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Patent code US9221797

Compile Data Set for Download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.440n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198873
PNG
(US9221797, 45)
Show SMILES CC1CCCC(=C1C)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(C)(C)N1CCCC1 |c:5|
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198904
PNG
(US9221797, 147)
Show SMILES COCCNCC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198891
PNG
(US9221797, 76)
Show SMILES CC(=O)NCCNC(C)(C)c1ccc(C(=O)NOC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C27H34N6O4/c1-17(34)29-12-13-31-27(4,5)19-6-7-21(22(14-19)18-8-10-26(2,3)11-9-18)24(35)33-37-25(36)23-30-16-20(15-28)32-23/h6-8,14,16,31H,9-13H2,1-5H3,(H,29,34)(H,30,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198878
PNG
(BDBM198879 | US9221797, 62)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198907
PNG
(US9221797, 150)
Show SMILES CC1(C)CCC(=CC1)c1cc(CN2CCN(CCO)CC2)ccc1NC(=O)c1nc(c[nH]1)C#N |c:5|
Show InChI InChI=1S/C26H34N6O2/c1-26(2)7-5-20(6-8-26)22-15-19(18-32-11-9-31(10-12-32)13-14-33)3-4-23(22)30-25(34)24-28-17-21(16-27)29-24/h3-5,15,17,33H,6-14,18H2,1-2H3,(H,28,29)(H,30,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119039
PNG
(CHEMBL3086316 | US8674100, 52 | US9221797, 52)
Show SMILES CN(C)CCOC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)33-14-13-31(5)6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119043
PNG
(CHEMBL3085978 | US8674100, 60 | US9221797, 60)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCN2CCOCC2)ccc1NC(=O)c1ncc([nH]1)C#N |c:5|
Show InChI InChI=1S/C25H31N5O2/c1-25(2)8-5-19(6-9-25)21-15-18(7-10-30-11-13-32-14-12-30)3-4-22(21)29-24(31)23-27-17-20(16-26)28-23/h3-5,15,17H,6-14H2,1-2H3,(H,27,28)(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198908
PNG
(US9221797, 151)
Show SMILES CC1(C)CCC(=CC1)c1cc(CN2CCNCC2)ccc1NC(=O)c1nc(c[nH]1)C#N |c:5|
Show InChI InChI=1S/C24H30N6O/c1-24(2)7-5-18(6-8-24)20-13-17(16-30-11-9-26-10-12-30)3-4-21(20)29-23(31)22-27-15-19(14-25)28-22/h3-5,13,15,26H,6-12,16H2,1-2H3,(H,27,28)(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198878
PNG
(BDBM198879 | US9221797, 62)
Show SMILES CC(C)(N1CCN(CCO)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)34-13-11-33(12-14-34)15-16-35)5-6-24(23)32-26(36)25-30-19-22(18-29)31-25/h5-7,17,19,35H,8-16H2,1-4H3,(H,30,31)(H,32,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198880
PNG
(US9221797, 64)
Show SMILES CC(C)(N1CCN(CC(O)=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:32|
Show InChI InChI=1S/C28H36N6O3/c1-27(2)9-7-19(8-10-27)22-15-20(28(3,4)34-13-11-33(12-14-34)18-24(35)36)5-6-23(22)32-26(37)25-30-17-21(16-29)31-25/h5-7,15,17H,8-14,18H2,1-4H3,(H,30,31)(H,32,37)(H,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198859
PNG
(US9221797, 22)
Show SMILES CC(C)(N1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-33-14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198852
PNG
(US9221797, 15)
Show SMILES CC(C)(N1CCS(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C26H33N5O2S/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-34(33)14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198894
PNG
(US9221797, 80)
Show SMILES CC(C)(OCCN1CCCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
Show InChI InChI=1S/C28H37N5O2/c1-27(2)11-9-20(10-12-27)23-17-21(28(3,4)35-16-15-33-13-5-6-14-33)7-8-24(23)32-26(34)25-30-19-22(18-29)31-25/h7-9,17,19H,5-6,10-16H2,1-4H3,(H,30,31)(H,32,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198861
PNG
(US9221797, 24)
