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Patent code US9192603

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192828
PNG
(US9192603, 1)
Show SMILES FC(F)(F)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C17H11ClF3N3O3S2/c18-11-6-2-1-5-10(11)9-29(26,27)15-13(17(19,20)21)23-16(28-15)24-14(25)12-7-3-4-8-22-12/h1-8H,9H2,(H,23,24,25)
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n/an/an/an/a 271n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192841
PNG
(US9192603, 14)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C17H13F2N3O3S2/c1-10-16(27(24,25)9-11-12(18)5-4-6-13(11)19)26-17(21-10)22-15(23)14-7-2-3-8-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 312n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192871
PNG
(US9192603, 45)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H12F3N3O3S2/c1-9-16(27-17(22-9)23-15(24)14-4-2-3-5-21-14)28(25,26)8-10-6-12(19)13(20)7-11(10)18/h2-7H,8H2,1H3,(H,22,23,24)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192874
PNG
(US9192603, 48)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C17H14FN3O3S2/c1-11-16(26(23,24)10-12-5-7-13(18)8-6-12)25-17(20-11)21-15(22)14-4-2-3-9-19-14/h2-9H,10H2,1H3,(H,20,21,22)
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n/an/an/an/a 1.51E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192880
PNG
(US9192603, 54)
Show SMILES Fc1cccc(F)c1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C(F)(F)F
Show InChI InChI=1S/C17H10F5N3O3S2/c18-10-4-3-5-11(19)9(10)8-30(27,28)15-13(17(20,21)22)24-16(29-15)25-14(26)12-6-1-2-7-23-12/h1-7H,8H2,(H,24,25,26)
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n/an/an/an/a 1.06E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192834
PNG
(US9192603, 7)
Show SMILES Fc1cc(Cl)ccc1CS(=O)(=O)c1cnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C16H11ClFN3O3S2/c17-11-5-4-10(12(18)7-11)9-26(23,24)14-8-20-16(25-14)21-15(22)13-3-1-2-6-19-13/h1-8H,9H2,(H,20,21,22)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192842
PNG
(US9192603, 15)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)C(C)c1ccccc1Cl
Show InChI InChI=1S/C20H20ClN3O3S2/c1-12(2)17-19(29(26,27)13(3)14-8-4-5-9-15(14)21)28-20(23-17)24-18(25)16-10-6-7-11-22-16/h4-13H,1-3H3,(H,23,24,25)
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n/an/an/an/a 3.75E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192858
PNG
(US9192603, 31)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1Cl
Show InChI InChI=1S/C18H15ClFN3O3S2/c1-2-14-17(28(25,26)10-11-12(19)6-5-7-13(11)20)27-18(22-14)23-16(24)15-8-3-4-9-21-15/h3-9H,2,10H2,1H3,(H,22,23,24)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192879
PNG
(US9192603, 53)
Show SMILES Clc1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C2CC2)c(Cl)c1
Show InChI InChI=1S/C19H15Cl2N3O3S2/c20-13-7-6-12(14(21)9-13)10-29(26,27)18-16(11-4-5-11)23-19(28-18)24-17(25)15-3-1-2-8-22-15/h1-3,6-9,11H,4-5,10H2,(H,23,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192881
PNG
(US9192603, 55)
Show SMILES Fc1cc(Cl)ccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C(F)(F)F
Show InChI InChI=1S/C17H10ClF4N3O3S2/c18-10-5-4-9(11(19)7-10)8-30(27,28)15-13(17(20,21)22)24-16(29-15)25-14(26)12-3-1-2-6-23-12/h1-7H,8H2,(H,24,25,26)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192893
PNG
(US9192603, 67)
Show SMILES O=C(Nc1nnc(s1)S(=O)(=O)Cc1ccccc1)c1ccccn1
Show InChI InChI=1S/C15H12N4O3S2/c20-13(12-8-4-5-9-16-12)17-14-18-19-15(23-14)24(21,22)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,17,18,20)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192833
PNG
(US9192603, 6)
Show SMILES Clc1ccc(CS(=O)(=O)c2cnc(NC(=O)c3ccccn3)s2)c(Cl)c1
