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Patent code US9193726

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193022
PNG
(US9193726, 10)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(c(F)c1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)18-3-4-19-24(36)33(7-8-34(19)23(18)35)14(2)20-5-6-21(37-20)15-9-16(26)22(17(27)10-15)25(28,29)30/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1
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n/an/a 3.34n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193067
PNG
(US9193726, 55)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)c(F)c1)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C24H23ClF2N4O3/c1-13-11-29(12-28-13)18-3-4-19-24(33)30(7-8-31(19)23(18)32)14(2)20-5-6-21(34-20)15-9-16(26)22(25)17(27)10-15/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1
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n/an/a 5.48n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193079
PNG
(US9193726, 67)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)c(Cl)c1)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C24H23Cl2FN4O3/c1-13-11-29(12-28-13)18-3-4-19-24(33)30(7-8-31(19)23(18)32)14(2)20-5-6-21(34-20)15-9-16(25)22(26)17(27)10-15/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1
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n/an/a 5.78n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193081
PNG
(US9193726, 69)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-18(27)17(26)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1
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n/an/a 7.84n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193063
PNG
(US9193726, 51)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H24F4N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)16-3-4-17(18(26)11-16)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1
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n/an/a 8.35n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193021
PNG
(US9193726, 9)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H24ClF3N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(26)11-18(17)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1
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n/an/a 9.10n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193082
PNG
(US9193726, 70)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)c(F)c1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)17-5-6-18-24(36)33(9-10-34(18)23(17)35)14(2)19-7-8-20(37-19)15-3-4-16(26)22(27)21(15)25(28,29)30/h3-6,11-12,14,19-20H,7-10H2,1-2H3/t14-,19-,20+/m0/s1
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n/an/a 10n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193062
PNG
(US9193726, 50)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1F)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)17-5-6-18-24(36)33(9-10-34(18)23(17)35)14(2)19-7-8-20(37-19)15-3-4-16(25(28,29)30)22(27)21(15)26/h3-6,11-12,14,19-20H,7-10H2,1-2H3/t14-,19-,20+/m0/s1
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n/an/a 11n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193069
PNG
(US9193726, 57)
Show SMILES COc1cc(Cl)c(F)cc1[C@H]1CC[C@H](O1)[C@H](C)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H26ClFN4O4/c1-14-12-29(13-28-14)19-4-5-20-25(33)30(8-9-31(20)24(19)32)15(2)21-6-7-22(35-21)16-10-18(27)17(26)11-23(16)34-3/h4-5,10-13,15,21-22H,6-9H2,1-3H3/t15-,21-,22+/m0/s1
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n/an/a 11.1n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193066
PNG
(US9193726, 54)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)cc1F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C24H23ClF2N4O3/c1-13-11-29(12-28-13)19-3-4-20-24(33)30(7-8-31(20)23(19)32)14(2)21-5-6-22(34-21)15-9-18(27)16(25)10-17(15)26/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1
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n/an/a 11.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193074
PNG
(US9193726, 62)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cc(F)c(Cl)c(F)c3)CCn2c1=O
Show InChI InChI=1S/C23H21ClF2N4O3/c1-13-10-29(12-27-13)18-3-4-19-22(31)28(6-7-30(19)23(18)32)11-15-2-5-20(33-15)14-8-16(25)21(24)17(26)9-14/h3-4,8-10,12,15,20H,2,5-7,11H2,1H3/t15-,20+/m0/s1
