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Patent code US9162979

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185707
PNG
(US9162979, 9)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCCON(=O)=O)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H26N2O8S/c1-17-19(16-24(27)33-13-4-14-34-26(28)29)15-23(18-5-11-22(12-6-18)35(3,30)31)25(17)20-7-9-21(32-2)10-8-20/h5-12,15H,4,13-14,16H2,1-3H3
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n/an/a 2n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185706
PNG
(US9162979, 8)
Show SMILES Cc1c(CC(=O)OCCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C23H23FN2O7S/c1-16-18(14-23(27)32-11-4-12-33-26(28)29)13-22(25(16)20-6-3-5-19(24)15-20)17-7-9-21(10-8-17)34(2,30)31/h3,5-10,13,15H,4,11-12,14H2,1-2H3
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n/an/a 7n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185732
PNG
(US9162979, 27-II)
Show SMILES Cc1c(CC(=O)NCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C23H25FN2O4S/c1-16-18(14-23(28)25-11-4-12-27)13-22(26(16)20-6-3-5-19(24)15-20)17-7-9-21(10-8-17)31(2,29)30/h3,5-10,13,15,27H,4,11-12,14H2,1-2H3,(H,25,28)
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n/an/a 14n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185720
PNG
(US9162979, 37)
Show SMILES Cc1c(CCOCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN2O6S/c1-16-18(11-12-30-13-14-31-25(26)27)15-22(24(16)20-7-5-19(23)6-8-20)17-3-9-21(10-4-17)32(2,28)29/h3-10,15H,11-14H2,1-2H3
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n/an/a 14n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185723
PNG
(US9162979, 40)
Show SMILES Cc1c(CCOCCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1
Show InChI InChI=1S/C23H26N2O6S/c1-18-20(13-16-30-14-6-15-31-25(26)27)17-23(24(18)21-7-4-3-5-8-21)19-9-11-22(12-10-19)32(2,28)29/h3-5,7-12,17H,6,13-16H2,1-2H3
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n/an/a 15n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185719
PNG
(US9162979, 36)
Show SMILES Cc1c(CCOCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1
Show InChI InChI=1S/C22H24N2O6S/c1-17-19(12-13-29-14-15-30-24(25)26)16-22(23(17)20-6-4-3-5-7-20)18-8-10-21(11-9-18)31(2,27)28/h3-11,16H,12-15H2,1-2H3
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n/an/a 17n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185704
PNG
(US9162979, 3)
Show SMILES Cc1c(CC(=O)OCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C22H21FN2O7S/c1-15-17(13-22(26)31-10-11-32-25(27)28)12-21(24(15)19-5-3-4-18(23)14-19)16-6-8-20(9-7-16)33(2,29)30/h3-9,12,14H,10-11,13H2,1-2H3
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n/an/a 19n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361592
PNG
(CHEMBL1939511 | US9162979, 8-II)
Show SMILES Cc1c(CC(=O)OCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C23H24FNO5S/c1-16-18(14-23(27)30-12-4-11-26)13-22(25(16)20-6-3-5-19(24)15-20)17-7-9-21(10-8-17)31(2,28)29/h3,5-10,13,15,26H,4,11-12,14H2,1-2H3
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n/an/a 23n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430954
PNG
(CHEMBL2337407 | US9162979, 36-II)
Show SMILES Cc1c(CCOCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1
Show InChI InChI=1S/C22H25NO4S/c1-17-19(12-14-27-15-13-24)16-22(23(17)20-6-4-3-5-7-20)18-8-10-21(11-9-18)28(2,25)26/h3-11,16,24H,12-15H2,1-2H3
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n/an/a 27n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361591
PNG
(CHEMBL1939678 | US9162979, 1-II)
Show SMILES Cc1c(CC(=O)OCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1
Show InChI InChI=1S/C22H23NO5S/c1-16-18(15-22(25)28-13-12-24)14-21(23(16)19-6-4-3-5-7-19)17-8-10-20(11-9-17)29(2,26)27/h3-11,14,24H,12-13,15H2,1-2H3