Show SMILES CC(C)(NCCN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)31-11-12-34-13-15-36-16-14-34)5-6-24(23)33-26(35)25-30-19-22(18-29)32-25/h5-7,17,19,31H,8-16H2,1-4H3,(H,30,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198892
PNG
(US9221797, 77)
Show SMILES COCCN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:32|
Show InChI InChI=1S/C29H40N6O2/c1-28(2)10-8-21(9-11-28)24-18-22(29(3,4)35-14-12-34(13-15-35)16-17-37-5)6-7-25(24)33-27(36)26-31-20-23(19-30)32-26/h6-8,18,20H,9-17H2,1-5H3,(H,31,32)(H,33,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198895
PNG
(US9221797, 138)
Show SMILES CSCCNCC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5OS/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-33-5)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198882
PNG
(US9221797, 67)
Show SMILES COCCNCC(=C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:26|
Show InChI InChI=1S/C23H27N5O2/c1-16(14-25-10-11-30-2)18-8-9-21(20(12-18)17-6-4-3-5-7-17)28-23(29)22-26-15-19(13-24)27-22/h6,8-9,12,15,25H,1,3-5,7,10-11,14H2,2H3,(H,26,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198854
PNG
(US9221797, 17)
Show SMILES CSCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C25H33N5OS/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM50443132
PNG
(CHEMBL3086175 | US9221797, 42)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N |t:19|
Show InChI InChI=1S/C23H27N5O2/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(8-9-28-10-12-30-13-11-28)14-20(21)18-4-2-1-3-5-18/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 1.43n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198906
PNG
(US9221797, 149)
Show SMILES CC1CCCC(=C1C)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C(C)(C)N1CCCCC1 |c:5|
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198874
PNG
(US9221797, 47)
Show SMILES COC[C@H](O)Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:24|
Show InChI InChI=1S/C23H28N4O3/c1-23(2)8-6-16(7-9-23)19-11-15(10-18(28)14-30-3)4-5-20(19)27-22(29)21-25-13-17(12-24)26-21/h4-6,11,13,18,28H,7-10,14H2,1-3H3,(H,25,26)(H,27,29)/t18-/m1/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198889
PNG
(US9221797, 74)
Show SMILES CCN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
Show InChI InChI=1S/C28H38N6O/c1-6-33-13-15-34(16-14-33)28(4,5)21-7-8-24(32-26(35)25-30-19-22(18-29)31-25)23(17-21)20-9-11-27(2,3)12-10-20/h7-9,17,19H,6,10-16H2,1-5H3,(H,30,31)(H,32,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198896
PNG
(US9221797, 139)
Show SMILES CC(C)(CNCCS(C)(=O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C26H35N5O3S/c1-25(2)10-8-18(9-11-25)21-14-19(26(3,4)17-28-12-13-35(5,33)34)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16,28H,9-13,17H2,1-5H3,(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198883
PNG
(US9221797, 68)
Show SMILES CNCC(=C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:23|
Show InChI InChI=1S/C21H23N5O/c1-14(12-23-2)16-8-9-19(18(10-16)15-6-4-3-5-7-15)26-21(27)20-24-13-17(11-22)25-20/h6,8-10,13,23H,1,3-5,7,12H2,2H3,(H,24,25)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198847
PNG
(US9221797, 10)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCC(N)=O)ccc1NC(=O)c1nc(c[nH]1)C#N |c:5|
Show InChI InChI=1S/C22H25N5O2/c1-22(2)9-7-15(8-10-22)17-11-14(4-6-19(24)28)3-5-18(17)27-21(29)20-25-13-16(12-23)26-20/h3,5,7,11,13H,4,6,8-10H2,1-2H3,(H2,24,28)(H,25,26)(H,27,29)
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n/an/a 1.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198905
PNG
(US9221797, 148)
Show SMILES CC(N1CC(C)NC(C)C1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198890
PNG
(US9221797, 75)
