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Patent code US9169246

Compile Data Set for Download or QSAR

Found 207 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188704
PNG
(US9169246, 246)
Show SMILES OC1CCN(C1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
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n/an/a 1.46n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188545
PNG
(US9169246, 30)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C22H20F3N5O/c23-22(24,25)13-30-19-11-15(3-6-17(19)20-18(21(30)31)12-27-28-20)14-1-4-16(5-2-14)29-9-7-26-8-10-29/h1-6,11-12,26H,7-10,13H2,(H,27,28)
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n/an/a 2.13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188567
PNG
(US9169246, 66)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-3-15(17)19-16(20(30)31)11-27-28-19)14-2-4-18(26-10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28)
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n/an/a 3.06n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188731
PNG
(US9169246, 273)
Show SMILES FC1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H19F4N5O/c23-14-5-8-30(9-6-14)20-15(2-1-7-27-20)13-3-4-16-18(10-13)31(12-22(24,25)26)21(32)17-11-28-29-19(16)17/h1-4,7,10-11,14H,5-6,8-9,12H2,(H,28,29)
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n/an/a 3.45n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188706
PNG
(US9169246, 248)
Show SMILES CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H16F3N5O/c1-26(2)17-12(4-3-7-23-17)11-5-6-13-15(8-11)27(10-19(20,21)22)18(28)14-9-24-25-16(13)14/h3-9H,10H2,1-2H3,(H,24,25)
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n/an/a 3.87n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188541
PNG
(US9169246, 19)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C23H22F3N5O/c1-29-8-10-30(11-9-29)17-5-2-15(3-6-17)16-4-7-18-20(12-16)31(14-23(24,25)26)22(32)19-13-27-28-21(18)19/h2-7,12-13H,8-11,14H2,1H3,(H,27,28)
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n/an/a 3.94n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188569
PNG
(US9169246, 68)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H21F3N6O/c1-29-6-8-30(9-7-29)19-11-15(4-5-26-19)14-2-3-16-18(10-14)31(13-22(23,24)25)21(32)17-12-27-28-20(16)17/h2-5,10-12H,6-9,13H2,1H3,(H,27,28)
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n/an/a 4.12n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188707
PNG
(US9169246, 249)
Show SMILES CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O/c1-3-27(2)18-13(5-4-8-24-18)12-6-7-14-16(9-12)28(11-20(21,22)23)19(29)15-10-25-26-17(14)15/h4-10H,3,11H2,1-2H3,(H,25,26)
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n/an/a 4.19n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188621
PNG
(US9169246, 121)
Show SMILES CCC(=O)Nc1ccc(C)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H19F3N4O2/c1-3-19(30)27-17-7-4-12(2)8-15(17)13-5-6-14-18(9-13)29(11-22(23,24)25)21(31)16-10-26-28-20(14)16/h4-10H,3,11H2,1-2H3,(H,26,28)(H,27,30)
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n/an/a 4.29n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188708
PNG
(US9169246, 250)
Show SMILES CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H18F3N5O2/c1-27(7-8-29)18-13(3-2-6-24-18)12-4-5-14-16(9-12)28(11-20(21,22)23)19(30)15-10-25-26-17(14)15/h2-6,9-10,29H,7-8,11H2,1H3,(H,25,26)
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n/an/a 4.41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188686
PNG
(US9169246, 226)
Show SMILES CC(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H14F3N5O2/c1-10(28)25-15-8-23-5-4-12(15)11-2-3-13-16(6-11)27(9-19(20,21)22)18(29)14-7-24-26-17(13)14/h2-8H,9H2,1H3,(H,24,26)(H,25,28)
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n/an/a 4.68n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188659
PNG
(US9169246, 199)
Show SMILES FC(F)(F)Cn1c2cc(c(Cl)cc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C17H9Cl2F3N4O/c18-12-4-10-13(5-9(12)8-2-1-3-23-15(8)19)26(7-17(20,21)22)16(27)11-6-24-25-14(10)11/h1-6H,7H2,(H,24,25)
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n/an/a 4.90n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188693
PNG
(US9169246, 235)
Show SMILES CN(C)CCS(=O)(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H22F3N5O3S/c1-29(2)9-10-34(32,33)28-18-6-4-3-5-15(18)14-7-8-16-19(11-14)30(13-22(23,24)25)21(31)17-12-26-27-20(16)17/h3-8,11-12,28H,9-10,13H2,1-2H3,(H,26,27)
