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Patent code US9181258

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191119
PNG
(US9181258, 120)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)S(N)(=O)=O)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N4O4S/c23-22(24,25)33-16-3-1-2-14(10-16)18-11-19-21(30)28-12-15(8-9-26)29(19)20(18)13-4-6-17(7-5-13)34(27,31)32/h1-7,10-11,15H,8-9,12,26H2,(H,28,30)(H2,27,31,32)/t15-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191104
PNG
(US9181258, 101)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H27F3N4O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(10-11-29)32(22)23/h3-9,12-13,19H,10-11,14-15,29H2,1-2H3,(H,30,33)/t19-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191095
PNG
(US9181258, 93)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c23-22(24,25)31-17-3-1-2-14(10-17)18-11-19-21(30)27-12-15(8-9-26)28(19)20(18)13-4-6-16(29)7-5-13/h1-7,10-11,15,29H,8-9,12,26H2,(H,27,30)/t15-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191129
PNG
(US9181258, 130)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)C3(N)CC3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N4O2/c26-25(27,28)34-19-3-1-2-16(12-19)20-13-21-23(33)31-14-18(8-11-29)32(21)22(20)15-4-6-17(7-5-15)24(30)9-10-24/h1-7,12-13,18H,8-11,14,29-30H2,(H,31,33)/t18-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191114
PNG
(US9181258, 135)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCCN)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C29H34F3N5O2/c1-35-12-14-36(15-13-35)19-20-7-9-21(10-8-20)27-25(22-4-2-6-24(16-22)39-29(30,31)32)17-26-28(38)34-18-23(37(26)27)5-3-11-33/h2,4,6-10,16-17,23H,3,5,11-15,18-19,33H2,1H3,(H,34,38)/t23-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191103
PNG
(US9181258, 100)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCN)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H32F3N5O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(29,30)31)16-25-27(37)33-17-22(9-10-32)36(25)26/h2-8,15-16,22H,9-14,17-18,32H2,1H3,(H,33,37)/t22-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191074
PNG
(US9181258, 82)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NCC(CCOC(=O)C(F)(F)F)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C30H30F6N4O4/c1-38-10-12-39(13-11-38)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)44-30(34,35)36)16-25-27(41)37-17-22(40(25)26)9-14-43-28(42)29(31,32)33/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,37,41)
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191100
PNG
(US9181258, 96)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)33-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 1n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191103
PNG
(US9181258, 100)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCN)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H32F3N5O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(29,30)31)16-25-27(37)33-17-22(9-10-32)36(25)26/h2-8,15-16,22H,9-14,17-18,32H2,1H3,(H,33,37)/t22-/m0/s1
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n/an/a 2n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191102
PNG
(US9181258, 99)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CN4CCOCC4)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)37-22-3-1-2-20(14-22)23-15-24-26(35)32-16-21(8-9-31)34(24)25(23)19-6-4-18(5-7-19)17-33-10-12-36-13-11-33/h1-7,14-15,21H,8-13,16-17,31H2,(H,32,35)/t21-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191113
PNG
(US9181258, 134)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H29F3N4O2/c1-32(2)16-17-8-10-18(11-9-17)24-22(19-5-3-7-21(13-19)35-26(27,28)29)14-23-25(34)31-15-20(33(23)24)6-4-12-30/h3,5,7-11,13-14,20H,4,6,12,15-16,30H2,1-2H3,(H,31,34)/t20-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191109
PNG
(US9181258, 116)
Show SMILES COc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c1-31-17-7-5-14(6-8-17)21-19(15-3-2-4-18(11-15)32-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 3n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191126
PNG
(US9181258, 121)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(F)c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H19F4N3O2/c23-15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)31-22(24,25)26)11-19-21(30)28-12-16(7-8-27)29(19)20/h1-6,9-11,16H,7-8,12,27H2,(H,28,30)/t16-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191120
PNG
(US9181258, 126 | US9181258, 129)
Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191129
PNG
(US9181258, 130)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)C3(N)CC3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N4O2/c26-25(27,28)34-19-3-1-2-16(12-19)20-13-21-23(33)31-14-18(8-11-29)32(21)22(20)15-4-6-17(7-5-15)24(30)9-10-24/h1-7,12-13,18H,8-11,14,29-30H2,(H,31,33)/t18-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191119
PNG
(US9181258, 120)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)S(N)(=O)=O)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N4O4S/c23-22(24,25)33-16-3-1-2-14(10-16)18-11-19-21(30)28-12-15(8-9-26)29(19)20(18)13-4-6-17(7-5-13)34(27,31)32/h1-7,10-11,15H,8-9,12,26H2,(H,28,30)(H2,27,31,32)/t15-/m0/s1
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n/an/a 3n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191110
PNG
(US9181258, 115)
Show SMILES CN(C)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H25F3N4O2/c1-30(2)17-8-6-15(7-9-17)22-20(16-4-3-5-19(12-16)33-24(25,26)27)13-21-23(32)29-14-18(10-11-28)31(21)22/h3-9,12-13,18H,10-11,14,28H2,1-2H3,(H,29,32)/t18-/m0/s1
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n/an/a 3n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191100
PNG
