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Patent code US9227956

Compile Data Set for Download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200316
PNG
(US9227956, 1)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12 |r|
Show InChI InChI=1S/C24H24N6O/c1-17-5-2-12-26-22(17)30(20-6-3-11-25-15-20)24(31)19-9-7-18(8-10-19)21-16-28-29-14-4-13-27-23(21)29/h2,4-5,7-10,12-14,16,20,25H,3,6,11,15H2,1H3/t20-/m1/s1
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n/an/a 440n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200332
PNG
(US9227956, 16)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12 |r|
Show InChI InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1
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n/an/a 520n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
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n/an/a 592n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200325
PNG
(US9227956, 10)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H24ClN5O3/c1-28-20(23(31)32-2)18(14-27-28)15-7-9-16(10-8-15)22(30)29(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3/t17-/m1/s1
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n/an/a 640n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200317
PNG
(US9227956, 2)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12 |r|
Show InChI InChI=1S/C23H21ClN6O/c24-20-5-2-11-27-22(20)30(18-4-1-10-25-14-18)23(31)17-8-6-16(7-9-17)19-15-28-29-13-3-12-26-21(19)29/h2-3,5-9,11-13,15,18,25H,1,4,10,14H2/t18-/m1/s1
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n/an/a 690n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200332
PNG
(US9227956, 16)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12 |r|
Show InChI InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200328
PNG
(US9227956, 13)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200318
PNG
(US9227956, 3)
Show SMILES Cc1cnc2n(nnc2c1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H22ClN7O/c1-15-12-20-22(27-13-15)31(29-28-20)17-8-6-16(7-9-17)23(32)30(18-4-2-10-25-14-18)21-19(24)5-3-11-26-21/h3,5-9,11-13,18,25H,2,4,10,14H2,1H3/t18-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200325
PNG
(US9227956, 10)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H24ClN5O3/c1-28-20(23(31)32-2)18(14-27-28)15-7-9-16(10-8-15)22(30)29(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3/t17-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200320
PNG
(US9227956, 5)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cn1)-n1nnc2cccnc12 |r|
Show InChI InChI=1S/C21H19ClN8O/c22-16-5-2-10-24-19(16)29(14-4-1-9-23-12-14)21(31)18-8-7-15(13-26-18)30-20-17(27-28-30)6-3-11-25-20/h2-3,5-8,10-11,13-14,23H,1,4,9,12H2/t14-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200321
PNG
(US9227956, 6)
Show SMILES CCOC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C24H26ClN5O3/c1-3-33-24(32)21-19(15-28-29(21)2)16-8-10-17(11-9-16)23(31)30(18-6-4-12-26-14-18)22-20(25)7-5-13-27-22/h5,7-11,13,15,18,26H,3-4,6,12,14H2,1-2H3/t18-/m1/s1
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200327
PNG
(US9227956, 12)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r|
Show InChI InChI=1S/C25H26N6O3/c1-29-13-10-17-9-12-27-23(21(17)29)31(19-4-3-11-26-14-19)24(32)18-7-5-16(6-8-18)20-15-28-30(2)22(20)25(33)34/h5-10,12-13,15,19,26H,3-4,11,14H2,1-2H3,(H,33,34)/t19-/m1/s1
PDB

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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200321
PNG
(US9227956, 6)
Show SMILES CCOC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C24H26ClN5O3/c1-3-33-24(32)21-19(15-28-29(21)2)16-8-10-17(11-9-16)23(31)30(18-6-4-12-26-14-18)22-20(25)7-5-13-27-22/h5,7-11,13,15,18,26H,3-4,6,12,14H2,1-2H3/t18-/m1/s1
PDB

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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200317
PNG
(US9227956, 2)
Show SMILES Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12 |r|
Show InChI InChI=1S/C23H21ClN6O/c24-20-5-2-11-27-22(20)30(18-4-1-10-25-14-18)23(31)17-8-6-16(7-9-17)19-15-28-29-13-3-12-26-21(19)29/h2-3,5-9,11-13,15,18,25H,1,4,10,14H2/t18-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200324
PNG
(US9227956, 9)
Show SMILES Cc1cnc2n(nnc2c1)-c1ccc(nc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C22H21ClN8O/c1-14-10-19-21(27-11-14)31(29-28-19)16-6-7-18(26-13-16)22(32)30(15-4-2-8-24-12-15)20-17(23)5-3-9-25-20/h3,5-7,9-11,13,15,24H,2,4,8,12H2,1H3/t15-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200326
PNG
(US9227956, 11)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12 |r|
Show InChI InChI=1S/C31H33N5O6/c1-4-40-31(39)42-20(2)41-30(38)27-26(19-34-35(27)3)22-11-13-23(14-12-22)29(37)36(24-9-7-16-32-18-24)28-25-10-6-5-8-21(25)15-17-33-28/h5-6,8,10-15,17,19-20,24,32H,4,7,9,16,18H2,1-3H3/t20?,24-/m1/s1
PDB

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n/an/a 2.10E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
PDB

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n/an/a 2.19E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200328
PNG
(US9227956, 13)
Show SMILES COC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C24H27N5O3/c1-16-6-4-13-26-22(16)29(19-7-5-12-25-14-19)23(30)18-10-8-17(9-11-18)20-15-27-28(2)21(20)24(31)32-3/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3/t19-/m1/s1
PDB

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n/an/a 2.30E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200341
PNG
(US9227956, 25)
Show SMILES Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C22H23ClN6O3/c1-28-19(21(30)27-32)17(13-26-28)14-6-8-15(9-7-14)22(31)29(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24,32H,2,4,10,12H2,1H3,(H,27,30)/t16-/m1/s1
PDB