Show SMILES CC(=O)N1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H36N6O2/c1-19(35)33-12-14-34(15-13-33)28(4,5)21-6-7-24(32-26(36)25-30-18-22(17-29)31-25)23(16-21)20-8-10-27(2,3)11-9-20/h6-8,16,18H,9-15H2,1-5H3,(H,30,31)(H,32,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198858
PNG
(US9221797, 21)
Show SMILES COCCN(C)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-33-6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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n/an/a 1.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198855
PNG
(US9221797, 18)
Show SMILES CC(C)(NCCS(C)(=O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C25H33N5O3S/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-34(5,32)33)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 1.80n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198877
PNG
(US9221797, 61)
Show SMILES CC(C)(OCCN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C28H37N5O3/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)36-16-13-33-11-14-35-15-12-33)5-6-24(23)32-26(34)25-30-19-22(18-29)31-25/h5-7,17,19H,8-16H2,1-4H3,(H,30,31)(H,32,34)
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n/an/a 1.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198893
PNG
(US9221797, 79)
Show SMILES CCOC(=O)CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:34|
Show InChI InChI=1S/C30H40N6O3/c1-6-39-26(37)20-35-13-15-36(16-14-35)30(4,5)22-7-8-25(34-28(38)27-32-19-23(18-31)33-27)24(17-22)21-9-11-29(2,3)12-10-21/h7-9,17,19H,6,10-16,20H2,1-5H3,(H,32,33)(H,34,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198903
PNG
(US9221797, 146)
Show SMILES CC(C)(CN1CCN(CCO)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:32|
Show InChI InChI=1S/C29H40N6O2/c1-28(2)9-7-21(8-10-28)24-17-22(29(3,4)20-35-13-11-34(12-14-35)15-16-36)5-6-25(24)33-27(37)26-31-19-23(18-30)32-26/h5-7,17,19,36H,8-16,20H2,1-4H3,(H,31,32)(H,33,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119041
PNG
(CHEMBL3086172 | US8674100, 54 | US9221797, 54)
Show SMILES CC1(C)CCC(=CC1)c1cc(CC(=O)NCCCO)ccc1NC(=O)c1ncc([nH]1)C#N |c:5|
Show InChI InChI=1S/C24H29N5O3/c1-24(2)8-6-17(7-9-24)19-12-16(13-21(31)26-10-3-11-30)4-5-20(19)29-23(32)22-27-15-18(14-25)28-22/h4-6,12,15,30H,3,7-11,13H2,1-2H3,(H,26,31)(H,27,28)(H,29,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119033
PNG
(US8674100, 46 | US9221797, 46)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(O)C(O)=O |c:5|
Show InChI InChI=1S/C21H22N4O4/c1-21(2)7-5-12(6-8-21)15-9-13(17(26)20(28)29)3-4-16(15)25-19(27)18-23-11-14(10-22)24-18/h3-5,9,11,17,26H,6-8H2,1-2H3,(H,23,24)(H,25,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198868
PNG
(US9221797, 31)
Show SMILES CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:25|
Show InChI InChI=1S/C22H27N5O3S/c1-22(2)9-6-16(7-10-22)18-12-15(8-11-31(29,30)24-3)4-5-19(18)27-21(28)20-25-14-17(13-23)26-20/h4-6,12,14,24H,7-11H2,1-3H3,(H,25,26)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198858
PNG
(US9221797, 21)
Show SMILES COCCN(C)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-33-6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198844
PNG
(US9221797, 7)
Show SMILES NC(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:23|
Show InChI InChI=1S/C20H21N5O2/c21-11-15-12-23-19(24-15)20(27)25-17-8-6-13(7-9-18(22)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H2,22,26)(H,23,24)(H,25,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198866
PNG
(US9221797, 29)
Show SMILES CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:26|
