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Patent code US9163021

Compile Data Set for Download or QSAR

Found 236 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186567
PNG
(US9163021, 235)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-21(20-13-30-7-6-22(20)33)24(36)17-10-19(12-31-11-17)32-23(35)9-16-4-3-5-18(8-16)26(27,28)29/h3-8,10-14,34H,9,15H2,1-2H3,(H,32,35)
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US Patent
n/an/a 2.87n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186437
PNG
(US9163021, 95)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C23H20F4N6O3/c1-22(2,12-34)33-10-16(15-8-29-9-17(24)20(15)33)21(36)13-5-14(7-28-6-13)30-19(35)11-32-4-3-18(31-32)23(25,26)27/h3-10,34H,11-12H2,1-2H3,(H,30,35)
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US Patent
n/an/a 2.92n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186376
PNG
(US9163021, 33)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-21(20-13-30-8-7-22(20)33)24(36)17-10-19(12-31-11-17)32-23(35)9-16-3-5-18(6-4-16)26(27,28)29/h3-8,10-14,34H,9,15H2,1-2H3,(H,32,35)
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US Patent
n/an/a 3.11n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186509
PNG
(US9163021, 173)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)c3cccc(OC(F)(F)F)c3)c2)c2cnccc12
Show InChI InChI=1S/C24H19F3N4O3/c1-14(2)31-13-19(18-12-28-8-7-20(18)31)22(32)15-6-9-29-21(11-15)30-23(33)16-4-3-5-17(10-16)34-24(25,26)27/h3-14H,1-2H3,(H,29,30,33)
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n/an/a 3.85n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186348
PNG
(US9163021, 5)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C26H22F4N4O3/c1-25(2,14-35)34-13-20(19-11-32-12-21(27)23(19)34)24(37)16-8-18(10-31-9-16)33-22(36)7-15-4-3-5-17(6-15)26(28,29)30/h3-6,8-13,35H,7,14H2,1-2H3,(H,33,36)
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n/an/a 4.41n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186511
PNG
(US9163021, 175)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C25H21F3N4O2/c1-15(2)32-14-20(19-13-29-9-8-21(19)32)24(34)17-7-10-30-22(12-17)31-23(33)11-16-3-5-18(6-4-16)25(26,27)28/h3-10,12-15H,11H2,1-2H3,(H,30,31,33)
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n/an/a 5.30n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186347
PNG
(US9163021, 4)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C23H20F4N6O3/c1-22(2,12-34)33-10-17(16-7-29-8-18(24)20(16)33)21(36)13-3-15(6-28-4-13)31-19(35)11-32-9-14(5-30-32)23(25,26)27/h3-10,34H,11-12H2,1-2H3,(H,31,35)
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n/an/a 5.33n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186345
PNG
(US9163021, 2)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C3CC3)c2)c2cncc(F)c12
Show InChI InChI=1S/C25H25FN6O3/c1-25(2,14-33)32-12-19(18-10-28-11-20(26)23(18)32)24(35)16-7-17(9-27-8-16)29-22(34)13-31-6-5-21(30-31)15-3-4-15/h5-12,15,33H,3-4,13-14H2,1-2H3,(H,29,34)
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n/an/a 5.58n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186502
PNG
(US9163021, 165)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)c(Cl)c3)c2)c2cnccc12
Show InChI InChI=1S/C24H20Cl2N4O2/c1-14(2)30-13-18(17-12-27-7-6-21(17)30)24(32)16-5-8-28-22(11-16)29-23(31)10-15-3-4-19(25)20(26)9-15/h3-9,11-14H,10H2,1-2H3,(H,28,29,31)
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US Patent
n/an/a 5.68n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186424
PNG
(US9163021, 82)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnccc12
Show InChI InChI=1S/C23H20ClN5O2/c1-14(2)29-13-19(18-12-25-7-6-20(18)29)23(31)15-5-8-26-21(9-15)28-22(30)10-17-4-3-16(24)11-27-17/h3-9,11-14H,10H2,1-2H3,(H,26,28,30)
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US Patent
n/an/a 6.16n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186344
PNG
(US9163021, 1)