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n/an/a 27n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185708
PNG
(US9162979, 10)
Show SMILES CSc1ccc(cc1)-n1c(C)c(CC(=O)OCCCON(=O)=O)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H26N2O7S2/c1-17-19(16-24(27)32-13-4-14-33-26(28)29)15-23(18-5-11-22(12-6-18)35(3,30)31)25(17)20-7-9-21(34-2)10-8-20/h5-12,15H,4,13-14,16H2,1-3H3
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n/an/a 27n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185721
PNG
(US9162979, 38)
Show SMILES Cc1c(CCOCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C22H23FN2O6S/c1-16-18(10-11-30-12-13-31-25(26)27)14-22(24(16)20-5-3-4-19(23)15-20)17-6-8-21(9-7-17)32(2,28)29/h3-9,14-15H,10-13H2,1-2H3
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n/an/a 28n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185703
PNG
(US9162979, 1)
Show SMILES Cc1c(CC(=O)OCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1
Show InChI InChI=1S/C22H22N2O7S/c1-16-18(15-22(25)30-12-13-31-24(26)27)14-21(23(16)19-6-4-3-5-7-19)17-8-10-20(11-9-17)32(2,28)29/h3-11,14H,12-13,15H2,1-2H3
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n/an/a 43n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430953
PNG
(CHEMBL2337408 | US9162979, 38-II)
Show SMILES Cc1c(CCOCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C22H24FNO4S/c1-16-18(10-12-28-13-11-25)14-22(24(16)20-5-3-4-19(23)15-20)17-6-8-21(9-7-17)29(2,26)27/h3-9,14-15,25H,10-13H2,1-2H3
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n/an/a 46n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185728
PNG
(US9162979, 14-II)
Show SMILES CSc1ccc(cc1)-n1c(C)c(CC(=O)OCCCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H29NO5S2/c1-18-20(17-25(28)31-15-5-4-14-27)16-24(19-6-12-23(13-7-19)33(3,29)30)26(18)21-8-10-22(32-2)11-9-21/h6-13,16,27H,4-5,14-15,17H2,1-3H3
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n/an/a 55n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185734
PNG
(US9162979, 30-II)
Show SMILES Cc1c(CC(=O)N[C@H](CO)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C23H23FN2O6S/c1-14-16(11-22(28)25-20(13-27)23(29)30)10-21(26(14)18-5-3-4-17(24)12-18)15-6-8-19(9-7-15)33(2,31)32/h3-10,12,20,27H,11,13H2,1-2H3,(H,25,28)(H,29,30)/t20-/m1/s1
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n/an/a 57n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185731
PNG
(US9162979, 26-II)
Show SMILES Cc1c(CC(=O)NCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN2O4S/c1-16-18(15-23(28)25-12-3-13-27)14-22(26(16)20-8-6-19(24)7-9-20)17-4-10-21(11-5-17)31(2,29)30/h4-11,14,27H,3,12-13,15H2,1-2H3,(H,25,28)
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n/an/a 68n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185709
PNG
(US9162979, 12)
Show SMILES Cc1c(CC(=O)OCCCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C24H25FN2O7S/c1-17-19(15-24(28)33-12-3-4-13-34-27(29)30)14-23(26(17)21-7-5-6-20(25)16-21)18-8-10-22(11-9-18)35(2,31)32/h5-11,14,16H,3-4,12-13,15H2,1-2H3
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n/an/a 69n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361595
PNG
(CHEMBL1939514 | US9162979, 5-II)
Show SMILES CSc1ccc(cc1)-n1c(C)c(CC(=O)OCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H25NO5S2/c1-16-18(15-23(26)29-13-12-25)14-22(17-4-10-21(11-5-17)31(3,27)28)24(16)19-6-8-20(30-2)9-7-19/h4-11,14,25H,12-13,15H2,1-3H3
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n/an/a 85n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361579
PNG
(CHEMBL1939680 | US9162979, 3-II)
Show SMILES Cc1c(CC(=O)OCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C22H22FNO5S/c1-15-17(13-22(26)29-11-10-25)12-21(24(15)19-5-3-4-18(23)14-19)16-6-8-20(9-7-16)30(2,27)28/h3-9,12,14,25H,10-11,13H2,1-2H3
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n/an/a 85n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185735
