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Patent code US9156830

Compile Data Set for Download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185339
PNG
(US9156830, I-7)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(Cl)c1 |t:11|
Show InChI InChI=1S/C24H26ClN5O2/c1-15-28-29-22(32-15)17-13-20(25)21(26-14-17)16-9-11-30(12-10-16)23(31)27-19-7-5-18(6-8-19)24(2,3)4/h5-9,13-14H,10-12H2,1-4H3,(H,27,31)
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n/an/a 0.5n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185343
PNG
(US9156830, I-44)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2C)-c2nnc(CO)o2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C23H22F3N5O3/c1-13-10-17(3-4-18(13)23(24,25)26)28-22(33)31-7-5-15(6-8-31)20-14(2)9-16(11-27-20)21-30-29-19(12-32)34-21/h3-5,9-11,32H,6-8,12H2,1-2H3,(H,28,33)
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n/an/a 1n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185349
PNG
(US9156830, I-76)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ccc(cc2Cl)-c2nnc(CO)o2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-10-16(3-5-18(13)23(25,26)27)28-22(33)31-8-6-14(7-9-31)17-4-2-15(11-19(17)24)21-30-29-20(12-32)34-21/h2-6,10-11,32H,7-9,12H2,1H3,(H,28,33)
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n/an/a 2.10n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185352
PNG
(US9156830, I-81)
Show SMILES OCc1nnc(o1)-c1ccc(C#CC(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H10Cl2F3N3O3/c20-14-7-11(18-27-26-17(9-28)30-18)2-1-10(14)3-6-16(29)25-12-4-5-13(15(21)8-12)19(22,23)24/h1-2,4-5,7-8,28H,9H2,(H,25,29)
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n/an/a 12.8n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185345
PNG
(US9156830, I-57)
Show SMILES OCc1noc(n1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H17ClF4N6O3/c21-13-7-11(17-28-15(10-32)30-34-17)8-27-16(13)19(22)3-5-31(6-4-19)18(33)29-14-2-1-12(9-26-14)20(23,24)25/h1-2,7-9,32H,3-6,10H2,(H,26,29,33)
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n/an/a 16.6n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185341
PNG
(US9156830, I-34)
Show SMILES OCc1cc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1 |t:12|
Show InChI InChI=1S/C22H17ClFN5O3S/c23-16-7-13(18-9-15(11-30)32-28-18)10-25-20(16)12-3-5-29(6-4-12)22(31)27-21-26-17-2-1-14(24)8-19(17)33-21/h1-3,7-10,30H,4-6,11H2,(H,26,27,31)
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n/an/a 33.6n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185350
PNG
(US9156830, I-77)
Show SMILES OCc1nnc(Cc2cnc(C3=CCN(CC3)C(=O)Nc3ccc(c(Cl)c3)C(F)(F)F)c(Cl)c2)o1 |t:11|
Show InChI InChI=1S/C22H18Cl2F3N5O3/c23-16-9-14(1-2-15(16)22(25,26)27)29-21(34)32-5-3-13(4-6-32)20-17(24)7-12(10-28-20)8-18-30-31-19(11-33)35-18/h1-3,7,9-10,33H,4-6,8,11H2,(H,29,34)
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n/an/a 38.8n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185344
PNG
(US9156830, I-50)
Show SMILES OCCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:13|
Show InChI InChI=1S/C22H18Cl2F3N5O3/c23-16-10-14(1-2-15(16)22(25,26)27)29-21(34)32-6-3-12(4-7-32)19-17(24)9-13(11-28-19)20-31-30-18(35-20)5-8-33/h1-3,9-11,33H,4-8H2,(H,29,34)
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n/an/a 60.8n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60736
PNG
(US9156830, I-2)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O3/c1-12-28-29-19(32-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)27-15-2-4-16(5-3-15)33-21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60737
PNG
(US9156830, I-3)
Show SMILES Cc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O2/c1-12-27-19(32-29-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)28-16-4-2-15(3-5-16)21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,28,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185353