(US9181258, 96)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)33-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 3n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191083
PNG
(US9181258, 33)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,30H,8-9,12-13,27H2,(H,28,31)
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n/an/a 4n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191075
PNG
(US9181258, 83)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NCC(CCOC(=O)C(F)(F)F)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N3O4/c1-35(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)40-27(31,32)33)13-22-24(37)34-14-19(36(22)23)10-11-39-25(38)26(28,29)30/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,34,37)
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n/an/a 4n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191107
PNG
(US9181258, 104)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-5-1-3-15(11-18)19-12-20-22(31)28-13-16(4-2-10-27)29(20)21(19)14-6-8-17(30)9-7-14/h1,3,5-9,11-12,16,30H,2,4,10,13,27H2,(H,28,31)/t16-/m0/s1
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n/an/a 4n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191078
PNG
(US9181258, 92)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)31-23(24,25)26)12-20-22(30)28-13-17(8-9-27)29(20)21/h2-7,10-12,17H,8-9,13,27H2,1H3,(H,28,30)/t17-/m0/s1
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n/an/a 5n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191099
PNG
(US9181258, 95)
Show SMILES CC(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O3/c1-14(31)15-5-7-16(8-6-15)22-20(17-3-2-4-19(11-17)33-24(25,26)27)12-21-23(32)29-13-18(9-10-28)30(21)22/h2-8,11-12,18H,9-10,13,28H2,1H3,(H,29,32)/t18-/m0/s1
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n/an/a 6n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191091
PNG
(US9181258, 78)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N4O4/c1-33(2)12-11-31-25(36)18-8-6-17(7-9-18)24-22(19-4-3-5-21(14-19)38-27(28,29)30)15-23-26(37)32-16-20(10-13-35)34(23)24/h3-9,14-15,20,35H,10-13,16H2,1-2H3,(H,31,36)(H,32,37)
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n/an/a 6n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191117
PNG
(US9181258, 112)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc4OCOc4c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-16-3-1-2-13(8-16)17-10-18-22(30)28-11-15(6-7-27)29(18)21(17)14-4-5-19-20(9-14)32-12-31-19/h1-5,8-10,15H,6-7,11-12,27H2,(H,28,30)/t15-/m0/s1
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n/an/a 6n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191102
PNG
(US9181258, 99)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CN4CCOCC4)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)37-22-3-1-2-20(14-22)23-15-24-26(35)32-16-21(8-9-31)34(24)25(23)19-6-4-18(5-7-19)17-33-10-12-36-13-11-33/h1-7,14-15,21H,8-13,16-17,31H2,(H,32,35)/t21-/m0/s1
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n/an/a 7n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191089
PNG
(US9181258, 77)
Show SMILES NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-17-3-1-2-15(10-17)18-11-19-22(32)28-12-16(8-9-30)29(19)20(18)13-4-6-14(7-5-13)21(27)31/h1-7,10-11,16,30H,8-9,12H2,(H2,27,31)(H,28,32)
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n/an/a 7n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191101
PNG
(US9181258, 97)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(C=O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,13,17H,8-9,12,27H2,(H,28,31)/t17-/m0/s1
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n/an/a 7n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191070
PNG
(US9181258, 28)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)
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n/an/a 7n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191122
PNG
(US9181258, 128)
Show SMILES COc1c(C)cc(cc1C)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N3O3/c1-14-9-17(10-15(2)23(14)33-3)22-20(16-5-4-6-19(11-16)34-25(26,27)28)12-21-24(32)30-13-18(7-8-29)31(21)22/h4-6,9-12,18H,7-8,13,29H2,1-3H3,(H,30,32)/t18-/m0/s1
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n/an/a 8n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191132
PNG
(US9181258, 148)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N5O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)34-24(25,26)27)12-20-22(33)31-13-17(32(20)21)8-9-30-23(28)29/h2-7,10-12,17H,8-9,13H2,1H3,(H,31,33)(H4,28,29,30)/t17-/m0/s1
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n/an/a 8n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191081
PNG
(US9181258, 32)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3cccc(N)c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-17-6-2-3-13(10-17)18-11-19-21(30)28-12-16(7-8-26)29(19)20(18)14-4-1-5-15(27)9-14/h1-6,9-11,16H,7-8,12,26-27H2,(H,28,30)
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n/an/a 8n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191133
PNG
(US9181258, 149)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N5O4S/c1-37(34,35)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)36-24(25,26)27)12-20-22(33)31-13-16(32(20)21)9-10-30-23(28)29/h2-8,11-12,16H,9-10,13H2,1H3,(H,31,33)(H4,28,29,30)/t16-/m0/s1
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n/an/a 8n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191104
PNG
(US9181258, 101)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H27F3N4O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(10-11-29)32(22)23/h3-9,12-13,19H,10-11,14-15,29H2,1-2H3,(H,30,33)/t19-/m0/s1
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n/an/a 9n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191077