PNG
(US9162979, 32-II)
Show SMILES Cc1c(CC(=O)NC(CCO)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H25FN2O6S/c1-15-17(14-23(29)26-21(11-12-28)24(30)31)13-22(27(15)19-7-5-18(25)6-8-19)16-3-9-20(10-4-16)34(2,32)33/h3-10,13,21,28H,11-12,14H2,1-2H3,(H,26,29)(H,30,31)
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n/an/a 86n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361593
PNG
(CHEMBL1939512 | US9162979, 2-II)
Show SMILES Cc1c(CC(=O)OCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FNO5S/c1-15-17(14-22(26)29-12-11-25)13-21(24(15)19-7-5-18(23)6-8-19)16-3-9-20(10-4-16)30(2,27)28/h3-10,13,25H,11-12,14H2,1-2H3
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n/an/a 89n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430947
PNG
(CHEMBL2337409 | US9162979, 37-II)
Show SMILES Cc1c(CCOCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H24FNO4S/c1-16-18(11-13-28-14-12-25)15-22(24(16)20-7-5-19(23)6-8-20)17-3-9-21(10-4-17)29(2,26)27/h3-10,15,25H,11-14H2,1-2H3
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n/an/a 89n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185726
PNG
(US9162979, 12-II)
Show SMILES Cc1c(CC(=O)OCCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C24H26FNO5S/c1-17-19(15-24(28)31-13-4-3-12-27)14-23(26(17)21-7-5-6-20(25)16-21)18-8-10-22(11-9-18)32(2,29)30/h5-11,14,16,27H,3-4,12-13,15H2,1-2H3
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n/an/a 110n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185717
PNG
(US9162979, 30)
Show SMILES Cc1c(CC(=O)N[C@H](CON(=O)=O)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C23H22FN3O8S/c1-14-16(11-22(28)25-20(23(29)30)13-35-27(31)32)10-21(26(14)18-5-3-4-17(24)12-18)15-6-8-19(9-7-15)36(2,33)34/h3-10,12,20H,11,13H2,1-2H3,(H,25,28)(H,29,30)/t20-/m1/s1
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n/an/a 140n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185717
PNG
(US9162979, 30)
Show SMILES Cc1c(CC(=O)N[C@H](CON(=O)=O)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C23H22FN3O8S/c1-14-16(11-22(28)25-20(23(29)30)13-35-27(31)32)10-21(26(14)18-5-3-4-17(24)12-18)15-6-8-19(9-7-15)36(2,33)34/h3-10,12,20H,11,13H2,1-2H3,(H,25,28)(H,29,30)/t20-/m1/s1
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n/an/a 140n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185733
PNG
(US9162979, 29-II)
Show SMILES Cc1c(CC(=O)N[C@H](CO)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H23FN2O6S/c1-14-16(12-22(28)25-20(13-27)23(29)30)11-21(26(14)18-7-5-17(24)6-8-18)15-3-9-19(10-4-15)33(2,31)32/h3-11,20,27H,12-13H2,1-2H3,(H,25,28)(H,29,30)/t20-/m1/s1
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n/an/a 160n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185705
PNG
(US9162979, 4)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCON(=O)=O)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H24N2O8S/c1-16-18(15-23(26)32-12-13-33-25(27)28)14-22(17-4-10-21(11-5-17)34(3,29)30)24(16)19-6-8-20(31-2)9-7-19/h4-11,14H,12-13,15H2,1-3H3
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n/an/a 170n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185724
PNG
(US9162979, 41)
Show SMILES Cc1c(CCOCCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN2O6S/c1-17-19(12-15-31-13-3-14-32-26(27)28)16-23(25(17)21-8-6-20(24)7-9-21)18-4-10-22(11-5-18)33(2,29)30/h4-11,16H,3,12-15H2,1-2H3
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n/an/a 190n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185711
PNG
(US9162979, 14)
Show SMILES CSc1ccc(cc1)-n1c(C)c(CC(=O)OCCCCON(=O)=O)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H28N2O7S2/c1-18-20(17-25(28)33-14-4-5-15-34-27(29)30)16-24(19-6-12-23(13-7-19)36(3,31)32)26(18)21-8-10-22(35-2)11-9-21/h6-13,16H,4-5,14-15,17H2,1-3H3