PNG
(US9156831, 4)
Show SMILES C[C@@H](O)CC(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-c2nnc(o2)C(C)(C)C)n(C)n1 |r|
Show InChI InChI=1S/C22H31N9O3/c1-12(32)10-15(33)31-8-6-13(7-9-31)18-26-19(30(5)29-18)14-11-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h11-13,32H,6-10H2,1-5H3,(H2,23,24)/t12-/m1/s1
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60740
PNG
(US9156830, I-9)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-29-28-16(10-31)33-18)8-26-17(14)11-3-5-30(6-4-11)19(32)27-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60748
PNG
(US9156830, I-33)
Show SMILES OCc1cc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-7-13(17-8-15(11-31)33-29-17)9-27-19(16)12-3-5-30(6-4-12)20(32)28-18-2-1-14(10-26-18)21(23,24)25/h1-3,7-10,31H,4-6,11H2,(H,26,28,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60752
PNG
(US9156830, I-43)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nnc(CO)o2)ccc1OC(F)(F)F |c:10|
Show InChI InChI=1S/C22H19ClF3N5O4/c1-12-8-15(2-3-17(12)35-22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-16(23)9-14(10-27-19)20-30-29-18(11-32)34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60754
PNG
(US9156830, I-45)
Show SMILES OCc1ncc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-15-7-13(16-10-27-18(11-31)33-16)8-28-19(15)12-3-5-30(6-4-12)20(32)29-17-2-1-14(9-26-17)21(23,24)25/h1-3,7-10,31H,4-6,11H2,(H,26,29,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60761
PNG
(US9156830, I-48)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nnc(CCO)o2)ccc1OC(F)(F)F |c:10|
Show InChI InChI=1S/C23H21ClF3N5O4/c1-13-10-16(2-3-18(13)36-23(25,26)27)29-22(34)32-7-4-14(5-8-32)20-17(24)11-15(12-28-20)21-31-30-19(35-21)6-9-33/h2-4,10-12,33H,5-9H2,1H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60764
PNG
(US9156830, I-53)
Show SMILES OCC1CC(=NO1)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F |c:4|
Show InChI InChI=1S/C21H20ClF4N5O3/c22-15-7-12(16-8-14(11-32)34-30-16)9-28-18(15)20(23)3-5-31(6-4-20)19(33)29-17-2-1-13(10-27-17)21(24,25)26/h1-2,7,9-10,14,32H,3-6,8,11H2,(H,27,29,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60767
PNG
(US9156830, I-56)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)-c2ocnc2CO)ccc1C(F)(F)F
Show InChI InChI=1S/C23H21ClF4N4O3/c1-13-8-15(2-3-16(13)23(26,27)28)31-21(34)32-6-4-22(25,5-7-32)20-17(24)9-14(10-29-20)19-18(11-33)30-12-35-19/h2-3,8-10,12,33H,4-7,11H2,1H3,(H,31,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60768
PNG
(US9156830, I-54)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)C2=NOC(CO)C2)ccc1C(F)(F)F |t:23|
Show InChI InChI=1S/C23H23ClF4N4O3/c1-13-8-15(2-3-17(13)23(26,27)28)30-21(34)32-6-4-22(25,5-7-32)20-18(24)9-14(11-29-20)19-10-16(12-33)35-31-19/h2-3,8-9,11,16,33H,4-7,10,12H2,1H3,(H,30,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60769
PNG
(US9156830, I-58)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F
Show InChI InChI=1S/C22H20ClF4N5O3/c1-12-8-14(2-3-15(12)22(25,26)27)29-20(34)32-6-4-21(24,5-7-32)18-16(23)9-13(10-28-18)19-30-17(11-33)31-35-19/h2-3,8-10,33H,4-7,11H2,1H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60780
PNG
(US9156830, I-94)
Show SMILES Cc1cc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)-c2nnc(CO)o2)ccc1C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O3/c1-12-8-14(2-3-15(12)21(23,24)25)27-20(33)31-6-4-30(5-7-31)18-16(22)9-13(10-26-18)19-29-28-17(11-32)34-19/h2-3,8-10,32H,4-7,11H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60743
PNG
(US9156830, I-25)
Show SMILES OCc1nc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-29-17(10-32)34-30-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60744
