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Patent code US9212186

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196826
PNG
(US9212186, 23)
Show SMILES CCNc1nc(Nc2cnn3CC(C)(C)OCc23)ncc1C(F)(F)F
Show InChI InChI=1S/C15H19F3N6O/c1-4-19-12-9(15(16,17)18)5-20-13(23-12)22-10-6-21-24-8-14(2,3)25-7-11(10)24/h5-6H,4,7-8H2,1-3H3,(H2,19,20,22,23)
PDB

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US Patent
 0.300n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196827
PNG
(US9212186, 24)
Show SMILES CNc1nc(Nc2cnn3CCCc23)ncc1C(F)(F)F
Show InChI InChI=1S/C12H13F3N6/c1-16-10-7(12(13,14)15)5-17-11(20-10)19-8-6-18-21-4-2-3-9(8)21/h5-6H,2-4H2,1H3,(H2,16,17,19,20)
PDB

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 0.600n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM50448126
PNG
(CHEMBL3122105 | US9212186, 22)
Show SMILES CNc1nc(Nc2cnn3CC(C)(C)OCc23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-13(2)7-23-10(6-24-13)9(5-20-23)21-12-19-4-8(14(15,16)17)11(18-3)22-12/h4-5H,6-7H2,1-3H3,(H2,18,19,21,22)
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 0.900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196820
PNG
(US9212186, 13 | US9212186, 14)
Show SMILES CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-3-18-12-9(14(15,16)17)6-19-13(22-12)21-10-7-20-23-4-5-24-8(2)11(10)23/h6-8H,3-5H2,1-2H3,(H2,18,19,21,22)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196822
PNG
(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Show SMILES CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-7-6-23-11(8(2)24-7)10(5-20-23)21-13-19-4-9(14(15,16)17)12(18-3)22-13/h4-5,7-8H,6H2,1-3H3,(H2,18,19,21,22)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM50448125
PNG
(CHEMBL3122106 | US9212186, 17)
Show SMILES CNc1nc(Nc2cnn3CCOCc23)ncc1C(F)(F)F
Show InChI InChI=1S/C12H13F3N6O/c1-16-10-7(12(13,14)15)4-17-11(20-10)19-8-5-18-21-2-3-22-6-9(8)21/h4-5H,2-3,6H2,1H3,(H2,16,17,19,20)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196818
PNG
(US9212186, 11 | US9212186, 12)
Show SMILES CNc1nc(Nc2cnn3c2C(C)OCC3(C)C)ncc1C(F)(F)F
Show InChI InChI=1S/C15H19F3N6O/c1-8-11-10(6-21-24(11)14(2,3)7-25-8)22-13-20-5-9(15(16,17)18)12(19-4)23-13/h5-6,8H,7H2,1-4H3,(H2,19,20,22,23)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM50448123
PNG
(CHEMBL3122108 | US9212186, 16)
Show SMILES CNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O/c1-7-10-9(6-19-22(10)3-4-23-7)20-12-18-5-8(13(14,15)16)11(17-2)21-12/h5-7H,3-4H2,1-2H3,(H2,17,18,20,21)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196816
PNG
(US9212186, 9)
Show SMILES C[C@@H]1N(C)CCn2ncc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)c12 |r|
Show InChI InChI=1S/C16H20F3N7/c1-9-13-12(8-21-26(13)6-5-25(9)2)23-15-20-7-11(16(17,18)19)14(24-15)22-10-3-4-10/h7-10H,3-6H2,1-2H3,(H2,20,22,23,24)/t9-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196822
PNG
(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Show SMILES CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-7-6-23-11(8(2)24-7)10(5-20-23)21-13-19-4-9(14(15,16)17)12(18-3)22-13/h4-5,7-8H,6H2,1-3H3,(H2,18,19,21,22)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196810
PNG
(US9212186, 3)
Show SMILES CNc1nc(Nc2cnn3CCCCc23)ncc1C(F)(F)F
Show InChI InChI=1S/C13H15F3N6/c1-17-11-8(13(14,15)16)6-18-12(21-11)20-9-7-19-22-5-3-2-4-10(9)22/h6-7H,2-5H2,1H3,(H2,17,18,20,21)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196814
PNG
(US9212186, 7)
Show SMILES CCNc1nc(Nc2cnn3CCN(C)[C@@H](C)c23)ncc1C(F)(F)F |r|
Show InChI InChI=1S/C15H20F3N7/c1-4-19-13-10(15(16,17)18)7-20-14(23-13)22-11-8-21-25-6-5-24(3)9(2)12(11)25/h7-9H,4-6H2,1-3H3,(H2,19,20,22,23)/t9-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196833
PNG
(US9212186, 30)
Show SMILES CNc1nc(Nc2cc3COCCn3n2)ncc1C(F)(F)F
Show InChI InChI=1S/C12H13F3N6O/c1-16-10-8(12(13,14)15)5-17-11(19-10)18-9-4-7-6-22-3-2-21(7)20-9/h4-5H,2-3,6H2,1H3,(H2,16,17,18,19,20)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196812
PNG
(US9212186, 5)
Show SMILES CNc1nc(Nc2cnn3CCN(C)[C@@H](C)c23)ncc1C(F)(F)F |r|
Show InChI InChI=1S/C14H18F3N7/c1-8-11-10(7-20-24(11)5-4-23(8)3)21-13-19-6-9(14(15,16)17)12(18-2)22-13/h6-8H,4-5H2,1-3H3,(H2,18,19,21,22)/t8-/m0/s1
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US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196828
PNG
(US9212186, 25)
Show SMILES CNc1nc(Nc2cnn3CCN(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C12H14F3N7/c1-16-9-7(12(13,14)15)5-17-11(20-9)19-8-6-18-22-4-3-21(2)10(8)22/h5-6H,3-4H2,1-2H3,(H2,16,17,19,20)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196829
PNG
(US9212186, 26)
Show SMILES CNc1nc(Nc2cnn3CCN(C)Cc23)ncc1C(F)(F)F
Show InChI InChI=1S/C13H16F3N7/c1-17-11-8(13(14,15)16)5-18-12(21-11)20-9-6-19-23-4-3-22(2)7-10(9)23/h5-6H,3-4,7H2,1-2H3,(H2,17,18,20,21)
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US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196817
PNG
(US9212186, 10)
Show SMILES C[C@H]1N(C)CCn2ncc(Nc3ncc(c(NC4CC4)n3)C(F)(F)F)c12 |r|
Show InChI InChI=1S/C16H20F3N7/c1-9-13-12(8-21-26(13)6-5-25(9)2)23-15-20-7-11(16(17,18)19)14(24-15)22-10-3-4-10/h7-10H,3-6H2,1-2H3,(H2,20,22,23,24)/t9-/m1/s1
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196820
PNG
(US9212186, 13 | US9212186, 14)
Show SMILES CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-3-18-12-9(14(15,16)17)6-19-13(22-12)21-10-7-20-23-4-5-24-8(2)11(10)23/h6-8H,3-5H2,1-2H3,(H2,18,19,21,22)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196822
PNG
(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Show SMILES CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-7-6-23-11(8(2)24-7)10(5-20-23)21-13-19-4-9(14(15,16)17)12(18-3)22-13/h4-5,7-8H,6H2,1-3H3,(H2,18,19,21,22)
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196815
PNG
(US9212186, 8)
Show SMILES CCNc1nc(Nc2cnn3CCN(C)[C@H](C)c23)ncc1C(F)(F)F |r|
Show InChI InChI=1S/C15H20F3N7/c1-4-19-13-10(15(16,17)18)7-20-14(23-13)22-11-8-21-25-6-5-24(3)9(2)12(11)25/h7-9H,4-6H2,1-3H3,(H2,19,20,22,23)/t9-/m1/s1
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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196813
PNG
(US9212186, 6)
Show SMILES CNc1nc(Nc2cnn3CCN(C)[C@H](C)c23)ncc1C(F)(F)F |r|
Show InChI InChI=1S/C14H18F3N7/c1-8-11-10(7-20-24(11)5-4-23(8)3)21-13-19-6-9(14(15,16)17)12(18-2)22-13/h6-8H,4-5H2,1-3H3,(H2,18,19,21,22)/t8-/m1/s1
PDB