Show InChI InChI=1S/C16H11Cl2N3O3S2/c17-11-5-4-10(12(18)7-11)9-26(23,24)14-8-20-16(25-14)21-15(22)13-3-1-2-6-19-13/h1-8H,9H2,(H,20,21,22)
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n/an/an/an/a 49.9n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192835
PNG
(US9192603, 8)
Show SMILES Fc1cccc(F)c1CS(=O)(=O)c1cnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C16H11F2N3O3S2/c17-11-4-3-5-12(18)10(11)9-26(23,24)14-8-20-16(25-14)21-15(22)13-6-1-2-7-19-13/h1-8H,9H2,(H,20,21,22)
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n/an/an/an/a 170n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192838
PNG
(US9192603, 11)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3O3S2/c1-10-16(27(24,25)9-11-5-6-12(18)8-13(11)19)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192844
PNG
(US9192603, 17)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C19H17F2N3O3S2/c1-11(2)16-18(29(26,27)10-12-13(20)6-5-7-14(12)21)28-19(23-16)24-17(25)15-8-3-4-9-22-15/h3-9,11H,10H2,1-2H3,(H,23,24,25)
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n/an/an/an/a 316n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192852
PNG
(US9192603, 25)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O3S2/c1-11-16(28-17(23-11)24-15(25)14-8-4-5-9-22-14)29(26,27)10-12-6-2-3-7-13(12)18(19,20)21/h2-9H,10H2,1H3,(H,23,24,25)
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n/an/an/an/a 1.02E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192856
PNG
(US9192603, 29)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(Cl)c1F
Show InChI InChI=1S/C18H15ClFN3O3S2/c1-2-13-17(28(25,26)10-11-6-5-7-12(19)15(11)20)27-18(22-13)23-16(24)14-8-3-4-9-21-14/h3-9H,2,10H2,1H3,(H,22,23,24)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192860
PNG
(US9192603, 33)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C18H15F2N3O3S2/c1-2-14-17(28(25,26)10-11-12(19)6-5-7-13(11)20)27-18(22-14)23-16(24)15-8-3-4-9-21-15/h3-9H,2,10H2,1H3,(H,22,23,24)
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Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192863
PNG
(US9192603, 36)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C17H14ClN3O3S2/c1-11-16(26(23,24)10-12-5-4-6-13(18)9-12)25-17(20-11)21-15(22)14-7-2-3-8-19-14/h2-9H,10H2,1H3,(H,20,21,22)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192868
PNG
(US9192603, 42)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(C)cc1
Show InChI InChI=1S/C18H17N3O3S2/c1-12-6-8-14(9-7-12)11-26(23,24)17-13(2)20-18(25-17)21-16(22)15-5-3-4-10-19-15/h3-10H,11H2,1-2H3,(H,20,21,22)
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n/an/an/an/a 445n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192870
PNG
(US9192603, 44)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H13F2N3O3S2/c1-10-16(27(24,25)9-11-8-12(18)5-6-13(11)19)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192878
PNG
(US9192603, 52)
Show SMILES Fc1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C2CC2)c(F)c1
Show InChI InChI=1S/C19H15F2N3O3S2/c20-13-7-6-12(14(21)9-13)10-29(26,27)18-16(11-4-5-11)23-19(28-18)24-17(25)15-3-1-2-8-22-15/h1-3,6-9,11H,4-5,10H2,(H,23,24,25)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192885
PNG
(US9192603, 59)
Show SMILES CC(c1ccccc1Cl)S(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C
Show InChI InChI=1S/C18H16ClN3O3S2/c1-11-17(27(24,25)12(2)13-7-3-4-8-14(13)19)26-18(21-11)22-16(23)15-9-5-6-10-20-15/h3-10,12H,1-2H3,(H,21,22,23)
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n/an/an/an/a 3.23E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192889
PNG
(US9192603, 63)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1F
