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Patent code US9181219

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190585
PNG
(US9181219, 2-{[3-fluoro-5-(trifluoromethyl)pyridin...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(cc3F)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F4N2OS/c1-11-4-2-5-12-6-3-7-24(16(11)12)15(25)10-26-17-14(19)8-13(9-23-17)18(20,21)22/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190588
PNG
(US9181219, 2-[(3,5-dichloropyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(Cl)cc3Cl)c12
Show InChI InChI=1S/C17H16Cl2N2OS/c1-11-4-2-5-12-6-3-7-21(16(11)12)15(22)10-23-17-14(19)8-13(18)9-20-17/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190583
PNG
(US9181219, 10)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(cc3Cl)C(F)(F)F)c12
Show InChI InChI=1S/C18H16ClF3N2OS/c1-11-4-2-5-12-6-3-7-24(16(11)12)15(25)10-26-17-14(19)8-13(9-23-17)18(20,21)22/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190588
PNG
(US9181219, 2-[(3,5-dichloropyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(Cl)cc3Cl)c12
Show InChI InChI=1S/C17H16Cl2N2OS/c1-11-4-2-5-12-6-3-7-21(16(11)12)15(22)10-23-17-14(19)8-13(18)9-20-17/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190585
PNG
(US9181219, 2-{[3-fluoro-5-(trifluoromethyl)pyridin...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(cc3F)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F4N2OS/c1-11-4-2-5-12-6-3-7-24(16(11)12)15(25)10-26-17-14(19)8-13(9-23-17)18(20,21)22/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190593
PNG
(US9181219, 2-[(4,5-dimethylpyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1cnc(SCC(=O)N2CCCc3cccc(C)c23)cc1C
Show InChI InChI=1S/C19H22N2OS/c1-13-6-4-7-16-8-5-9-21(19(13)16)18(22)12-23-17-10-14(2)15(3)11-20-17/h4,6-7,10-11H,5,8-9,12H2,1-3H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190593
PNG
(US9181219, 2-[(4,5-dimethylpyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1cnc(SCC(=O)N2CCCc3cccc(C)c23)cc1C
Show InChI InChI=1S/C19H22N2OS/c1-13-6-4-7-16-8-5-9-21(19(13)16)18(22)12-23-17-10-14(2)15(3)11-20-17/h4,6-7,10-11H,5,8-9,12H2,1-3H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190579
PNG
(US9181219, 20)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-5-2-6-13-7-4-10-20(16(12)13)15(21)11-22-17-14(18)8-3-9-19-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
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n/an/a<200n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190578
PNG
(US9181219, 16)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Cl)cn3)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190583
PNG
(US9181219, 10)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncc(cc3Cl)C(F)(F)F)c12
Show InChI InChI=1S/C18H16ClF3N2OS/c1-11-4-2-5-12-6-3-7-24(16(11)12)15(25)10-26-17-14(19)8-13(9-23-17)18(20,21)22/h2,4-5,8-9H,3,6-7,10H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190578
PNG
(US9181219, 16)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Cl)cn3)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190586
PNG
(US9181219, 2-[(5-bromopyridin-2-yl)sulfanyl]-1-(8-...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Br)cn3)c12
Show InChI InChI=1S/C17H17BrN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190591
PNG
(US9181219, 2-[(3-chloropyridin-2-yl)sulfanyl]-1-(8...)
Show SMILES COc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2O2S/c1-22-14-8-2-5-12-6-4-10-20(16(12)14)15(21)11-23-17-13(18)7-3-9-19-17/h2-3,5,7-9H,4,6,10-11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190591
PNG
(US9181219, 2-[(3-chloropyridin-2-yl)sulfanyl]-1-(8...)
Show SMILES COc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2O2S/c1-22-14-8-2-5-12-6-4-10-20(16(12)14)15(21)11-23-17-13(18)7-3-9-19-17/h2-3,5,7-9H,4,6,10-11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190586
PNG
(US9181219, 2-[(5-bromopyridin-2-yl)sulfanyl]-1-(8-...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Br)cn3)c12
Show InChI InChI=1S/C17H17BrN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190590
PNG
(US9181219, 2-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-5-2-6-14-8-4-10-21(17(13)14)16(22)12-23-18-15(11-19)7-3-9-20-18/h2-3,5-7,9H,4,8,10,12H2,1H3
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n/an/a<500n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190592
PNG
(US9181219, 2-[(3,4-dimethylpyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1ccnc(SCC(=O)N2CCCc3cccc(C)c23)c1C
Show InChI InChI=1S/C19H22N2OS/c1-13-9-10-20-19(15(13)3)23-12-17(22)21-11-5-8-16-7-4-6-14(2)18(16)21/h4,6-7,9-10H,5,8,11-12H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190581
PNG
(US9181219, 8)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-5-2-6-13-7-4-10-23(16(12)13)15(24)11-25-17-14(18(19,20)21)8-3-9-22-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190590
PNG
(US9181219, 2-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-5-2-6-14-8-4-10-21(17(13)14)16(22)12-23-18-15(11-19)7-3-9-20-18/h2-3,5-7,9H,4,8,10,12H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190579
PNG
(US9181219, 20)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-5-2-6-13-7-4-10-20(16(12)13)15(21)11-22-17-14(18)8-3-9-19-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190575
PNG