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n/an/a 13.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193020
PNG
(US9193726, 8)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(cc1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-15-13-30(14-29-15)19-7-8-20-24(34)31(11-12-32(20)23(19)33)16(2)21-9-10-22(35-21)17-3-5-18(6-4-17)25(26,27)28/h3-8,13-14,16,21-22H,9-12H2,1-2H3/t16-,21-,22+/m0/s1
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n/an/a 14.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193070
PNG
(US9193726, 58)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1OC(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H24ClF3N4O4/c1-14-12-31(13-30-14)18-5-6-19-24(35)32(9-10-33(19)23(18)34)15(2)20-7-8-21(36-20)17-4-3-16(26)11-22(17)37-25(27,28)29/h3-6,11-13,15,20-21H,7-10H2,1-2H3/t15-,20-,21+/m0/s1
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n/an/a 14.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193064
PNG
(US9193726, 52)
Show SMILES COc1cc(ccc1[C@H]1CC[C@H](O1)[C@H](C)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O4/c1-15-13-31(14-30-15)19-6-7-20-25(35)32(10-11-33(20)24(19)34)16(2)21-8-9-22(37-21)18-5-4-17(26(27,28)29)12-23(18)36-3/h4-7,12-14,16,21-22H,8-11H2,1-3H3/t16-,21-,22+/m0/s1
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n/an/a 15n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193059
PNG
(US9193726, 47)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(c(F)c3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-31(13-29-14)19-5-6-20-22(33)30(8-9-32(20)23(19)34)12-16-3-7-21(35-16)15-2-4-17(18(25)10-15)24(26,27)28/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3/t16-,21+/m0/s1
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n/an/a 15.7n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193030
PNG
(US9193726, 18)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cc(F)c(c(F)c3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H21F5N4O3/c1-13-10-32(12-30-13)18-3-4-19-22(34)31(6-7-33(19)23(18)35)11-15-2-5-20(36-15)14-8-16(25)21(17(26)9-14)24(27,28)29/h3-4,8-10,12,15,20H,2,5-7,11H2,1H3/t15-,20+/m0/s1
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n/an/a 16n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193085
PNG
(US9193726, 73)
Show SMILES C[C@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-30(14-29-15)20-8-9-21-24(34)31(16(2)12-32(21)23(20)33)13-19-7-10-22(35-19)17-3-5-18(6-4-17)25(26,27)28/h3-6,8-9,11,14,16,19,22H,7,10,12-13H2,1-2H3/t16-,19+,22-/m0/s1
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n/an/a 19.8n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193061
PNG
(US9193726, 49)
Show SMILES COc1cc(Cl)ccc1[C@H]1CC[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O1
Show InChI InChI=1S/C24H25ClN4O4/c1-15-12-28(14-26-15)19-6-7-20-23(30)27(9-10-29(20)24(19)31)13-17-4-8-21(33-17)18-5-3-16(25)11-22(18)32-2/h3,5-7,11-12,14,17,21H,4,8-10,13H2,1-2H3/t17-,21+/m0/s1
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n/an/a 21.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193080
PNG
(US9193726, 68)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(F)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H24F4N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(26)11-18(17)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1
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n/an/a 24.2n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193073
PNG
(US9193726, 61)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1OC(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H25ClF2N4O4/c1-14-12-30(13-29-14)18-5-6-19-24(34)31(9-10-32(19)23(18)33)15(2)20-7-8-21(35-20)17-4-3-16(26)11-22(17)36-25(27)28/h3-6,11-13,15,20-21,25H,7-10H2,1-2H3/t15-,20-,21+/m0/s1
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n/an/a 24.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193018
PNG
(US9193726, 6)
Show SMILES C[C@H]1C[C@@H](O[C@@H]1CN1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-21(17-3-5-18(6-4-17)25(26,27)28)35-22(15)13-30-9-10-32-20(23(30)33)8-7-19(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,21-22H,9-11,13H2,1-2H3/t15-,21+,22+/m0/s1
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n/an/a 25n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193057
PNG
