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Patent code US9206164

Compile Data Set for Download or QSAR
Found 111 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197024
PNG
(US9206164, 88 | US9206164, 98)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C27H31FN4O2/c1-6-21-19(14-25(33)34)24(7-2)32(31-21)15-17-9-8-16(12-20(17)28)26-29-22-11-10-18(27(3,4)5)13-23(22)30-26/h8-13H,6-7,14-15H2,1-5H3,(H,29,30)(H,33,34)
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 0.100n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196955
PNG
(US9206164, 19)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc4ccccc4cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C27H26N4O2/c1-3-22-21(15-26(32)33)25(4-2)31(30-22)16-17-9-11-18(12-10-17)27-28-23-13-19-7-5-6-8-20(19)14-24(23)29-27/h5-14H,3-4,15-16H2,1-2H3,(H,28,29)(H,32,33)
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 0.100n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197004
PNG
(US9206164, 68)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C27H32N4O2/c1-6-21-20(15-25(32)33)24(7-2)31(30-21)16-17-8-10-18(11-9-17)26-28-22-13-12-19(27(3,4)5)14-23(22)29-26/h8-14H,6-7,15-16H2,1-5H3,(H,28,29)(H,32,33)
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 0.200n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196952
PNG
(US9206164, 16)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22Cl2N4O2/c1-3-18-15(9-22(30)31)21(4-2)29(28-18)12-13-5-7-14(8-6-13)23-26-19-10-16(24)17(25)11-20(19)27-23/h5-8,10-11H,3-4,9,12H2,1-2H3,(H,26,27)(H,30,31)
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 0.200n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196956
PNG
(US9206164, 20)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(F)(F)F)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H23F3N4O2/c1-3-18-17(12-22(32)33)21(4-2)31(30-18)13-14-5-7-15(8-6-14)23-28-19-10-9-16(24(25,26)27)11-20(19)29-23/h5-11H,3-4,12-13H2,1-2H3,(H,28,29)(H,32,33)
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 0.200n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196943
PNG
(US9206164, 4)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2cc3ccc(cc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C23H20F3N3O2/c1-13-19(11-22(30)31)14(2)29(28-13)12-15-3-5-16(6-4-15)20-9-17-7-8-18(23(24,25)26)10-21(17)27-20/h3-10,27H,11-12H2,1-2H3,(H,30,31)
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 0.300n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196964
PNG
(US9206164, 28)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Br)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22BrClN4O2/c1-3-18-15(9-22(30)31)21(4-2)29(28-18)12-13-5-7-14(8-6-13)23-26-19-10-16(24)17(25)11-20(19)27-23/h5-8,10-11H,3-4,9,12H2,1-2H3,(H,26,27)(H,30,31)
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 0.300n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196981
PNG
(US9206164, 45)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H23ClN4O2/c1-3-18-17(12-22(29)30)21(4-2)28(27-18)13-14-5-7-15(8-6-14)23-25-19-10-9-16(24)11-20(19)26-23/h5-11H,3-4,12-13H2,1-2H3,(H,25,26)(H,29,30)
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 0.300n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197042
PNG
(US9206164, 106)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(C)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H24ClFN4O2/c1-4-19-16(10-23(31)32)22(5-2)30(29-19)12-15-7-6-14(9-18(15)26)24-27-20-8-13(3)17(25)11-21(20)28-24/h6-9,11H,4-5,10,12H2,1-3H3,(H,27,28)(H,31,32)
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 0.300n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197001
PNG
(US9206164, 65)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c(Cl)cc(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22Cl2N4O2/c1-3-18-16(11-21(30)31)20(4-2)29(28-18)12-13-5-7-14(8-6-13)23-26-19-10-15(24)9-17(25)22(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 0.400n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197023
PNG
(US9206164, 87)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(Br)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22BrFN4O2/c1-3-18-16(11-22(30)31)21(4-2)29(28-18)12-14-6-5-13(9-17(14)25)23-26-19-8-7-15(24)10-20(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 0.400n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196963
PNG
(US9206164, 27)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(F)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22ClFN4O2/c1-3-18-15(9-22(30)31)21(4-2)29(28-18)12-13-5-7-14(8-6-13)23-26-19-10-16(24)17(25)11-20(19)27-23/h5-8,10-11H,3-4,9,12H2,1-2H3,(H,26,27)(H,30,31)
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 0.400n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196944
PNG
(US9206164, 5)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2cc3ccc(cc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C23H19F4N3O2/c1-12-18(10-22(31)32)13(2)30(29-12)11-16-4-3-14(7-19(16)24)20-8-15-5-6-17(23(25,26)27)9-21(15)28-20/h3-9,28H,10-11H2,1-2H3,(H,31,32)
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 0.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196991
PNG