PNG
(US9181258, 87)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)/t16-/m0/s1
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n/an/a 9n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191094
PNG
(US9181258, 84)
Show SMILES OCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F3N2O4/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)27-12-17(8-9-29)28(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,29-30H,8-9,12-13H2,(H,27,31)
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n/an/a 11n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191106
PNG
(US9181258, 103)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H20F3N3O2S/c22-21(23,24)29-16-5-1-3-13(9-16)17-10-18-20(28)26-11-15(4-2-7-25)27(18)19(17)14-6-8-30-12-14/h1,3,5-6,8-10,12,15H,2,4,7,11,25H2,(H,26,28)/t15-/m0/s1
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n/an/a 11n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191092
PNG
(US9181258, 81)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C29H31F3N4O4/c1-35-12-9-21(10-13-35)34-27(38)19-7-5-18(6-8-19)26-24(20-3-2-4-23(15-20)40-29(30,31)32)16-25-28(39)33-17-22(11-14-37)36(25)26/h2-8,15-16,21-22,37H,9-14,17H2,1H3,(H,33,39)(H,34,38)
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n/an/a 11n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191112
PNG
(US9181258, 109)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O4S/c1-35(32,33)19-9-7-15(8-10-19)22-20(16-4-2-6-18(12-16)34-24(25,26)27)13-21-23(31)29-14-17(30(21)22)5-3-11-28/h2,4,6-10,12-13,17H,3,5,11,14,28H2,1H3,(H,29,31)/t17-/m0/s1
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n/an/a 11n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191126
PNG
(US9181258, 121)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(F)c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H19F4N3O2/c23-15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)31-22(24,25)26)11-19-21(30)28-12-16(7-8-27)29(19)20/h1-6,9-11,16H,7-8,12,27H2,(H,28,30)/t16-/m0/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191076
PNG
(US9181258, 85)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)28-15-3-1-2-12(8-15)16-9-17-19(27)25-10-14(4-6-24)26(17)18(16)13-5-7-29-11-13/h1-3,5,7-9,11,14H,4,6,10,24H2,(H,25,27)/t14-/m0/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191088
PNG
(US9181258, 43)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)15-3-1-2-14(10-15)18-11-19-21(30)27-12-16(8-9-26)28(19)20(18)13-4-6-17(29)7-5-13/h1-7,10-11,16,29H,8-9,12,26H2,(H,27,30)
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191120
PNG
(US9181258, 126 | US9181258, 129)
Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191132
PNG
(US9181258, 148)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N5O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)34-24(25,26)27)12-20-22(33)31-13-17(32(20)21)8-9-30-23(28)29/h2-7,10-12,17H,8-9,13H2,1H3,(H,31,33)(H4,28,29,30)/t17-/m0/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191121
PNG
(US9181258, 127)
Show SMILES CCOc1ccc(cc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H23F4N3O3/c1-2-33-21-7-6-15(11-19(21)25)22-18(14-4-3-5-17(10-14)34-24(26,27)28)12-20-23(32)30-13-16(8-9-29)31(20)22/h3-7,10-12,16H,2,8-9,13,29H2,1H3,(H,30,32)/t16-/m0/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191131
PNG
(US9181258, 138)
Show SMILES CC(C)[C@H]1CNC(=O)c2cc(c(-c3ccc(CN)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O2/c1-14(2)21-13-29-23(31)20-11-19(17-4-3-5-18(10-17)32-24(25,26)27)22(30(20)21)16-8-6-15(12-28)7-9-16/h3-11,14,21H,12-13,28H2,1-2H3,(H,29,31)/t21-/m1/s1
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n/an/a 12n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191120
PNG
(US9181258, 126 | US9181258, 129)
Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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n/an/a 13n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191090
PNG
(US9181258, 79)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N3O4/c1-30(2)24(34)16-8-6-15(7-9-16)22-20(17-4-3-5-19(12-17)35-25(26,27)28)13-21-23(33)29-14-18(10-11-32)31(21)22/h3-9,12-13,18,32H,10-11,14H2,1-2H3,(H,29,33)
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n/an/a 13n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191114
PNG
(US9181258, 135)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCCN)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C29H34F3N5O2/c1-35-12-14-36(15-13-35)19-20-7-9-21(10-8-20)27-25(22-4-2-6-24(16-22)39-29(30,31)32)17-26-28(38)34-18-23(37(26)27)5-3-11-33/h2,4,6-10,16-17,23H,3,5,11-15,18-19,33H2,1H3,(H,34,38)/t23-/m0/s1
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n/an/a 13n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191097
PNG
(US9181258, 71)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NCC(CCCl)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H30ClF3N4O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(30,31)32)16-25-27(37)33-17-22(9-10-29)36(25)26/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,33,37)
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n/an/a 14n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191078
PNG
(US9181258, 92)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)31-23(24,25)26)12-20-22(30)28-13-17(8-9-27)29(20)21/h2-7,10-12,17H,8-9,13,27H2,1H3,(H,28,30)/t17-/m0/s1
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n/an/a 15n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191083
PNG
(US9181258, 33)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,30H,8-9,12-13,27H2,(H,28,31)
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n/an/a 15n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191117
