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Patent code US9187486

Compile Data Set for Download or QSAR

Found 205 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192558
PNG
(US9187486, 20)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7O/c1-13-11-31(12-17(26)22(13)33)20-7-8-27-10-19(20)29-23-28-9-14-5-6-18(30-32(14)23)21-15(24)3-2-4-16(21)25/h2-10,13,17,22,33H,11-12,26H2,1H3,(H,28,29)/t13-,17+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192539
PNG
(US9187486, 1)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C22H21F2N7/c23-16-4-1-5-17(24)21(16)18-7-6-15-11-27-22(31(15)29-18)28-19-12-26-9-8-20(19)30-10-2-3-14(25)13-30/h1,4-9,11-12,14H,2-3,10,13,25H2,(H,27,28)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192558
PNG
(US9187486, 20)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7O/c1-13-11-31(12-17(26)22(13)33)20-7-8-27-10-19(20)29-23-28-9-14-5-6-18(30-32(14)23)21-15(24)3-2-4-16(21)25/h2-10,13,17,22,33H,11-12,26H2,1H3,(H,28,29)/t13-,17+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192599
PNG
(US9187486, 72)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1cc(ccc1F)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C27H29FN8O/c1-16-10-18(29)15-35(14-16)25-8-9-30-13-24(25)33-27-31-12-20-5-7-23(34-36(20)27)21-11-17(2-6-22(21)28)26(37)32-19-3-4-19/h2,5-9,11-13,16,18-19H,3-4,10,14-15,29H2,1H3,(H,31,33)(H,32,37)/t16-,18+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192575
PNG
(US9187486, 38)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192642
PNG
(US9187486, 87)
Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192641
PNG
(US9187486, 86)
Show SMILES C[C@@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192648
PNG
(US9187486, 100)
Show SMILES C[C@@H]1CCN(C[C@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192599
PNG
(US9187486, 72)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1cc(ccc1F)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C27H29FN8O/c1-16-10-18(29)15-35(14-16)25-8-9-30-13-24(25)33-27-31-12-20-5-7-23(34-36(20)27)21-11-17(2-6-22(21)28)26(37)32-19-3-4-19/h2,5-9,11-13,16,18-19H,3-4,10,14-15,29H2,1H3,(H,31,33)(H,32,37)/t16-,18+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192561
PNG
(US9187486, 23)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(cc1F)S(C)(=O)=O |r|
Show InChI InChI=1S/C24H26FN7O3S/c1-14-12-31(13-19(26)23(14)33)22-7-8-27-11-21(22)29-24-28-10-15-3-6-20(30-32(15)24)17-5-4-16(9-18(17)25)36(2,34)35/h3-11,14,19,23,33H,12-13,26H2,1-2H3,(H,28,29)/t14-,19+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192628
PNG
(US9187486, 45)
Show SMILES NC1CN(CCC1F)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C22H20F3N7/c23-14-7-9-31(12-17(14)26)20-6-8-27-11-19(20)29-22-28-10-13-4-5-18(30-32(13)22)21-15(24)2-1-3-16(21)25/h1-6,8,10-11,14,17H,7,9,12,26H2,(H,28,29)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192586
PNG
(US9187486, 54)
Show SMILES C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192644
PNG
(US9187486, 95)
Show SMILES C[C@@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192575
PNG
(US9187486, 38)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192629
PNG
(US9187486, 46)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1F |r|
Show InChI InChI=1S/C23H24FN7/c1-15-10-16(25)14-30(13-15)22-8-9-26-12-21(22)28-23-27-11-17-6-7-20(29-31(17)23)18-4-2-3-5-19(18)24/h2-9,11-12,15-16H,10,13-14,25H2,1H3,(H,27,28)/t15-,16+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192578
PNG
(US9187486, 41)
