)27/h4-8,10-15,38H,2-3,9H2,1H3,(H,36,37)(H,32,34,35)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182238
PNG
(US9145391, 10)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(C[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |r,wU:23.24,wD:26.31,(2.67,7.34,;1.33,8.11,;,7.34,;-1.33,8.11,;-2.67,7.34,;-4,8.11,;-4,9.65,;-5.33,10.42,;-6.67,9.65,;-6.67,8.11,;-5.33,7.34,;-5.33,11.96,;-6.67,12.73,;-4,12.73,;-5.33,13.5,;-1.33,9.65,;,10.42,;1.33,9.65,;,11.96,;-1.33,12.73,;-1.33,14.27,;,15.04,;,16.58,;1.33,17.35,;1.33,18.89,;2.67,19.66,;4,18.89,;4,17.35,;2.67,16.58,;5.33,19.66,;6.67,18.89,;5.33,21.2,;1.33,14.27,;1.33,12.73,)|
Show InChI InChI=1S/C25H25F3N4O2/c1-15-10-21(31-23(11-15)32-22-13-19(8-9-29-22)25(26,27)28)18-6-7-20(30-14-18)12-16-2-4-17(5-3-16)24(33)34/h6-11,13-14,16-17H,2-5,12H2,1H3,(H,33,34)(H,29,31,32)/t16-,17-
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM60650
PNG
(US9145391, 23)
Show SMILES CN=C.[H][C@@]1(CC[C@H](CO)CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |r,wD:4.2,7.6,(6.64,-4.64,;7.41,-3.31,;6.64,-1.97,;-4.95,-.87,;-3.62,-1.64,;-3.62,-.1,;-2.28,.67,;-.95,-.1,;.39,.67,;1.72,-.1,;-.95,-1.64,;-2.28,-2.41,;-4.95,-2.41,;-3.62,-3.18,;-4.95,-3.95,;-6.28,-1.64,;-7.62,-2.41,;-8.95,-1.64,;-8.95,-.1,;-7.62,.67,;-6.28,-.1,;-10.28,.67,;-11.62,-.1,;-12.95,.67,;-14.29,-.1,;-12.95,2.21,;-11.62,2.98,;-11.62,4.52,;-10.28,5.29,;-8.95,4.52,;-7.62,5.29,;-7.62,6.83,;-8.95,7.6,;-10.28,6.83,;-6.28,4.52,;-4.95,5.29,;-6.27,2.92,;-10.28,2.21,)|
Show InChI InChI=1S/C26H30F2N4O2.C2H5N/c1-16-11-21(31-24(12-16)32-23-13-18(25(27)28)9-10-29-23)19-5-8-22(30-14-19)26(2,34)20-6-3-17(15-33)4-7-20;1-3-2/h5,8-14,17,20,25,33-34H,3-4,6-7,15H2,1-2H3,(H,29,31,32);1H2,2H3/t17-,20-,26?;
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182060
PNG
(US9145391, 1-28)
Show SMILES Cc1cc(Nc2cc(ccn2)C(C)(C)C)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(.33,-9.24,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-9,-3.85,;-7.27,-3.13,;-6.18,-5.02,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)|
Show InChI InChI=1S/C29H36N4O3/c1-18-14-23(32-26(15-18)33-25-16-22(12-13-30-25)28(2,3)4)20-8-11-24(31-17-20)29(5,36)21-9-6-19(7-10-21)27(34)35/h8,11-17,19,21,36H,6-7,9-10H2,1-5H3,(H,34,35)(H,30,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182066
PNG
(US9145391, 1-34)
Show SMILES CC(C)(O)c1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(O)C1CCC(CC1)C(O)=O |(1.67,-8.47,;.33,-9.24,;.33,-10.78,;1.67,-10.01,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-9,-3.85,;-6.24,-3.86,;-3.67,-6.93,;-2.33,-6.16,;-1,-6.93,;-2.33,-4.62,;-1,-3.85,;-1,-2.31,;-2.33,-1.54,;-3.67,-2.31,;-3.67,-3.85,;-2.33,,;-3.1,1.33,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,)|
Show InChI InChI=1S/C28H32F2N4O4/c1-27(2,37)20-13-21(33-24(14-20)34-23-12-17(25(29)30)10-11-31-23)18-6-9-22(32-15-18)28(3,38)19-7-4-16(5-8-19)26(35)36/h6,9-16,19,25,37-38H,4-5,7-8H2,1-3H3,(H,35,36)(H,31,33,34)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182068
PNG
(US9145391, 1-36)