PNG
(US9181258, 112)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc4OCOc4c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-16-3-1-2-13(8-16)17-10-18-22(30)28-11-15(6-7-27)29(18)21(17)14-4-5-19-20(9-14)32-12-31-19/h1-5,8-10,15H,6-7,11-12,27H2,(H,28,30)/t15-/m0/s1
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191096
PNG
(US9181258, 70)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NCC(CCCl)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H25ClF3N3O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(27,28)29)13-22-24(33)30-14-19(10-11-26)32(22)23/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,30,33)
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191123
PNG
(US9181258, 123)
Show SMILES CSc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2S/c1-32-18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)31-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191073
PNG
(US9181258, 57)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C21H19ClFN3O/c22-14-6-7-18(23)16(10-14)17-11-19-21(27)25-12-15(8-9-24)26(19)20(17)13-4-2-1-3-5-13/h1-7,10-11,15H,8-9,12,24H2,(H,25,27)
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191108
PNG
(US9181258, 105)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O3/c25-24(26,27)33-19-5-1-3-17(11-19)20-12-21-23(32)29-13-18(4-2-10-28)30(21)22(20)16-8-6-15(14-31)7-9-16/h1,3,5-9,11-12,18,31H,2,4,10,13-14,28H2,(H,29,32)/t18-/m0/s1
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191095
PNG
(US9181258, 93)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O3/c23-22(24,25)31-17-3-1-2-14(10-17)18-11-19-21(30)27-12-15(8-9-26)28(19)20(18)13-4-6-16(29)7-5-13/h1-7,10-11,15,29H,8-9,12,26H2,(H,27,30)/t15-/m0/s1
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n/an/a 16n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191072
PNG
(US9181258, 55)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C19H17ClFN3OS/c20-12-1-2-16(21)14(7-12)15-8-17-19(25)23-9-13(3-5-22)24(17)18(15)11-4-6-26-10-11/h1-2,4,6-8,10,13H,3,5,9,22H2,(H,23,25)
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n/an/a 17n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191099
PNG
(US9181258, 95)
Show SMILES CC(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O3/c1-14(31)15-5-7-16(8-6-15)22-20(17-3-2-4-19(11-17)33-24(25,26)27)12-21-23(32)29-13-18(9-10-28)30(21)22/h2-8,11-12,18H,9-10,13,28H2,1H3,(H,29,32)/t18-/m0/s1
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n/an/a 17n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191127
PNG
(US9181258, 122)
Show SMILES Cc1cc(ccc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F4N3O2/c1-13-9-15(5-6-19(13)24)21-18(14-3-2-4-17(10-14)32-23(25,26)27)11-20-22(31)29-12-16(7-8-28)30(20)21/h2-6,9-11,16H,7-8,12,28H2,1H3,(H,29,31)/t16-/m0/s1
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n/an/a 17n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191071
PNG
(US9181258, 29)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)28-15-3-1-2-12(8-15)16-9-17-19(27)25-10-14(4-6-24)26(17)18(16)13-5-7-29-11-13/h1-3,5,7-9,11,14H,4,6,10,24H2,(H,25,27)
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n/an/a 19n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191105
PNG
(US9181258, 102)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)31-18-10-4-8-16(12-18)19-13-20-22(30)28-14-17(9-5-11-27)29(20)21(19)15-6-2-1-3-7-15/h1-4,6-8,10,12-13,17H,5,9,11,14,27H2,(H,28,30)/t17-/m0/s1
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n/an/a 19n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191133
PNG
(US9181258, 149)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCNC(N)=N)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N5O4S/c1-37(34,35)18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)36-24(25,26)27)12-20-22(33)31-13-16(32(20)21)9-10-30-23(28)29/h2-8,11-12,16H,9-10,13H2,1H3,(H,31,33)(H4,28,29,30)/t16-/m0/s1
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n/an/a 19n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191084
PNG
(US9181258, 38)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)17-3-1-2-16(10-17)19-11-20-22(31)28-12-18(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,18,30H,8-9,12-13,27H2,(H,28,31)
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n/an/a 20n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191093
PNG
(US9181258, 80)
Show SMILES CNC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O4/c1-28-22(32)15-7-5-14(6-8-15)21-19(16-3-2-4-18(11-16)34-24(25,26)27)12-20-23(33)29-13-17(9-10-31)30(20)21/h2-8,11-12,17,31H,9-10,13H2,1H3,(H,28,32)(H,29,33)
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n/an/a 20n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191098
PNG
(US9181258, 94)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(F)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H19F4N3O2/c23-15-6-4-13(5-7-15)20-18(14-2-1-3-17(10-14)31-22(24,25)26)11-19-21(30)28-12-16(8-9-27)29(19)20/h1-7,10-11,16H,8-9,12,27H2,(H,28,30)/t16-/m0/s1
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n/an/a 20n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191120
PNG
(US9181258, 126 | US9181258, 129)
Show SMILES COc1ccc(cc1Cl)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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n/an/a 21n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191088
PNG
(US9181258, 43)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)15-3-1-2-14(10-15)18-11-19-21(30)27-12-16(8-9-26)28(19)20(18)13-4-6-17(29)7-5-13/h1-7,10-11,16,29H,8-9,12,26H2,(H,27,30)
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n/an/a 21n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191109
PNG
(US9181258, 116)
