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Patent code US9181185

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190561
PNG
(US9181185, 19 | US9624194, Compound 19)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m0/s1
PDB

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US Patent
 347 -38.4n/an/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Media...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190560
PNG
(US9181185, 15 | US9624194, Compound 15)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m1/s1
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US Patent
 917 -35.8n/an/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Media...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190562
PNG
(US9181185, 26 | US9624194, Compound 26)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1ccnc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H16FN3O4/c20-12-3-7-14(8-4-12)27-13-5-1-11(2-6-13)19-22-10-9-15(23-19)16(24)17(25)18(21)26/h1-10,16-17,24-25H,(H2,21,26)/t16-,17+/m0/s1
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 2.26E+3 -33.5n/an/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Media...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190541
PNG
(US9181185, 30b | US9624194, Compound 30b)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C21H17F3N2O4/c22-21(23,24)13-6-10-15(11-7-13)30-14-8-4-12(5-9-14)16-2-1-3-17(26-16)18(27)19(28)20(25)29/h1-11,18-19,27-28H,(H2,25,29)/t18-,19+/m1/s1
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n/an/a 130n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190556
PNG
(US9181185, 6)
Show SMILES CCOC(=O)[C@H](O)[C@H](O)c1cn(-c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C25H21F3N2O5/c1-2-34-24(33)23(32)22(31)19-14-30(20-6-4-3-5-18(19)20)16-8-10-17(11-9-16)35-21-12-7-15(13-29-21)25(26,27)28/h3-14,22-23,31-32H,2H2,1H3/t22-,23-/m1/s1
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n/an/a 152n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190558
PNG
(US9181185, 8 | US9624194, Compound 8)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cn(-c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C23H18F3N3O4/c24-23(25,26)13-5-10-19(28-11-13)33-15-8-6-14(7-9-15)29-12-17(20(30)21(31)22(27)32)16-3-1-2-4-18(16)29/h1-12,20-21,30-31H,(H2,27,32)/t20-,21+/m1/s1
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n/an/a 193n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190561
PNG
(US9181185, 19 | US9624194, Compound 19)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m0/s1
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n/an/a 244n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190559
PNG
(US9181185, 14)
Show SMILES CCOC(=O)[C@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
Show InChI InChI=1S/C24H19F3N2O5/c1-2-33-23(32)22(31)21(30)20-5-3-4-19(29-20)14-6-8-16(9-7-14)34-17-10-11-18(24(25,26)27)15(12-17)13-28/h3-12,21-22,30-31H,2H2,1H3/t21-,22-/m1/s1
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n/an/a 246n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190553
PNG
(US9181185, 30g | US9624194, Compound 30g)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cc2)C#N)cc1 |r|
Show InChI InChI=1S/C21H17N3O4/c22-12-13-4-8-15(9-5-13)28-16-10-6-14(7-11-16)17-2-1-3-18(24-17)19(25)20(26)21(23)27/h1-11,19-20,25-26H,(H2,23,27)/t19-,20+/m1/s1
PDB

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n/an/a 262n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190557
PNG
(US9181185, 7 | US9624194, Compound 7)
Show SMILES CNC(=O)[C@@H](O)[C@H](O)c1cn(-c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C24H20F3N3O4/c1-28-23(33)22(32)21(31)18-13-30(19-5-3-2-4-17(18)19)15-7-9-16(10-8-15)34-20-11-6-14(12-29-20)24(25,26)27/h2-13,21-22,31-32H,1H3,(H,28,33)/t21-,22+/m1/s1
PDB

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n/an/a 282n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190560
PNG
(US9181185, 15 | US9624194, Compound 15)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-9-8-15(10-13(16)11-26)32-14-6-4-12(5-7-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m1/s1
PDB

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n/an/a 304n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190555
PNG
(US9181185, 5 | US9624194, Compound 5)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cn(-c2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C23H18F3N3O4/c24-23(25,26)13-5-10-19(28-11-13)33-15-8-6-14(7-9-15)29-12-17(20(30)21(31)22(27)32)16-3-1-2-4-18(16)29/h1-12,20-21,30-31H,(H2,27,32)/t20-,21+/m0/s1
PDB

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n/an/a 314n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190551
PNG
(US9181185, 30f | US9624194, Compound 30f)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(Cl)nc2)cc1 |r|
Show InChI InChI=1S/C19H16ClN3O4/c20-16-9-8-13(10-22-16)27-12-6-4-11(5-7-12)14-2-1-3-15(23-14)17(24)18(25)19(21)26/h1-10,17-18,24-25H,(H2,21,26)/t17-,18+/m1/s1
PDB

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n/an/a 376n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190542
PNG
(US9181185, 31b | US9624194, Compound 31b)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C21H17F3N2O4/c22-21(23,24)13-6-10-15(11-7-13)30-14-8-4-12(5-9-14)16-2-1-3-17(26-16)18(27)19(28)20(25)29/h1-11,18-19,27-28H,(H2,25,29)/t18-,19+/m0/s1
PDB