(US9206164, 55)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(C)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H25ClN4O2/c1-4-19-17(11-23(30)31)22(5-2)29(28-19)13-15-6-8-16(9-7-15)24-26-20-10-14(3)18(25)12-21(20)27-24/h6-10,12H,4-5,11,13H2,1-3H3,(H,26,27)(H,30,31)
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 0.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196969
PNG
(US9206164, 33)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(C)c1CC(O)=O
Show InChI InChI=1S/C25H28N4O2/c1-15-20(13-23(30)31)16(2)29(28-15)14-17-6-8-18(9-7-17)24-26-21-11-10-19(25(3,4)5)12-22(21)27-24/h6-12H,13-14H2,1-5H3,(H,26,27)(H,30,31)
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 0.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197016
PNG
(US9206164, 80)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(Cl)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22ClFN4O2/c1-3-18-16(11-22(30)31)21(4-2)29(28-18)12-14-6-5-13(9-17(14)25)23-26-19-8-7-15(24)10-20(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 0.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197012
PNG
(US9206164, 76)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(F)c(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H21ClF2N4O2/c1-3-18-14(8-22(31)32)21(4-2)30(29-18)11-13-6-5-12(7-16(13)25)23-27-19-9-15(24)17(26)10-20(19)28-23/h5-7,9-10H,3-4,8,11H2,1-2H3,(H,27,28)(H,31,32)
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 0.600n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197040
PNG
(US9206164, 104)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c(Cl)cc(Cl)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H21Cl2FN4O2/c1-3-18-15(10-21(31)32)20(4-2)30(29-18)11-13-6-5-12(7-17(13)26)23-27-19-9-14(24)8-16(25)22(19)28-23/h5-9H,3-4,10-11H2,1-2H3,(H,27,28)(H,31,32)
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 0.700n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197028
PNG
(US9206164, 92)
Show SMILES COc1ccc2[nH]c(nc2n1)-c1ccc(Cn2nc(C)c(CC(O)=O)c2C)c(F)c1
Show InChI InChI=1S/C21H20FN5O3/c1-11-15(9-19(28)29)12(2)27(26-11)10-14-5-4-13(8-16(14)22)20-23-17-6-7-18(30-3)24-21(17)25-20/h4-8H,9-10H2,1-3H3,(H,28,29)(H,23,24,25)
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 0.700n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196947
PNG
(US9206164, 11)
Show SMILES Cc1nn(Cc2ccc(cc2C(F)(F)F)-c2cc3ccc(cc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C24H19F6N3O2/c1-12-18(10-22(34)35)13(2)33(32-12)11-16-4-3-14(7-19(16)24(28,29)30)20-8-15-5-6-17(23(25,26)27)9-21(15)31-20/h3-9,31H,10-11H2,1-2H3,(H,34,35)
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 0.700n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196940
PNG
(US9206164, 1)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2cc3ccc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H20ClN3O2/c1-13-19(11-22(27)28)14(2)26(25-13)12-15-3-5-16(6-4-15)20-9-17-7-8-18(23)10-21(17)24-20/h3-10,24H,11-12H2,1-2H3,(H,27,28)
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 0.800n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196954
PNG
(US9206164, 18)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc4ccccc4cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C25H22N4O2/c1-15-21(13-24(30)31)16(2)29(28-15)14-17-7-9-18(10-8-17)25-26-22-11-19-5-3-4-6-20(19)12-23(22)27-25/h3-12H,13-14H2,1-2H3,(H,26,27)(H,30,31)
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 0.800n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196945
PNG
(US9206164, 6)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2cc3ccc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H19ClFN3O2/c1-12-18(10-22(28)29)13(2)27(26-12)11-16-4-3-14(7-19(16)24)20-8-15-5-6-17(23)9-21(15)25-20/h3-9,25H,10-11H2,1-2H3,(H,28,29)
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 0.800n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197020
PNG
(US9206164, 84)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c(F)c(F)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H21F3N4O2/c1-3-17-14(10-20(31)32)19(4-2)30(29-17)11-13-6-5-12(9-16(13)25)23-27-18-8-7-15(24)21(26)22(18)28-23/h5-9H,3-4,10-11H2,1-2H3,(H,27,28)(H,31,32)
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 0.800n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197033
PNG
(US9206164, 97)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(C)c1CC(O)=O
Show InChI InChI=1S/C25H27FN4O2/c1-14-19(12-23(31)32)15(2)30(29-14)13-17-7-6-16(10-20(17)26)24-27-21-9-8-18(25(3,4)5)11-22(21)28-24/h6-11H,12-13H2,1-5H3,(H,27,28)(H,31,32)
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 0.900n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197002
PNG
(US9206164, 66)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c(Cl)cc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-16(9-19(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-18-8-15(22)7-17(23)20(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 1n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197011
PNG
(US9206164, 75)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(OC)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H25FN4O3/c1-4-19-17(12-23(30)31)22(5-2)29(28-19)13-15-7-6-14(10-18(15)25)24-26-20-9-8-16(32-3)11-21(20)27-24/h6-11H,4-5,12-13H2,1-3H3,(H,26,27)(H,30,31)
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 1n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197018