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Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196818
PNG
(US9212186, 11 | US9212186, 12)
Show SMILES CNc1nc(Nc2cnn3c2C(C)OCC3(C)C)ncc1C(F)(F)F
Show InChI InChI=1S/C15H19F3N6O/c1-8-11-10(6-21-24(11)14(2,3)7-25-8)22-13-20-5-9(15(16,17)18)12(19-4)23-13/h5-6,8H,7H2,1-4H3,(H2,19,20,22,23)
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US Patent
 212n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM50448123
PNG
(CHEMBL3122108 | US9212186, 16)
Show SMILES CNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O/c1-7-10-9(6-19-22(10)3-4-23-7)20-12-18-5-8(13(14,15)16)11(17-2)21-12/h5-7H,3-4H2,1-2H3,(H2,17,18,20,21)
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Similars
US Patent
 279n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196822
PNG
(US9212186, 18 | US9212186, 19 | US9212186, 20 | US...)
Show SMILES CNc1nc(Nc2cnn3CC(C)OC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-7-6-23-11(8(2)24-7)10(5-20-23)21-13-19-4-9(14(15,16)17)12(18-3)22-13/h4-5,7-8H,6H2,1-3H3,(H2,18,19,21,22)
PDB

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UniProtKB/SwissProt

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 390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM196830
PNG
(US9212186, 27)
Show SMILES CNc1nc(Nc2cnn3CCOC4(COC4)c23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6O2/c1-18-11-8(14(15,16)17)4-19-12(22-11)21-9-5-20-23-2-3-25-13(10(9)23)6-24-7-13/h4-5H,2-3,6-7H2,1H3,(H2,18,19,21,22)
PDB

KEGG

UniProtKB/SwissProt

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antibodypedia
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US Patent
 819n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...

US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%