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n/an/a 383n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190549
PNG
(US9181185, 30e | US9624194, Compound 30e)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(C#N)c(c2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-10-15(9-6-13(16)11-26)32-14-7-4-12(5-8-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m1/s1
PDB

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n/an/a 461n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190550
PNG
(US9181185, 31e | US9624194, Compound 31e)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(C#N)c(c2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C22H16F3N3O4/c23-22(24,25)16-10-15(9-6-13(16)11-26)32-14-7-4-12(5-8-14)17-2-1-3-18(28-17)19(29)20(30)21(27)31/h1-10,19-20,29-30H,(H2,27,31)/t19-,20+/m0/s1
PDB

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n/an/a 489n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190562
PNG
(US9181185, 26 | US9624194, Compound 26)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1ccnc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H16FN3O4/c20-12-3-7-14(8-4-12)27-13-5-1-11(2-6-13)19-22-10-9-15(23-19)16(24)17(25)18(21)26/h1-10,16-17,24-25H,(H2,21,26)/t16-,17+/m0/s1
PDB

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n/an/a 625n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190554
PNG
(US9181185, 31g | US9624194, Compound 31g)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cc2)C#N)cc1 |r|
Show InChI InChI=1S/C21H17N3O4/c22-12-13-4-8-15(9-5-13)28-16-10-6-14(7-11-16)17-2-1-3-18(24-17)19(25)20(26)21(23)27/h1-11,19-20,25-26H,(H2,23,27)/t19-,20+/m0/s1
PDB

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n/an/a 690n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190545
PNG
(US9181185, 30c | US9624194, Compound 30c)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C20H16F3N3O4/c21-20(22,23)12-6-9-16(25-10-12)30-13-7-4-11(5-8-13)14-2-1-3-15(26-14)17(27)18(28)19(24)29/h1-10,17-18,27-28H,(H2,24,29)/t17-,18+/m1/s1
PDB

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n/an/a 711n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190552
PNG
(US9181185, 31f | US9624194, Compound 31f)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(Cl)nc2)cc1 |r|
Show InChI InChI=1S/C19H16ClN3O4/c20-16-9-8-13(10-22-16)27-12-6-4-11(5-7-12)14-2-1-3-15(23-14)17(24)18(25)19(21)26/h1-10,17-18,24-25H,(H2,21,26)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 804n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190547
PNG
(US9181185, 30d | US9624194, Compound 30d)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(Cl)cn2)cc1 |r|
Show InChI InChI=1S/C19H16ClN3O4/c20-12-6-9-16(22-10-12)27-13-7-4-11(5-8-13)14-2-1-3-15(23-14)17(24)18(25)19(21)26/h1-10,17-18,24-25H,(H2,21,26)/t17-,18+/m1/s1
PDB

KEGG

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US Patent
n/an/a 1.19E+3n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190543
PNG
(US9181185, 30a | US9624194, Compound 30a)
Show SMILES NC(=O)[C@@H](O)[C@H](O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1 |r|
Show InChI InChI=1S/C20H17FN2O4/c21-13-6-10-15(11-7-13)27-14-8-4-12(5-9-14)16-2-1-3-17(23-16)18(24)19(25)20(22)26/h1-11,18-19,24-25H,(H2,22,26)/t18-,19+/m1/s1
PDB

KEGG

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US Patent
n/an/a 1.41E+3n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190548
PNG
(US9181185, 31d | US9624194, Compound 31d)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(Cl)cn2)cc1 |r|
Show InChI InChI=1S/C19H16ClN3O4/c20-12-6-9-16(22-10-12)27-13-7-4-11(5-8-13)14-2-1-3-15(23-14)17(24)18(25)19(21)26/h1-10,17-18,24-25H,(H2,21,26)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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n/an/a 1.44E+3n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190546
PNG
(US9181185, 31c | US9624194, Compound 31c)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(cn2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C20H16F3N3O4/c21-20(22,23)12-6-9-16(25-10-12)30-13-7-4-11(5-8-13)14-2-1-3-15(26-14)17(27)18(28)19(24)29/h1-10,17-18,27-28H,(H2,24,29)/t17-,18+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 1.69E+3n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM190544
PNG
(US9181185, 31a | US9624194, Compound 31a)
Show SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1 |r|
Show InChI InChI=1S/C20H17FN2O4/c21-13-6-10-15(11-7-13)27-14-8-4-12(5-9-14)16-2-1-3-17(23-16)18(24)19(25)20(22)26/h1-11,18-19,24-25H,(H2,22,26)/t18-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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UniChem

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US Patent
n/an/a 1.85E+3n/an/an/an/an/a37



Purdue Pharma L.P.

US Patent


Assay Description
FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...

US Patent US9181185 (2015)


BindingDB Entry DOI: 10.7270/Q2PC315D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%