Show InChI InChI=1S/C19H18FN3O3S2/c1-12(2)16-18(28(25,26)11-13-7-3-4-8-14(13)20)27-19(22-16)23-17(24)15-9-5-6-10-21-15/h3-10,12H,11H2,1-2H3,(H,22,23,24)
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n/an/an/an/a 3.66E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192829
PNG
(US9192603, 2)
Show SMILES Fc1ccccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C(F)(F)F
Show InChI InChI=1S/C17H11F4N3O3S2/c18-11-6-2-1-5-10(11)9-29(26,27)15-13(17(19,20)21)23-16(28-15)24-14(25)12-7-3-4-8-22-12/h1-8H,9H2,(H,23,24,25)
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n/an/an/an/a 401n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192840
PNG
(US9192603, 13)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)cc1F
Show InChI InChI=1S/C17H13F2N3O3S2/c1-10-16(27(24,25)9-11-5-6-12(18)8-13(11)19)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 1.01E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192843
PNG
(US9192603, 16)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)C(C)c1ccccc1F
Show InChI InChI=1S/C20H20FN3O3S2/c1-12(2)17-19(29(26,27)13(3)14-8-4-5-9-15(14)21)28-20(23-17)24-18(25)16-10-6-7-11-22-16/h4-13H,1-3H3,(H,23,24,25)
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n/an/an/an/a 9.57E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192850
PNG
(US9192603, 23)
Show SMILES FCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C17H12F3N3O3S2/c18-8-14-16(28(25,26)9-10-11(19)4-3-5-12(10)20)27-17(22-14)23-15(24)13-6-1-2-7-21-13/h1-7H,8-9H2,(H,22,23,24)
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n/an/an/an/a 463n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192851
PNG
(US9192603, 24)
Show SMILES CC(C)c1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C)cc1
Show InChI InChI=1S/C20H21N3O3S2/c1-13(2)16-9-7-15(8-10-16)12-28(25,26)19-14(3)22-20(27-19)23-18(24)17-6-4-5-11-21-17/h4-11,13H,12H2,1-3H3,(H,22,23,24)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192861
PNG
(US9192603, 34)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C17H15N3O3S2/c1-11-6-8-13(9-7-11)25(22,23)16-12(2)19-17(24-16)20-15(21)14-5-3-4-10-18-14/h3-10H,1-2H3,(H,19,20,21)
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n/an/an/an/a 1.61E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192866
PNG
(US9192603, 39)
Show SMILES COc1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C)cc1
Show InChI InChI=1S/C18H17N3O4S2/c1-12-17(27(23,24)11-13-6-8-14(25-2)9-7-13)26-18(20-12)21-16(22)15-5-3-4-10-19-15/h3-10H,11H2,1-2H3,(H,20,21,22)
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n/an/an/an/a 1.96E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192894
PNG
(US9192603, 40)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C17H13F2N3O3S2/c1-10-16(27(24,25)9-11-5-6-12(18)13(19)8-11)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 937n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192869
PNG
(US9192603, 43)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1C
Show InChI InChI=1S/C18H17N3O3S2/c1-12-7-3-4-8-14(12)11-26(23,24)17-13(2)20-18(25-17)21-16(22)15-9-5-6-10-19-15/h3-10H,11H2,1-2H3,(H,20,21,22)
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n/an/an/an/a 709n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192873
PNG
(US9192603, 47)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1Cl
Show InChI InChI=1S/C17H13ClFN3O3S2/c1-10-16(27(24,25)9-11-12(18)5-4-6-13(11)19)26-17(21-10)22-15(23)14-7-2-3-8-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 192n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192875
PNG
(US9192603, 49)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O3S2/c1-11-16(26(23,24)10-12-5-7-13(18)8-6-12)25-17(20-11)21-15(22)14-4-2-3-9-19-14/h2-9H,10H2,1H3,(H,20,21,22)