PNG
(US9206164, 82)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(F)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22F2N4O2/c1-3-18-16(11-22(30)31)21(4-2)29(28-18)12-14-6-5-13(9-17(14)25)23-26-19-8-7-15(24)10-20(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 1n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196990
PNG
(US9206164, 54)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(C)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H21ClN4O2/c1-12-8-19-20(10-18(12)23)25-22(24-19)16-6-4-15(5-7-16)11-27-14(3)17(9-21(28)29)13(2)26-27/h4-8,10H,9,11H2,1-3H3,(H,24,25)(H,28,29)
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 1.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196986
PNG
(US9206164, 50)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c(F)cc(F)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22F2N4O2/c1-3-18-16(11-21(30)31)20(4-2)29(28-18)12-13-5-7-14(8-6-13)23-26-19-10-15(24)9-17(25)22(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 1.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197037
PNG
(US9206164, 101)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c(F)cc(F)cc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H21F3N4O2/c1-3-18-15(10-21(31)32)20(4-2)30(29-18)11-13-6-5-12(7-16(13)25)23-27-19-9-14(24)8-17(26)22(19)28-23/h5-9H,3-4,10-11H2,1-2H3,(H,27,28)(H,31,32)
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 1.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196979
PNG
(US9206164, 43)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c(F)c(F)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22F2N4O2/c1-3-17-15(11-20(30)31)19(4-2)29(28-17)12-13-5-7-14(8-6-13)23-26-18-10-9-16(24)21(25)22(18)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 1.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196953
PNG
(US9206164, 17 | US9206164, 49)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-15(7-20(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-18-8-16(22)17(23)9-19(18)25-21/h3-6,8-9H,7,10H2,1-2H3,(H,24,25)(H,28,29)
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 1.20n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197010
PNG
(US9206164, 74)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c(F)cccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H22F2N4O2/c1-3-18-15(11-21(30)31)20(4-2)29(28-18)12-14-9-8-13(10-17(14)25)23-26-19-7-5-6-16(24)22(19)27-23/h5-10H,3-4,11-12H2,1-2H3,(H,26,27)(H,30,31)
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 1.20n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196968
PNG
(US9206164, 32)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Br)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H19BrN4O2/c1-12-17(10-20(27)28)13(2)26(25-12)11-14-3-5-15(6-4-14)21-23-18-8-7-16(22)9-19(18)24-21/h3-9H,10-11H2,1-2H3,(H,23,24)(H,27,28)
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 1.20n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196975
PNG
(US9206164, 39)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(OC)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H26N4O3/c1-4-19-18(13-23(29)30)22(5-2)28(27-19)14-15-6-8-16(9-7-15)24-25-20-11-10-17(31-3)12-21(20)26-24/h6-12H,4-5,13-14H2,1-3H3,(H,25,26)(H,29,30)
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 1.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196994
PNG
(US9206164, 58)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(C)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H26N4O2/c1-4-19-18(13-23(29)30)22(5-2)28(27-19)14-16-7-9-17(10-8-16)24-25-20-11-6-15(3)12-21(20)26-24/h6-12H,4-5,13-14H2,1-3H3,(H,25,26)(H,29,30)
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 1.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197019
PNG
(US9206164, 83)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c(C)cccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H25FN4O2/c1-4-19-17(12-22(30)31)21(5-2)29(28-19)13-16-10-9-15(11-18(16)25)24-26-20-8-6-7-14(3)23(20)27-24/h6-11H,4-5,12-13H2,1-3H3,(H,26,27)(H,30,31)
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 1.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196992
PNG
(US9206164, 56)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(F)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H23FN4O2/c1-3-18-17(12-22(29)30)21(4-2)28(27-18)13-14-5-7-15(8-6-14)23-25-19-10-9-16(24)11-20(19)26-23/h5-11H,3-4,12-13H2,1-2H3,(H,25,26)(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197015
PNG
(US9206164, 79)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3nc(OC)ccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H24FN5O3/c1-4-17-15(11-21(30)31)19(5-2)29(28-17)12-14-7-6-13(10-16(14)24)22-25-18-8-9-20(32-3)26-23(18)27-22/h6-10H,4-5,11-12H2,1-3H3,(H,30,31)(H,25,26,27)
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 1.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196957
PNG
(US9206164, 21)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H19F3N4O2/c1-12-17(10-20(30)31)13(2)29(28-12)11-14-3-5-15(6-4-14)21-26-18-8-7-16(22(23,24)25)9-19(18)27-21/h3-9H,10-11H2,1-2H3,(H,26,27)(H,30,31)
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 1.40n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197024