Show InChI InChI=1S/C23H29N5O3S/c1-23(2)10-7-17(8-11-23)19-13-16(9-12-32(30,31)28(3)4)5-6-20(19)27-22(29)21-25-15-18(14-24)26-21/h5-7,13,15H,8-12H2,1-4H3,(H,25,26)(H,27,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198860
PNG
(US9221797, 23)
Show SMILES CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C27H36N6O/c1-26(2)10-8-19(9-11-26)22-16-20(27(3,4)33-14-12-32(5)13-15-33)6-7-23(22)31-25(34)24-29-18-21(17-28)30-24/h6-8,16,18H,9-15H2,1-5H3,(H,29,30)(H,31,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198876
PNG
(US9221797, 53)
Show SMILES CN(C)CCNC(=O)Cc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C25H32N6O2/c1-25(2)9-7-18(8-10-25)20-13-17(14-22(32)27-11-12-31(3)4)5-6-21(20)30-24(33)23-28-16-19(15-26)29-23/h5-7,13,16H,8-12,14H2,1-4H3,(H,27,32)(H,28,29)(H,30,33)
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N |t:22|
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198853
PNG
(US9221797, 16)
Show SMILES CC(C)(N1CCS(=O)(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
Show InChI InChI=1S/C26H33N5O3S/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-35(33,34)14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 3.30n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198902
PNG
(US9221797, 145)
Show SMILES CC(C)(CN1CCS(=O)(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:31|
Show InChI InChI=1S/C27H35N5O3S/c1-26(2)9-7-19(8-10-26)22-15-20(27(3,4)18-32-11-13-36(34,35)14-12-32)5-6-23(22)31-25(33)24-29-17-21(16-28)30-24/h5-7,15,17H,8-14,18H2,1-4H3,(H,29,30)(H,31,33)
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n/an/a 3.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N |t:22|
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N |t:22|
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198881
PNG
(US9221797, 66)
Show SMILES C=C(CN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:28|
Show InChI InChI=1S/C24H27N5O2/c1-17(16-29-9-11-31-12-10-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(30)23-26-15-20(14-25)27-23/h5,7-8,13,15H,1-4,6,9-12,16H2,(H,26,27)(H,28,30)
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n/an/a 3.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198875
PNG
(US9221797, 48)
Show SMILES OC(=O)C=Cc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |w:3.2,t:23|
Show InChI InChI=1S/C20H18N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6-10,12H,1-3,5H2,(H,22,23)(H,24,27)(H,25,26)/b9-7-
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198849
PNG
(US9221797, 12)
Show SMILES CC(=O)OCC(COC(C)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:29|
Show InChI InChI=1S/C24H26N4O5/c1-15(29)32-13-19(14-33-16(2)30)18-8-9-22(21(10-18)17-6-4-3-5-7-17)28-24(31)23-26-12-20(11-25)27-23/h6,8-10,12,19H,3-5,7,13-14H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 4.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198864
PNG
(US9221797, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCS(=O)(=O)N2CCOCC2)ccc1NC(=O)c1nc(c[nH]1)C#N |c:5|
Show InChI InChI=1S/C25H31N5O4S/c1-25(2)8-5-19(6-9-25)21-15-18(7-14-35(32,33)30-10-12-34-13-11-30)3-4-22(21)29-24(31)23-27-17-20(16-26)28-23/h3-5,15,17H,6-14H2,1-2H3,(H,27,28)(H,29,31)
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n/an/a 4.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM50443141
PNG
(CHEMBL3085983 | US9221797, 44)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N |t:18|
Show InChI InChI=1S/C22H25N5O2/c23-13-18-14-24-21(25-18)22(28)26-20-7-6-16(15-27-8-10-29-11-9-27)12-19(20)17-4-2-1-3-5-17/h4,6-7,12,14H,1-3,5,8-11,15H2,(H,24,25)(H,26,28)
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n/an/a 4.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198838
PNG
(US9221797, 1)
