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Patent code US9212187

Compile Data Set for Download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196842
PNG
(US9212187, 48)
Show SMILES Cn1c2ccccc2cc(OCCCN(CCc2cccnc2)Cc2ccncc2)c1=O
Show InChI InChI=1S/C26H28N4O2/c1-29-24-8-3-2-7-23(24)18-25(26(29)31)32-17-5-15-30(20-22-9-13-27-14-10-22)16-11-21-6-4-12-28-19-21/h2-4,6-10,12-14,18-19H,5,11,15-17,20H2,1H3
PDB

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US Patent
n/an/a 300n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196841
PNG
(US9212187, 43)
Show SMILES CCn1c2ccc(OCCCN(CCc3cccnc3)Cc3ccncc3)cc2ccc1=O
Show InChI InChI=1S/C27H30N4O2/c1-2-31-26-8-7-25(19-24(26)6-9-27(31)32)33-18-4-16-30(21-23-10-14-28-15-11-23)17-12-22-5-3-13-29-20-22/h3,5-11,13-15,19-20H,2,4,12,16-18,21H2,1H3
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n/an/a 320n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196836
PNG
(US9212187, 16)
Show SMILES Cn1c2ccc(OCCCCCN(Cc3cccnc3)Cc3cccnc3)cc2ccc1=O
Show InChI InChI=1S/C27H30N4O2/c1-30-26-11-10-25(17-24(26)9-12-27(30)32)33-16-4-2-3-15-31(20-22-7-5-13-28-18-22)21-23-8-6-14-29-19-23/h5-14,17-19H,2-4,15-16,20-21H2,1H3
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n/an/a 510n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196837
PNG
(US9212187, 18)
Show SMILES Cn1c2ccc(OCCCCCN(CCCc3ccccc3)c3cccnc3)cc2ccc1=O
Show InChI InChI=1S/C29H33N3O2/c1-31-28-16-15-27(22-25(28)14-17-29(31)33)34-21-7-3-6-19-32(26-13-8-18-30-23-26)20-9-12-24-10-4-2-5-11-24/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21H2,1H3
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n/an/a 600n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196834
PNG
(US9212187, 10)
Show SMILES CCN1c2ccc(CCCN(CCn3ccc4oc(C)cc4c3=O)Cc3ccncc3)cc2N(C)C(=O)C(C)(C)C1=O
Show InChI InChI=1S/C33H39N5O4/c1-6-38-27-10-9-24(21-28(27)35(5)31(40)33(3,4)32(38)41)8-7-16-36(22-25-11-14-34-15-12-25)18-19-37-17-13-29-26(30(37)39)20-23(2)42-29/h9-15,17,20-21H,6-8,16,18-19,22H2,1-5H3
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n/an/a 620n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196844
PNG
(US9212187, 317)
Show SMILES CCN1c2ccc(CN(CCn3ccc4oc(C)cc4c3=O)Cc3cccnc3COC)cc2N(C)C(=O)C(C)(C)C1=O
Show InChI InChI=1S/C33H39N5O5/c1-7-38-27-11-10-23(18-28(27)35(5)31(40)33(3,4)32(38)41)19-36(20-24-9-8-13-34-26(24)21-42-6)15-16-37-14-12-29-25(30(37)39)17-22(2)43-29/h8-14,17-18H,7,15-16,19-21H2,1-6H3
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n/an/a 630n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196835
PNG
(US9212187, 15)
Show SMILES Cn1c2ccc(OCCCCCN(CCCc3ccccc3)Cc3cccnc3)cc2ccc1=O
Show InChI InChI=1S/C30H35N3O2/c1-32-29-16-15-28(22-27(29)14-17-30(32)34)35-21-7-3-6-19-33(24-26-12-8-18-31-23-26)20-9-13-25-10-4-2-5-11-25/h2,4-5,8,10-12,14-18,22-23H,3,6-7,9,13,19-21,24H2,1H3
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n/an/a 810n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196846
PNG
(US9212187, 330)
Show SMILES CCN1c2ccc(CN(CCc3cccnc3)C(=O)Cc3cn(C)c4ccccc34)cc2N(C)C(=O)C(C)(C)C1=O
Show InChI InChI=1S/C33H37N5O3/c1-6-38-28-14-13-24(18-29(28)36(5)31(40)33(2,3)32(38)41)21-37(17-15-23-10-9-16-34-20-23)30(39)19-25-22-35(4)27-12-8-7-11-26(25)27/h7-14,16,18,20,22H,6,15,17,19,21H2,1-5H3
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n/an/a 860n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196838
PNG
(US9212187, 35)
Show SMILES O=C1NCCc2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc12
Show InChI InChI=1S/C25H28N4O2/c30-25-24-5-4-23(17-22(24)8-13-28-25)31-16-2-14-29(19-21-6-11-26-12-7-21)15-9-20-3-1-10-27-18-20/h1,3-7,10-12,17-18H,2,8-9,13-16,19H2,(H,28,30)
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n/an/a 940n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196843
PNG
(US9212187, 104)
Show SMILES Cn1c2ccc(OCCCCCN(CCc3cccnc3)C(=O)c3cccnc3)cc2ccc1=O
Show InChI InChI=1S/C28H30N4O3/c1-31-26-11-10-25(19-23(26)9-12-27(31)33)35-18-4-2-3-16-32(17-13-22-7-5-14-29-20-22)28(34)24-8-6-15-30-21-24/h5-12,14-15,19-21H,2-4,13,16-18H2,1H3
PDB

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US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196840
PNG
(US9212187, 42)
Show SMILES CN(CCN(CCCOc1ccc2n(C)c(=O)ccc2c1)Cc1ccncc1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H32N4O3/c1-31(29(35)24-7-4-3-5-8-24)18-19-33(22-23-13-15-30-16-14-23)17-6-20-36-26-10-11-27-25(21-26)9-12-28(34)32(27)2/h3-5,7-16,21H,6,17-20,22H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196845
PNG
(US9212187, 318)
Show SMILES CCN1c2ccc(CN(CCn3cc(C)c4occc4c3=O)Cc3cccnc3COC)cc2N(C)C(=O)C(C)(C)C1=O
Show InChI InChI=1S/C33H39N5O5/c1-7-38-27-11-10-23(17-28(27)35(5)31(40)33(3,4)32(38)41)19-36(20-24-9-8-13-34-26(24)21-42-6)14-15-37-18-22(2)29-25(30(37)39)12-16-43-29/h8-13,16-18H,7,14-15,19-21H2,1-6H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM196839
PNG
(US9212187, 41)
Show SMILES Cn1c2ccc(OCCCN(CCc3ccccn3)Cc3ccncc3)cc2ccc1=O
Show InChI InChI=1S/C26H28N4O2/c1-29-25-8-7-24(19-22(25)6-9-26(29)31)32-18-4-16-30(20-21-10-14-27-15-11-21)17-12-23-5-2-3-13-28-23/h2-3,5-11,13-15,19H,4,12,16-18,20H2,1H3
PDB

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n/an/a 6.30E+3n/an/an/an/an/an/a



OTSUKA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
CHO-K1 cell lines stably expressing human Kv1.5 channels were prepared in the following manner.Full-length human Kv1.5 cDNA was cloned from a human h...

US Patent US9212187 (2015)


BindingDB Entry DOI: 10.7270/Q2J101ZW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%