PNG
(US9206164, 88 | US9206164, 98)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C(C)(C)C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C27H31FN4O2/c1-6-21-19(14-25(33)34)24(7-2)32(31-21)15-17-9-8-16(12-20(17)28)26-29-22-11-10-18(27(3,4)5)13-23(22)30-26/h8-13H,6-7,14-15H2,1-5H3,(H,29,30)(H,33,34)
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 1.40n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196993
PNG
(US9206164, 57)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Br)cnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H22BrN5O2/c1-3-17-16(10-20(29)30)19(4-2)28(27-17)12-13-5-7-14(8-6-13)21-25-18-9-15(23)11-24-22(18)26-21/h5-9,11H,3-4,10,12H2,1-2H3,(H,29,30)(H,24,25,26)
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 1.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197030
PNG
(US9206164, 94)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(Br)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18BrFN4O2/c1-11-16(9-20(28)29)12(2)27(26-11)10-14-4-3-13(7-17(14)23)21-24-18-6-5-15(22)8-19(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 1.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196978
PNG
(US9206164, 42)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)cnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H22ClN5O2/c1-3-17-16(10-20(29)30)19(4-2)28(27-17)12-13-5-7-14(8-6-13)21-25-18-9-15(23)11-24-22(18)26-21/h5-9,11H,3-4,10,12H2,1-2H3,(H,29,30)(H,24,25,26)
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 1.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197003
PNG
(US9206164, 67)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c(F)cccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H23FN4O2/c1-3-18-16(12-21(29)30)20(4-2)28(27-18)13-14-8-10-15(11-9-14)23-25-19-7-5-6-17(24)22(19)26-23/h5-11H,3-4,12-13H2,1-2H3,(H,25,26)(H,29,30)
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 1.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197045
PNG
(US9206164, 109)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(C)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H20ClFN4O2/c1-11-6-19-20(9-17(11)23)26-22(25-19)14-4-5-15(18(24)7-14)10-28-13(3)16(8-21(29)30)12(2)27-28/h4-7,9H,8,10H2,1-3H3,(H,25,26)(H,29,30)
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 1.80n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196960
PNG
(US9206164, 24)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H19ClN4O2/c1-12-17(10-20(27)28)13(2)26(25-12)11-14-3-5-15(6-4-14)21-23-18-8-7-16(22)9-19(18)24-21/h3-9H,10-11H2,1-2H3,(H,23,24)(H,27,28)
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 1.90n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197038
PNG
(US9206164, 102)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(F)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H17ClF2N4O2/c1-10-14(6-20(29)30)11(2)28(27-10)9-13-4-3-12(5-16(13)23)21-25-18-7-15(22)17(24)8-19(18)26-21/h3-5,7-8H,6,9H2,1-2H3,(H,25,26)(H,29,30)
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 2.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196987
PNG
(US9206164, 51)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c(C)cccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H26N4O2/c1-4-19-18(13-22(29)30)21(5-2)28(27-19)14-16-9-11-17(12-10-16)24-25-20-8-6-7-15(3)23(20)26-24/h6-12H,4-5,13-14H2,1-3H3,(H,25,26)(H,29,30)
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 2.20n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196989
PNG
(US9206164, 53)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(F)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18ClFN4O2/c1-11-15(7-20(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-18-8-16(22)17(23)9-19(18)25-21/h3-6,8-9H,7,10H2,1-2H3,(H,24,25)(H,28,29)
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 2.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197044
PNG
(US9206164, 108)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(Cl)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18ClFN4O2/c1-11-16(9-20(28)29)12(2)27(26-11)10-14-4-3-13(7-17(14)23)21-24-18-6-5-15(22)8-19(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 2.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196951
PNG
(US9206164, 15)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3ccccc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C23H24N4O2/c1-3-18-17(13-22(28)29)21(4-2)27(26-18)14-15-9-11-16(12-10-15)23-24-19-7-5-6-8-20(19)25-23/h5-12H,3-4,13-14H2,1-2H3,(H,24,25)(H,28,29)
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 2.30n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197009
PNG
(US9206164, 73)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3c(Cl)cc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H17Cl2FN4O2/c1-10-15(8-19(29)30)11(2)28(27-10)9-13-4-3-12(5-17(13)24)21-25-18-7-14(22)6-16(23)20(18)26-21/h3-7H,8-9H2,1-2H3,(H,25,26)(H,29,30)
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 2.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197046
PNG
(US9206164, 111)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H18F4N4O2/c1-11-16(9-20(31)32)12(2)30(29-11)10-14-4-3-13(7-17(14)23)21-27-18-6-5-15(22(24,25)26)8-19(18)28-21/h3-8H,9-10H2,1-2H3,(H,27,28)(H,31,32)