(US9193726, 45)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)S(F)(F)(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C23H23F5N4O3S/c1-15-12-31(14-29-15)19-7-8-20-22(33)30(10-11-32(20)23(19)34)13-17-4-9-21(35-17)16-2-5-18(6-3-16)36(24,25,26,27)28/h2-3,5-8,12,14,17,21H,4,9-11,13H2,1H3/t17-,21+/m0/s1
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n/an/a 26.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193077
PNG
(US9193726, 65)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(Cl)cc3C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H22ClF3N4O3/c1-14-11-31(13-29-14)19-5-6-20-22(33)30(8-9-32(20)23(19)34)12-16-3-7-21(35-16)17-4-2-15(25)10-18(17)24(26,27)28/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3/t16-,21+/m0/s1
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n/an/a 26.8n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193055
PNG
(US9193726, 43)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-18-6-9-21(34-18)16-2-4-17(5-3-16)24(25,26)27/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1
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n/an/a 27.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193065
PNG
(US9193726, 53)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(cc1Cl)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H24ClF3N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(11-18(17)26)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1
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n/an/a 29.1n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193027
PNG
(US9193726, 15)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CCC[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-9-10-21-23(33)30(11-12-32(21)24(20)34)14-19-3-2-4-22(35-19)17-5-7-18(8-6-17)25(26,27)28/h5-10,13,15,19,22H,2-4,11-12,14H2,1H3/t19-,22-/m1/s1
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n/an/a 29.9n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193078
PNG
(US9193726, 66)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(F)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-17(26)18(27)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1
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n/an/a 33.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193029
PNG
(US9193726, 17)
Show SMILES C[C@H]1C[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O[C@H]1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-19(35-22(15)17-3-5-18(6-4-17)25(26,27)28)13-30-9-10-32-21(23(30)33)8-7-20(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,19,22H,9-11,13H2,1-2H3/t15-,19-,22+/m0/s1
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n/an/a 38.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193023
PNG
(US9193726, 11)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@](C)(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-7-8-21-22(33)30(11-12-32(21)23(20)34)14-19-9-10-24(2,35-19)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,19H,9-12,14H2,1-2H3/t19-,24+/m0/s1
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n/an/a 40.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193084
PNG
(US9193726, 72)
Show SMILES C[C@@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-30(14-29-15)20-8-9-21-24(34)31(16(2)12-32(21)23(20)33)13-19-7-10-22(35-19)17-3-5-18(6-4-17)25(26,27)28/h3-6,8-9,11,14,16,19,22H,7,10,12-13H2,1-2H3/t16-,19-,22+/m1/s1
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n/an/a 46.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193056
PNG
(US9193726, 44)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(Cl)cc3)CCn2c1=O
Show InChI InChI=1S/C23H23ClN4O3/c1-15-12-27(14-25-15)19-7-8-20-22(29)26(10-11-28(20)23(19)30)13-18-6-9-21(31-18)16-2-4-17(24)5-3-16/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1
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n/an/a 52.1n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193083
PNG
(US9193726, 71)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(s1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C23H23F3N4O3S/c1-13-11-28(12-27-13)15-3-4-16-22(32)29(9-10-30(16)21(15)31)14(2)17-5-6-18(33-17)19-7-8-20(34-19)23(24,25)26/h3-4,7-8,11-12,14,17-18H,5-6,9-10H2,1-2H3/t14-,17-,18+/m0/s1
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n/an/a 52.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193058
PNG
(US9193726, 46)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(OC(F)(F)F)cc3)CCn2c1=O