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n/an/a 220n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185715
PNG
(US9162979, 23)
Show SMILES Cc1c(CC(=O)NCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FN3O6S/c1-15-17(14-22(27)24-11-12-32-26(28)29)13-21(25(15)19-7-5-18(23)6-8-19)16-3-9-20(10-4-16)33(2,30)31/h3-10,13H,11-12,14H2,1-2H3,(H,24,27)
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n/an/a 240n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185715
PNG
(US9162979, 23)
Show SMILES Cc1c(CC(=O)NCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H22FN3O6S/c1-15-17(14-22(27)24-11-12-32-26(28)29)13-21(25(15)19-7-5-18(23)6-8-19)16-3-9-20(10-4-16)33(2,30)31/h3-10,13H,11-12,14H2,1-2H3,(H,24,27)
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n/an/a 240n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361596
PNG
(CHEMBL1939515 | US9162979, 10-II)
Show SMILES CSc1ccc(cc1)-n1c(C)c(CC(=O)OCCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H27NO5S2/c1-17-19(16-24(27)30-14-4-13-26)15-23(18-5-11-22(12-6-18)32(3,28)29)25(17)20-7-9-21(31-2)10-8-20/h5-12,15,26H,4,13-14,16H2,1-3H3
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n/an/a 260n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185730
PNG
(US9162979, 24-II)
Show SMILES Cc1c(CC(=O)NCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C22H23FN2O4S/c1-15-17(13-22(27)24-10-11-26)12-21(25(15)19-5-3-4-18(23)14-19)16-6-8-20(9-7-16)30(2,28)29/h3-9,12,14,26H,10-11,13H2,1-2H3,(H,24,27)
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n/an/a 290n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185729
PNG
(US9162979, 23-II)
Show SMILES Cc1c(CC(=O)NCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN2O4S/c1-15-17(14-22(27)24-11-12-26)13-21(25(15)19-7-5-18(23)6-8-19)16-3-9-20(10-4-16)30(2,28)29/h3-10,13,26H,11-12,14H2,1-2H3,(H,24,27)
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n/an/a 300n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185716
PNG
(US9162979, 29)
Show SMILES Cc1c(CC(=O)N[C@H](CON(=O)=O)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H22FN3O8S/c1-14-16(12-22(28)25-20(23(29)30)13-35-27(31)32)11-21(26(14)18-7-5-17(24)6-8-18)15-3-9-19(10-4-15)36(2,33)34/h3-11,20H,12-13H2,1-2H3,(H,25,28)(H,29,30)/t20-/m1/s1
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n/an/a 310n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430952
PNG
(CHEMBL2337396 | US9162979, 39-II)
Show SMILES Cc1c(CCOCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F2NO4S/c1-15-17(9-11-29-12-10-26)13-22(16-3-6-19(7-4-16)30(2,27)28)25(15)18-5-8-20(23)21(24)14-18/h3-8,13-14,26H,9-12H2,1-2H3
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n/an/a 420n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185725
PNG
(US9162979, 42)
Show SMILES Cc1c(CCOCCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C23H25FN2O6S/c1-17-19(11-14-31-12-4-13-32-26(27)28)15-23(25(17)21-6-3-5-20(24)16-21)18-7-9-22(10-8-18)33(2,29)30/h3,5-10,15-16H,4,11-14H2,1-2H3
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n/an/a 430n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185710
PNG
(US9162979, 13)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCCCON(=O)=O)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H28N2O8S/c1-18-20(17-25(28)34-14-4-5-15-35-27(29)30)16-24(19-6-12-23(13-7-19)36(3,31)32)26(18)21-8-10-22(33-2)11-9-21/h6-13,16H,4-5,14-15,17H2,1-3H3
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n/an/a 550n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361598
PNG
(CHEMBL1939517 | US9162979, 9-II)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H27NO6S/c1-17-19(16-24(27)31-14-4-13-26)15-23(18-5-11-22(12-6-18)32(3,28)29)25(17)20-7-9-21(30-2)10-8-20/h5-12,15,26H,4,13-14,16H2,1-3H3