Show SMILES CC(C)(NS(C)(=O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:26|
Show InChI InChI=1S/C21H25N5O3S/c1-21(2,26-30(3,28)29)15-9-10-18(17(11-15)14-7-5-4-6-8-14)25-20(27)19-23-13-16(12-22)24-19/h7,9-11,13,26H,4-6,8H2,1-3H3,(H,23,24)(H,25,27)
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n/an/a 4.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198860
PNG
(US9221797, 23)
Show SMILES CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C27H36N6O/c1-26(2)10-8-19(9-11-26)22-16-20(27(3,4)33-14-12-32(5)13-15-33)6-7-23(22)31-25(34)24-29-18-21(17-28)30-24/h6-8,16,18H,9-15H2,1-5H3,(H,29,30)(H,31,34)
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n/an/a 5.10n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198875
PNG
(US9221797, 48)
Show SMILES OC(=O)C=Cc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |w:3.2,t:23|
Show InChI InChI=1S/C20H18N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6-10,12H,1-3,5H2,(H,22,23)(H,24,27)(H,25,26)/b9-7-
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198867
PNG
(US9221797, 30)
Show SMILES CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:25|
Show InChI InChI=1S/C20H23N5O3S/c1-22-29(27,28)10-9-14-7-8-18(17(11-14)15-5-3-2-4-6-15)25-20(26)19-23-13-16(12-21)24-19/h5,7-8,11,13,22H,2-4,6,9-10H2,1H3,(H,23,24)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119039
PNG
(CHEMBL3086316 | US8674100, 52 | US9221797, 52)
Show SMILES CN(C)CCOC(C)(C)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:27|
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)33-14-13-31(5)6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198900
PNG
(US9221797, 143)
Show SMILES CC(=O)N1CCN(CC(C)(C)c2ccc(NC(=O)c3nc(c[nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)CC1 |t:29|
Show InChI InChI=1S/C29H38N6O2/c1-20(36)35-14-12-34(13-15-35)19-29(4,5)22-6-7-25(33-27(37)26-31-18-23(17-30)32-26)24(16-22)21-8-10-28(2,3)11-9-21/h6-8,16,18H,9-15,19H2,1-5H3,(H,31,32)(H,33,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198845
PNG
(US9221797, 8)
Show SMILES OC(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:23|
Show InChI InChI=1S/C20H20N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H,22,23)(H,24,27)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198840
PNG
(US9221797, 3)
Show SMILES CC(=O)NC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:25|
Show InChI InChI=1S/C22H25N5O2/c1-14(28)27-22(2,3)16-9-10-19(18(11-16)15-7-5-4-6-8-15)26-21(29)20-24-13-17(12-23)25-20/h7,9-11,13H,4-6,8H2,1-3H3,(H,24,25)(H,26,29)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198856
PNG
(US9221797, 19)
Show SMILES CN(CCS(C)(=O)=O)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C26H35N5O3S/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-35(6,33)34)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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n/an/a 7.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198862
PNG
(US9221797, 25)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)S(=O)(=O)Cc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:31|
Show InChI InChI=1S/C24H30N6O3S/c1-16-13-30(14-17(2)27-16)34(32,33)15-18-8-9-22(21(10-18)19-6-4-3-5-7-19)29-24(31)23-26-12-20(11-25)28-23/h6,8-10,12,16-17,27H,3-5,7,13-15H2,1-2H3,(H,26,28)(H,29,31)/t16-,17+
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n/an/a 7.74n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198899
PNG
(US9221797, 142)
Show SMILES CC(C)(CN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C27H35N5O2/c1-26(2)9-7-19(8-10-26)22-15-20(27(3,4)18-32-11-13-34-14-12-32)5-6-23(22)31-25(33)24-29-17-21(16-28)30-24/h5-7,15,17H,8-14,18H2,1-4H3,(H,29,30)(H,31,33)