Show InChI InChI=1S/C24H23F3N4O4/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-18-6-9-21(34-18)16-2-4-17(5-3-16)35-24(25,26)27/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1
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n/an/a 60.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193015
PNG
(US9193726, 3)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2cc(F)c(F)cc12
Show InChI InChI=1S/C26H22F2N4O3/c1-15-13-30(14-29-15)21-5-6-22-26(34)31(9-10-32(22)25(21)33)20-7-8-24(20)35-23-4-2-3-16-11-18(27)19(28)12-17(16)23/h2-6,11-14,20,24H,7-10H2,1H3/t20-,24-/m1/s1
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n/an/a 60.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193060
PNG
(US9193726, 48)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C3CC3)CCn2c1=O
Show InChI InChI=1S/C26H28N4O3/c1-17-14-29(16-27-17)22-9-10-23-25(31)28(12-13-30(23)26(22)32)15-21-8-11-24(33-21)20-6-4-19(5-7-20)18-2-3-18/h4-7,9-10,14,16,18,21,24H,2-3,8,11-13,15H2,1H3/t21-,24+/m0/s1
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n/an/a 63.8n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193075
PNG
(US9193726, 63)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccccc3C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-16-6-9-21(34-16)17-4-2-3-5-18(17)24(25,26)27/h2-5,7-8,12,14,16,21H,6,9-11,13H2,1H3/t16-,21+/m0/s1
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n/an/a 73.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193072
PNG
(US9193726, 60)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(C)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H26F2N4O3/c1-16-13-30(15-28-16)20-8-9-21-23(32)29(11-12-31(21)24(20)33)14-19-7-10-22(34-19)17-3-5-18(6-4-17)25(2,26)27/h3-6,8-9,13,15,19,22H,7,10-12,14H2,1-2H3/t19-,22+/m0/s1
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n/an/a 73.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193076
PNG
(US9193726, 64)
Show SMILES C[C@@H]1C[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O[C@H]1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-19(35-22(15)17-3-5-18(6-4-17)25(26,27)28)13-30-9-10-32-21(23(30)33)8-7-20(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,19,22H,9-11,13H2,1-2H3/t15-,19+,22-/m1/s1
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n/an/a 73.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193019
PNG
(US9193726, 7)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3C[C@@H](F)[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-31(13-29-14)19-6-7-20-22(33)30(8-9-32(20)23(19)34)12-17-10-18(25)21(35-17)15-2-4-16(5-3-15)24(26,27)28/h2-7,11,13,17-18,21H,8-10,12H2,1H3/t17-,18+,21-/m0/s1
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n/an/a 73.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193041
PNG
(US9193726, 29)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CCC[C@@H](C3)c3ccc(Cl)cc3)CCn2c1=O
Show InChI InChI=1S/C25H27ClN4O2/c1-17-14-29(16-27-17)22-9-10-23-24(31)28(11-12-30(23)25(22)32)15-18-3-2-4-20(13-18)19-5-7-21(26)8-6-19/h5-10,14,16,18,20H,2-4,11-13,15H2,1H3/t18-,20+/m1/s1
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n/an/a 80n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193068
PNG
(US9193726, 56)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cccc(c3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-6-7-20-22(32)29(9-10-31(20)23(19)33)13-18-5-8-21(34-18)16-3-2-4-17(11-16)24(25,26)27/h2-4,6-7,11-12,14,18,21H,5,8-10,13H2,1H3/t18-,21+/m0/s1
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n/an/a 81.2n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193028
PNG
(US9193726, 16)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CCC[C@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-9-10-21-23(33)30(11-12-32(21)24(20)34)14-19-3-2-4-22(35-19)17-5-7-18(8-6-17)25(26,27)28/h5-10,13,15,19,22H,2-4,11-12,14H2,1H3/t19-,22+/m1/s1
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n/an/a 96.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193035
PNG
(US9193726, 23)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CCCC(C3)c3ccc(Cl)cc3)CCn2c1=O
Show InChI InChI=1S/C25H27ClN4O2/c1-17-14-29(16-27-17)22-9-10-23-24(31)28(11-12-30(23)25(22)32)15-18-3-2-4-20(13-18)19-5-7-21(26)8-6-19/h5-10,14,16,18,20H,2-4,11-13,15H2,1H3
