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Patent code US9169224

Compile Data Set for Download or QSAR

Found 209 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394629
PNG
(CHEMBL2164596 | US9169224, 60)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C24H24ClN3O2/c25-20-9-11-22(12-10-20)30-23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29)
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n/an/a 9n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394626
PNG
(CHEMBL2164599 | US9169224, 65)
Show SMILES COc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O3/c1-30-22-10-12-23(13-11-22)31-24-9-5-6-20(18-24)19-27-14-16-28(17-15-27)25(29)26-21-7-3-2-4-8-21/h2-13,18H,14-17,19H2,1H3,(H,26,29)
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n/an/a 9n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188375
PNG
(US9169224, 59)
Show SMILES Oc1c(CN2CCN(CC2)C(=O)Nc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c26-21-18(11-10-17-6-4-5-9-20(17)21)16-24-12-14-25(15-13-24)22(27)23-19-7-2-1-3-8-19/h1-11,26H,12-16H2,(H,23,27)
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n/an/a 16n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188339
PNG
(US9169224, 18)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22(23-21-8-2-1-3-9-21)25-14-12-24(13-15-25)17-18-10-11-19-6-4-5-7-20(19)16-18/h1-11,16H,12-15,17H2,(H,23,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394627
PNG
(CHEMBL2164598 | US9169224, 62)
Show SMILES Cc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O2/c1-20-10-12-23(13-11-20)30-24-9-5-6-21(18-24)19-27-14-16-28(17-15-27)25(29)26-22-7-3-2-4-8-22/h2-13,18H,14-17,19H2,1H3,(H,26,29)
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n/an/a 18n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26741
PNG
(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3n2)CC1
Show InChI InChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188340
PNG
(US9169224, 20)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cc3ccccc3s2)CC1
Show InChI InChI=1S/C20H21N3OS/c24-20(21-17-7-2-1-3-8-17)23-12-10-22(11-13-23)15-18-14-16-6-4-5-9-19(16)25-18/h1-9,14H,10-13,15H2,(H,21,24)
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n/an/a 19n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188396
PNG
(US9169224, 85)
Show SMILES Fc1cccc(NC(=O)N2CCN(Cc3ccc(Br)c(Br)c3)CC2)c1
Show InChI InChI=1S/C18H18Br2FN3O/c19-16-5-4-13(10-17(16)20)12-23-6-8-24(9-7-23)18(25)22-15-3-1-2-14(21)11-15/h1-5,10-11H,6-9,12H2,(H,22,25)
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n/an/a 19n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188341
PNG
(US9169224, 162 | US9169224, 21)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1Br
Show InChI InChI=1S/C18H19Br2N3O/c19-16-7-6-14(12-17(16)20)13-22-8-10-23(11-9-22)18(24)21-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,21,24)
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n/an/a 19n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188376
PNG
(US9169224, 61)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1Cl
Show InChI InChI=1S/C24H23Cl2N3O2/c25-22-10-9-21(16-23(22)26)31-20-8-4-5-18(15-20)17-28-11-13-29(14-12-28)24(30)27-19-6-2-1-3-7-19/h1-10,15-16H,11-14,17H2,(H,27,30)
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n/an/a 20n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188375
PNG
(US9169224, 59)
Show SMILES Oc1c(CN2CCN(CC2)C(=O)Nc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c26-21-18(11-10-17-6-4-5-9-20(17)21)16-24-12-14-25(15-13-24)22(27)23-19-7-2-1-3-8-19/h1-11,26H,12-16H2,(H,23,27)
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n/an/a 21n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188397
PNG
(US9169224, 86)
Show SMILES Fc1ccc(NC(=O)N2CCN(Cc3ccc(Br)c(Br)c3)CC2)cc1
Show InChI InChI=1S/C18H18Br2FN3O/c19-16-6-1-13(11-17(16)20)12-23-7-9-24(10-8-23)18(25)22-15-4-2-14(21)3-5-15/h1-6,11H,7-10,12H2,(H,22,25)
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n/an/a 21n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188400
PNG
(US9169224, 89)
Show SMILES Fc1ccccc1NC(=O)N1CCN(Cc2ccc(Br)c(Br)c2)CC1
Show InChI InChI=1S/C18H18Br2FN3O/c19-14-6-5-13(11-15(14)20)12-23-7-9-24(10-8-23)18(25)22-17-4-2-1-3-16(17)21/h1-6,11H,7-10,12H2,(H,22,25)