Show SMILES COc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c1-31-17-7-5-14(6-8-17)21-19(15-3-2-4-18(11-15)32-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 22n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191111
PNG
(US9181258, 110)
Show SMILES CC(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N3O3/c1-15(32)16-7-9-17(10-8-16)23-21(18-4-2-6-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(31(22)23)5-3-11-29/h2,4,6-10,12-13,19H,3,5,11,14,29H2,1H3,(H,30,33)/t19-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191101
PNG
(US9181258, 97)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(C=O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O3/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)28-12-17(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,13,17H,8-9,12,27H2,(H,28,31)/t17-/m0/s1
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n/an/a 22n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191134
PNG
(US9181258, 113)
Show SMILES COc1ccc(cc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F4N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191080
PNG
(US9181258, 31)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)31-23(24,25)26)12-20-22(30)28-13-17(8-9-27)29(20)21/h2-7,10-12,17H,8-9,13,27H2,1H3,(H,28,30)
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n/an/a 23n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191086
PNG
(US9181258, 44)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1ccnc(Cl)c1
Show InChI InChI=1S/C21H21ClN4O2/c22-19-9-15(6-8-24-19)17-10-18-21(28)25-11-16(5-7-23)26(18)20(17)14-3-1-13(12-27)2-4-14/h1-4,6,8-10,16,27H,5,7,11-12,23H2,(H,25,28)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191121
PNG
(US9181258, 127)
Show SMILES CCOc1ccc(cc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H23F4N3O3/c1-2-33-21-7-6-15(11-19(21)25)22-18(14-4-3-5-17(10-14)34-24(26,27)28)12-20-23(32)30-13-16(8-9-29)31(20)22/h3-7,10-12,16H,2,8-9,13,29H2,1H3,(H,30,32)/t16-/m0/s1
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n/an/a 24n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191124
PNG
(US9181258, 124)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N3O2/c1-25(2,3)18-9-7-16(8-10-18)23-21(17-5-4-6-20(13-17)34-26(27,28)29)14-22-24(33)31-15-19(11-12-30)32(22)23/h4-10,13-14,19H,11-12,15,30H2,1-3H3,(H,31,33)/t19-/m0/s1
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n/an/a 24n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191115
PNG
(US9181258, 147)
Show SMILES CS(=O)(=O)NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)28-11-10-17-14-27-22(30)20-13-19(21(29(17)20)15-6-3-2-4-7-15)16-8-5-9-18(12-16)33-23(24,25)26/h2-9,12-13,17,28H,10-11,14H2,1H3,(H,27,30)/t17-/m0/s1
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n/an/a 26n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191118
PNG
(US9181258, 118)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc4ccccc4c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H22F3N3O2/c27-26(28,29)34-21-7-3-6-18(13-21)22-14-23-25(33)31-15-20(10-11-30)32(23)24(22)19-9-8-16-4-1-2-5-17(16)12-19/h1-9,12-14,20H,10-11,15,30H2,(H,31,33)/t20-/m0/s1
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n/an/a 27n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191130
PNG
(US9181258, 106)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCCl)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H30ClF3N4O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(30,31)32)16-25-27(37)33-17-22(9-10-29)36(25)26/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,33,37)/t22-/m0/s1
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n/an/a 27n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191098
PNG
(US9181258, 94)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(F)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H19F4N3O2/c23-15-6-4-13(5-7-15)20-18(14-2-1-3-17(10-14)31-22(24,25)26)11-19-21(30)28-12-16(8-9-27)29(19)20/h1-7,10-11,16H,8-9,12,27H2,(H,28,30)/t16-/m0/s1
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n/an/a 27n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191122
PNG
(US9181258, 128)
Show SMILES COc1c(C)cc(cc1C)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N3O3/c1-14-9-17(10-15(2)23(14)33-3)22-20(16-5-4-6-19(11-16)34-25(26,27)28)12-21-24(32)30-13-18(7-8-29)31(21)22/h4-6,9-12,18H,7-8,13,29H2,1-3H3,(H,30,32)/t18-/m0/s1
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n/an/a 32n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191073
PNG
(US9181258, 57)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C21H19ClFN3O/c22-14-6-7-18(23)16(10-14)17-11-19-21(27)25-12-15(8-9-24)26(19)20(17)13-4-2-1-3-5-13/h1-7,10-11,15H,8-9,12,24H2,(H,25,27)
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n/an/a 32n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191116
PNG
(US9181258, 142)
Show SMILES CC(=O)NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O3/c1-15(31)28-11-10-18-14-29-23(32)21-13-20(22(30(18)21)16-6-3-2-4-7-16)17-8-5-9-19(12-17)33-24(25,26)27/h2-9,12-13,18H,10-11,14H2,1H3,(H,28,31)(H,29,32)/t18-/m0/s1
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n/an/a 34n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191079
PNG
(US9181258, 17)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H20ClN3O/c22-16-8-4-7-15(11-16)18-12-19-21(26)24-13-17(9-10-23)25(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,17H,9-10,13,23H2,(H,24,26)
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n/an/a 34n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191074
PNG