PNG
(US9156830, I-26)
Show SMILES OCc1nc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-28-16(10-31)33-29-18)8-26-17(14)11-3-5-30(6-4-11)19(32)27-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60769
PNG
(US9156830, I-58)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F
Show InChI InChI=1S/C22H20ClF4N5O3/c1-12-8-14(2-3-15(12)22(25,26)27)29-20(34)32-6-4-21(24,5-7-32)18-16(23)9-13(10-28-18)19-30-17(11-33)31-35-19/h2-3,8-10,33H,4-7,11H2,1H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60780
PNG
(US9156830, I-94)
Show SMILES Cc1cc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)-c2nnc(CO)o2)ccc1C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O3/c1-12-8-14(2-3-15(12)21(23,24)25)27-20(33)31-6-4-30(5-7-31)18-16(22)9-13(10-26-18)19-29-28-17(11-32)34-19/h2-3,8-10,32H,4-7,11H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60759
PNG
(US9156830, I-63)
Show SMILES OCc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(F)c1 |t:12|
Show InChI InChI=1S/C20H16F4N6O3/c21-14-7-12(18-27-16(10-31)29-33-18)8-26-17(14)11-3-5-30(6-4-11)19(32)28-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,28,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60739
PNG
(US9156830, I-5)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:11|
Show InChI InChI=1S/C20H16ClF3N6O2/c1-11-28-29-18(32-11)13-8-15(21)17(26-9-13)12-4-6-30(7-5-12)19(31)27-16-3-2-14(10-25-16)20(22,23)24/h2-4,8-10H,5-7H2,1H3,(H,25,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60779
PNG
(US9156830, I-93)
Show SMILES OCc1nnc(o1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H17ClF3N7O3/c20-13-7-11(17-28-27-15(10-31)33-17)8-25-16(13)29-3-5-30(6-4-29)18(32)26-14-2-1-12(9-24-14)19(21,22)23/h1-2,7-9,31H,3-6,10H2,(H,24,26,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60782
PNG
(US9156830, I-96)
Show SMILES Cc1cc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O3/c1-12-8-14(2-3-15(12)21(23,24)25)27-20(33)31-6-4-30(5-7-31)18-16(22)9-13(10-26-18)19-28-17(11-32)29-34-19/h2-3,8-10,32H,4-7,11H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60744
PNG
(US9156830, I-26)
Show SMILES OCc1nc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-28-16(10-31)33-29-18)8-26-17(14)11-3-5-30(6-4-11)19(32)27-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60743
PNG
(US9156830, I-25)
Show SMILES OCc1nc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-29-17(10-32)34-30-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60751
PNG
(US9156830, I-38)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C22H19ClF3N5O3/c1-12-8-15(2-3-16(12)22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-17(23)9-14(10-27-19)20-29-18(11-32)30-34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60755
PNG
(US9156830, I-46)
Show SMILES OCc1nc(no1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H17Cl2F4N5O3/c22-14-8-12(1-2-13(14)21(25,26)27)29-19(34)32-5-3-20(24,4-6-32)17-15(23)7-11(9-28-17)18-30-16(10-33)35-31-18/h1-2,7-9,33H,3-6,10H2,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60755
PNG
(US9156830, I-46)
Show SMILES OCc1nc(no1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H17Cl2F4N5O3/c22-14-8-12(1-2-13(14)21(25,26)27)29-19(34)32-5-3-20(24,4-6-32)17-15(23)7-11(9-28-17)18-30-16(10-33)35-31-18/h1-2,7-9,33H,3-6,10H2,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60757
PNG
(US9156830, I-47)
Show SMILES OCc1nc(no1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H17ClF4N6O3/c21-13-7-11(17-29-15(10-32)34-30-17)8-27-16(13)19(22)3-5-31(6-4-19)18(33)28-14-2-1-12(9-26-14)20(23,24)25/h1-2,7-9,32H,3-6,10H2,(H,26,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60762
PNG