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n/an/a 8n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198850
PNG
(US9221797, 13)
Show SMILES CC(C)(C(O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:24|
Show InChI InChI=1S/C21H22N4O3/c1-21(2,20(27)28)14-8-9-17(16(10-14)13-6-4-3-5-7-13)25-19(26)18-23-12-15(11-22)24-18/h6,8-10,12H,3-5,7H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 8n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198872
PNG
(US9221797, 41)
Show SMILES Clc1cnc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:26|
Show InChI InChI=1S/C22H27ClN4O2/c23-20-15-24-21(26-20)22(28)25-19-7-6-16(8-9-27-10-12-29-13-11-27)14-18(19)17-4-2-1-3-5-17/h4,6-7,14-15H,1-3,5,8-13H2,(H,24,26)(H,25,28)
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n/an/a 8.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198843
PNG
(US9221797, 6)
Show SMILES CC(C)(NC(=O)C(N)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:27|
Show InChI InChI=1S/C22H24N6O3/c1-22(2,28-20(30)18(24)29)14-8-9-17(16(10-14)13-6-4-3-5-7-13)27-21(31)19-25-12-15(11-23)26-19/h6,8-10,12H,3-5,7H2,1-2H3,(H2,24,29)(H,25,26)(H,27,31)(H,28,30)
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n/an/a 8.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198888
PNG
(US9221797, 73)
Show SMILES Cc1cccc(NC(C)(C)c2ccc(NC(=O)c3nc(c[nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)n1 |t:28|
Show InChI InChI=1S/C28H32N6O/c1-18-7-6-8-24(31-18)34-28(4,5)20-9-10-23(33-26(35)25-30-17-21(16-29)32-25)22(15-20)19-11-13-27(2,3)14-12-19/h6-11,15,17H,12-14H2,1-5H3,(H,30,32)(H,31,34)(H,33,35)
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n/an/a 8.80n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198851
PNG
(US9221797, 14)
Show SMILES CC(C)(N1CCSCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:28|
Show InChI InChI=1S/C26H33N5OS/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-33-14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 9.30n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198865
PNG
(US9221797, 28)
Show SMILES CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:26|
Show InChI InChI=1S/C21H25N5O3S/c1-26(2)30(28,29)11-10-15-8-9-19(18(12-15)16-6-4-3-5-7-16)25-21(27)20-23-14-17(13-22)24-20/h6,8-9,12,14H,3-5,7,10-11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/a 9.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198841
PNG
(US9221797, 4)
Show SMILES CC(C)(NC(N)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:25|
Show InChI InChI=1S/C21H24N6O2/c1-21(2,27-20(23)29)14-8-9-17(16(10-14)13-6-4-3-5-7-13)26-19(28)18-24-12-15(11-22)25-18/h6,8-10,12H,3-5,7H2,1-2H3,(H,24,25)(H,26,28)(H3,23,27,29)
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n/an/a 12.4n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198869
PNG
(US9221797, 32)
Show SMILES O=C(Nc1ccc(CS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N |t:21|
Show InChI InChI=1S/C22H25N5O4S/c23-13-18-14-24-21(25-18)22(28)26-20-7-6-16(12-19(20)17-4-2-1-3-5-17)15-32(29,30)27-8-10-31-11-9-27/h4,6-7,12,14H,1-3,5,8-11,15H2,(H,24,25)(H,26,28)
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n/an/a 12.8n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198898
PNG
(US9221797, 141)
Show SMILES CC(C)(CN1CC(O)C(O)C1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
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n/an/a 18n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198887
PNG
(US9221797, 72)
Show SMILES CC(C)(Nc1ccccn1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C27H30N6O/c1-26(2)12-10-18(11-13-26)21-15-19(27(3,4)33-23-7-5-6-14-29-23)8-9-22(21)32-25(34)24-30-17-20(16-28)31-24/h5-10,14-15,17H,11-13H2,1-4H3,(H,29,33)(H,30,31)(H,32,34)