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n/an/a 98n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193051
PNG
(US9193726, 39)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2ccc(F)cc12
Show InChI InChI=1S/C26H23FN4O3/c1-16-14-29(15-28-16)21-7-8-22-26(33)30(11-12-31(22)25(21)32)20-9-10-24(20)34-23-4-2-3-17-5-6-18(27)13-19(17)23/h2-8,13-15,20,24H,9-12H2,1H3/t20-,24-/m1/s1
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n/an/a 112n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193054
PNG
(US9193726, 42)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CCC(O3)c3ccc(Cl)c(Cl)c3)CCn2c1=O
Show InChI InChI=1S/C23H22Cl2N4O3/c1-14-11-28(13-26-14)19-5-6-20-22(30)27(8-9-29(20)23(19)31)12-16-3-7-21(32-16)15-2-4-17(24)18(25)10-15/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3
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n/an/a 117n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193046
PNG
(US9193726, 34)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-11-29(12-28-13)17-3-4-18-22(33)30(8-9-31(18)21(17)32)16-5-7-20(16)34-19-6-2-14(24)10-15(19)23(25,26)27/h2-4,6,10-12,16,20H,5,7-9H2,1H3/t16-,20-/m1/s1
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n/an/a 120n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193017
PNG
(US9193726, 5)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Oc1ccc(F)cc1C(F)(F)F
Show InChI InChI=1S/C24H22F4N4O3/c1-14-12-30(13-29-14)18-6-7-19-23(34)31(9-10-32(19)22(18)33)17-3-2-4-21(17)35-20-8-5-15(25)11-16(20)24(26,27)28/h5-8,11-13,17,21H,2-4,9-10H2,1H3/t17-,21+/m1/s1
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n/an/a 140n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193048
PNG
(US9193726, 36)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(F)c(Cl)c1C
Show InChI InChI=1S/C23H22ClFN4O3/c1-13-11-27(12-26-13)17-4-5-18-23(31)28(9-10-29(18)22(17)30)16-6-8-20(16)32-19-7-3-15(25)21(24)14(19)2/h3-5,7,11-12,16,20H,6,8-10H2,1-2H3/t16-,20-/m1/s1
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n/an/a 146n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193052
PNG
(US9193726, 40)
Show SMILES CC(C)c1c(F)cccc1O[C@@H]1CC[C@H]1N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C25H27FN4O3/c1-15(2)23-17(26)5-4-6-22(23)33-21-10-9-18(21)29-11-12-30-20(25(29)32)8-7-19(24(30)31)28-13-16(3)27-14-28/h4-8,13-15,18,21H,9-12H2,1-3H3/t18-,21-/m1/s1
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n/an/a 153n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193053
PNG
(US9193726, 41)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-11-29(12-28-13)16-5-6-17-22(33)30(9-10-31(17)21(16)32)15-7-8-18(15)34-19-4-2-3-14(20(19)24)23(25,26)27/h2-6,11-12,15,18H,7-10H2,1H3/t15-,18-/m1/s1
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n/an/a 157n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193071
PNG
(US9193726, 59)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CC[C@H](O3)c3ccc(cc3)C(F)(F)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H23F5N4O3/c1-15-12-33(14-31-15)19-7-8-20-22(35)32(10-11-34(20)23(19)36)13-18-6-9-21(37-18)16-2-4-17(5-3-16)24(26,27)25(28,29)30/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m1/s1
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n/an/a 157n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193049
PNG
(US9193726, 37)
Show SMILES CC(C)c1cc(O[C@@H]2CC[C@H]2N2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)ccc1Cl
Show InChI InChI=1S/C25H27ClN4O3/c1-15(2)18-12-17(4-5-19(18)26)33-23-9-8-20(23)29-10-11-30-22(25(29)32)7-6-21(24(30)31)28-13-16(3)27-14-28/h4-7,12-15,20,23H,8-11H2,1-3H3/t20-,23-/m1/s1
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n/an/a 158n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193047
PNG
(US9193726, 35)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(F)c2CCCc12
Show InChI InChI=1S/C25H25FN4O3/c1-15-13-28(14-27-15)20-6-7-21-25(32)29(11-12-30(21)24(20)31)19-8-10-23(19)33-22-9-5-18(26)16-3-2-4-17(16)22/h5-7,9,13-14,19,23H,2-4,8,10-12H2,1H3/t19-,23-/m1/s1
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n/an/a 162n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193050
PNG
(US9193726, 38)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2ccccc12
Show InChI InChI=1S/C26H24N4O3/c1-17-15-28(16-27-17)21-9-10-22-26(32)29(13-14-30(22)25(21)31)20-11-12-24(20)33-23-8-4-6-18-5-2-3-7-19(18)23/h2-10,15-16,20,24H,11-14H2,1H3/t20-,24-/m1/s1