Show SMILES Cc1cc(nn1CC(=O)Nc1cncc(c1)C(=O)c1cn(c2c(F)cncc12)C(C)(C)CO)C(F)(F)F
Show InChI InChI=1S/C24H22F4N6O3/c1-13-4-19(24(26,27)28)32-34(13)11-20(36)31-15-5-14(6-29-7-15)22(37)17-10-33(23(2,3)12-35)21-16(17)8-30-9-18(21)25/h4-10,35H,11-12H2,1-3H3,(H,31,36)
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n/an/a 6.32n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186349
PNG
(US9163021, 6)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cncc(F)c12
Show InChI InChI=1S/C25H22ClFN4O3/c1-25(2,14-32)31-13-20(19-11-29-12-21(27)23(19)31)24(34)16-8-18(10-28-9-16)30-22(33)7-15-3-5-17(26)6-4-15/h3-6,8-13,32H,7,14H2,1-2H3,(H,30,33)
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n/an/a 6.53n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186350
PNG
(US9163021, 7)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C26H22F4N4O3/c1-25(2,14-35)34-13-20(19-11-32-12-21(27)23(19)34)24(37)16-8-18(10-31-9-16)33-22(36)7-15-3-5-17(6-4-15)26(28,29)30/h3-6,8-13,35H,7,14H2,1-2H3,(H,33,36)
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n/an/a 6.61n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186524
PNG
(US9163021, 191)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)c2)c2cnccc12
Show InChI InChI=1S/C25H21F3N4O3/c1-15(2)32-14-20(19-13-29-8-7-21(19)32)24(34)17-6-9-30-22(12-17)31-23(33)11-16-4-3-5-18(10-16)35-25(26,27)28/h3-10,12-15H,11H2,1-2H3,(H,30,31,33)
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n/an/a 7.41n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186346
PNG
(US9163021, 3)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cncc(F)c12
Show InChI InChI=1S/C24H21ClFN5O3/c1-24(2,13-32)31-12-19(18-10-28-11-20(26)22(18)31)23(34)14-5-17(9-27-7-14)30-21(33)6-16-4-3-15(25)8-29-16/h3-5,7-12,32H,6,13H2,1-2H3,(H,30,33)
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n/an/a 7.85n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM60799
PNG
(US9163021, 172)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(c(F)c3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C25H20F4N4O2/c1-14(2)33-13-18(17-12-30-7-6-21(17)33)24(35)16-5-8-31-22(11-16)32-23(34)10-15-3-4-19(20(26)9-15)25(27,28)29/h3-9,11-14H,10H2,1-2H3,(H,31,32,34)
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n/an/a 8.49n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186355
PNG
(US9163021, 12)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cnccc12
Show InChI InChI=1S/C26H23N5O3/c1-26(2,16-32)31-15-22(21-14-28-8-7-23(21)31)25(34)19-10-20(13-29-12-19)30-24(33)9-17-3-5-18(11-27)6-4-17/h3-8,10,12-15,32H,9,16H2,1-2H3,(H,30,33)
PDB
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n/an/a 9.54n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186365
PNG
(US9163021, 22)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnccc12
Show InChI InChI=1S/C23H20ClN5O2/c1-14(2)29-13-20(19-12-25-6-5-21(19)29)23(31)15-7-18(11-26-9-15)28-22(30)8-17-4-3-16(24)10-27-17/h3-7,9-14H,8H2,1-2H3,(H,28,30)
PDB
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US Patent
n/an/a 9.64n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186374
PNG
(US9163021, 31)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C22H18F4N6O2/c1-12(2)32-10-17(16-7-28-8-18(23)20(16)32)21(34)13-3-15(6-27-4-13)30-19(33)11-31-9-14(5-29-31)22(24,25)26/h3-10,12H,11H2,1-2H3,(H,30,33)
PDB
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UniProtKB/SwissProt

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US Patent
n/an/a 9.66n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186356
PNG
(US9163021, 13)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(nn3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C22H20F3N7O3/c1-21(2,12-33)32-9-16(15-8-26-4-3-17(15)32)20(35)13-5-14(7-27-6-13)28-19(34)11-31-10-18(29-30-31)22(23,24)25/h3-10,33H,11-12H2,1-2H3,(H,28,34)
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n/an/a 9.86n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186357
PNG
(US9163021, 14)