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 2.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197017
PNG
(US9206164, 81)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C#N)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H22FN5O2/c1-3-19-17(11-23(31)32)22(4-2)30(29-19)13-16-7-6-15(10-18(16)25)24-27-20-8-5-14(12-26)9-21(20)28-24/h5-10H,3-4,11,13H2,1-2H3,(H,27,28)(H,31,32)
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 2.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197025
PNG
(US9206164, 89)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(Br)cnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H21BrFN5O2/c1-3-17-15(9-20(30)31)19(4-2)29(28-17)11-13-6-5-12(7-16(13)24)21-26-18-8-14(23)10-25-22(18)27-21/h5-8,10H,3-4,9,11H2,1-2H3,(H,30,31)(H,25,26,27)
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 2.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197000
PNG
(US9206164, 64)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3[nH]c(OC)ccc3[nH]2)c(CC)c1CC(O)=O
PDB

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 3.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196970
PNG
(US9206164, 34)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C#N)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H23N5O2/c1-3-19-18(12-23(30)31)22(4-2)29(28-19)14-15-5-8-17(9-6-15)24-26-20-10-7-16(13-25)11-21(20)27-24/h5-11H,3-4,12,14H2,1-2H3,(H,26,27)(H,30,31)
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 3.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197027
PNG
(US9206164, 91)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(C)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H21FN4O2/c1-12-4-7-19-20(8-12)25-22(24-19)15-5-6-16(18(23)9-15)11-27-14(3)17(10-21(28)29)13(2)26-27/h4-9H,10-11H2,1-3H3,(H,24,25)(H,28,29)
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 3.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196942
PNG
(US9206164, 3)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2cc3cc(Cl)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H20ClN3O2/c1-13-19(11-22(27)28)14(2)26(25-13)12-15-3-5-16(6-4-15)21-10-17-9-18(23)7-8-20(17)24-21/h3-10,24H,11-12H2,1-2H3,(H,27,28)
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 4.20n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196977
PNG
(US9206164, 41)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(C)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H22N4O2/c1-13-4-9-19-20(10-13)24-22(23-19)17-7-5-16(6-8-17)12-26-15(3)18(11-21(27)28)14(2)25-26/h4-10H,11-12H2,1-3H3,(H,23,24)(H,27,28)
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 4.80n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196983
PNG
(US9206164, 47)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c(F)c(F)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18F2N4O2/c1-11-15(9-18(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-17-8-7-16(22)19(23)20(17)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 4.90n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197031
PNG
(US9206164, 95)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cc(Cl)cnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H21ClFN5O2/c1-3-17-15(9-20(30)31)19(4-2)29(28-17)11-13-6-5-12(7-16(13)24)21-26-18-8-14(23)10-25-22(18)27-21/h5-8,10H,3-4,9,11H2,1-2H3,(H,30,31)(H,25,26,27)
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 5.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197041
PNG
(US9206164, 105)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3c(F)c(F)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H17F3N4O2/c1-10-14(8-18(29)30)11(2)28(27-10)9-13-4-3-12(7-16(13)23)21-25-17-6-5-15(22)19(24)20(17)26-21/h3-7H,8-9H2,1-2H3,(H,25,26)(H,29,30)
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 5.10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197013
PNG
(US9206164, 77)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3c(F)cc(F)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H17F3N4O2/c1-10-15(8-19(29)30)11(2)28(27-10)9-13-4-3-12(5-16(13)23)21-25-18-7-14(22)6-17(24)20(18)26-21/h3-7H,8-9H2,1-2H3,(H,25,26)(H,29,30)
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 5.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196972
PNG
(US9206164, 36)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c(F)cc(F)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18F2N4O2/c1-11-16(9-19(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-18-8-15(22)7-17(23)20(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 5.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197032
PNG
(US9206164, 96)
Show SMILES COc1ccc2[nH]c(nc2c1)-c1ccc(Cn2nc(C)c(CC(O)=O)c2C)c(F)c1
Show InChI InChI=1S/C22H21FN4O3/c1-12-17(10-21(28)29)13(2)27(26-12)11-15-5-4-14(8-18(15)23)22-24-19-7-6-16(30-3)9-20(19)25-22/h4-9H,10-11H2,1-3H3,(H,24,25)(H,28,29)
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 5.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197022
PNG
(US9206164, 86)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(F)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18F2N4O2/c1-11-16(9-20(28)29)12(2)27(26-11)10-14-4-3-13(7-17(14)23)21-24-18-6-5-15(22)8-19(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 6.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196974