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n/an/a 700n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185712
PNG
(US9162979, 16)
Show SMILES Cc1c(cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1)C(N)C(=O)OCCON(=O)=O
Show InChI InChI=1S/C22H22FN3O7S/c1-14-19(21(24)22(27)32-11-12-33-26(28)29)13-20(25(14)17-7-5-16(23)6-8-17)15-3-9-18(10-4-15)34(2,30)31/h3-10,13,21H,11-12,24H2,1-2H3
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n/an/a 740n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185713
PNG
(US9162979, 18)
Show SMILES Cc1c(cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1)C(N)C(=O)OCCCON(=O)=O
Show InChI InChI=1S/C23H24FN3O7S/c1-15-20(22(25)23(28)33-12-3-13-34-27(29)30)14-21(26(15)18-8-6-17(24)7-9-18)16-4-10-19(11-5-16)35(2,31)32/h4-11,14,22H,3,12-13,25H2,1-2H3
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n/an/a 820n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185722
PNG
(US9162979, 39)
Show SMILES Cc1c(CCOCCON(=O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H22F2N2O6S/c1-15-17(9-10-31-11-12-32-26(27)28)13-22(16-3-6-19(7-4-16)33(2,29)30)25(15)18-5-8-20(23)21(24)14-18/h3-8,13-14H,9-12H2,1-2H3
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n/an/a 920n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430949
PNG
(CHEMBL2337399 | US9162979, 41-II)
Show SMILES Cc1c(CCOCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H26FNO4S/c1-17-19(12-15-29-14-3-13-26)16-23(25(17)21-8-6-20(24)7-9-21)18-4-10-22(11-5-18)30(2,27)28/h4-11,16,26H,3,12-15H2,1-2H3
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n/an/a 940n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185714
PNG
(US9162979, 20)
Show SMILES Cc1c(cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1)C(N)C(=O)OCCCCON(=O)=O
Show InChI InChI=1S/C24H26FN3O7S/c1-16-21(23(26)24(29)34-13-3-4-14-35-28(30)31)15-22(27(16)19-9-7-18(25)8-10-19)17-5-11-20(12-6-17)36(2,32)33/h5-12,15,23H,3-4,13-14,26H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50361597
PNG
(CHEMBL1939516 | US9162979, 4-II)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H25NO6S/c1-16-18(15-23(26)30-13-12-25)14-22(17-4-10-21(11-5-17)31(3,27)28)24(16)19-6-8-20(29-2)9-7-19/h4-11,14,25H,12-13,15H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185727
PNG
(US9162979, 13-II)
Show SMILES COc1ccc(cc1)-n1c(C)c(CC(=O)OCCCCO)cc1-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H29NO6S/c1-18-20(17-25(28)32-15-5-4-14-27)16-24(19-6-12-23(13-7-19)33(3,29)30)26(18)21-8-10-22(31-2)11-9-21/h6-13,16,27H,4-5,14-15,17H2,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50430950
PNG
(CHEMBL2337398 | US9162979, 42-II)
Show SMILES Cc1c(CCOCCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C23H26FNO4S/c1-17-19(11-14-29-13-4-12-26)15-23(25(17)21-6-3-5-20(24)16-21)18-7-9-22(10-8-18)30(2,27)28/h3,5-10,15-16,26H,4,11-14H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185718
PNG
(US9162979, 32)
Show SMILES Cc1c(CC(=O)NC(CCON(=O)=O)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN3O8S/c1-15-17(14-23(29)26-21(24(30)31)11-12-36-28(32)33)13-22(27(15)19-7-5-18(25)6-8-19)16-3-9-20(10-4-16)37(2,34)35/h3-10,13,21H,11-12,14H2,1-2H3,(H,26,29)(H,30,31)
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n/an/a 1.60E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM185718
PNG
(US9162979, 32)
Show SMILES Cc1c(CC(=O)NC(CCON(=O)=O)C(O)=O)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN3O8S/c1-15-17(14-23(29)26-21(24(30)31)11-12-36-28(32)33)13-22(27(15)19-7-5-18(25)6-8-19)16-3-9-20(10-4-16)37(2,34)35/h3-10,13,21H,11-12,14H2,1-2H3,(H,26,29)(H,30,31)
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n/an/a 1.60E+3n/an/an/an/an/a37



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...

US Patent US9162979 (2015)


BindingDB Entry DOI: 10.7270/Q23T9G01
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%