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n/an/a 4.99n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188692
PNG
(US9169246, 234)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H15F3N4O3S/c1-30(28,29)25-15-5-3-2-4-12(15)11-6-7-13-16(8-11)26(10-19(20,21)22)18(27)14-9-23-24-17(13)14/h2-9,25H,10H2,1H3,(H,23,24)
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n/an/a 5.33n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188709
PNG
(US9169246, 251)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)12-29-17-10-13(5-6-15(17)18-16(20(29)30)11-26-27-18)14-4-3-7-25-19(14)28-8-1-2-9-28/h3-7,10-11H,1-2,8-9,12H2,(H,26,27)
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n/an/a 5.34n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188571
PNG
(US9169246, 70)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-2-15(17)19-16(20(30)31)11-27-28-19)14-3-4-26-18(10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28)
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n/an/a 5.62n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188728
PNG
(US9169246, 270)
Show SMILES CN1CCCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C23H23F3N6O/c1-30-8-3-9-31(11-10-30)21-16(4-2-7-27-21)15-5-6-17-19(12-15)32(14-23(24,25)26)22(33)18-13-28-29-20(17)18/h2,4-7,12-13H,3,8-11,14H2,1H3,(H,28,29)
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n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188702
PNG
(US9169246, 244)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCNCC1
Show InChI InChI=1S/C22H21F3N6O/c23-22(24,25)13-31-18-11-14(4-5-16(18)19-17(21(31)32)12-28-29-19)15-3-1-7-27-20(15)30-9-2-6-26-8-10-30/h1,3-5,7,11-12,26H,2,6,8-10,13H2,(H,28,29)
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n/an/a 6.08n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188705
PNG
(US9169246, 247)
Show SMILES OC1CN(CC1O)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
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n/an/a 6.41n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188531
PNG
(US9169246, 2)
Show SMILES Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H12F3N5O/c18-17(19,20)8-25-13-6-9(10-2-1-5-22-15(10)21)3-4-11(13)14-12(16(25)26)7-23-24-14/h1-7H,8H2,(H2,21,22)(H,23,24)
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n/an/a 7.06n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188609
PNG
(US9169246, 109)
Show SMILES Fc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1ccccn1
Show InChI InChI=1S/C17H10F4N4O/c18-12-5-10-14(6-9(12)13-3-1-2-4-22-13)25(8-17(19,20)21)16(26)11-7-23-24-15(10)11/h1-7H,8H2,(H,23,24)
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n/an/a 7.10n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188628
PNG
(US9169246, 166)
Show SMILES CN1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C22H21F3N6O/c1-29-7-9-30(10-8-29)20-15(3-2-6-26-20)14-4-5-16-18(11-14)31(13-22(23,24)25)21(32)17-12-27-28-19(16)17/h2-6,11-12H,7-10,13H2,1H3,(H,27,28)
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n/an/a 7.24n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188573
PNG
(US9169246, 72)
Show SMILES Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N4O/c1-10-12(3-2-6-22-10)11-4-5-13-15(7-11)25(9-18(19,20)21)17(26)14-8-23-24-16(13)14/h2-8H,9H2,1H3,(H,23,24)
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n/an/a 7.38n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188611
PNG
(US9169246, 111)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1Cl
Show InChI InChI=1S/C17H10ClF3N4O/c18-15-10(2-1-5-22-15)9-3-4-11-13(6-9)25(8-17(19,20)21)16(26)12-7-23-24-14(11)12/h1-7H,8H2,(H,23,24)
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n/an/a 7.42n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188530
PNG
(US9169246, 1)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccccn1
Show InChI InChI=1S/C17H11F3N4O/c18-17(19,20)9-24-14-7-10(13-3-1-2-6-21-13)4-5-11(14)15-12(16(24)25)8-22-23-15/h1-8H,9H2,(H,22,23)
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n/an/a 7.53n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188629
PNG
(US9169246, 167)
Show SMILES Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H12F3N5O/c18-17(19,20)8-25-14-5-9(10-3-4-22-7-13(10)21)1-2-11(14)15-12(16(25)26)6-23-24-15/h1-7H,8,21H2,(H,23,24)
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n/an/a 7.64n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188656