(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Show SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C17H15F3N2OS/c18-17(19,20)13-7-8-15(21-10-13)24-11-16(23)22-9-3-5-12-4-1-2-6-14(12)22/h1-2,4,6-8,10H,3,5,9,11H2
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n/an/a<1.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190577
PNG
(US9181219, 21)
Show SMILES Clc1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C16H15ClN2OS/c17-13-7-8-15(18-10-13)21-11-16(20)19-9-3-5-12-4-1-2-6-14(12)19/h1-2,4,6-8,10H,3,5,9,11H2
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190592
PNG
(US9181219, 2-[(3,4-dimethylpyridin-2-yl)sulfanyl]-...)
Show SMILES Cc1ccnc(SCC(=O)N2CCCc3cccc(C)c23)c1C
Show InChI InChI=1S/C19H22N2OS/c1-13-9-10-20-19(15(13)3)23-12-17(22)21-11-5-8-16-7-4-6-14(2)18(16)21/h4,6-7,9-10H,5,8,11-12H2,1-3H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190575
PNG
(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Show SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C17H15F3N2OS/c18-17(19,20)13-7-8-15(21-10-13)24-11-16(23)22-9-3-5-12-4-1-2-6-14(12)22/h1-2,4,6-8,10H,3,5,9,11H2
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190594
PNG
(US9181219, 2-{[3-ethyl-5-(trifluoromethyl)pyridin-...)
Show SMILES CCc1cc(cnc1SCC(=O)N1CCCc2cccc(C)c12)C(F)(F)F
Show InChI InChI=1S/C20H21F3N2OS/c1-3-14-10-16(20(21,22)23)11-24-19(14)27-12-17(26)25-9-5-8-15-7-4-6-13(2)18(15)25/h4,6-7,10-11H,3,5,8-9,12H2,1-2H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190581
PNG
(US9181219, 8)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-5-2-6-13-7-4-10-23(16(12)13)15(24)11-25-17-14(18(19,20)21)8-3-9-22-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM190578
PNG
(US9181219, 16)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Cl)cn3)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190594
PNG
(US9181219, 2-{[3-ethyl-5-(trifluoromethyl)pyridin-...)
Show SMILES CCc1cc(cnc1SCC(=O)N1CCCc2cccc(C)c12)C(F)(F)F
Show InChI InChI=1S/C20H21F3N2OS/c1-3-14-10-16(20(21,22)23)11-24-19(14)27-12-17(26)25-9-5-8-15-7-4-6-13(2)18(15)25/h4,6-7,10-11H,3,5,8-9,12H2,1-2H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190587
PNG
(US9181219, methyl 5-chloro-6-{[2-(8-methyl-1,2,3,4...)
Show SMILES COC(=O)c1cnc(SCC(=O)N2CCCc3cccc(C)c23)c(Cl)c1
Show InChI InChI=1S/C19H19ClN2O3S/c1-12-5-3-6-13-7-4-8-22(17(12)13)16(23)11-26-18-15(20)9-14(10-21-18)19(24)25-2/h3,5-6,9-10H,4,7-8,11H2,1-2H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190584
PNG
(US9181219, 6-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-5-15-6-3-9-21(18(13)15)17(22)12-23-16-8-7-14(10-19)11-20-16/h2,4-5,7-8,11H,3,6,9,12H2,1H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190587
PNG
(US9181219, methyl 5-chloro-6-{[2-(8-methyl-1,2,3,4...)
Show SMILES COC(=O)c1cnc(SCC(=O)N2CCCc3cccc(C)c23)c(Cl)c1
Show InChI InChI=1S/C19H19ClN2O3S/c1-12-5-3-6-13-7-4-8-22(17(12)13)16(23)11-26-18-15(20)9-14(10-21-18)19(24)25-2/h3,5-6,9-10H,4,7-8,11H2,1-2H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190580
PNG
(US9181219, 12)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccccn3)c12
Show InChI InChI=1S/C17H18N2OS/c1-13-6-4-7-14-8-5-11-19(17(13)14)16(20)12-21-15-9-2-3-10-18-15/h2-4,6-7,9-10H,5,8,11-12H2,1H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190582
PNG
(US9181219, 24)
Show SMILES Cc1ccc(SCC(=O)N2CCCc3cccc(C)c23)nc1
Show InChI InChI=1S/C18H20N2OS/c1-13-8-9-16(19-11-13)22-12-17(21)20-10-4-7-15-6-3-5-14(2)18(15)20/h3,5-6,8-9,11H,4,7,10,12H2,1-2H3
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190577
PNG
(US9181219, 21)
Show SMILES Clc1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C16H15ClN2OS/c17-13-7-8-15(18-10-13)21-11-16(20)19-9-3-5-12-4-1-2-6-14(12)19/h1-2,4,6-8,10H,3,5,9,11H2
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n/an/a<5.00E+3n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190584
PNG
(US9181219, 6-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-5-15-6-3-9-21(18(13)15)17(22)12-23-16-8-7-14(10-19)11-20-16/h2,4-5,7-8,11H,3,6,9,12H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190589
PNG
(US9181219, 2-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3cc(ccn3)C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-5-15-6-3-9-21(18(13)15)17(22)12-23-16-10-14(11-19)7-8-20-16/h2,4-5,7-8,10H,3,6,9,12H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190580
PNG
(US9181219, 12)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccccn3)c12
Show InChI InChI=1S/C17H18N2OS/c1-13-6-4-7-14-8-5-11-19(17(13)14)16(20)12-21-15-9-2-3-10-18-15/h2-4,6-7,9-10H,5,8,11-12H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190589
PNG
(US9181219, 2-{[2-(8-methyl-1,2,3,4-tetrahydroquino...)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3cc(ccn3)C#N)c12
Show InChI InChI=1S/C18H17N3OS/c1-13-4-2-5-15-6-3-9-21(18(13)15)17(22)12-23-16-10-14(11-19)7-8-20-16/h2,4-5,7-8,10H,3,6,9,12H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))		BDBM190582
PNG
(US9181219, 24)
Show SMILES Cc1ccc(SCC(=O)N2CCCc3cccc(C)c23)nc1
Show InChI InChI=1S/C18H20N2OS/c1-13-8-9-16(19-11-13)22-12-17(21)20-10-4-7-15-6-3-5-14(2)18(15)20/h3,5-6,8-9,11H,4,7,10,12H2,1-2H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM190579
PNG
(US9181219, 20)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-5-2-6-13-7-4-10-20(16(12)13)15(21)11-22-17-14(18)8-3-9-19-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Sodium channel protein type 2 subunit alpha