PNG
(US9206164, 38)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Br)cnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H18BrN5O2/c1-11-16(8-18(27)28)12(2)26(25-11)10-13-3-5-14(6-4-13)19-23-17-7-15(21)9-22-20(17)24-19/h3-7,9H,8,10H2,1-2H3,(H,27,28)(H,22,23,24)
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 7.40n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196995
PNG
(US9206164, 59)
Show SMILES COc1ccc2[nH]c(nc2c1)-c1ccc(Cn2nc(C)c(CC(O)=O)c2C)cc1
Show InChI InChI=1S/C22H22N4O3/c1-13-18(11-21(27)28)14(2)26(25-13)12-15-4-6-16(7-5-15)22-23-19-9-8-17(29-3)10-20(19)24-22/h4-10H,11-12H2,1-3H3,(H,23,24)(H,27,28)
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 7.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197007
PNG
(US9206164, 71)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(F)ccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H19FN4O2/c1-12-17(10-20(27)28)13(2)26(25-12)11-14-3-5-15(6-4-14)21-23-18-8-7-16(22)9-19(18)24-21/h3-9H,10-11H2,1-2H3,(H,23,24)(H,27,28)
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 8.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196988
PNG
(US9206164, 52)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c(F)cccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H19FN4O2/c1-12-16(10-19(27)28)13(2)26(25-12)11-14-6-8-15(9-7-14)21-23-18-5-3-4-17(22)20(18)24-21/h3-9H,10-11H2,1-2H3,(H,23,24)(H,27,28)
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 8.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196980
PNG
(US9206164, 44)
Show SMILES COc1ccc2[nH]c(nc2[nH]1)-c1ccc(Cn2nc(C)c(CC(O)=O)c2C)cc1
PDB

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 9.60n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197035
PNG
(US9206164, 99)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3c(F)cccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18F2N4O2/c1-11-15(9-19(28)29)12(2)27(26-11)10-14-7-6-13(8-17(14)23)21-24-18-5-3-4-16(22)20(18)25-21/h3-8H,9-10H2,1-2H3,(H,24,25)(H,28,29)
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 9.70n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196999
PNG
(US9206164, 63)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c(C)cccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H22N4O2/c1-13-5-4-6-19-21(13)24-22(23-19)17-9-7-16(8-10-17)12-26-15(3)18(11-20(27)28)14(2)25-26/h4-10H,11-12H2,1-3H3,(H,23,24)(H,27,28)
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 10n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196941
PNG
(US9206164, 2)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2cc3cc(ccc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C23H20F3N3O2/c1-13-19(11-22(30)31)14(2)29(28-13)12-15-3-5-16(6-4-15)21-10-17-9-18(23(24,25)26)7-8-20(17)27-21/h3-10,27H,11-12H2,1-2H3,(H,30,31)
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 11.3n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196976
PNG
(US9206164, 40)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)cnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H18ClN5O2/c1-11-16(8-18(27)28)12(2)26(25-11)10-13-3-5-14(6-4-13)19-23-17-7-15(21)9-22-20(17)24-19/h3-7,9H,8,10H2,1-2H3,(H,27,28)(H,22,23,24)
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 12.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197029
PNG
(US9206164, 93)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3c(C)cccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H21FN4O2/c1-12-5-4-6-19-21(12)25-22(24-19)15-7-8-16(18(23)9-15)11-27-14(3)17(10-20(28)29)13(2)26-27/h4-9H,10-11H2,1-3H3,(H,24,25)(H,28,29)
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 12.8n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196984
PNG
(US9206164, 48)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cccnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H23N5O2/c1-3-17-16(12-20(28)29)19(4-2)27(26-17)13-14-7-9-15(10-8-14)21-24-18-6-5-11-23-22(18)25-21/h5-11H,3-4,12-13H2,1-2H3,(H,28,29)(H,23,24,25)
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 12.9n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196950
PNG
(US9206164, 14)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3ccccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H20N4O2/c1-13-17(11-20(26)27)14(2)25(24-13)12-15-7-9-16(10-8-15)21-22-18-5-3-4-6-19(18)23-21/h3-10H,11-12H2,1-2H3,(H,22,23)(H,26,27)
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 13.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196949
PNG
(US9206164, 13)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3cccnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H22FN5O2/c1-3-17-15(11-20(29)30)19(4-2)28(27-17)12-14-8-7-13(10-16(14)23)21-25-18-6-5-9-24-22(18)26-21/h5-10H,3-4,11-12H2,1-2H3,(H,29,30)(H,24,25,26)
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 16.2n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196998
PNG
(US9206164, 62)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C#N)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H19N5O2/c1-13-18(10-21(28)29)14(2)27(26-13)12-15-3-6-17(7-4-15)22-24-19-8-5-16(11-23)9-20(19)25-22/h3-9H,10,12H2,1-2H3,(H,24,25)(H,28,29)
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 18.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197036