Show SMILES CC(=O)C(C)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |(2.04,-3.23,;1.27,-1.9,;2.04,-.56,;-.27,-1.9,;-1.81,-1.9,;-.27,-.36,;1.06,.41,;1.06,1.95,;-.27,2.72,;-1.6,1.95,;-1.6,.41,;-.27,4.26,;1.06,5.03,;-1.6,5.03,;-.27,-3.44,;1.06,-4.21,;1.06,-5.75,;-.27,-6.52,;-1.6,-5.75,;-1.6,-4.21,;-.27,-8.06,;1.06,-8.83,;1.06,-10.37,;2.4,-11.14,;-.27,-11.14,;-1.6,-10.37,;-2.94,-11.14,;-4.27,-10.37,;-4.27,-8.83,;-5.6,-8.06,;-6.94,-8.83,;-6.94,-10.37,;-5.6,-11.14,;-5.6,-6.52,;-6.94,-5.75,;-4.23,-5.71,;-1.6,-8.83,)|
Show InChI InChI=1S/C28H30F2N4O3/c1-16-12-22(33-25(13-16)34-24-14-19(26(29)30)10-11-31-24)20-6-9-23(32-15-20)28(3,17(2)35)21-7-4-18(5-8-21)27(36)37/h6,9-15,18,21,26H,4-5,7-8H2,1-3H3,(H,36,37)(H,31,33,34)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182192
PNG
(US9145391, 4-89)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)CCCN2CCCC2=O)nc1
Show InChI InChI=1S/C30H34F3N7O2/c1-20-16-24(37-27(17-20)38-26-18-22(8-11-34-26)30(31,32)33)21-6-7-25(35-19-21)36-23-9-14-40(15-10-23)29(42)5-3-13-39-12-2-4-28(39)41/h6-8,11,16-19,23H,2-5,9-10,12-15H2,1H3,(H,35,36)(H,34,37,38)
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182227
PNG
(US9145391, 5)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)N1CC[C@H](N)C1 |r|
Show InChI InChI=1S/C21H21F3N6/c1-13-8-17(14-2-3-20(27-11-14)30-7-5-16(25)12-30)28-19(9-13)29-18-10-15(4-6-26-18)21(22,23)24/h2-4,6,8-11,16H,5,7,12,25H2,1H3,(H,26,28,29)/t16-/m0/s1
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n/an/a 1n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182264
PNG
(US9145391, 19-18)
Show SMILES CN(C)C(=O)COC(=O)[C@H]1CCC(CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |r,wD:9.8,(3.05,-.39,;1.72,.38,;1.72,1.92,;.38,-.39,;.38,-1.92,;-.95,.38,;-2.28,-.39,;-3.62,.38,;-3.62,1.92,;-4.95,-.39,;-6.28,.38,;-7.62,-.39,;-7.62,-1.93,;-6.28,-2.7,;-4.95,-1.93,;-8.95,-2.7,;-10.28,-3.47,;-10.28,-1.93,;-8.95,-4.24,;-10.28,-5.01,;-10.28,-6.55,;-8.95,-7.32,;-7.62,-6.55,;-7.62,-5.01,;-8.95,-8.86,;-7.62,-9.63,;-7.62,-11.17,;-6.28,-11.94,;-8.95,-11.94,;-10.28,-11.17,;-11.62,-11.94,;-12.95,-11.17,;-12.95,-9.63,;-14.29,-8.86,;-15.62,-9.63,;-15.62,-11.17,;-14.29,-11.94,;-14.29,-7.32,;-12.95,-6.55,;-15.62,-6.55,;-10.28,-9.63,)|
Show InChI InChI=1S/C30H35F2N5O4/c1-18-13-23(35-26(14-18)36-25-15-20(28(31)32)11-12-33-25)21-7-10-24(34-16-21)30(2,40)22-8-5-19(6-9-22)29(39)41-17-27(38)37(3)4/h7,10-16,19,22,28,40H,5-6,8-9,17H2,1-4H3,(H,33,35,36)/t19-,22?,30?
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n/an/a 1.20n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182281
PNG
(US9145391, 21-2 | US9145391, 21-3)
Show SMILES CC(OC(C)=O)OC(=O)[C@H]1CCC(CC1)C(C)(O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)F)n1 |r,wD:9.8,(-.95,1.82,;-.95,.28,;.38,-.49,;1.72,.28,;3.05,-.49,;1.72,1.82,;-2.28,-.49,;-3.62,.28,;-3.62,1.82,;-4.95,-.49,;-6.28,.28,;-7.62,-.49,;-7.62,-2.03,;-6.28,-2.8,;-4.95,-2.03,;-8.95,-2.8,;-10.28,-3.57,;-10.28,-2.03,;-8.95,-4.34,;-10.28,-5.11,;-10.28,-6.65,;-8.95,-7.42,;-7.62,-6.65,;-7.62,-5.11,;-8.95,-8.96,;-7.62,-9.73,;-7.62,-11.27,;-6.28,-12.04,;-8.95,-12.04,;-10.28,-11.27,;-11.62,-12.04,;-12.95,-11.27,;-12.95,-9.73,;-14.29,-8.96,;-15.62,-9.73,;-15.62,-11.27,;-14.29,-12.04,;-14.29,-7.42,;-12.95,-6.65,;-15.62,-6.65,;-10.28,-9.73,)|
Show InChI InChI=1S/C30H34F2N4O5/c1-17-13-24(35-27(14-17)36-26-15-21(28(31)32)11-12-33-26)22-7-10-25(34-16-22)30(4,39)23-8-5-20(6-9-23)29(38)41-19(3)40-18(2)37/h7,10-16,19-20,23,28,39H,5-6,8-9H2,1-4H3,(H,33,35,36)/t19?,20-,23?,30?