(Homo sapiens (Human))		BDBM190579
PNG
(US9181219, 20)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ncccc3Cl)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-5-2-6-13-7-4-10-20(16(12)13)15(21)11-22-17-14(18)8-3-9-19-17/h2-3,5-6,8-9H,4,7,10-11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Sodium channel protein type 2 subunit alpha


(Homo sapiens (Human))		BDBM190578
PNG
(US9181219, 16)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(Cl)cn3)c12
Show InChI InChI=1S/C17H17ClN2OS/c1-12-4-2-5-13-6-3-9-20(17(12)13)16(21)11-22-15-8-7-14(18)10-19-15/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Sodium channel protein type 2 subunit alpha


(Homo sapiens (Human))		BDBM190575
PNG
(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Show SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1
Show InChI InChI=1S/C17H15F3N2OS/c18-17(19,20)13-7-8-15(21-10-13)24-11-16(23)22-9-3-5-12-4-1-2-6-14(12)22/h1-2,4,6-8,10H,3,5,9,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
Sodium channel protein type 2 subunit alpha


(Homo sapiens (Human))		BDBM190576
PNG
(US9181219, 6)
Show SMILES Cc1cccc2CCCN(C(=O)CSc3ccc(cn3)C(F)(F)F)c12
Show InChI InChI=1S/C18H17F3N2OS/c1-12-4-2-5-13-6-3-9-23(17(12)13)16(24)11-25-15-8-7-14(10-22-15)18(19,20)21/h2,4-5,7-8,10H,3,6,9,11H2,1H3
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US Patent
n/an/a>3.00E+4n/an/an/an/an/an/a



HYDRA BIOSCIENCES, INC.

US Patent


Assay Description
To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...

US Patent US9181219 (2015)


BindingDB Entry DOI: 10.7270/Q2DV1HPH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%