Show SMILES C[C@@H]1CN(C[C@@H](N)[C@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7O/c1-13-11-31(12-17(26)22(13)33)20-7-8-27-10-19(20)29-23-28-9-14-5-6-18(30-32(14)23)21-15(24)3-2-4-16(21)25/h2-10,13,17,22,33H,11-12,26H2,1H3,(H,28,29)/t13-,17-,22+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192593
PNG
(US9187486, 65)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192629
PNG
(US9187486, 46)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1F |r|
Show InChI InChI=1S/C23H24FN7/c1-15-10-16(25)14-30(13-15)22-8-9-26-12-21(22)28-23-27-11-17-6-7-20(29-31(17)23)18-4-2-3-5-19(18)24/h2-9,11-12,15-16H,10,13-14,25H2,1H3,(H,27,28)/t15-,16+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192649
PNG
(US9187486, 43)
Show SMILES N[C@H]1CN(CC[C@@H]1F)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C22H20F3N7/c23-14-7-9-31(12-17(14)26)20-6-8-27-11-19(20)29-22-28-10-13-4-5-18(30-32(13)22)21-15(24)2-1-3-16(21)25/h1-6,8,10-11,14,17H,7,9,12,26H2,(H,28,29)/t14-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192577
PNG
(US9187486, 40)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192601
PNG
(US9187486, 74)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1cc(ccc1F)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C26H27FN8O/c27-21-7-3-16(25(36)31-18-4-5-18)12-20(21)22-8-6-19-13-30-26(35(19)33-22)32-23-14-29-10-9-24(23)34-11-1-2-17(28)15-34/h3,6-10,12-14,17-18H,1-2,4-5,11,15,28H2,(H,30,32)(H,31,36)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192648
PNG
(US9187486, 100)
Show SMILES C[C@@H]1CCN(C[C@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192553
PNG
(US9187486, 15)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1F |r|
Show InChI InChI=1S/C22H22FN7/c23-18-6-2-1-5-17(18)19-8-7-16-12-26-22(30(16)28-19)27-20-13-25-10-9-21(20)29-11-3-4-15(24)14-29/h1-2,5-10,12-13,15H,3-4,11,14,24H2,(H,26,27)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192619
PNG
(US9187486, 97)
Show SMILES C[C@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192605
PNG
(US9187486, 79)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1Cl |r|
Show InChI InChI=1S/C22H23ClN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192591
PNG
(US9187486, 63)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccn1 |r|
Show InChI InChI=1S/C22H24N8/c1-15-10-16(23)14-29(13-15)21-7-9-24-12-20(21)27-22-26-11-17-5-6-19(28-30(17)22)18-4-2-3-8-25-18/h2-9,11-12,15-16H,10,13-14,23H2,1H3,(H,26,27)/t15-,16+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192590
PNG
(US9187486, 62)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r|
Show InChI InChI=1S/C20H22N8S/c1-13-8-14(21)12-27(11-13)18-4-5-22-10-17(18)25-20-24-9-15-2-3-16(26-28(15)20)19-23-6-7-29-19/h2-7,9-10,13-14H,8,11-12,21H2,1H3,(H,24,25)/t13-,14+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192586
PNG
(US9187486, 54)
Show SMILES C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192647
PNG
(US9187486, 99)
Show SMILES C[C@@H]1CCN(C[C@@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18+/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192559
PNG
(US9187486, 21)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r|
Show InChI InChI=1S/C20H22N8OS/c1-12-10-27(11-14(21)18(12)29)17-4-5-22-9-16(17)25-20-24-8-13-2-3-15(26-28(13)20)19-23-6-7-30-19/h2-9,12,14,18,29H,10-11,21H2,1H3,(H,24,25)/t12-,14+,18+/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192642
PNG
(US9187486, 87)
Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192637
PNG
(US9187486, 76)