(US9181258, 82)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NCC(CCOC(=O)C(F)(F)F)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C30H30F6N4O4/c1-38-10-12-39(13-11-38)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)44-30(34,35)36)16-25-27(41)37-17-22(40(25)26)9-14-43-28(42)29(31,32)33/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,37,41)
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n/an/a 35n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191134
PNG
(US9181258, 113)
Show SMILES COc1ccc(cc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F4N3O3/c1-32-20-6-5-14(10-18(20)24)21-17(13-3-2-4-16(9-13)33-23(25,26)27)11-19-22(31)29-12-15(7-8-28)30(19)21/h2-6,9-11,15H,7-8,12,28H2,1H3,(H,29,31)/t15-/m0/s1
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n/an/a 36n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191077
PNG
(US9181258, 87)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)/t16-/m0/s1
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n/an/a 38n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191075
PNG
(US9181258, 83)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NCC(CCOC(=O)C(F)(F)F)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N3O4/c1-35(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)40-27(31,32)33)13-22-24(37)34-14-19(36(22)23)10-11-39-25(38)26(28,29)30/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,34,37)
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n/an/a 38n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191082
PNG
(US9181258, 59)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H21ClFN3O/c1-13-3-2-4-14(9-13)21-18(17-10-15(23)5-6-19(17)24)11-20-22(28)26-12-16(7-8-25)27(20)21/h2-6,9-11,16H,7-8,12,25H2,1H3,(H,26,28)
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n/an/a 40n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191087
PNG
(US9181258, 45)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1ccnc(Cl)c1
Show InChI InChI=1S/C21H21ClN4O/c1-13-3-2-4-15(9-13)20-17(14-6-8-24-19(22)10-14)11-18-21(27)25-12-16(5-7-23)26(18)20/h2-4,6,8-11,16H,5,7,12,23H2,1H3,(H,25,27)
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n/an/a 41n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191085
PNG
(US9181258, 40)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3OS/c21-20(22,23)14-3-1-2-12(8-14)16-9-17-19(27)25-10-15(4-6-24)26(17)18(16)13-5-7-28-11-13/h1-3,5,7-9,11,15H,4,6,10,24H2,(H,25,27)
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n/an/a 43n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191097
PNG
(US9181258, 71)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NCC(CCCl)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H30ClF3N4O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(30,31)32)16-25-27(37)33-17-22(9-10-29)36(25)26/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,33,37)
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n/an/a 44n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM191125
PNG
(US9181258, 125)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(c3)C(F)(F)F)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H19F6N3O2/c24-22(25,26)15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)34-23(27,28)29)11-19-21(33)31-12-16(7-8-30)32(19)20/h1-6,9-11,16H,7-8,12,30H2,(H,31,33)/t16-/m0/s1
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n/an/a 44n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay. Spec...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191123
PNG
(US9181258, 123)
Show SMILES CSc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2S/c1-32-18-7-5-14(6-8-18)21-19(15-3-2-4-17(11-15)31-23(24,25)26)12-20-22(30)28-13-16(9-10-27)29(20)21/h2-8,11-12,16H,9-10,13,27H2,1H3,(H,28,30)/t16-/m0/s1
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n/an/a 45n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191110
PNG
(US9181258, 115)
Show SMILES CN(C)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H25F3N4O2/c1-30(2)17-8-6-15(7-9-17)22-20(16-4-3-5-19(12-16)33-24(25,26)27)13-21-23(32)29-14-18(10-11-28)31(21)22/h3-9,12-13,18H,10-11,14,28H2,1-2H3,(H,29,32)/t18-/m0/s1
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n/an/a 46n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191107
PNG
(US9181258, 104)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccc(O)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O3/c24-23(25,26)32-18-5-1-3-15(11-18)19-12-20-22(31)28-13-16(4-2-10-27)29(20)21(19)14-6-8-17(30)9-7-14/h1,3,5-9,11-12,16,30H,2,4,10,13,27H2,(H,28,31)/t16-/m0/s1
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n/an/a 48n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191080
PNG
(US9181258, 31)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c1-14-4-2-6-16(10-14)21-19(15-5-3-7-18(11-15)31-23(24,25)26)12-20-22(30)28-13-17(8-9-27)29(20)21/h2-7,10-12,17H,8-9,13,27H2,1H3,(H,28,30)
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n/an/a 51n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191070
PNG
(US9181258, 28)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H20F3N3O2/c23-22(24,25)30-17-8-4-7-15(11-17)18-12-19-21(29)27-13-16(9-10-26)28(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,16H,9-10,13,26H2,(H,27,29)
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n/an/a 55n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191089
PNG
(US9181258, 77)
Show SMILES NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H20F3N3O4/c24-23(25,26)33-17-3-1-2-15(10-17)18-11-19-22(32)28-12-16(8-9-30)29(19)20(18)13-4-6-14(7-5-13)21(27)31/h1-7,10-11,16,30H,8-9,12H2,(H2,27,31)(H,28,32)
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n/an/a 58n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191113
PNG