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n/an/a 19n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119036
PNG
(US8674100, 49 | US9221797, 49)
Show SMILES CC1(C)CCC(=CC1)c1nc(CC(O)=O)ccc1NC(=O)c1ncc([nH]1)C#N |c:5|
Show InChI InChI=1S/C20H21N5O3/c1-20(2)7-5-12(6-8-20)17-15(4-3-13(23-17)9-16(26)27)25-19(28)18-22-11-14(10-21)24-18/h3-5,11H,6-9H2,1-2H3,(H,22,24)(H,25,28)(H,26,27)
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n/an/a 26n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119028
PNG
(US8674100, 40 | US9221797, 40)
Show SMILES Brc1cnc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:26|
Show InChI InChI=1S/C22H27BrN4O2/c23-20-15-24-21(26-20)22(28)25-19-7-6-16(8-9-27-10-12-29-13-11-27)14-18(19)17-4-2-1-3-5-17/h4,6-7,14-15H,1-3,5,8-13H2,(H,24,26)(H,25,28)
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n/an/a 27.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198842
PNG
(US9221797, 5)
Show SMILES CC(C)(NC(=O)NCCO)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:28|
Show InChI InChI=1S/C23H28N6O3/c1-23(2,29-22(32)25-10-11-30)16-8-9-19(18(12-16)15-6-4-3-5-7-15)28-21(31)20-26-14-17(13-24)27-20/h6,8-9,12,14,30H,3-5,7,10-11H2,1-2H3,(H,26,27)(H,28,31)(H2,25,29,32)
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n/an/a 31.7n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198839
PNG
(US9221797, 2)
Show SMILES CC(=C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:21|
Show InChI InChI=1S/C20H20N4O/c1-13(2)15-8-9-18(17(10-15)14-6-4-3-5-7-14)24-20(25)19-22-12-16(11-21)23-19/h6,8-10,12H,1,3-5,7H2,2H3,(H,22,23)(H,24,25)
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n/an/a 32.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198886
PNG
(US9221797, 71)
Show SMILES CC(=O)SC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:25|
Show InChI InChI=1S/C24H28N4O2S/c1-15(29)31-24(4,5)17-6-7-20(28-22(30)21-26-14-18(13-25)27-21)19(12-17)16-8-10-23(2,3)11-9-16/h6-8,12,14H,9-11H2,1-5H3,(H,26,27)(H,28,30)
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n/an/a 33n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198901
PNG
(US9221797, 144)
Show SMILES CC(C)(CN1CCSCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:29|
Show InChI InChI=1S/C27H35N5OS/c1-26(2)9-7-19(8-10-26)22-15-20(27(3,4)18-32-11-13-34-14-12-32)5-6-23(22)31-25(33)24-29-17-21(16-28)30-24/h5-7,15,17H,8-14,18H2,1-4H3,(H,29,30)(H,31,33)
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n/an/a 36n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119038
PNG
(US8674100, 51 | US9221797, 51)
Show SMILES CC1(C)CCC(=CC1)c1nc(CC(O)=O)ccc1NC(=O)c1cc(c[nH]1)C#N |c:5|
Show InChI InChI=1S/C21H22N4O3/c1-21(2)7-5-14(6-8-21)19-16(4-3-15(24-19)10-18(26)27)25-20(28)17-9-13(11-22)12-23-17/h3-5,9,12,23H,6-8,10H2,1-2H3,(H,25,28)(H,26,27)
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n/an/a 36.2n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119042
PNG
(US8674100, 55 | US9221797, 55)
Show SMILES CCN(C)CCCc1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCC(C)CC1
Show InChI InChI=1S/C24H32N4O2/c1-4-27(3)13-5-6-19-7-9-21(22(16-19)28-14-11-18(2)12-15-28)26-24(29)23-10-8-20(17-25)30-23/h7-10,16,18H,4-6,11-15H2,1-3H3,(H,26,29)
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n/an/a 50n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119037
PNG
(US8674100, 50 | US9221797, 50)
Show SMILES CCOC(=O)Cc1ccc(NC(=O)c2cc(c[nH]2)C#N)c(n1)C1=CCC(C)(C)CC1 |t:24|
Show InChI InChI=1S/C23H26N4O3/c1-4-30-20(28)12-17-5-6-18(27-22(29)19-11-15(13-24)14-25-19)21(26-17)16-7-9-23(2,3)10-8-16/h5-7,11,14,25H,4,8-10,12H2,1-3H3,(H,27,29)