PNG
(US9169246, 196)
Show SMILES FC(F)(F)Cn1c2cc(c(Cl)cc2c2[nH]ncc2c1=O)-c1ccncc1
Show InChI InChI=1S/C17H10ClF3N4O/c18-13-5-11-14(6-10(13)9-1-3-22-4-2-9)25(8-17(19,20)21)16(26)12-7-23-24-15(11)12/h1-7H,8H2,(H,23,24)
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n/an/a 7.77n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188654
PNG
(US9169246, 194)
Show SMILES FC(F)(F)Cn1c2cc(c(Cl)cc2c2[nH]ncc2c1=O)-c1ccccn1
Show InChI InChI=1S/C17H10ClF3N4O/c18-12-5-10-14(6-9(12)13-3-1-2-4-22-13)25(8-17(19,20)21)16(26)11-7-23-24-15(10)11/h1-7H,8H2,(H,23,24)
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n/an/a 8.22n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188710
PNG
(US9169246, 252)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCOCC1
Show InChI InChI=1S/C22H20F3N5O2/c23-22(24,25)13-30-18-11-14(4-5-16(18)19-17(21(30)31)12-27-28-19)15-3-1-6-26-20(15)29-7-2-9-32-10-8-29/h1,3-6,11-12H,2,7-10,13H2,(H,27,28)
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n/an/a 8.35n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188630
PNG
(US9169246, 168)
Show SMILES Cc1cc(cc(C)n1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H15F3N4O/c1-10-5-13(6-11(2)24-10)12-3-4-14-16(7-12)26(9-19(20,21)22)18(27)15-8-23-25-17(14)15/h3-8H,9H2,1-2H3,(H,23,25)
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n/an/a 8.81n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188631
PNG
(US9169246, 169)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ncccc1Cl
Show InChI InChI=1S/C17H10ClF3N4O/c18-12-2-1-5-22-14(12)9-3-4-10-13(6-9)25(8-17(19,20)21)16(26)11-7-23-24-15(10)11/h1-7H,8H2,(H,23,24)
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n/an/a 8.83n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188669
PNG
(US9169246, 209)
Show SMILES CN1CCCN(CC1)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C25H24F3N5O2/c1-31-9-4-10-32(12-11-31)23(34)18-6-3-2-5-17(18)16-7-8-19-21(13-16)33(15-25(26,27)28)24(35)20-14-29-30-22(19)20/h2-3,5-8,13-14H,4,9-12,15H2,1H3,(H,29,30)
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n/an/a 8.98n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188683
PNG
(US9169246, 223)
Show SMILES CC(=O)Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H14F3N5O2/c1-10(28)25-17-12(3-2-6-23-17)11-4-5-13-15(7-11)27(9-19(20,21)22)18(29)14-8-24-26-16(13)14/h2-8H,9H2,1H3,(H,24,26)(H,23,25,28)
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n/an/a 9.01n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188624
PNG
(US9169246, 124)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccccc1CN1CCCNCC1
Show InChI InChI=1S/C24H24F3N5O/c25-24(26,27)15-32-21-12-16(6-7-19(21)22-20(23(32)33)13-29-30-22)18-5-2-1-4-17(18)14-31-10-3-8-28-9-11-31/h1-2,4-7,12-13,28H,3,8-11,14-15H2,(H,29,30)
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n/an/a 9.22n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188632
PNG
(US9169246, 170)
Show SMILES COC(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C19H13F3N4O3/c1-29-18(28)16-11(3-2-6-23-16)10-4-5-12-14(7-10)26(9-19(20,21)22)17(27)13-8-24-25-15(12)13/h2-8H,9H2,1H3,(H,24,25)
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n/an/a 9.36n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188711
PNG
(US9169246, 253)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCNC(=O)C1
Show InChI InChI=1S/C21H17F3N6O2/c22-21(23,24)11-30-16-8-12(3-4-14(16)18-15(20(30)32)9-27-28-18)13-2-1-5-26-19(13)29-7-6-25-17(31)10-29/h1-5,8-9H,6-7,10-11H2,(H,25,31)(H,27,28)
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n/an/a 9.44n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188667
PNG
(US9169246, 207)
Show SMILES CN(C)CCN(C)C(=O)c1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C24H24F3N5O2/c1-30(2)10-11-31(3)22(33)17-7-5-4-6-16(17)15-8-9-18-20(12-15)32(14-24(25,26)27)23(34)19-13-28-29-21(18)19/h4-9,12-13H,10-11,14H2,1-3H3,(H,28,29)
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n/an/a 9.53n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188694
PNG
(US9169246, 236)
Show SMILES CS(=O)(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O3S/c1-30(28,29)25-14-8-22-5-4-11(14)10-2-3-12-15(6-10)26(9-18(19,20)21)17(27)13-7-23-24-16(12)13/h2-8,25H,9H2,1H3,(H,23,24)
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n/an/a 9.66n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188695
PNG