(US9181258, 134)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H29F3N4O2/c1-32(2)16-17-8-10-18(11-9-17)24-22(19-5-3-7-21(13-19)35-26(27,28)29)14-23-25(34)31-15-20(33(23)24)6-4-12-30/h3,5,7-11,13-14,20H,4,6,12,15-16,30H2,1-2H3,(H,31,34)/t20-/m0/s1
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n/an/a 66n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191092
PNG
(US9181258, 81)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C29H31F3N4O4/c1-35-12-9-21(10-13-35)34-27(38)19-7-5-18(6-8-19)26-24(20-3-2-4-23(15-20)40-29(30,31)32)16-25-28(39)33-17-22(11-14-37)36(25)26/h2-8,15-16,21-22,37H,9-14,17H2,1H3,(H,33,39)(H,34,38)
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n/an/a 69n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191076
PNG
(US9181258, 85)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)28-15-3-1-2-12(8-15)16-9-17-19(27)25-10-14(4-6-24)26(17)18(16)13-5-7-29-11-13/h1-3,5,7-9,11,14H,4,6,10,24H2,(H,25,27)/t14-/m0/s1
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n/an/a 69n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191081
PNG
(US9181258, 32)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3cccc(N)c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)31-17-6-2-3-13(10-17)18-11-19-21(30)28-12-16(7-8-26)29(19)20(18)14-4-1-5-15(27)9-14/h1-6,9-11,16H,7-8,12,26-27H2,(H,28,30)
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n/an/a 69n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191093
PNG
(US9181258, 80)
Show SMILES CNC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O4/c1-28-22(32)15-7-5-14(6-8-15)21-19(16-3-2-4-18(11-16)34-24(25,26)27)12-20-23(33)29-13-17(9-10-31)30(20)21/h2-8,11-12,17,31H,9-10,13H2,1H3,(H,28,32)(H,29,33)
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n/an/a 75n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191072
PNG
(US9181258, 55)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C19H17ClFN3OS/c20-12-1-2-16(21)14(7-12)15-8-17-19(25)23-9-13(3-5-22)24(17)18(15)11-4-6-26-10-11/h1-2,4,6-8,10,13H,3,5,9,22H2,(H,23,25)
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n/an/a 77n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191112
PNG
(US9181258, 109)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O4S/c1-35(32,33)19-9-7-15(8-10-19)22-20(16-4-2-6-18(12-16)34-24(25,26)27)13-21-23(31)29-14-17(30(21)22)5-3-11-28/h2,4,6-10,12-13,17H,3,5,11,14,28H2,1H3,(H,29,31)/t17-/m0/s1
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n/an/a 82n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191127
PNG
(US9181258, 122)
Show SMILES Cc1cc(ccc1F)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F4N3O2/c1-13-9-15(5-6-19(13)24)21-18(14-3-2-4-17(10-14)32-23(25,26)27)11-20-22(31)29-12-16(7-8-28)30(20)21/h2-6,9-11,16H,7-8,12,28H2,1H3,(H,29,31)/t16-/m0/s1
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n/an/a 86n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191094
PNG
(US9181258, 84)
Show SMILES OCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F3N2O4/c24-23(25,26)32-18-3-1-2-16(10-18)19-11-20-22(31)27-12-17(8-9-29)28(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,17,29-30H,8-9,12-13H2,(H,27,31)
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n/an/a 90n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191091
PNG
(US9181258, 78)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C27H29F3N4O4/c1-33(2)12-11-31-25(36)18-8-6-17(7-9-18)24-22(19-4-3-5-21(14-19)38-27(28,29)30)15-23-26(37)32-16-20(10-13-35)34(23)24/h3-9,14-15,20,35H,10-13,16H2,1-2H3,(H,31,36)(H,32,37)
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n/an/a 90n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191090
PNG
(US9181258, 79)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1c(cc2C(=O)NCC(CCO)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N3O4/c1-30(2)24(34)16-8-6-15(7-9-16)22-20(17-4-3-5-19(12-17)35-25(26,27)28)13-21-23(33)29-14-18(10-11-32)31(21)22/h3-9,12-13,18,32H,10-11,14H2,1-2H3,(H,29,33)
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n/an/a 93n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191125
PNG
(US9181258, 125)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3cccc(c3)C(F)(F)F)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H19F6N3O2/c24-22(25,26)15-5-1-4-14(9-15)20-18(13-3-2-6-17(10-13)34-23(27,28)29)11-19-21(33)31-12-16(7-8-30)32(19)20/h1-6,9-11,16H,7-8,12,30H2,(H,31,33)/t16-/m0/s1
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n/an/a 97n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191130
PNG
(US9181258, 106)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2c(cc3C(=O)NC[C@H](CCCl)n23)-c2cccc(OC(F)(F)F)c2)CC1
Show InChI InChI=1S/C28H30ClF3N4O2/c1-34-11-13-35(14-12-34)18-19-5-7-20(8-6-19)26-24(21-3-2-4-23(15-21)38-28(30,31)32)16-25-27(37)33-17-22(9-10-29)36(25)26/h2-8,15-16,22H,9-14,17-18H2,1H3,(H,33,37)/t22-/m0/s1
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n/an/a 99n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191087
PNG
(US9181258, 45)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1ccnc(Cl)c1
Show InChI InChI=1S/C21H21ClN4O/c1-13-3-2-4-15(9-13)20-17(14-6-8-24-19(22)10-14)11-18-21(27)25-12-16(5-7-23)26(18)20/h2-4,6,8-11,16H,5,7,12,23H2,1H3,(H,25,27)
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n/an/a 102n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191084
PNG
(US9181258, 38)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)17-3-1-2-16(10-17)19-11-20-22(31)28-12-18(8-9-27)29(20)21(19)15-6-4-14(13-30)5-7-15/h1-7,10-11,18,30H,8-9,12-13,27H2,(H,28,31)
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n/an/a 102n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191108
PNG
(US9181258, 105)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O3/c25-24(26,27)33-19-5-1-3-17(11-19)20-12-21-23(32)29-13-18(4-2-10-28)30(21)22(20)16-8-6-15(14-31)7-9-16/h1,3,5-9,11-12,18,31H,2,4,10,13-14,28H2,(H,29,32)/t18-/m0/s1
