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Patent code US9181279

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191549
PNG
(US9181279, E9)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC2(CC2)CCN1Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N2O3/c27-26(28,29)20-3-1-2-17(14-20)16-31-13-12-24(8-9-24)15-21(31)22(32)30-25(10-11-25)19-6-4-18(5-7-19)23(33)34/h1-7,14,21H,8-13,15-16H2,(H,30,32)(H,33,34)
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n/an/a 4n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191551
PNG
(US9181279, E13)
Show SMILES C[C@H](NC(=O)C1CC(C)(C)CCN1Cc1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C25H29F3N2O3/c1-16(18-6-8-19(9-7-18)23(32)33)29-22(31)21-14-24(2,3)12-13-30(21)15-17-4-10-20(11-5-17)25(26,27)28/h4-11,16,21H,12-15H2,1-3H3,(H,29,31)(H,32,33)/t16-,21?/m0/s1
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n/an/a 8n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191552
PNG
(US9181279, E16)
Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CCN1Cc1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C23H23F5N2O3/c1-14(16-4-6-17(7-5-16)21(32)33)29-20(31)19-12-22(24,25)10-11-30(19)13-15-2-8-18(9-3-15)23(26,27)28/h2-9,14,19H,10-13H2,1H3,(H,29,31)(H,32,33)/t14-,19+/m0/s1
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n/an/a 9n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191554
PNG
(US9181279, E18)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC(F)(F)CCN1Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H23F5N2O3/c25-23(26)11-12-31(14-15-1-5-18(6-2-15)24(27,28)29)19(13-23)20(32)30-22(9-10-22)17-7-3-16(4-8-17)21(33)34/h1-8,19H,9-14H2,(H,30,32)(H,33,34)
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n/an/a 11n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191557
PNG
(US9181279, E23)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC2CC2CN1Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N2O3/c26-25(27,28)20-5-1-15(2-6-20)13-30-14-18-11-17(18)12-21(30)22(31)29-24(9-10-24)19-7-3-16(4-8-19)23(32)33/h1-8,17-18,21H,9-14H2,(H,29,31)(H,32,33)
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n/an/a 11.5n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191555
PNG
(US9181279, E19 | US9181279, E20)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC(F)(F)CCN1Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F5N2O3/c25-23(26)10-11-31(14-15-2-1-3-18(12-15)24(27,28)29)19(13-23)20(32)30-22(8-9-22)17-6-4-16(5-7-17)21(33)34/h1-7,12,19H,8-11,13-14H2,(H,30,32)(H,33,34)
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n/an/a 15n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191561
PNG
(US9181279, E29)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1C[C@H]2C[C@H]2N1Cc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N2O3/c25-24(26,27)18-3-1-2-14(10-18)13-29-19-11-16(19)12-20(29)21(30)28-23(8-9-23)17-6-4-15(5-7-17)22(31)32/h1-7,10,16,19-20H,8-9,11-13H2,(H,28,30)(H,31,32)/t16-,19-,20-/m1/s1
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n/an/a 16n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191562
PNG
(US9181279, E30)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1C[C@H]2C[C@H]2N1Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N2O3/c25-24(26,27)18-5-1-14(2-6-18)13-29-19-11-16(19)12-20(29)21(30)28-23(9-10-23)17-7-3-15(4-8-17)22(31)32/h1-8,16,19-20H,9-13H2,(H,28,30)(H,31,32)/t16-,19-,20-/m1/s1
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n/an/a 21n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191548
PNG
(US9181279, E7)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC2(CC2)CCN1Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N2O3/c27-26(28,29)20-5-1-17(2-6-20)16-31-14-13-24(9-10-24)15-21(31)22(32)30-25(11-12-25)19-7-3-18(4-8-19)23(33)34/h1-8,21H,9-16H2,(H,30,32)(H,33,34)
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n/an/a 22n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191555
PNG
(US9181279, E19 | US9181279, E20)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)C1CC(F)(F)CCN1Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F5N2O3/c25-23(26)10-11-31(14-15-2-1-3-18(12-15)24(27,28)29)19(13-23)20(32)30-22(8-9-22)17-6-4-16(5-7-17)21(33)34/h1-7,12,19H,8-11,13-14H2,(H,30,32)(H,33,34)
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n/an/a 23n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191553
PNG
(US9181279, E17)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CC(F)(F)CCN1Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F5N2O3/c25-23(26)11-12-31(14-15-1-5-18(6-2-15)24(27,28)29)19(13-23)20(32)30-22(9-10-22)17-7-3-16(4-8-17)21(33)34/h1-8,19H,9-14H2,(H,30,32)(H,33,34)/t19-/m1/s1
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n/an/a 28n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191550
PNG
(US9181279, E10)
Show SMILES C[C@H](NC(=O)C1CC2(CC2)CCN1Cc1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C25H27F3N2O3/c1-16(18-4-6-19(7-5-18)23(32)33)29-22(31)21-14-24(10-11-24)12-13-30(21)15-17-2-8-20(9-3-17)25(26,27)28/h2-9,16,21H,10-15H2,1H3,(H,29,31)(H,32,33)/t16-,21?/m0/s1
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n/an/a 29n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191547
PNG
(US9181279, E4)
Show SMILES [Li]OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCCCN1Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H25F3N2O3.Li/c25-24(26,27)19-8-4-16(5-9-19)15-29-14-2-1-3-20(29)21(30)28-23(12-13-23)18-10-6-17(7-11-18)22(31)32;/h4-11,20H,1-3,12-15H2,(H,28,30)(H,31,32);/q;+1/p-1/t20-;/m1./s1
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n/an/a 32n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191559
PNG
(US9181279, E26)
Show SMILES C[C@H](NC(=O)[C@H]1CCC2CC2N1Cc1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C24H25F3N2O3/c1-14(16-4-6-17(7-5-16)23(31)32)28-22(30)20-11-8-18-12-21(18)29(20)13-15-2-9-19(10-3-15)24(25,26)27/h2-7,9-10,14,18,20-21H,8,11-13H2,1H3,(H,28,30)(H,31,32)/t14-,18?,20+,21?/m0/s1
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n/an/a 42n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191558
PNG
(US9181279, E25)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)[C@H]1CCC2CC2N1Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H25F3N2O3/c26-25(27,28)19-6-1-15(2-7-19)14-30-20(10-5-17-13-21(17)30)22(31)29-24(11-12-24)18-8-3-16(4-9-18)23(32)33/h1-4,6-9,17,20-21H,5,10-14H2,(H,29,31)(H,32,33)/t17?,20-,21?/m1/s1
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n/an/a 43n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM191560
PNG
(US9181279, E27)
Show SMILES [Li]OC(=O)c1ccc(cc1)[C@H](C)NC(=O)[C@H]1CCCN1Cc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C22H23F3N2O3.Li/c1-14(16-6-8-17(9-7-16)21(29)30)26-20(28)19-3-2-12-27(19)13-15-4-10-18(11-5-15)22(23,24)25;/h4-11,14,19H,2-3,12-13H2,1H3,(H,26,28)(H,29,30);/q;+1/p-1/t14-,19+;/m0./s1
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n/an/a 50n/an/an/an/a7.423



ROTTAPHARM BIOTECH S.R.L.

US Patent


Assay Description
The assay is based on the competition between endogenous cAMP and exogenously added biotinylated cAMP. The capture of cAMP is achieved by using a spe...

US Patent US9181279 (2015)


BindingDB Entry DOI: 10.7270/Q2MC8XTZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%