Show SMILES CC(C)c1cn(CC(=O)Nc2cncc(c2)C(=O)c2cn(c3ccncc23)C(C)(C)CO)nn1
Show InChI InChI=1S/C24H27N7O3/c1-15(2)20-12-30(29-28-20)13-22(33)27-17-7-16(8-26-9-17)23(34)19-11-31(24(3,4)14-32)21-5-6-25-10-18(19)21/h5-12,15,32H,13-14H2,1-4H3,(H,27,33)
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n/an/a 9.89n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186371
PNG
(US9163021, 28)
Show SMILES CC(C)n1cc(C(=O)c2cc(NC(=O)Cn3nc(cc3C)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)31-11-17(16-10-27-6-5-19(16)31)22(34)18-9-15(4-7-28-18)29-21(33)12-32-14(3)8-20(30-32)23(24,25)26/h4-11,13H,12H2,1-3H3,(H,28,29,33)
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n/an/a 10.6n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186500
PNG
(US9163021, 163)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cn3cc(nn3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C21H18F3N7O2/c1-12(2)31-9-15(14-8-25-5-4-16(14)31)20(33)13-3-6-26-18(7-13)27-19(32)11-30-10-17(28-29-30)21(22,23)24/h3-10,12H,11H2,1-2H3,(H,26,27,32)
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n/an/a 10.7n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186458
PNG
(US9163021, 116)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnccc12
Show InChI InChI=1S/C24H21ClN4O2/c1-15(2)29-14-21(20-13-26-8-7-22(20)29)24(31)17-10-19(12-27-11-17)28-23(30)9-16-3-5-18(25)6-4-16/h3-8,10-15H,9H2,1-2H3,(H,28,30)
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n/an/a 11.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186558
PNG
(US9163021, 226)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C25H20F4N4O3/c1-14(13-34)33-12-20(19-10-31-11-21(26)23(19)33)24(36)16-7-18(9-30-8-16)32-22(35)6-15-3-2-4-17(5-15)25(27,28)29/h2-5,7-12,14,34H,6,13H2,1H3,(H,32,35)
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n/an/a 11.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186564
PNG
(US9163021, 232)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cc3cccc(c3)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-20(19-13-30-8-7-22(19)33)24(36)21-12-18(6-9-31-21)32-23(35)11-16-4-3-5-17(10-16)26(27,28)29/h3-10,12-14,34H,11,15H2,1-2H3,(H,31,32,35)
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n/an/a 11.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186375
PNG
(US9163021, 32)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C23H20F4N6O2/c1-12(2)32-10-17(16-8-29-9-18(24)21(16)32)22(35)14-5-15(7-28-6-14)30-20(34)11-33-13(3)4-19(31-33)23(25,26)27/h4-10,12H,11H2,1-3H3,(H,30,34)
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n/an/a 11.4n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186358
PNG
(US9163021, 15)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(nn3)C3CC3)c2)c2cnccc12
Show InChI InChI=1S/C24H25N7O3/c1-24(2,14-32)31-11-19(18-10-25-6-5-21(18)31)23(34)16-7-17(9-26-8-16)27-22(33)13-30-12-20(28-29-30)15-3-4-15/h5-12,15,32H,3-4,13-14H2,1-2H3,(H,27,33)
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n/an/a 12.4n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186563
PNG
(US9163021, 231)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cc3ccc(cc3)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C26H23F3N4O3/c1-25(2,15-34)33-14-20(19-13-30-9-8-22(19)33)24(36)21-12-18(7-10-31-21)32-23(35)11-16-3-5-17(6-4-16)26(27,28)29/h3-10,12-14,34H,11,15H2,1-2H3,(H,31,32,35)
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n/an/a 12.8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186521
PNG
(US9163021, 186)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(F)cc3)c2)c2cnccc12
Show InChI InChI=1S/C24H21FN4O2/c1-15(2)29-14-20(19-13-26-9-8-21(19)29)24(31)17-7-10-27-22(12-17)28-23(30)11-16-3-5-18(25)6-4-16/h3-10,12-15H,11H2,1-2H3,(H,27,28,30)
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n/an/a 13.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186373
PNG
(US9163021, 30)