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n/an/a 22n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188339
PNG
(US9169224, 18)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22(23-21-8-2-1-3-9-21)25-14-12-24(13-15-25)17-18-10-11-19-6-4-5-7-20(19)16-18/h1-11,16H,12-15,17H2,(H,23,26)
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n/an/a 23n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM26741
PNG
(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3n2)CC1
Show InChI InChI=1S/C21H22N4O/c26-21(23-18-7-2-1-3-8-18)25-14-12-24(13-15-25)16-19-11-10-17-6-4-5-9-20(17)22-19/h1-11H,12-16H2,(H,23,26)
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n/an/a 23n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188381
PNG
(US9169224, 69)
Show SMILES Clc1ccc2ncc(CN3CCN(CC3)C(=O)Nc3ccccc3)cc2c1
Show InChI InChI=1S/C21H21ClN4O/c22-18-6-7-20-17(13-18)12-16(14-23-20)15-25-8-10-26(11-9-25)21(27)24-19-4-2-1-3-5-19/h1-7,12-14H,8-11,15H2,(H,24,27)
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n/an/a 23n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188386
PNG
(US9169224, 75)
Show SMILES Cc1cccc2cc(CN3CCN(CC3)C(=O)Nc3ccccc3)c(Cl)nc12
Show InChI InChI=1S/C22H23ClN4O/c1-16-6-5-7-17-14-18(21(23)25-20(16)17)15-26-10-12-27(13-11-26)22(28)24-19-8-3-2-4-9-19/h2-9,14H,10-13,15H2,1H3,(H,24,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188342
PNG
(US9169224, 22)
Show SMILES Cn1c(CN2CCN(CC2)C(=O)Nc2ccccc2)cc2ccccc12
Show InChI InChI=1S/C21H24N4O/c1-23-19(15-17-7-5-6-10-20(17)23)16-24-11-13-25(14-12-24)21(26)22-18-8-3-2-4-9-18/h2-10,15H,11-14,16H2,1H3,(H,22,26)
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n/an/a 26n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188429
PNG
(US9169224, 118)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)Nc2cccnc2)cc1Br
Show InChI InChI=1S/C17H18Br2N4O/c18-15-4-3-13(10-16(15)19)12-22-6-8-23(9-7-22)17(24)21-14-2-1-5-20-11-14/h1-5,10-11H,6-9,12H2,(H,21,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188371
PNG
(US9169224, 55)
Show SMILES Clc1cccc2ccc(CN3CCN(CC3)C(=O)Nc3ccccc3)nc12
Show InChI InChI=1S/C21H21ClN4O/c22-19-8-4-5-16-9-10-18(23-20(16)19)15-25-11-13-26(14-12-25)21(27)24-17-6-2-1-3-7-17/h1-10H,11-15H2,(H,24,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188385
PNG
(US9169224, 73)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3cc[nH]c3c2)CC1
Show InChI InChI=1S/C20H22N4O/c25-20(22-18-4-2-1-3-5-18)24-12-10-23(11-13-24)15-16-6-7-17-8-9-21-19(17)14-16/h1-9,14,21H,10-13,15H2,(H,22,25)
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n/an/a 29n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188341
PNG
(US9169224, 162 | US9169224, 21)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1Br
Show InChI InChI=1S/C18H19Br2N3O/c19-16-7-6-14(12-17(16)20)13-22-8-10-23(11-9-22)18(24)21-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,21,24)
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n/an/a 31n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188388
PNG
(US9169224, 77)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc(OCc3ccccc3)cc2)CC1
Show InChI InChI=1S/C25H27N3O2/c29-25(26-23-9-5-2-6-10-23)28-17-15-27(16-18-28)19-21-11-13-24(14-12-21)30-20-22-7-3-1-4-8-22/h1-14H,15-20H2,(H,26,29)
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n/an/a 32n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188442
PNG
(US9169224, 131)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccc4ccccc4c3)c2)CC1
Show InChI InChI=1S/C28H27N3O2/c32-28(29-25-10-2-1-3-11-25)31-17-15-30(16-18-31)21-22-7-6-12-26(19-22)33-27-14-13-23-8-4-5-9-24(23)20-27/h1-14,19-20H,15-18,21H2,(H,29,32)
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n/an/a 33n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188341
PNG
(US9169224, 162 | US9169224, 21)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1Br
Show InChI InChI=1S/C18H19Br2N3O/c19-16-7-6-14(12-17(16)20)13-22-8-10-23(11-9-22)18(24)21-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,21,24)
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n/an/a 38n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188398
PNG
(US9169224, 87)