(US9156830, I-51)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nnc(CCO)o2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C23H21ClF3N5O3/c1-13-10-16(2-3-17(13)23(25,26)27)29-22(34)32-7-4-14(5-8-32)20-18(24)11-15(12-28-20)21-31-30-19(35-21)6-9-33/h2-4,10-12,33H,5-9H2,1H3,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60763
PNG
(US9156830, I-52)
Show SMILES OCC1CC(=NO1)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F |c:4|
Show InChI InChI=1S/C22H20Cl2F4N4O3/c23-16-8-13(1-2-15(16)22(26,27)28)30-20(34)32-5-3-21(25,4-6-32)19-17(24)7-12(10-29-19)18-9-14(11-33)35-31-18/h1-2,7-8,10,14,33H,3-6,9,11H2,(H,30,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60764
PNG
(US9156830, I-53)
Show SMILES OCC1CC(=NO1)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F |c:4|
Show InChI InChI=1S/C21H20ClF4N5O3/c22-15-7-12(16-8-14(11-32)34-30-16)9-28-18(15)20(23)3-5-31(6-4-20)19(33)29-17-2-1-13(10-27-17)21(24,25)26/h1-2,7,9-10,14,32H,3-6,8,11H2,(H,27,29,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60775
PNG
(US9156830, I-89)
Show SMILES OCc1nnc(o1)-c1ccc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-9-13(19-29-28-18(11-31)33-19)1-3-15(16)12-5-7-30(8-6-12)20(32)27-17-4-2-14(10-26-17)21(23,24)25/h1-5,9-10,31H,6-8,11H2,(H,26,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60775
PNG
(US9156830, I-89)
Show SMILES OCc1nnc(o1)-c1ccc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-9-13(19-29-28-18(11-31)33-19)1-3-15(16)12-5-7-30(8-6-12)20(32)27-17-4-2-14(10-26-17)21(23,24)25/h1-5,9-10,31H,6-8,11H2,(H,26,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185339
PNG
(US9156830, I-7)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(Cl)c1 |t:11|
Show InChI InChI=1S/C24H26ClN5O2/c1-15-28-29-22(32-15)17-13-20(25)21(26-14-17)16-9-11-30(12-10-16)23(31)27-19-7-5-18(6-8-19)24(2,3)4/h5-9,13-14H,10-12H2,1-4H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60741
PNG
(US9156830, I-10)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-9-13(19-29-28-17(11-31)33-19)10-26-18(16)12-5-7-30(8-6-12)20(32)27-15-3-1-14(2-4-15)21(23,24)25/h1-5,9-10,31H,6-8,11H2,(H,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60770
PNG
(US9156830, I-59)
Show SMILES OCc1noc(n1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H17Cl2F4N5O3/c22-14-8-12(1-2-13(14)21(25,26)27)29-19(34)32-5-3-20(24,4-6-32)17-15(23)7-11(9-28-17)18-30-16(10-33)31-35-18/h1-2,7-9,33H,3-6,10H2,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60779
PNG
(US9156830, I-93)
Show SMILES OCc1nnc(o1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H17ClF3N7O3/c20-13-7-11(17-28-27-15(10-31)33-17)8-25-16(13)29-3-5-30(6-4-29)18(32)26-14-2-1-12(9-24-14)19(21,22)23/h1-2,7-9,31H,3-6,10H2,(H,24,26,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60781
PNG
(US9156830, I-95)
Show SMILES OCc1noc(n1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H17ClF3N7O3/c20-13-7-11(17-26-15(10-31)28-33-17)8-25-16(13)29-3-5-30(6-4-29)18(32)27-14-2-1-12(9-24-14)19(21,22)23/h1-2,7-9,31H,3-6,10H2,(H,24,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60735
PNG
(US9156830, I-1)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O2/c1-12-28-29-19(32-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)27-16-4-2-15(3-5-16)21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60738
PNG
(US9156830, I-4)
Show SMILES Cc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O3/c1-12-27-19(33-29-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)28-15-2-4-16(5-3-15)32-21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,28,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60740
PNG
(US9156830, I-9)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-29-28-16(10-31)33-18)8-26-17(14)11-3-5-30(6-4-11)19(32)27-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60741
PNG