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n/an/a 164n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193033
PNG
(US9193726, 21)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CCCC3Oc3cccc(c3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-8-9-21-23(33)30(10-11-32(21)24(20)34)14-17-4-2-7-22(17)35-19-6-3-5-18(12-19)25(26,27)28/h3,5-6,8-9,12-13,15,17,22H,2,4,7,10-11,14H2,1H3
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n/an/a 188n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193013
PNG
(US9193726, 1)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H21F3N4O3/c1-14-12-28(13-27-14)17-6-7-18-22(32)29(10-11-30(18)21(17)31)16-8-9-20(16)33-19-5-3-2-4-15(19)23(24,25)26/h2-7,12-13,16,20H,8-11H2,1H3/t16-,20-/m1/s1
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n/an/a 211n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193045
PNG
(US9193726, 33)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H21F3N4O3/c1-14-12-28(13-27-14)18-5-6-19-22(32)29(9-10-30(19)21(18)31)17-7-8-20(17)33-16-4-2-3-15(11-16)23(24,25)26/h2-6,11-13,17,20H,7-10H2,1H3/t17-,20-/m1/s1
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US Patent
n/an/a 217n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193025
PNG
(US9193726, 13 | US9193726, 14)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3(C)CCC(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)19-7-8-20-22(33)30(11-12-32(20)23(19)34)14-24(2)10-9-21(35-24)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,21H,9-12,14H2,1-2H3
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n/an/a 236n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193014
PNG
(US9193726, 2)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@H]1Oc1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3/c1-15-13-29(14-28-15)18-9-10-19-23(33)30(11-12-31(19)22(18)32)17-6-4-8-21(17)34-20-7-3-2-5-16(20)24(25,26)27/h2-3,5,7,9-10,13-14,17,21H,4,6,8,11-12H2,1H3/t17-,21-/m1/s1
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n/an/a 300n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193038
PNG
(US9193726, 26)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@H](COc2ccc(F)cc2C(F)(F)F)C1 |wU:18.20,wD:20.23,(14.36,-6.96,;13.73,-5.55,;12.22,-5.23,;12.06,-3.7,;13.47,-3.07,;14.5,-4.22,;10.73,-2.93,;10.73,-1.39,;9.4,-.62,;8.06,-1.39,;6.73,-.62,;6.73,.92,;5.39,-1.39,;5.39,-2.93,;6.73,-3.7,;8.06,-2.93,;9.4,-3.7,;9.4,-5.24,;4.06,-.62,;2.57,-1.02,;2.17,.47,;.84,1.24,;-.49,.47,;-1.83,1.24,;-1.83,2.78,;-3.16,3.55,;-4.49,2.78,;-5.83,3.55,;-4.49,1.24,;-3.16,.47,;-3.16,-1.07,;-3.16,-2.61,;-4.7,-1.07,;-1.62,-1.07,;3.66,.87,)|
Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-30(13-29-14)19-3-4-20-23(34)31(6-7-32(20)22(19)33)17-8-15(9-17)12-35-21-5-2-16(25)10-18(21)24(26,27)28/h2-5,10-11,13,15,17H,6-9,12H2,1H3/t15-,17-
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n/an/a 303n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193043
PNG
(US9193726, 31)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3cc(cc(Cl)c3F)C(F)(F)F)CCn2c1=O |c:17|
Show InChI InChI=1S/C23H18ClF4N5O3/c1-12-9-32(11-29-12)18-2-3-19-21(34)31(4-5-33(19)22(18)35)10-14-8-17(30-36-14)15-6-13(23(26,27)28)7-16(24)20(15)25/h2-3,6-7,9,11,14H,4-5,8,10H2,1H3
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n/an/a 353n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193044
PNG
(US9193726, 32)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3cccc(c3Cl)C(F)(F)F)CCn2c1=O |c:17|
Show InChI InChI=1S/C23H19ClF3N5O3/c1-13-10-31(12-28-13)18-5-6-19-21(33)30(7-8-32(19)22(18)34)11-14-9-17(29-35-14)15-3-2-4-16(20(15)24)23(25,26)27/h2-6,10,12,14H,7-9,11H2,1H3
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n/an/a 429n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193039
PNG
(US9193726, 27)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@@H]1Oc1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H21F3N4O3/c1-14-12-28(13-27-14)17-6-7-18-22(32)29(10-11-30(18)21(17)31)16-8-9-20(16)33-19-5-3-2-4-15(19)23(24,25)26/h2-7,12-13,16,20H,8-11H2,1H3/t16-,20+/m1/s1
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n/an/a 469n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193016
PNG
(US9193726, 4)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3ccc(Cl)c(c3)C(F)(F)F)CCn2c1=O |c:17|