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n/an/a 1.5n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182229
PNG
(US9145391, 5-1)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)N1CCCC(N)C1
Show InChI InChI=1S/C22H23F3N6/c1-14-9-18(15-4-5-21(28-12-15)31-8-2-3-17(26)13-31)29-20(10-14)30-19-11-16(6-7-27-19)22(23,24)25/h4-7,9-12,17H,2-3,8,13,26H2,1H3,(H,27,29,30)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182053
PNG
(US9145391, 1-21 | US9145391, 1-22)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)C1(O)CCCc2cc(ccc12)C(O)=O
Show InChI InChI=1S/C28H23F3N4O3/c1-16-11-22(34-25(12-16)35-24-14-20(8-10-32-24)28(29,30)31)19-5-7-23(33-15-19)27(38)9-2-3-17-13-18(26(36)37)4-6-21(17)27/h4-8,10-15,38H,2-3,9H2,1H3,(H,36,37)(H,32,34,35)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182207
PNG
(US9145391, 4-104)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2ccccn2)nc1
Show InChI InChI=1S/C28H26F3N7O/c1-18-14-23(36-26(15-18)37-25-16-20(7-11-33-25)28(29,30)31)19-5-6-24(34-17-19)35-21-8-12-38(13-9-21)27(39)22-4-2-3-10-32-22/h2-7,10-11,14-17,21H,8-9,12-13H2,1H3,(H,34,35)(H,33,36,37)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182100
PNG
(US9145391, 3-4 | US9145391, 3-5)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCC(C(O)=O)C(C)(C)C2)nc1
Show InChI InChI=1S/C26H28F3N5O2/c1-15-10-20(33-23(11-15)34-22-12-17(8-9-30-22)26(27,28)29)16-4-7-21(31-14-16)32-18-5-6-19(24(35)36)25(2,3)13-18/h4,7-12,14,18-19H,5-6,13H2,1-3H3,(H,31,32)(H,35,36)(H,30,33,34)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182086
PNG
(US9145391, 2-21)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)N1CC(C1)C1CCCC(C1)C(O)=O
Show InChI InChI=1S/C27H28F3N5O2/c1-16-9-22(33-24(10-16)34-23-12-21(7-8-31-23)27(28,29)30)19-5-6-25(32-13-19)35-14-20(15-35)17-3-2-4-18(11-17)26(36)37/h5-10,12-13,17-18,20H,2-4,11,14-15H2,1H3,(H,36,37)(H,31,33,34)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182085
PNG
(US9145391, 2-20)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(nc1)N1CCN(CC1)C(=O)N1CCCC(C1)C(O)=O
Show InChI InChI=1S/C28H30F3N7O3/c1-18-13-22(34-24(14-18)35-23-15-21(6-7-32-23)28(29,30)31)19-4-5-25(33-16-19)36-9-11-37(12-10-36)27(41)38-8-2-3-20(17-38)26(39)40/h4-7,13-16,20H,2-3,8-12,17H2,1H3,(H,39,40)(H,32,34,35)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182200
PNG
(US9145391, 4-97)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2ccc3nc(C)c(C)nc3c2)nc1
Show InChI InChI=1S/C33H31F3N8O/c1-19-14-27(42-31(15-19)43-30-17-24(8-11-37-30)33(34,35)36)23-5-7-29(38-18-23)41-25-9-12-44(13-10-25)32(45)22-4-6-26-28(16-22)40-21(3)20(2)39-26/h4-8,11,14-18,25H,9-10,12-13H2,1-3H3,(H,38,41)(H,37,42,43)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182171
PNG
(US9145391, 4-68)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)Cc2ccccn2)nc1
Show InChI InChI=1S/C29H28F3N7O/c1-19-14-24(37-27(15-19)38-26-16-21(7-11-34-26)29(30,31)32)20-5-6-25(35-18-20)36-22-8-12-39(13-9-22)28(40)17-23-4-2-3-10-33-23/h2-7,10-11,14-16,18,22H,8-9,12-13,17H2,1H3,(H,35,36)(H,34,37,38)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM182114
PNG
(US9145391, 4-11)
Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)CCN2CCCC2=O)nc1
Show InChI InChI=1S/C29H32F3N7O2/c1-19-15-23(36-26(16-19)37-25-17-21(6-10-33-25)29(30,31)32)20-4-5-24(34-18-20)35-22-7-12-39(13-8-22)28(41)9-14-38-11-2-3-27(38)40/h4-6,10,15-18,22H,2-3,7-9,11-14H2,1H3,(H,34,35)(H,33,36,37)
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n/an/a 2n/an/an/an/a7.525



Merck Sharp & Dohme Corp.; Merck Canada Inc.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9145391 (2015)


BindingDB Entry DOI: 10.7270/Q2SQ8Z5V
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 266 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%