(US9156830, I-10)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-9-13(19-29-28-17(11-31)33-19)10-26-18(16)12-5-7-30(8-6-12)20(32)27-15-3-1-14(2-4-15)21(23,24)25/h1-5,9-10,31H,6-8,11H2,(H,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60750
PNG
(US9156830, I-37)
Show SMILES OCc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-27-16(10-31)29-33-18)8-26-17(14)11-3-5-30(6-4-11)19(32)28-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,28,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60757
PNG
(US9156830, I-47)
Show SMILES OCc1nc(no1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C20H17ClF4N6O3/c21-13-7-11(17-29-15(10-32)34-30-17)8-27-16(13)19(22)3-5-31(6-4-19)18(33)28-14-2-1-12(9-26-14)20(23,24)25/h1-2,7-9,32H,3-6,10H2,(H,26,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60763
PNG
(US9156830, I-52)
Show SMILES OCC1CC(=NO1)c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F |c:4|
Show InChI InChI=1S/C22H20Cl2F4N4O3/c23-16-8-13(1-2-15(16)22(26,27)28)30-20(34)32-5-3-21(25,4-6-32)19-17(24)7-12(10-29-19)18-9-14(11-33)35-31-18/h1-2,7-8,10,14,33H,3-6,9,11H2,(H,30,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60770
PNG
(US9156830, I-59)
Show SMILES OCc1noc(n1)-c1cnc(c(Cl)c1)C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C21H17Cl2F4N5O3/c22-14-8-12(1-2-13(14)21(25,26)27)29-19(34)32-5-3-20(24,4-6-32)17-15(23)7-11(9-28-17)18-30-16(10-33)31-35-18/h1-2,7-9,33H,3-6,10H2,(H,29,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60781
PNG
(US9156830, I-95)
Show SMILES OCc1noc(n1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H17ClF3N7O3/c20-13-7-11(17-26-15(10-31)28-33-17)8-25-16(13)29-3-5-30(6-4-29)18(32)27-14-2-1-12(9-24-14)19(21,22)23/h1-2,7-9,31H,3-6,10H2,(H,24,27,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60782
PNG
(US9156830, I-96)
Show SMILES Cc1cc(NC(=O)N2CCN(CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6O3/c1-12-8-14(2-3-15(12)21(23,24)25)27-20(33)31-6-4-30(5-7-31)18-16(22)9-13(10-26-18)19-28-17(11-32)29-34-19/h2-3,8-10,32H,4-7,11H2,1H3,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60746
PNG
(US9156830, I-29)
Show SMILES OCc1cc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C22H17Cl2F3N4O3/c23-17-8-14(1-2-16(17)22(25,26)27)29-21(33)31-5-3-12(4-6-31)20-18(24)7-13(10-28-20)19-9-15(11-32)34-30-19/h1-3,7-10,32H,4-6,11H2,(H,29,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60735
PNG
(US9156830, I-1)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O2/c1-12-28-29-19(32-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)27-16-4-2-15(3-5-16)21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60739
PNG
(US9156830, I-5)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:11|
Show InChI InChI=1S/C20H16ClF3N6O2/c1-11-28-29-18(32-11)13-8-15(21)17(26-9-13)12-4-6-30(7-5-12)19(31)27-16-3-2-14(10-25-16)20(22,23)24/h2-4,8-10H,5-7H2,1H3,(H,25,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185352
PNG
(US9156830, I-81)
Show SMILES OCc1nnc(o1)-c1ccc(C#CC(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H10Cl2F3N3O3/c20-14-7-11(18-27-26-17(9-28)30-18)2-1-10(14)3-6-16(29)25-12-4-5-13(15(21)8-12)19(22,23)24/h1-2,4-5,7-8,28H,9H2,(H,25,29)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60748
PNG
(US9156830, I-33)
Show SMILES OCc1cc(no1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-16-7-13(17-8-15(11-31)33-29-17)9-27-19(16)12-3-5-30(6-4-12)20(32)28-18-2-1-14(10-26-18)21(23,24)25/h1-3,7-10,31H,4-6,11H2,(H,26,28,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60750
PNG
(US9156830, I-37)
Show SMILES OCc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C20H16ClF3N6O3/c21-14-7-12(18-27-16(10-31)29-33-18)8-26-17(14)11-3-5-30(6-4-11)19(32)28-15-2-1-13(9-25-15)20(22,23)24/h1-3,7-9,31H,4-6,10H2,(H,25,28,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60754