PNG
(US9206164, 100)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(Cl)cnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H17ClFN5O2/c1-10-15(7-18(28)29)11(2)27(26-10)9-13-4-3-12(5-16(13)22)19-24-17-6-14(21)8-23-20(17)25-19/h3-6,8H,7,9H2,1-2H3,(H,28,29)(H,23,24,25)
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 18.5n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197014
PNG
(US9206164, 78)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cc(ccc3[nH]2)C#N)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H18FN5O2/c1-12-17(9-21(29)30)13(2)28(27-12)11-16-5-4-15(8-18(16)23)22-25-19-6-3-14(10-24)7-20(19)26-22/h3-8H,9,11H2,1-2H3,(H,25,26)(H,29,30)
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 21.7n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196958
PNG
(US9206164, 22)
Show SMILES Cc1nn(Cc2ccc(-c3nc4ccccc4[nH]3)c(C)c2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H22N4O2/c1-13-10-16(12-26-15(3)18(11-21(27)28)14(2)25-26)8-9-17(13)22-23-19-6-4-5-7-20(19)24-22/h4-10H,11-12H2,1-3H3,(H,23,24)(H,27,28)
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 21.9n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196962
PNG
(US9206164, 26)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3c[nH]cc(C)c3[nH]2)c(CC)c1CC(O)=O
PDB

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 22.6n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196959
PNG
(US9206164, 23)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3[nH]2)c(C2CC2)c1CC(O)=O
Show InChI InChI=1S/C24H22Cl2N4O2/c1-2-19-16(9-22(31)32)23(14-7-8-14)30(29-19)12-13-3-5-15(6-4-13)24-27-20-10-17(25)18(26)11-21(20)28-24/h3-6,10-11,14H,2,7-9,12H2,1H3,(H,27,28)(H,31,32)
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 41.1n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196997
PNG
(US9206164, 61)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3ccncc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H23N5O2/c1-3-17-16(11-21(28)29)20(4-2)27(26-17)13-14-5-7-15(8-6-14)22-24-18-9-10-23-12-19(18)25-22/h5-10,12H,3-4,11,13H2,1-2H3,(H,24,25)(H,28,29)
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 56.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197026
PNG
(US9206164, 90)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3ccncc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C22H22FN5O2/c1-3-17-15(10-21(29)30)20(4-2)28(27-17)12-14-6-5-13(9-16(14)23)22-25-18-7-8-24-11-19(18)26-22/h5-9,11H,3-4,10,12H2,1-2H3,(H,25,26)(H,29,30)
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 60.9n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197005
PNG
(US9206164, 69)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)ccc3n2C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H25ClN4O2/c1-4-19-18(13-23(30)31)21(5-2)29(27-19)14-15-6-8-16(9-7-15)24-26-20-12-17(25)10-11-22(20)28(24)3/h6-12H,4-5,13-14H2,1-3H3,(H,30,31)
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 61.2n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196971
PNG
(US9206164, 35)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3n2C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H24Cl2N4O2/c1-4-19-16(10-23(31)32)21(5-2)30(28-19)13-14-6-8-15(9-7-14)24-27-20-11-17(25)18(26)12-22(20)29(24)3/h6-9,11-12H,4-5,10,13H2,1-3H3,(H,31,32)
PDB

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 66.7n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196973
PNG
(US9206164, 37)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3cncnc3[nH]2)c(CC)c1CC(O)=O
Show InChI InChI=1S/C21H22N6O2/c1-3-16-15(9-19(28)29)18(4-2)27(26-16)11-13-5-7-14(8-6-13)20-24-17-10-22-12-23-21(17)25-20/h5-8,10,12H,3-4,9,11H2,1-2H3,(H,28,29)(H,22,23,24,25)
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 85.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197043
PNG
(US9206164, 107)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cccnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H18FN5O2/c1-11-15(9-18(27)28)12(2)26(25-11)10-14-6-5-13(8-16(14)21)19-23-17-4-3-7-22-20(17)24-19/h3-8H,9-10H2,1-2H3,(H,27,28)(H,22,23,24)
PDB

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 87.4n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197039
PNG
(US9206164, 103)
Show SMILES CCc1nn(Cc2ccc(cc2F)-c2nc3c[nH]cc(C)c3[nH]2)c(CC)c1CC(O)=O
PDB

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 87.6n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197048
PNG
(US9206164, 9)
Show SMILES Cc1nn(Cc2cccc(c2)-c2cc3ccc(cc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C23H20F3N3O2/c1-13-19(11-22(30)31)14(2)29(28-13)12-15-4-3-5-16(8-15)20-9-17-6-7-18(23(24,25)26)10-21(17)27-20/h3-10,27H,11-12H2,1-2H3,(H,30,31)
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 97.8n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196967
PNG
(US9206164, 31)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cccnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H19N5O2/c1-12-16(10-18(26)27)13(2)25(24-12)11-14-5-7-15(8-6-14)19-22-17-4-3-9-21-20(17)23-19/h3-9H,10-11H2,1-2H3,(H,26,27)(H,21,22,23)
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 119n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196953
PNG