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n/an/an/an/a 486n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192884
PNG
(US9192603, 58)
Show SMILES CC(c1ccccc1F)S(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C
Show InChI InChI=1S/C18H16FN3O3S2/c1-11-17(27(24,25)12(2)13-7-3-4-8-14(13)19)26-18(21-11)22-16(23)15-9-5-6-10-20-15/h3-10,12H,1-2H3,(H,21,22,23)
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n/an/an/an/a 4.78E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192890
PNG
(US9192603, 64)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C19H18ClN3O3S2/c1-12(2)16-18(28(25,26)11-13-7-3-4-8-14(13)20)27-19(22-16)23-17(24)15-9-5-6-10-21-15/h3-10,12H,11H2,1-2H3,(H,22,23,24)
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n/an/an/an/a 1.95E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192886
PNG
(US9192603, 60 | US9192603, 65)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)cc1F
Show InChI InChI=1S/C19H17F2N3O3S2/c1-11(2)16-18(29(26,27)10-12-6-7-13(20)9-14(12)21)28-19(23-16)24-17(25)15-5-3-4-8-22-15/h3-9,11H,10H2,1-2H3,(H,23,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192830
PNG
(US9192603, 3)
Show SMILES Clc1ccccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C1CC1
Show InChI InChI=1S/C19H16ClN3O3S2/c20-14-6-2-1-5-13(14)11-28(25,26)18-16(12-8-9-12)22-19(27-18)23-17(24)15-7-3-4-10-21-15/h1-7,10,12H,8-9,11H2,(H,22,23,24)
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n/an/an/an/a 2.98E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192845
PNG
(US9192603, 18)
Show SMILES Clc1ccc(CSc2cnc(NC(=O)c3ccccn3)s2)c(Cl)c1
Show InChI InChI=1S/C16H11Cl2N3OS2/c17-11-5-4-10(12(18)7-11)9-23-14-8-20-16(24-14)21-15(22)13-3-1-2-6-19-13/h1-8H,9H2,(H,20,21,22)
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n/an/an/an/a 5.00E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192849
PNG
(US9192603, 22)
Show SMILES FC(F)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C17H11F4N3O3S2/c18-10-4-3-5-11(19)9(10)8-29(26,27)16-13(14(20)21)23-17(28-16)24-15(25)12-6-1-2-7-22-12/h1-7,14H,8H2,(H,23,24,25)
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n/an/an/an/a 683n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192864
PNG
(US9192603, 37)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H13ClFN3O3S2/c1-10-16(27(24,25)9-11-5-6-13(19)12(18)8-11)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 2.35E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192867
PNG
(US9192603, 41)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H13Cl2N3O3S2/c1-10-16(27(24,25)9-11-12(18)5-4-6-13(11)19)26-17(21-10)22-15(23)14-7-2-3-8-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 117n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192876
PNG
(US9192603, 50)
Show SMILES Fc1cccc(F)c1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C1CC1
Show InChI InChI=1S/C19H15F2N3O3S2/c20-13-4-3-5-14(21)12(13)10-29(26,27)18-16(11-7-8-11)23-19(28-18)24-17(25)15-6-1-2-9-22-15/h1-6,9,11H,7-8,10H2,(H,23,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192886
PNG
(US9192603, 60 | US9192603, 65)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(F)cc1F
Show InChI InChI=1S/C19H17F2N3O3S2/c1-11(2)16-18(29(26,27)10-12-6-7-13(20)9-14(12)21)28-19(23-16)24-17(25)15-5-3-4-8-22-15/h3-9,11H,10H2,1-2H3,(H,23,24,25)
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n/an/an/an/a 3.11E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192839
PNG
(US9192603, 12)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C17H13ClFN3O3S2/c1-10-16(27(24,25)9-11-5-6-12(18)8-13(11)19)26-17(21-10)22-15(23)14-4-2-3-7-20-14/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 255n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192848