PNG
(US9156830, I-45)
Show SMILES OCc1ncc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(cn2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H17ClF3N5O3/c22-15-7-13(16-10-27-18(11-31)33-16)8-28-19(15)12-3-5-30(6-4-12)20(32)29-17-2-1-14(9-26-17)21(23,24)25/h1-3,7-10,31H,4-6,11H2,(H,26,29,32)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60771
PNG
(US9156830, I-64)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)-c2nc(CO)no2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C22H19F4N5O3/c1-12-8-15(2-3-16(12)22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-17(23)9-14(10-27-19)20-29-18(11-32)30-34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60771
PNG
(US9156830, I-64)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2F)-c2nc(CO)no2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C22H19F4N5O3/c1-12-8-15(2-3-16(12)22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-17(23)9-14(10-27-19)20-29-18(11-32)30-34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60776
PNG
(US9156830, I-92)
Show SMILES OCc1nnc(o1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H17Cl2F3N6O3/c21-14-8-12(1-2-13(14)20(23,24)25)27-19(33)31-5-3-30(4-6-31)17-15(22)7-11(9-26-17)18-29-28-16(10-32)34-18/h1-2,7-9,32H,3-6,10H2,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60745
PNG
(US9156830, I-28)
Show SMILES OCc1ncoc1-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C22H17Cl2F3N4O3/c23-16-8-14(1-2-15(16)22(25,26)27)30-21(33)31-5-3-12(4-6-31)19-17(24)7-13(9-28-19)20-18(10-32)29-11-34-20/h1-3,7-9,11,32H,4-6,10H2,(H,30,33)
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SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60736
PNG
(US9156830, I-2)
Show SMILES Cc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(Cl)c1 |t:11|
Show InChI InChI=1S/C21H17ClF3N5O3/c1-12-28-29-19(32-12)14-10-17(22)18(26-11-14)13-6-8-30(9-7-13)20(31)27-15-2-4-16(5-3-15)33-21(23,24)25/h2-6,10-11H,7-9H2,1H3,(H,27,31)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60749
PNG
(US9156830, I-36)
Show SMILES OCc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-29-17(10-32)30-34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60749
PNG
(US9156830, I-36)
Show SMILES OCc1noc(n1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-29-17(10-32)30-34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60751
PNG
(US9156830, I-38)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nc(CO)no2)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C22H19ClF3N5O3/c1-12-8-15(2-3-16(12)22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-17(23)9-14(10-27-19)20-29-18(11-32)30-34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60752
PNG
(US9156830, I-43)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(cc2Cl)-c2nnc(CO)o2)ccc1OC(F)(F)F |c:10|
Show InChI InChI=1S/C22H19ClF3N5O4/c1-12-8-15(2-3-17(12)35-22(24,25)26)28-21(33)31-6-4-13(5-7-31)19-16(23)9-14(10-27-19)20-30-29-18(11-32)34-20/h2-4,8-10,32H,5-7,11H2,1H3,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60768
PNG
(US9156830, I-54)
Show SMILES Cc1cc(NC(=O)N2CCC(F)(CC2)c2ncc(cc2Cl)C2=NOC(CO)C2)ccc1C(F)(F)F |t:23|
Show InChI InChI=1S/C23H23ClF4N4O3/c1-13-8-15(2-3-17(13)23(26,27)28)30-21(34)32-6-4-22(25,5-7-32)20-18(24)9-14(11-29-20)19-10-16(12-33)35-31-19/h2-3,8-9,11,16,33H,4-7,10,12H2,1H3,(H,30,34)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60742
PNG
(BDBM60772 | BDBM60773 | US9156830, I-11)
Show SMILES OCc1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |t:12|
Show InChI InChI=1S/C21H16Cl2F3N5O3/c22-15-8-13(1-2-14(15)21(24,25)26)28-20(33)31-5-3-11(4-6-31)18-16(23)7-12(9-27-18)19-30-29-17(10-32)34-19/h1-3,7-9,32H,4-6,10H2,(H,28,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60774
PNG
(US9156830, I-82)