Show InChI InChI=1S/C23H19ClF3N5O3/c1-13-10-31(12-28-13)19-4-5-20-21(33)30(6-7-32(20)22(19)34)11-15-9-18(29-35-15)14-2-3-17(24)16(8-14)23(25,26)27/h2-5,8,10,12,15H,6-7,9,11H2,1H3
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n/an/a 483n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193037
PNG
(US9193726, 25)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Cc1cc(F)cc(F)c1
Show InChI InChI=1S/C24H24F2N4O2/c1-15-13-28(14-27-15)21-5-6-22-24(32)29(7-8-30(22)23(21)31)20-4-2-3-17(20)9-16-10-18(25)12-19(26)11-16/h5-6,10-14,17,20H,2-4,7-9H2,1H3/t17-,20-/m1/s1
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n/an/a 561n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193036
PNG
(US9193726, 24)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H22F2N4O2/c1-14-12-27(13-26-14)20-5-6-21-23(31)28(7-8-29(21)22(20)30)19-4-2-3-18(19)15-9-16(24)11-17(25)10-15/h5-6,9-13,18-19H,2-4,7-8H2,1H3/t18-,19-/m1/s1
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n/an/a 563n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193040
PNG
(US9193726, 28)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)C1CCCCC1Oc1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN4O3/c1-16-14-27(15-26-16)20-10-11-21-24(31)28(12-13-29(21)23(20)30)19-4-2-3-5-22(19)32-18-8-6-17(25)7-9-18/h6-11,14-15,19,22H,2-5,12-13H2,1H3
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n/an/a 591n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193042
PNG
(US9193726, 30)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CC(=NO3)c3cc(ccc3Cl)C(F)(F)F)CCn2c1=O |c:17|
Show InChI InChI=1S/C23H19ClF3N5O3/c1-13-10-31(12-28-13)19-4-5-20-21(33)30(6-7-32(20)22(19)34)11-15-9-18(29-35-15)16-8-14(23(25,26)27)2-3-17(16)24/h2-5,8,10,12,15H,6-7,9,11H2,1H3
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n/an/a 711n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193024
PNG
(US9193726, 12)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CC[C@](C)(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-7-8-21-22(33)30(11-12-32(21)23(20)34)14-19-9-10-24(2,35-19)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,19H,9-12,14H2,1-2H3/t19-,24+/m1/s1
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n/an/a 725n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193034
PNG
(US9193726, 22)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@@H](C1)Oc1ccccc1C(F)(F)F |wU:18.20,wD:20.25,(11.86,-6.76,;11.24,-5.36,;9.73,-5.04,;9.57,-3.5,;10.98,-2.88,;12.01,-4.02,;8.24,-2.73,;8.24,-1.19,;6.9,-.42,;5.57,-1.19,;4.24,-.42,;4.24,1.12,;2.9,-1.19,;2.9,-2.73,;4.24,-3.5,;5.57,-2.73,;6.9,-3.5,;6.9,-5.04,;1.57,-.42,;.08,-.82,;-.32,.66,;1.17,1.06,;-1.65,1.43,;-1.65,2.97,;-.32,3.74,;-.32,5.28,;-1.65,6.05,;-2.98,5.28,;-2.98,3.74,;-4.32,2.97,;-5.65,2.2,;-5.09,4.31,;-3.55,1.64,)|
Show InChI InChI=1S/C23H21F3N4O3/c1-14-12-28(13-27-14)18-6-7-19-22(32)29(8-9-30(19)21(18)31)15-10-16(11-15)33-20-5-3-2-4-17(20)23(24,25)26/h2-7,12-13,15-16H,8-11H2,1H3/t15-,16-
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n/an/a 789n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193025
PNG
(US9193726, 13 | US9193726, 14)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3(C)CCC(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)19-7-8-20-22(33)30(11-12-32(20)23(19)34)14-24(2)10-9-21(35-24)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,21H,9-12,14H2,1-2H3
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n/an/a 1.04E+3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193032
PNG
(US9193726, 20)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H](C1)Oc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3/c1-15-13-29(14-28-15)20-7-8-21-23(33)30(9-10-31(21)22(20)32)17-5-6-19(12-17)34-18-4-2-3-16(11-18)24(25,26)27/h2-4,7-8,11,13-14,17,19H,5-6,9-10,12H2,1H3/t17-,19-/m1/s1
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n/an/a 1.36E+3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))		BDBM193031
PNG
(US9193726, 19)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1CON=C1c1ccc(F)c(F)c1 |c:24|
Show InChI InChI=1S/C21H17F2N5O3/c1-12-9-26(11-24-12)16-4-5-17-21(30)28(7-6-27(17)20(16)29)18-10-31-25-19(18)13-2-3-14(22)15(23)8-13/h2-5,8-9,11,18H,6-7,10H2,1H3/t18-/m0/s1
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n/an/a 1.46E+3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%