PNG
(US9192603, 21)
Show SMILES OCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(F)cccc1F
Show InChI InChI=1S/C17H13F2N3O4S2/c18-11-4-3-5-12(19)10(11)9-28(25,26)16-14(8-23)21-17(27-16)22-15(24)13-6-1-2-7-20-13/h1-7,23H,8-9H2,(H,21,22,24)
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n/an/an/an/a 8.81E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192855
PNG
(US9192603, 28)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(C)cc1
Show InChI InChI=1S/C19H19N3O3S2/c1-3-15-18(27(24,25)12-14-9-7-13(2)8-10-14)26-19(21-15)22-17(23)16-6-4-5-11-20-16/h4-11H,3,12H2,1-2H3,(H,21,22,23)
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n/an/an/an/a 450n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192859
PNG
(US9192603, 32)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H15Cl2N3O3S2/c1-2-14-17(28(25,26)10-11-12(19)6-5-7-13(11)20)27-18(22-14)23-16(24)15-8-3-4-9-21-15/h3-9H,2,10H2,1H3,(H,22,23,24)
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n/an/an/an/a 88n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192865
PNG
(US9192603, 38)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O3S2/c1-11-16(28-17(23-11)24-15(25)14-7-2-3-8-22-14)29(26,27)10-12-5-4-6-13(9-12)18(19,20)21/h2-9H,10H2,1H3,(H,23,24,25)
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n/an/an/an/a 2.46E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192877
PNG
(US9192603, 51)
Show SMILES Fc1cc(Cl)ccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C1CC1
Show InChI InChI=1S/C19H15ClFN3O3S2/c20-13-7-6-12(14(21)9-13)10-29(26,27)18-16(11-4-5-11)23-19(28-18)24-17(25)15-3-1-2-8-22-15/h1-3,6-9,11H,4-5,10H2,(H,23,24,25)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192892
PNG
(US9192603, 66)
Show SMILES Clc1ccccc1CS(=O)(=O)c1cnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C16H12ClN3O3S2/c17-12-6-2-1-5-11(12)10-25(22,23)14-9-19-16(24-14)20-15(21)13-7-3-4-8-18-13/h1-9H,10H2,(H,19,20,21)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192832
PNG
(US9192603, 5)
Show SMILES Fc1ccccc1CS(=O)(=O)c1cnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C16H12FN3O3S2/c17-12-6-2-1-5-11(12)10-25(22,23)14-9-19-16(24-14)20-15(21)13-7-3-4-8-18-13/h1-9H,10H2,(H,19,20,21)
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n/an/an/an/a 398n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192846
PNG
(US9192603, 19)
Show SMILES Fc1cc(Cl)ccc1CSc1cnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C16H11ClFN3OS2/c17-11-5-4-10(12(18)7-11)9-23-14-8-20-16(24-14)21-15(22)13-3-1-2-6-19-13/h1-8H,9H2,(H,20,21,22)
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n/an/an/an/a 8.24E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192847
PNG
(US9192603, 20)
Show SMILES Clc1ccccc1CSc1nnc(NC(=O)c2ccccn2)s1
Show InChI InChI=1S/C15H11ClN4OS2/c16-11-6-2-1-5-10(11)9-22-15-20-19-14(23-15)18-13(21)12-7-3-4-8-17-12/h1-8H,9H2,(H,18,19,21)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192853
PNG
(US9192603, 26)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H15Cl2N3O3S2/c1-2-14-17(28(25,26)10-11-6-7-12(19)9-13(11)20)27-18(22-14)23-16(24)15-5-3-4-8-21-15/h3-9H,2,10H2,1H3,(H,22,23,24)
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n/an/an/an/a 939n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192854
PNG
(US9192603, 27)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H23N3O3S2/c1-5-17-20(28-21(23-17)24-19(25)18-8-6-7-9-22-18)29(26,27)12-16-14(3)10-13(2)11-15(16)4/h6-11H,5,12H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 354n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192857
PNG
(US9192603, 30)