Show SMILES C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8/c1-14-17(24)5-3-11-30(14)20-8-10-25-13-19(20)28-22-27-12-15-6-7-18(29-31(15)22)21-16(23)4-2-9-26-21/h2,4,6-10,12-14,17H,3,5,11,24H2,1H3,(H,27,28)/t14-,17+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192594
PNG
(US9187486, 66)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8O/c1-13-11-30(12-16(24)21(13)32)19-6-8-25-10-18(19)28-22-27-9-14-4-5-17(29-31(14)22)20-15(23)3-2-7-26-20/h2-10,13,16,21,32H,11-12,24H2,1H3,(H,27,28)/t13-,16+,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192550
PNG
(US9187486, 12)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192593
PNG
(US9187486, 65)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r|
Show InChI InChI=1S/C22H23FN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192571
PNG
(US9187486, 33 | US9187486, 61)
Show SMILES C[C@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192571
PNG
(US9187486, 33 | US9187486, 61)
Show SMILES C[C@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192590
PNG
(US9187486, 62)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r|
Show InChI InChI=1S/C20H22N8S/c1-13-8-14(21)12-27(11-13)18-4-5-22-10-17(18)25-20-24-9-15-2-3-16(26-28(15)20)19-23-6-7-29-19/h2-7,9-10,13-14H,8,11-12,21H2,1H3,(H,24,25)/t13-,14+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192578
PNG
(US9187486, 41)
Show SMILES C[C@@H]1CN(C[C@@H](N)[C@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7O/c1-13-11-31(12-17(26)22(13)33)20-7-8-27-10-19(20)29-23-28-9-14-5-6-18(30-32(14)23)21-15(24)3-2-4-16(21)25/h2-10,13,17,22,33H,11-12,26H2,1H3,(H,28,29)/t13-,17-,22+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192561
PNG
(US9187486, 23)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(cc1F)S(C)(=O)=O |r|
Show InChI InChI=1S/C24H26FN7O3S/c1-14-12-31(13-19(26)23(14)33)22-7-8-27-11-21(22)29-24-28-10-15-3-6-20(30-32(15)24)17-5-4-16(9-18(17)25)36(2,34)35/h3-11,14,19,23,33H,12-13,26H2,1-2H3,(H,28,29)/t14-,19+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192601
PNG
(US9187486, 74)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1cc(ccc1F)C(=O)NC1CC1 |r|
Show InChI InChI=1S/C26H27FN8O/c27-21-7-3-16(25(36)31-18-4-5-18)12-20(21)22-8-6-19-13-30-26(35(19)33-22)32-23-14-29-10-9-24(23)34-11-1-2-17(28)15-34/h3,6-10,12-14,17-18H,1-2,4-5,11,15,28H2,(H,30,32)(H,31,36)/t17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192539
PNG
(US9187486, 1)
Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C22H21F2N7/c23-16-4-1-5-17(24)21(16)18-7-6-15-11-27-22(31(15)29-18)28-19-12-26-9-8-20(19)30-10-2-3-14(25)13-30/h1,4-9,11-12,14H,2-3,10,13,25H2,(H,27,28)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192634
PNG
(US9187486, 57)
Show SMILES C[C@H]1[C@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192605
PNG
(US9187486, 79)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1Cl |r|
Show InChI InChI=1S/C22H23ClN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM192559
PNG
(US9187486, 21)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r|
Show InChI InChI=1S/C20H22N8OS/c1-12-10-27(11-14(21)18(12)29)17-4-5-22-9-16(17)25-20-24-8-13-2-3-15(26-28(13)20)19-23-6-7-30-19/h2-9,12,14,18,29H,10-11,21H2,1H3,(H,24,25)/t12-,14+,18+/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM192582
PNG
(US9187486, 48)
Show SMILES N[C@H]1C[C@@H](F)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Show InChI InChI=1S/C22H20F3N7/c23-13-8-14(26)12-31(11-13)20-6-7-27-10-19(20)29-22-28-9-15-4-5-18(30-32(15)22)21-16(24)2-1-3-17(21)25/h1-7,9-10,13-14H,8,11-12,26H2,(H,28,29)/t13-,14+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%