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n/an/a 60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119027
PNG
(US8674100, 39 | US9221797, 39)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1nc2ccccc2[nH]1 |t:19|
Show InChI InChI=1S/C26H30N4O2/c31-26(25-27-23-8-4-5-9-24(23)28-25)29-22-11-10-19(12-13-30-14-16-32-17-15-30)18-21(22)20-6-2-1-3-7-20/h4-6,8-11,18H,1-3,7,12-17H2,(H,27,28)(H,29,31)
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n/an/a>60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198848
PNG
(US9221797, 11)
Show SMILES OCC(CO)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:23|
Show InChI InChI=1S/C20H22N4O3/c21-9-16-10-22-19(23-16)20(27)24-18-7-6-14(15(11-25)12-26)8-17(18)13-4-2-1-3-5-13/h4,6-8,10,15,25-26H,1-3,5,11-12H2,(H,22,23)(H,24,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198870
PNG
(US9221797, 33)
Show SMILES Cc1nc([nH]c1C#N)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:28|
Show InChI InChI=1S/C24H29N5O2/c1-17-22(16-25)27-23(26-17)24(30)28-21-8-7-18(9-10-29-11-13-31-14-12-29)15-20(21)19-5-3-2-4-6-19/h5,7-8,15H,2-4,6,9-14H2,1H3,(H,26,27)(H,28,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119026
PNG
(US8674100, 38 | US9221797, 38)
Show SMILES Clc1nc([nH]c1Cl)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:27|
Show InChI InChI=1S/C22H26Cl2N4O2/c23-19-20(24)27-21(26-19)22(29)25-18-7-6-15(8-9-28-10-12-30-13-11-28)14-17(18)16-4-2-1-3-5-16/h4,6-7,14H,1-3,5,8-13H2,(H,25,29)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198846
PNG
(US9221797, 9)
Show SMILES NC(=O)c1c[nH]c(n1)C(=O)Nc1ccc(CCC(O)=O)cc1C1=CCCCC1 |t:24|
Show InChI InChI=1S/C20H22N4O4/c21-18(27)16-11-22-19(23-16)20(28)24-15-8-6-12(7-9-17(25)26)10-14(15)13-4-2-1-3-5-13/h4,6,8,10-11H,1-3,5,7,9H2,(H2,21,27)(H,22,23)(H,24,28)(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198897
PNG
(US9221797, 140)
Show SMILES CC(C)(CN1CC2OC(C)(C)OC2C1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:34|
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198885
PNG
(US9221797, 70)
Show SMILES COc1ccc(CSC(C)(C)c2ccc(NC(=O)c3nc(c[nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)cc1 |t:29|
Show InChI InChI=1S/C30H34N4O2S/c1-29(2)14-12-21(13-15-29)25-16-22(30(3,4)37-19-20-6-9-24(36-5)10-7-20)8-11-26(25)34-28(35)27-32-18-23(17-31)33-27/h6-12,16,18H,13-15,19H2,1-5H3,(H,32,33)(H,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198871
PNG
(US9221797, 37)
Show SMILES Cc1c[nH]c(n1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:26|
Show InChI InChI=1S/C23H30N4O2/c1-17-16-24-22(25-17)23(28)26-21-8-7-18(9-10-27-11-13-29-14-12-27)15-20(21)19-5-3-2-4-6-19/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,25)(H,26,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119022
PNG
(US8674100, 34 | US9221797, 34)
Show SMILES CSc1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:27|
Show InChI InChI=1S/C23H30N4O2S/c1-30-23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-29-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119024
PNG
(US8674100, 36 | US9221797, 36)
Show SMILES CS(=O)(=O)c1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:29|
Show InChI InChI=1S/C23H30N4O4S/c1-32(29,30)23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-31-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM119023
PNG
(US8674100, 35 | US9221797, 35)
Show SMILES CS(=O)c1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1 |t:28|
Show InChI InChI=1S/C23H30N4O3S/c1-31(29)23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-30-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%