Show SMILES CCc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C18H15ClFN3O3S2/c1-2-14-17(28(25,26)10-11-6-7-12(19)9-13(11)20)27-18(22-14)23-16(24)15-5-3-4-8-21-15/h3-9H,2,10H2,1H3,(H,22,23,24)
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n/an/an/an/a 294n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192872
PNG
(US9192603, 46)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1cccc(Cl)c1F
Show InChI InChI=1S/C17H13ClFN3O3S2/c1-10-16(27(24,25)9-11-5-4-6-12(18)14(11)19)26-17(21-10)22-15(23)13-7-2-3-8-20-13/h2-8H,9H2,1H3,(H,21,22,23)
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n/an/an/an/a 535n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192882
PNG
(US9192603, 56)
Show SMILES Fc1ccc(CS(=O)(=O)c2sc(NC(=O)c3ccccn3)nc2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C17H10F5N3O3S2/c18-10-5-4-9(11(19)7-10)8-30(27,28)15-13(17(20,21)22)24-16(29-15)25-14(26)12-3-1-2-6-23-12/h1-7H,8H2,(H,24,25,26)
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n/an/an/an/a 1.73E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192831
PNG
(US9192603, 4)
Show SMILES Fc1ccccc1CS(=O)(=O)c1sc(NC(=O)c2ccccn2)nc1C1CC1
Show InChI InChI=1S/C19H16FN3O3S2/c20-14-6-2-1-5-13(14)11-28(25,26)18-16(12-8-9-12)22-19(27-18)23-17(24)15-7-3-4-10-21-15/h1-7,10,12H,8-9,11H2,(H,22,23,24)
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n/an/an/an/a 249n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192836
PNG
(US9192603, 9)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O3S2/c1-11-16(26(23,24)10-12-6-2-3-7-13(12)18)25-17(20-11)21-15(22)14-8-4-5-9-19-14/h2-9H,10H2,1H3,(H,20,21,22)
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n/an/an/an/a 504n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192837
PNG
(US9192603, 10)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccccc1F
Show InChI InChI=1S/C17H14FN3O3S2/c1-11-16(26(23,24)10-12-6-2-3-7-13(12)18)25-17(20-11)21-15(22)14-8-4-5-9-19-14/h2-9H,10H2,1H3,(H,20,21,22)
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n/an/an/an/a 1.33E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192862
PNG
(US9192603, 35)
Show SMILES Cc1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)c1cccc(C)c1
Show InChI InChI=1S/C17H15N3O3S2/c1-11-6-5-7-13(10-11)25(22,23)16-12(2)19-17(24-16)20-15(21)14-8-3-4-9-18-14/h3-10H,1-2H3,(H,19,20,21)
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n/an/an/an/a 6.97E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192883
PNG
(US9192603, 57)
Show SMILES FC(F)(F)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H10Cl2F3N3O3S2/c18-10-5-4-9(11(19)7-10)8-30(27,28)15-13(17(20,21)22)24-16(29-15)25-14(26)12-3-1-2-6-23-12/h1-7H,8H2,(H,24,25,26)
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n/an/an/an/a 497n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192887
PNG
(US9192603, 61)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C19H17ClFN3O3S2/c1-11(2)16-18(29(26,27)10-12-6-7-13(20)9-14(12)21)28-19(23-16)24-17(25)15-5-3-4-8-22-15/h3-9,11H,10H2,1-2H3,(H,23,24,25)
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n/an/an/an/a 2.93E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM192888
PNG
(US9192603, 62)
Show SMILES CC(C)c1nc(NC(=O)c2ccccn2)sc1S(=O)(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H17Cl2N3O3S2/c1-11(2)16-18(29(26,27)10-12-6-7-13(20)9-14(12)21)28-19(23-16)24-17(25)15-5-3-4-8-22-15/h3-9,11H,10H2,1-2H3,(H,23,24,25)
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n/an/an/an/a 3.30E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...

US Patent US9192603 (2015)


BindingDB Entry DOI: 10.7270/Q2FJ2FKX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%