(US9169246, 237)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccncc1NS(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C24H18F3N5O3S/c25-24(26,27)14-32-21-10-16(6-7-18(21)22-19(23(32)33)11-29-30-22)17-8-9-28-12-20(17)31-36(34,35)13-15-4-2-1-3-5-15/h1-12,31H,13-14H2,(H,29,30)
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n/an/a 10.2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188626
PNG
(US9169246, 126)
Show SMILES Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N4O/c19-18(20,21)9-25-15-7-10(11-3-1-2-4-14(11)22)5-6-12(15)16-13(17(25)26)8-23-24-16/h1-8H,9,22H2,(H,23,24)
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n/an/a 10.4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188701
PNG
(US9169246, 243)
Show SMILES CNc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H14F3N5O/c1-22-16-11(3-2-6-23-16)10-4-5-12-14(7-10)26(9-18(19,20)21)17(27)13-8-24-25-15(12)13/h2-8H,9H2,1H3,(H,22,23)(H,24,25)
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n/an/a 10.6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188610
PNG
(US9169246, 110)
Show SMILES Cc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1cccnc1Cl
Show InChI InChI=1S/C18H12ClF3N4O/c1-9-5-12-14(6-11(9)10-3-2-4-23-16(10)19)26(8-18(20,21)22)17(27)13-7-24-25-15(12)13/h2-7H,8H2,1H3,(H,24,25)
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n/an/a 11.1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188732
PNG
(US9169246, 274)
Show SMILES Oc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C17H11F3N4O2/c18-17(19,20)8-24-13-6-9(10-2-1-5-21-15(10)25)3-4-11(13)14-12(16(24)26)7-22-23-14/h1-7H,8H2,(H,21,25)(H,22,23)
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n/an/a 11.3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188619
PNG
(US9169246, 119)
Show SMILES COCC(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C21H17F3N4O3/c1-31-10-18(29)26-16-5-3-2-4-13(16)12-6-7-14-17(8-12)28(11-21(22,23)24)20(30)15-9-25-27-19(14)15/h2-9H,10-11H2,1H3,(H,25,27)(H,26,29)
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n/an/a 11.8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188537
PNG
(US9169246, 12)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccccc1C(=O)N1CCOCC1
Show InChI InChI=1S/C23H19F3N4O3/c24-23(25,26)13-30-19-11-14(5-6-17(19)20-18(22(30)32)12-27-28-20)15-3-1-2-4-16(15)21(31)29-7-9-33-10-8-29/h1-6,11-12H,7-10,13H2,(H,27,28)
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n/an/a 12.1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188576
PNG
(US9169246, 75)
Show SMILES Cc1ccc(c(Cl)n1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N4O/c1-9-2-4-11(16(19)24-9)10-3-5-12-14(6-10)26(8-18(20,21)22)17(27)13-7-23-25-15(12)13/h2-7H,8H2,1H3,(H,23,25)
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n/an/a 12.3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188673
PNG
(US9169246, 213)
Show SMILES CN(C)C(=O)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1
Show InChI InChI=1S/C20H16F3N5O2/c1-27(2)19(30)17-12(4-3-7-24-17)11-5-6-13-15(8-11)28(10-20(21,22)23)18(29)14-9-25-26-16(13)14/h3-9H,10H2,1-2H3,(H,25,26)
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n/an/a 12.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188674
PNG
(US9169246, 214)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccccc1C(=O)NCCc1ccncc1
Show InChI InChI=1S/C26H20F3N5O2/c27-26(28,29)15-34-22-13-17(5-6-20(22)23-21(25(34)36)14-32-33-23)18-3-1-2-4-19(18)24(35)31-12-9-16-7-10-30-11-8-16/h1-8,10-11,13-14H,9,12,15H2,(H,31,35)(H,32,33)
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n/an/a 12.9n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188712
PNG
(US9169246, 254)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCC1
Show InChI InChI=1S/C20H16F3N5O/c21-20(22,23)11-28-16-9-12(13-3-1-6-24-18(13)27-7-2-8-27)4-5-14(16)17-15(19(28)29)10-25-26-17/h1,3-6,9-10H,2,7-8,11H2,(H,25,26)
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n/an/a 13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM188666
PNG
(US9169246, 206)
Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1C(=O)N1CCOCC1
Show InChI InChI=1S/C22H18F3N5O3/c23-22(24,25)12-30-17-10-13(3-4-15(17)18-16(20(30)31)11-27-28-18)14-2-1-5-26-19(14)21(32)29-6-8-33-9-7-29/h1-5,10-11H,6-9,12H2,(H,27,28)
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n/an/a 14.1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me...

US Patent US9169246 (2015)


BindingDB Entry DOI: 10.7270/Q2B856XZ
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%