(US9206164, 17 | US9206164, 49)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)c(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-15(7-20(28)29)12(2)27(26-11)10-13-3-5-14(6-4-13)21-24-18-8-16(22)17(23)9-19(18)25-21/h3-6,8-9H,7,10H2,1-2H3,(H,24,25)(H,28,29)
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 138n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196948
PNG
(US9206164, 12)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2cc3cccnc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H19FN4O2/c1-12-17(10-20(27)28)13(2)26(25-12)11-16-6-5-14(8-18(16)22)19-9-15-4-3-7-23-21(15)24-19/h3-9H,10-11H2,1-2H3,(H,23,24)(H,27,28)
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 155n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196961
PNG
(US9206164, 25)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3cc(Cl)ccc3n2C)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H21ClN4O2/c1-13-18(11-21(28)29)14(2)27(25-13)12-15-4-6-16(7-5-15)22-24-19-10-17(23)8-9-20(19)26(22)3/h4-10H,11-12H2,1-3H3,(H,28,29)
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 176n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197049
PNG
(US9206164, 110)
Show SMILES Cc1nn(Cc2cccc(c2)-c2nc3cc(ccc3[nH]2)C(F)(F)F)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H19F3N4O2/c1-12-17(10-20(30)31)13(2)29(28-12)11-14-4-3-5-15(8-14)21-26-18-7-6-16(22(23,24)25)9-19(18)27-21/h3-9H,10-11H2,1-2H3,(H,26,27)(H,30,31)
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 287n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196996
PNG
(US9206164, 60)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3ccncc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H19N5O2/c1-12-16(9-19(26)27)13(2)25(24-12)11-14-3-5-15(6-4-14)20-22-17-7-8-21-10-18(17)23-20/h3-8,10H,9,11H2,1-2H3,(H,22,23)(H,26,27)
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 299n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196946
PNG
(US9206164, 10)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2cc3ncccc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H20N4O2/c1-13-17(10-21(26)27)14(2)25(24-13)12-15-5-7-16(8-6-15)19-11-20-18(23-19)4-3-9-22-20/h3-9,11,23H,10,12H2,1-2H3,(H,26,27)
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 308n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196982
PNG
(US9206164, 46)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2nc3ccccc3n2C)c(CC)c1CC(O)=O
Show InChI InChI=1S/C24H26N4O2/c1-4-19-18(14-23(29)30)21(5-2)28(26-19)15-16-10-12-17(13-11-16)24-25-20-8-6-7-9-22(20)27(24)3/h6-13H,4-5,14-15H2,1-3H3,(H,29,30)
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 340n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197050
PNG
(US9206164, 8)
Show SMILES Cc1nn(Cc2ccccc2-c2cc3ccc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H20ClN3O2/c1-13-19(11-22(27)28)14(2)26(25-13)12-16-5-3-4-6-18(16)21-9-15-7-8-17(23)10-20(15)24-21/h3-10,24H,11-12H2,1-2H3,(H,27,28)
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 394n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197047
PNG
(US9206164, 7)
Show SMILES Cc1nn(Cc2cccc(c2)-c2cc3ccc(Cl)cc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H20ClN3O2/c1-13-19(11-22(27)28)14(2)26(25-13)12-15-4-3-5-16(8-15)20-9-17-6-7-18(23)10-21(17)24-20/h3-10,24H,11-12H2,1-2H3,(H,27,28)
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 397n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197006
PNG
(US9206164, 70)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c[nH]cnc3[nH]2)c(C)c1CC(O)=O
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 432n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197008
PNG
(US9206164, 72)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3ccncc3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C20H18FN5O2/c1-11-15(8-19(27)28)12(2)26(25-11)10-14-4-3-13(7-16(14)21)20-23-17-5-6-22-9-18(17)24-20/h3-7,9H,8,10H2,1-2H3,(H,23,24)(H,27,28)
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 636n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196965
PNG
(US9206164, 29)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3c[nH]cc(C)c3[nH]2)c(C)c1CC(O)=O
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 647n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM197021
PNG
(US9206164, 85)
Show SMILES Cc1nn(Cc2ccc(cc2F)-c2nc3cncc(C)c3[nH]2)c(C)c1CC(O)=O
Show InChI InChI=1S/C21H20FN5O2/c1-11-8-23-9-18-20(11)25-21(24-18)14-4-5-15(17(22)6-14)10-27-13(3)16(7-19(28)29)12(2)26-27/h4-6,8-9H,7,10H2,1-3H3,(H,24,25)(H,28,29)
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 683n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM196966
PNG
(US9206164, 30)
Show SMILES Cc1nn(Cc2ccc(cc2)-c2nc3ccccc3n2C)c(C)c1CC(O)=O
Show InChI InChI=1S/C22H22N4O2/c1-14-18(12-21(27)28)15(2)26(24-14)13-16-8-10-17(11-9-16)22-23-19-6-4-5-7-20(19)25(22)3/h4-11H,12-13H2,1-3H3,(H,27,28)
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 753n/an/an/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The CRTH2 receptor binding assay is performed in a scintillation proximity assay (SPA) format with the radioligand [3H]-PGD2 (Perkin Elmer, NET616000...

US Patent US9206164 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TS9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%