Show SMILES COc1cccc(NC(=O)N2CCN(Cc3ccc(Br)c(Br)c3)CC2)c1
Show InChI InChI=1S/C19H21Br2N3O2/c1-26-16-4-2-3-15(12-16)22-19(25)24-9-7-23(8-10-24)13-14-5-6-17(20)18(21)11-14/h2-6,11-12H,7-10,13H2,1H3,(H,22,25)
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n/an/a 48n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188375
PNG
(US9169224, 59)
Show SMILES Oc1c(CN2CCN(CC2)C(=O)Nc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C22H23N3O2/c26-21-18(11-10-17-6-4-5-9-20(17)21)16-24-12-14-25(15-13-24)22(27)23-19-7-2-1-3-8-19/h1-11,26H,12-16H2,(H,23,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188444
PNG
(US9169224, 133)
Show SMILES COC(=O)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C26H27N3O4/c1-32-25(30)21-10-12-23(13-11-21)33-24-9-5-6-20(18-24)19-28-14-16-29(17-15-28)26(31)27-22-7-3-2-4-8-22/h2-13,18H,14-17,19H2,1H3,(H,27,31)
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n/an/a 50n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188344
PNG
(US9169224, 24)
Show SMILES Ic1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20IN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
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n/an/a 52n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188373
PNG
(US9169224, 57)
Show SMILES Fc1ccc(NC(=O)N2CCN(Cc3ccc4ccccc4c3)CC2)cc1
Show InChI InChI=1S/C22H22FN3O/c23-20-7-9-21(10-8-20)24-22(27)26-13-11-25(12-14-26)16-17-5-6-18-3-1-2-4-19(18)15-17/h1-10,15H,11-14,16H2,(H,24,27)
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n/an/a 54n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188345
PNG
(US9169224, 25)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(OCc3ccccc3)c2)CC1
Show InChI InChI=1S/C25H27N3O2/c29-25(26-23-11-5-2-6-12-23)28-16-14-27(15-17-28)19-22-10-7-13-24(18-22)30-20-21-8-3-1-4-9-21/h1-13,18H,14-17,19-20H2,(H,26,29)
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n/an/a 57n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188449
PNG
(US9169224, 138)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(OS(=O)(=O)c3ccccc3)c2)CC1
Show InChI InChI=1S/C24H25N3O4S/c28-24(25-21-9-3-1-4-10-21)27-16-14-26(15-17-27)19-20-8-7-11-22(18-20)31-32(29,30)23-12-5-2-6-13-23/h1-13,18H,14-17,19H2,(H,25,28)
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n/an/a 59n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188423
PNG
(US9169224, 112)
Show SMILES Fc1ccccc1NC(=O)N1CCN(Cc2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C21H21FN4O/c22-18-6-2-4-8-20(18)24-21(27)26-11-9-25(10-12-26)15-16-13-17-5-1-3-7-19(17)23-14-16/h1-8,13-14H,9-12,15H2,(H,24,27)
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n/an/a 61n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188445
PNG
(US9169224, 134)
Show SMILES CS(=O)(=O)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O4S/c1-33(30,31)24-12-10-22(11-13-24)32-23-9-5-6-20(18-23)19-27-14-16-28(17-15-27)25(29)26-21-7-3-2-4-8-21/h2-13,18H,14-17,19H2,1H3,(H,26,29)
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n/an/a 65n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188468
PNG
(US9169224, 157)
Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1Cl
Show InChI InChI=1S/C18H19Cl2N3O/c19-16-7-6-14(12-17(16)20)13-22-8-10-23(11-9-22)18(24)21-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,21,24)
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n/an/a 65n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188447
PNG
(US9169224, 136)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C25H25N3O4/c29-25(26-20-6-2-1-3-7-20)28-13-11-27(12-14-28)17-19-5-4-8-21(15-19)32-22-9-10-23-24(16-22)31-18-30-23/h1-10,15-16H,11-14,17-18H2,(H,26,29)
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n/an/a 67n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188346
PNG
(US9169224, 27)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20BrN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
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n/an/a 69n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394625
PNG
(CHEMBL2164600 | US9169224, 63)
Show SMILES CC(C)(C)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C28H33N3O2/c1-28(2,3)23-12-14-25(15-13-23)33-26-11-7-8-22(20-26)21-30-16-18-31(19-17-30)27(32)29-24-9-5-4-6-10-24/h4-15,20H,16-19,21H2,1-3H3,(H,29,32)
