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Patent code US9145418

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50021618
PNG
(CHEMBL3297762 | US9145418, 2)
Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C28H38ClN5O2/c1-32-10-12-33(13-11-32)19-25(20-6-3-2-4-7-20)31-27(35)16-24-17-30-28(36)26-15-22(18-34(24)26)21-8-5-9-23(29)14-21/h5,8-9,14-15,18,20,24-25H,2-4,6-7,10-13,16-17,19H2,1H3,(H,30,36)(H,31,35)/t24-,25+/m0/s1
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n/an/a 1n/an/an/an/a3.0n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50021624
PNG
(CHEMBL3297766 | US9145418, 23)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C30H42ClN5O2/c1-34(2)25-11-13-35(14-12-25)20-27(21-7-4-3-5-8-21)33-29(37)17-26-18-32-30(38)28-16-23(19-36(26)28)22-9-6-10-24(31)15-22/h6,9-10,15-16,19,21,25-27H,3-5,7-8,11-14,17-18,20H2,1-2H3,(H,32,38)(H,33,37)/t26-,27+/m0/s1
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n/an/a 1n/an/an/an/a3.0n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50021620
PNG
(CHEMBL3297764 | US9145418, 26)
Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cc(Cl)ccc2F)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C28H37ClFN5O2/c1-33-9-11-34(12-10-33)18-25(19-5-3-2-4-6-19)32-27(36)15-22-16-31-28(37)26-13-20(17-35(22)26)23-14-21(29)7-8-24(23)30/h7-8,13-14,17,19,22,25H,2-6,9-12,15-16,18H2,1H3,(H,31,37)(H,32,36)/t22-,25+/m0/s1
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n/an/a 2n/an/an/an/a3.0n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM182824
PNG
(US9145418, 10)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2ccnc(F)c2)C2CCCCC2)CC1
Show InChI InChI=1S/C29H41FN6O2/c1-34(2)23-9-12-35(13-10-23)19-25(20-6-4-3-5-7-20)33-28(37)16-24-17-32-29(38)26-14-22(18-36(24)26)21-8-11-31-27(30)15-21/h8,11,14-15,18,20,23-25H,3-7,9-10,12-13,16-17,19H2,1-2H3,(H,32,38)(H,33,37)/t24-,25+/m0/s1
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n/an/a 6n/an/an/an/a3.0n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM182823
PNG
(US9145418, 6)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2ccc(F)c(F)c2)C2CCCCC2)CC1
Show InChI InChI=1S/C30H41F2N5O2/c1-35(2)23-10-12-36(13-11-23)19-27(20-6-4-3-5-7-20)34-29(38)16-24-17-33-30(39)28-15-22(18-37(24)28)21-8-9-25(31)26(32)14-21/h8-9,14-15,18,20,23-24,27H,3-7,10-13,16-17,19H2,1-2H3,(H,33,39)(H,34,38)/t24-,27+/m0/s1
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n/an/a 8n/an/an/an/a3.0n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50021624
PNG
(CHEMBL3297766 | US9145418, 23)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C30H42ClN5O2/c1-34(2)25-11-13-35(14-12-25)20-27(21-7-4-3-5-8-21)33-29(37)17-26-18-32-30(38)28-16-23(19-36(26)28)22-9-6-10-24(31)15-22/h6,9-10,15-16,19,21,25-27H,3-5,7-8,11-14,17-18,20H2,1-2H3,(H,32,38)(H,33,37)/t26-,27+/m0/s1
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n/an/a 36n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50021618
PNG
(CHEMBL3297762 | US9145418, 2)
Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C28H38ClN5O2/c1-32-10-12-33(13-11-32)19-25(20-6-3-2-4-7-20)31-27(35)16-24-17-30-28(36)26-15-22(18-34(24)26)21-8-5-9-23(29)14-21/h5,8-9,14-15,18,20,24-25H,2-4,6-7,10-13,16-17,19H2,1H3,(H,30,36)(H,31,35)/t24-,25+/m0/s1
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n/an/a 37n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM182824
PNG
(US9145418, 10)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2ccnc(F)c2)C2CCCCC2)CC1
Show InChI InChI=1S/C29H41FN6O2/c1-34(2)23-9-12-35(13-10-23)19-25(20-6-4-3-5-7-20)33-28(37)16-24-17-32-29(38)26-14-22(18-36(24)26)21-8-11-31-27(30)15-21/h8,11,14-15,18,20,23-25H,3-7,9-10,12-13,16-17,19H2,1-2H3,(H,32,38)(H,33,37)/t24-,25+/m0/s1
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n/an/a 57n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50021620
PNG
(CHEMBL3297764 | US9145418, 26)
Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cc(Cl)ccc2F)C2CCCCC2)CC1 |r|
Show InChI InChI=1S/C28H37ClFN5O2/c1-33-9-11-34(12-10-33)18-25(19-5-3-2-4-6-19)32-27(36)15-22-16-31-28(37)26-13-20(17-35(22)26)23-14-21(29)7-8-24(23)30/h7-8,13-14,17,19,22,25H,2-6,9-12,15-16,18H2,1H3,(H,31,37)(H,32,36)/t22-,25+/m0/s1
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n/an/a 132n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM182823
PNG
(US9145418, 6)
Show SMILES CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2ccc(F)c(F)c2)C2CCCCC2)CC1
Show InChI InChI=1S/C30H41F2N5O2/c1-35(2)23-10-12-36(13-11-23)19-27(20-6-4-3-5-7-20)34-29(38)16-24-17-33-30(39)28-15-22(18-37(24)28)21-8-9-25(31)26(32)14-21/h8-9,14-15,18,20,23-24,27H,3-7,10-13,16-17,19H2,1-2H3,(H,33,39)(H,34,38)/t24-,27+/m0/s1
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n/an/a 171n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...

US Patent US9145418 (2015)


BindingDB Entry DOI: 10.7270/Q218359X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%