Show SMILES CC(C)n1cc(C(=O)c2cc(NC(=O)Cn3cc(cn3)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C22H19F3N6O2/c1-13(2)31-11-17(16-9-26-5-4-19(16)31)21(33)18-7-15(3-6-27-18)29-20(32)12-30-10-14(8-28-30)22(23,24)25/h3-11,13H,12H2,1-2H3,(H,27,29,32)
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n/an/a 13.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186522
PNG
(US9163021, 189)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3coc(n3)C3CC3)c2)c2cnccc12
Show InChI InChI=1S/C24H23N5O3/c1-14(2)29-12-19(18-11-25-7-6-20(18)29)23(31)16-5-8-26-21(9-16)28-22(30)10-17-13-32-24(27-17)15-3-4-15/h5-9,11-15H,3-4,10H2,1-2H3,(H,26,28,30)
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n/an/a 13.6n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186527
PNG
(US9163021, 194)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2cc(ccn2)C(=O)c2cn(C3COC3)c3ccncc23)c1
Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)36-18-3-1-2-15(8-18)9-23(33)31-22-10-16(4-7-30-22)24(34)20-12-32(17-13-35-14-17)21-5-6-29-11-19(20)21/h1-8,10-12,17H,9,13-14H2,(H,30,31,33)
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n/an/a 13.8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186438
PNG
(US9163021, 96)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3cccc(Cl)c3)c2)c2cnccc12
Show InChI InChI=1S/C24H21ClN4O2/c1-15(2)29-14-20(19-13-26-8-7-21(19)29)24(31)17-6-9-27-22(12-17)28-23(30)11-16-4-3-5-18(25)10-16/h3-10,12-15H,11H2,1-2H3,(H,27,28,30)
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n/an/a 13.8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186446
PNG
(US9163021, 104)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)31-11-17(16-10-27-6-5-18(16)31)22(34)15-4-7-28-20(9-15)29-21(33)12-32-14(3)8-19(30-32)23(24,25)26/h4-11,13H,12H2,1-3H3,(H,28,29,33)
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n/an/a 13.8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186353
PNG
(US9163021, 10)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cn3ccc(n3)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C23H21F3N6O3/c1-22(2,13-33)32-11-16(15-10-27-6-4-18(15)32)21(35)17-9-14(3-7-28-17)29-20(34)12-31-8-5-19(30-31)23(24,25)26/h3-11,33H,12-13H2,1-2H3,(H,28,29,34)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM60795
PNG
(US9163021, 121)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C23H21F3N6O2/c1-13(2)31-11-18(17-10-27-5-4-19(17)31)22(34)15-7-16(9-28-8-15)29-21(33)12-32-14(3)6-20(30-32)23(24,25)26/h4-11,13H,12H2,1-3H3,(H,29,33)
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n/an/a 14.3n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186505
PNG
(US9163021, 168)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(OC(F)(F)F)cc3)c2)c2cnccc12
Show InChI InChI=1S/C25H21F3N4O3/c1-15(2)32-14-20(19-13-29-9-8-21(19)32)24(34)17-7-10-30-22(12-17)31-23(33)11-16-3-5-18(6-4-16)35-25(26,27)28/h3-10,12-15H,11H2,1-2H3,(H,30,31,33)
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n/an/a 14.7n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186433
PNG
(US9163021, 91)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C3CC3)c2)c2cncc(F)c12
Show InChI InChI=1S/C24H23FN6O2/c1-14(2)31-12-20(19-9-27-10-21(25)23(19)31)24(33)16-5-18(8-26-6-16)29-22(32)13-30-11-17(7-28-30)15-3-4-15/h5-12,14-15H,3-4,13H2,1-2H3,(H,29,32)
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n/an/a 15n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186551
PNG
(US9163021, 219 | US9163021, 227)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C22H18F4N6O3/c1-12(11-33)32-9-17(16-6-28-7-18(23)20(16)32)21(35)13-2-15(5-27-3-13)30-19(34)10-31-8-14(4-29-31)22(24,25)26/h2-9,12,33H,10-11H2,1H3,(H,30,34)
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n/an/a 15.2n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186445
PNG
(US9163021, 103)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(Cl)cc3)c2)c2cnccc12
Show InChI InChI=1S/C24H21ClN4O2/c1-15(2)29-14-20(19-13-26-9-8-21(19)29)24(31)17-7-10-27-22(12-17)28-23(30)11-16-3-5-18(25)6-4-16/h3-10,12-15H,11H2,1-2H3,(H,27,28,30)