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n/an/a 109n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191086
PNG
(US9181258, 44)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccc(CO)cc3)n12)-c1ccnc(Cl)c1
Show InChI InChI=1S/C21H21ClN4O2/c22-19-9-15(6-8-24-19)17-10-18-21(28)25-11-16(5-7-23)26(18)20(17)14-3-1-13(12-27)2-4-14/h1-4,6,8-10,16,27H,5,7,11-12,23H2,(H,25,28)
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n/an/a 110n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191096
PNG
(US9181258, 70)
Show SMILES CN(C)Cc1ccc(cc1)-c1c(cc2C(=O)NCC(CCCl)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H25ClF3N3O2/c1-31(2)15-16-6-8-17(9-7-16)23-21(18-4-3-5-20(12-18)34-25(27,28)29)13-22-24(33)30-14-19(10-11-26)32(22)23/h3-9,12-13,19H,10-11,14-15H2,1-2H3,(H,30,33)
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n/an/a 113n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191082
PNG
(US9181258, 59)
Show SMILES Cc1cccc(c1)-c1c(cc2C(=O)NCC(CCN)n12)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H21ClFN3O/c1-13-3-2-4-14(9-13)21-18(17-10-15(23)5-6-19(17)24)11-20-22(28)26-12-16(7-8-25)27(20)21/h2-6,9-11,16H,7-8,12,25H2,1H3,(H,26,28)
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n/an/a 114n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191079
PNG
(US9181258, 17)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H20ClN3O/c22-16-8-4-7-15(11-16)18-12-19-21(26)24-13-17(9-10-23)25(19)20(18)14-5-2-1-3-6-14/h1-8,11-12,17H,9-10,13,23H2,(H,24,26)
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n/an/a 117n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191111
PNG
(US9181258, 110)
Show SMILES CC(=O)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N3O3/c1-15(32)16-7-9-17(10-8-16)23-21(18-4-2-6-20(12-18)34-25(26,27)28)13-22-24(33)30-14-19(31(22)23)5-3-11-29/h2,4,6-10,12-13,19H,3,5,11,14,29H2,1H3,(H,30,33)/t19-/m0/s1
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n/an/a 129n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191071
PNG
(US9181258, 29)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)28-15-3-1-2-12(8-15)16-9-17-19(27)25-10-14(4-6-24)26(17)18(16)13-5-7-29-11-13/h1-3,5,7-9,11,14H,4,6,10,24H2,(H,25,27)
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n/an/a 143n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191118
PNG
(US9181258, 118)
Show SMILES NCC[C@H]1CNC(=O)c2cc(c(-c3ccc4ccccc4c3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H22F3N3O2/c27-26(28,29)34-21-7-3-6-18(13-21)22-14-23-25(33)31-15-20(10-11-30)32(23)24(22)19-9-8-16-4-1-2-5-17(16)12-19/h1-9,12-14,20H,10-11,15,30H2,(H,31,33)/t20-/m0/s1
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n/an/a 152n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191106
PNG
(US9181258, 103)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H20F3N3O2S/c22-21(23,24)29-16-5-1-3-13(9-16)17-10-18-20(28)26-11-15(4-2-7-25)27(18)19(17)14-6-8-30-12-14/h1,3,5-6,8-10,12,15H,2,4,7,11,25H2,(H,26,28)/t15-/m0/s1
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n/an/a 153n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191085
PNG
(US9181258, 40)
Show SMILES NCCC1CNC(=O)c2cc(c(-c3ccsc3)n12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3OS/c21-20(22,23)14-3-1-2-12(8-14)16-9-17-19(27)25-10-15(4-6-24)26(17)18(16)13-5-7-28-11-13/h1-3,5,7-9,11,15H,4,6,10,24H2,(H,25,27)
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n/an/a 155n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191105
PNG
(US9181258, 102)
Show SMILES NCCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)31-18-10-4-8-16(12-18)19-13-20-22(30)28-14-17(9-5-11-27)29(20)21(19)15-6-2-1-3-7-15/h1-4,6-8,10,12-13,17H,5,9,11,14,27H2,(H,28,30)/t17-/m0/s1
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n/an/a 156n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191124
PNG
(US9181258, 124)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(cc2C(=O)NC[C@H](CCN)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N3O2/c1-25(2,3)18-9-7-16(8-10-18)23-21(17-5-4-6-20(13-17)34-26(27,28)29)14-22-24(33)31-15-19(11-12-30)32(22)23/h4-10,13-14,19H,11-12,15,30H2,1-3H3,(H,31,33)/t19-/m0/s1
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n/an/a 160n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191115
PNG
(US9181258, 147)
Show SMILES CS(=O)(=O)NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H22F3N3O4S/c1-34(31,32)28-11-10-17-14-27-22(30)20-13-19(21(29(17)20)15-6-3-2-4-7-15)16-8-5-9-18(12-16)33-23(24,25)26/h2-9,12-13,17,28H,10-11,14H2,1H3,(H,27,30)/t17-/m0/s1
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n/an/a 172n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191131
PNG
(US9181258, 138)
Show SMILES CC(C)[C@H]1CNC(=O)c2cc(c(-c3ccc(CN)cc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N3O2/c1-14(2)21-13-29-23(31)20-11-19(17-4-3-5-18(10-17)32-24(25,26)27)22(30(20)21)16-8-6-15(12-28)7-9-16/h3-11,14,21H,12-13,28H2,1-2H3,(H,29,31)/t21-/m1/s1
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n/an/a 173n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM191116
PNG
(US9181258, 142)
Show SMILES CC(=O)NCC[C@H]1CNC(=O)c2cc(c(-c3ccccc3)n12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N3O3/c1-15(31)28-11-10-18-14-29-23(32)21-13-20(22(30(18)21)16-6-3-2-4-7-16)17-8-5-9-19(12-17)33-24(25,26)27/h2-9,12-13,18H,10-11,14H2,1H3,(H,28,31)(H,29,32)/t18-/m0/s1
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n/an/a 174n/an/an/an/a7.5n/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...

US Patent US9181258 (2015)


BindingDB Entry DOI: 10.7270/Q2862F7F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%