Show SMILES OCc1nnc(o1)-c1ccc(C#CC(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF3N3O3/c20-15-9-12(18-26-25-17(10-27)29-18)2-1-11(15)3-8-16(28)24-14-6-4-13(5-7-14)19(21,22)23/h1-2,4-7,9,27H,10H2,(H,24,28)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60774
PNG
(US9156830, I-82)
Show SMILES OCc1nnc(o1)-c1ccc(C#CC(=O)Nc2ccc(cc2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C19H11ClF3N3O3/c20-15-9-12(18-26-25-17(10-27)29-18)2-1-11(15)3-8-16(28)24-14-6-4-13(5-7-14)19(21,22)23/h1-2,4-7,9,27H,10H2,(H,24,28)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60776
PNG
(US9156830, I-92)
Show SMILES OCc1nnc(o1)-c1cnc(N2CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C20H17Cl2F3N6O3/c21-14-8-12(1-2-13(14)20(23,24)25)27-19(33)31-5-3-30(4-6-31)17-15(22)7-11(9-26-17)18-29-28-16(10-32)34-18/h1-2,7-9,32H,3-6,10H2,(H,27,33)
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n/an/a<100n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185340
PNG
(US9156830, I-20)
Show SMILES OC[C@@H](O)c1nnc(o1)-c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |r,t:14|
Show InChI InChI=1S/C22H18Cl2F3N5O4/c23-15-8-13(1-2-14(15)22(25,26)27)29-21(35)32-5-3-11(4-6-32)18-16(24)7-12(9-28-18)19-30-31-20(36-19)17(34)10-33/h1-3,7-9,17,33-34H,4-6,10H2,(H,29,35)/t17-/m1/s1
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n/an/a 147n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185348
PNG
(US9156830, I-73)
Show SMILES O[C@H]1CN(C[C@H]1O)c1cnc(C2CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |r|
Show InChI InChI=1S/C22H23Cl2F3N4O3/c23-16-7-13(1-2-15(16)22(25,26)27)29-21(34)30-5-3-12(4-6-30)20-17(24)8-14(9-28-20)31-10-18(32)19(33)11-31/h1-2,7-9,12,18-19,32-33H,3-6,10-11H2,(H,29,34)/t18-,19+
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n/an/a 160n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185351
PNG
(US9156830, I-80)
Show SMILES Cc1cc(NC(=O)N2CCC(=CC2)c2ncc(Cc3ncco3)cc2Cl)ccc1C(F)(F)F |c:10|
Show InChI InChI=1S/C23H20ClF3N4O2/c1-14-10-17(2-3-18(14)23(25,26)27)30-22(32)31-7-4-16(5-8-31)21-19(24)11-15(13-29-21)12-20-28-6-9-33-20/h2-4,6,9-11,13H,5,7-8,12H2,1H3,(H,30,32)
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n/an/a 223n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185347
PNG
(US9156830, I-71)
Show SMILES O[C@@H]1CN(C(=O)[C@@H]1O)c1cnc(C2=CCN(CC2)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1 |r,t:13|
Show InChI InChI=1S/C22H19Cl2F3N4O4/c23-15-7-12(1-2-14(15)22(25,26)27)29-21(35)30-5-3-11(4-6-30)18-16(24)8-13(9-28-18)31-10-17(32)19(33)20(31)34/h1-3,7-9,17,19,32-33H,4-6,10H2,(H,29,35)/t17-,19-/m1/s1
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n/an/a 322n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185342
PNG
(US9156830, I-39)
Show SMILES Cc1cc(cnc1C1(F)CCN(CC1)C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F)-c1ccc(CO)o1
Show InChI InChI=1S/C24H22ClF4N3O3/c1-14-10-15(20-5-3-17(13-33)35-20)12-30-21(14)23(26)6-8-32(9-7-23)22(34)31-16-2-4-18(19(25)11-16)24(27,28)29/h2-5,10-12,33H,6-9,13H2,1H3,(H,31,34)
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n/an/a 342n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM185346
PNG
(US9156830, I-60)
Show SMILES OCc1nnc(o1)-c1cnc(NCCNC(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C18H15Cl2F3N6O3/c19-12-6-10(1-2-11(12)18(21,22)23)27-17(31)25-4-3-24-15-13(20)5-9(7-26-15)16-29-28-14(8-30)32-16/h1-2,5-7,30H,3-4,8H2,(H,24,26)(H2,25,27,31)
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n/an/a 357n/an/an/an/a7.4n/a



SHIONOGI & CO., LTD.

US Patent


Assay Description
Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...

US Patent US9156830 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07R2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%