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n/an/a 69n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188343
PNG
(US9169224, 23)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C21H22N4O/c26-21(23-19-7-2-1-3-8-19)25-12-10-24(11-13-25)16-17-14-18-6-4-5-9-20(18)22-15-17/h1-9,14-15H,10-13,16H2,(H,23,26)
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n/an/a 73n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188401
PNG
(US9169224, 90)
Show SMILES COc1ccc(NC(=O)N2CCN(Cc3ccc(Br)c(Br)c3)CC2)cc1
Show InChI InChI=1S/C19H21Br2N3O2/c1-26-16-5-3-15(4-6-16)22-19(25)24-10-8-23(9-11-24)13-14-2-7-17(20)18(21)12-14/h2-7,12H,8-11,13H2,1H3,(H,22,25)
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n/an/a 75n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394621
PNG
(CHEMBL2164605 | US9169224, 26)
Show SMILES COc1cc(Br)cc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1O
Show InChI InChI=1S/C19H22BrN3O3/c1-26-17-12-15(20)11-14(18(17)24)13-22-7-9-23(10-8-22)19(25)21-16-5-3-2-4-6-16/h2-6,11-12,24H,7-10,13H2,1H3,(H,21,25)
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n/an/a 79n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394631
PNG
(CHEMBL2164594 | US9169224, 28)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Show InChI InChI=1S/C24H25N3O2/c28-24(25-21-9-3-1-4-10-21)27-16-14-26(15-17-27)19-20-8-7-13-23(18-20)29-22-11-5-2-6-12-22/h1-13,18H,14-17,19H2,(H,25,28)
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n/an/a 80n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188393
PNG
(US9169224, 82)
Show SMILES FC(F)(F)c1cc(CN2CCN(CC2)C(=O)Nc2ccccc2)ccc1Cl
Show InChI InChI=1S/C19H19ClF3N3O/c20-17-7-6-14(12-16(17)19(21,22)23)13-25-8-10-26(11-9-25)18(27)24-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,24,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188446
PNG
(US9169224, 135)
Show SMILES COc1cccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)c1
Show InChI InChI=1S/C25H27N3O3/c1-30-22-10-6-12-24(18-22)31-23-11-5-7-20(17-23)19-27-13-15-28(16-14-27)25(29)26-21-8-3-2-4-9-21/h2-12,17-18H,13-16,19H2,1H3,(H,26,29)
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n/an/a 83n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188368
PNG
(US9169224, 52)
Show SMILES FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3ccccc3)cc2O1
Show InChI InChI=1S/C19H19F2N3O3/c20-19(21)26-16-7-6-14(12-17(16)27-19)13-23-8-10-24(11-9-23)18(25)22-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,22,25)
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n/an/a 87n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188380
PNG
(US9169224, 68)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccc4cccc5ccc2c3c45)CC1
Show InChI InChI=1S/C28H25N3O/c32-28(29-24-7-2-1-3-8-24)31-17-15-30(16-18-31)19-23-12-11-22-10-9-20-5-4-6-21-13-14-25(23)27(22)26(20)21/h1-14H,15-19H2,(H,29,32)
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n/an/a 95n/an/an/an/a9.0n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188368
PNG
(US9169224, 52)
Show SMILES FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3ccccc3)cc2O1
Show InChI InChI=1S/C19H19F2N3O3/c20-19(21)26-16-7-6-14(12-17(16)27-19)13-23-8-10-24(11-9-23)18(25)22-15-4-2-1-3-5-15/h1-7,12H,8-11,13H2,(H,22,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188399
PNG
(US9169224, 88)
Show SMILES Cc1cccc(NC(=O)N2CCN(Cc3ccc(Br)c(Br)c3)CC2)c1
Show InChI InChI=1S/C19H21Br2N3O/c1-14-3-2-4-16(11-14)22-19(25)24-9-7-23(8-10-24)13-15-5-6-17(20)18(21)12-15/h2-6,11-12H,7-10,13H2,1H3,(H,22,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188374
PNG
(US9169224, 58)
Show SMILES Fc1ccc(NC(=O)N2CCN(Cc3ccc4ccccc4n3)CC2)cc1
Show InChI InChI=1S/C21H21FN4O/c22-17-6-9-18(10-7-17)24-21(27)26-13-11-25(12-14-26)15-19-8-5-16-3-1-2-4-20(16)23-19/h1-10H,11-15H2,(H,24,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM188384
PNG
(US9169224, 72)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C24H24ClN3O3S/c25-20-9-11-22(12-10-20)32(30,31)23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....

US Patent US9169224 (2015)


BindingDB Entry DOI: 10.7270/Q24Q7ST1
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%