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n/an/a 15.2n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186541
PNG
(US9163021, 209 | US9163021, 222 | US9163021, 224)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C25H20F4N4O3/c1-14(13-34)33-12-20(19-10-31-11-21(26)23(19)33)24(36)16-7-18(9-30-8-16)32-22(35)6-15-2-4-17(5-3-15)25(27,28)29/h2-5,7-12,14,34H,6,13H2,1H3,(H,32,35)
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n/an/a 15.4n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186420
PNG
(US9163021, 78)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3nc(oc3C)C3CC3)c2)c2cnccc12
Show InChI InChI=1S/C25H25N5O3/c1-14(2)30-13-19(18-12-26-8-7-21(18)30)24(32)17-6-9-27-22(10-17)29-23(31)11-20-15(3)33-25(28-20)16-4-5-16/h6-10,12-14,16H,4-5,11H2,1-3H3,(H,27,29,31)
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n/an/a 15.8n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186541
PNG
(US9163021, 209 | US9163021, 222 | US9163021, 224)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncc(F)c12
Show InChI InChI=1S/C25H20F4N4O3/c1-14(13-34)33-12-20(19-10-31-11-21(26)23(19)33)24(36)16-7-18(9-30-8-16)32-22(35)6-15-2-4-17(5-3-15)25(27,28)29/h2-5,7-12,14,34H,6,13H2,1H3,(H,32,35)
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n/an/a 16.4n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186566
PNG
(US9163021, 234)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cc(NC(=O)Cn3ccc(n3)C3CC3)ccn2)c2cnccc12
Show InChI InChI=1S/C25H26N6O3/c1-25(2,15-32)31-13-19(18-12-26-8-6-22(18)31)24(34)21-11-17(5-9-27-21)28-23(33)14-30-10-7-20(29-30)16-3-4-16/h5-13,16,32H,3-4,14-15H2,1-2H3,(H,27,28,33)
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n/an/a 16.5n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186377
PNG
(US9163021, 34 | US9163021, 36)
Show SMILES CC(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3cccc(c3)C(F)(F)F)c2)c2cnccc12
Show InChI InChI=1S/C25H21F3N4O3/c1-15(14-33)32-13-21(20-12-29-6-5-22(20)32)24(35)17-9-19(11-30-10-17)31-23(34)8-16-3-2-4-18(7-16)25(26,27)28/h2-7,9-13,15,33H,8,14H2,1H3,(H,31,34)
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n/an/a 17.1n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186518
PNG
(US9163021, 183)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cnccc12
Show InChI InChI=1S/C25H21N5O2/c1-16(2)30-15-21(20-14-27-9-8-22(20)30)25(32)19-7-10-28-23(12-19)29-24(31)11-17-3-5-18(13-26)6-4-17/h3-10,12,14-16H,11H2,1-2H3,(H,28,29,31)
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n/an/a 17.7n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186448
PNG
(US9163021, 106)
Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(F)cc3F)c2)c2cnccc12
Show InChI InChI=1S/C24H20F2N4O2/c1-14(2)30-13-19(18-12-27-7-6-21(18)30)24(32)16-5-8-28-22(9-16)29-23(31)10-15-3-4-17(25)11-20(15)26/h3-9,11-14H,10H2,1-2H3,(H,28,29,31)
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n/an/a 17.9n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186426
PNG
(US9163021, 230 | US9163021, 84)
Show SMILES CC(CO)n1cc(C(=O)c2cc(NC(=O)Cc3ccc(cc3)C(F)(F)F)ccn2)c2cnccc12
Show InChI InChI=1S/C25H21F3N4O3/c1-15(14-33)32-13-20(19-12-29-8-7-22(19)32)24(35)21-11-18(6-9-30-21)31-23(34)10-16-2-4-17(5-3-16)25(26,27)28/h2-9,11-13,15,33H,10,14H2,1H3,(H,30,31,34)
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n/an/a 18.1n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM186359
PNG
(US9163021, 16)
Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(F)cn3)c2)c2cnccc12
Show InChI InChI=1S/C24H22FN5O3/c1-24(2,14-31)30-13-20(19-12-26-6-5-21(19)30)23(33)15-7-18(11-27-9-15)29-22(32)8-17-4-3-16(25)10-28-17/h3-7,9-13,31H,8,14H2,1-2H3,(H,29,32)
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n/an/a 18.2n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...

US Patent US9163021 (2015)


BindingDB Entry DOI: 10.7270/Q29C6W7C
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%