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n/an/a 2.97E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200333
PNG
(US9227956, 17)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1nn[nH]n1 |r|
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 3.05E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200330
PNG
(US9227956, 15a)
Show SMILES CCOC(=O)O[C@@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20+/m0/s1
PDB

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US Patent
n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200316
PNG
(US9227956, 1)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn2cccnc12 |r|
Show InChI InChI=1S/C24H24N6O/c1-17-5-2-12-26-22(17)30(20-6-3-11-25-15-20)24(31)19-9-7-18(8-10-19)21-16-28-29-14-4-13-27-23(21)29/h2,4-5,7-10,12-14,16,20,25H,3,6,11,15H2,1H3/t20-/m1/s1
PDB

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US Patent
n/an/a 3.20E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
PDB

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n/an/a 3.56E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200323
PNG
(US9227956, 8)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17?,20-/m1/s1
PDB

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US Patent
n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200319
PNG
(US9227956, 4)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12 |r|
Show InChI InChI=1S/C26H25N5O3/c1-30-23(26(33)34)22(16-29-30)18-8-10-19(11-9-18)25(32)31(20-6-4-13-27-15-20)24-21-7-3-2-5-17(21)12-14-28-24/h2-3,5,7-12,14,16,20,27H,4,6,13,15H2,1H3,(H,33,34)/t20-/m1/s1
PDB

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n/an/a 3.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

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n/an/a 4.39E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200329
PNG
(US9227956, 14)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r|
Show InChI InChI=1S/C30H34N6O6/c1-5-40-30(39)42-19(2)41-29(38)26-24(18-33-35(26)4)20-8-10-22(11-9-20)28(37)36(23-7-6-14-31-17-23)27-25-21(12-15-32-27)13-16-34(25)3/h8-13,15-16,18-19,23,31H,5-7,14,17H2,1-4H3/t19?,23-/m1/s1
PDB

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n/an/a 4.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200362
PNG
(US9227956, 46 | US9227956, 47)
Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
PDB

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n/an/a 4.67E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200331
PNG
(US9227956, 15b)
Show SMILES CCOC(=O)O[C@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20-/m1/s1
PDB

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n/an/a 5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/m1/s1
PDB

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n/an/a 5.22E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200352
PNG
(US9227956, 36 | US9227956, 37)
Show SMILES CCOC(=O)OC(n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)C(C)(C)C |r|
Show InChI InChI=1S/C31H39N9O4/c1-7-43-30(42)44-29(31(3,4)5)40-36-26(35-37-40)25-24(19-34-38(25)6)21-12-14-22(15-13-21)28(41)39(23-11-9-16-32-18-23)27-20(2)10-8-17-33-27/h8,10,12-15,17,19,23,29,32H,7,9,11,16,18H2,1-6H3/t23-,29?/m1/s1
PDB

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n/an/a 5.43E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200334
PNG
(US9227956, 18)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1noc(=O)[nH]1 |r|
PDB

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n/an/a 5.61E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200342
PNG
(US9227956, 26)
Show SMILES Cn1ncc(c1-c1nn[nH]n1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
PDB

UniProtKB/SwissProt

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n/an/a 5.75E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200338
PNG
(US9227956, 22)
Show SMILES Cn1ncc(c1C(=O)NS(=O)(=O)C(F)(F)F)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H22ClF3N6O4S/c1-32-19(21(34)31-38(36,37)23(25,26)27)17(13-30-32)14-6-8-15(9-7-14)22(35)33(16-4-2-10-28-12-16)20-18(24)5-3-11-29-20/h3,5-9,11,13,16,28H,2,4,10,12H2,1H3,(H,31,34)/t16-/m1/s1
PDB

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n/an/a 5.80E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/m1/s1
PDB

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n/an/a 6.20E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200348
PNG
(US9227956, 32 | US9227956, 33)
Show SMILES CCOC(=O)OC(CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-5-24(42-29(40)41-6-2)38-34-26(33-35-38)25-23(18-32-36(25)4)20-11-13-21(14-12-20)28(39)37(22-10-8-15-30-17-22)27-19(3)9-7-16-31-27/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
PDB

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n/an/a 7.26E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200330
PNG
(US9227956, 15a)
Show SMILES CCOC(=O)O[C@@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20+/m0/s1
PDB

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n/an/a 7.30E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200358
PNG
(US9227956, 42 | US9227956, 43)
Show SMILES CC(C)OC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O4/c1-19(2)30(44-31(42)43-20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

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n/an/a 7.38E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200364
PNG
(US9227956, 48 | US9227956, 49)
Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1
PDB

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n/an/a 7.68E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 8.03E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200323
PNG
(US9227956, 8)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17?,20-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
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n/an/a 9.50E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200331
PNG
(US9227956, 15b)
Show SMILES CCOC(=O)O[C@H](C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C27H30ClN5O6/c1-4-37-27(36)39-17(2)38-26(35)23-21(16-31-32(23)3)18-9-11-19(12-10-18)25(34)33(20-7-5-13-29-15-20)24-22(28)8-6-14-30-24/h6,8-12,14,16-17,20,29H,4-5,7,13,15H2,1-3H3/t17-,20-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.07E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200368
PNG
(US9227956, 52 | US9227956, 53)
Show SMILES CCC(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(42-30(41)19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 1.07E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200326
PNG
(US9227956, 11)
Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12 |r|
Show InChI InChI=1S/C31H33N5O6/c1-4-40-31(39)42-20(2)41-30(38)27-26(19-34-35(27)3)22-11-13-23(14-12-22)29(37)36(24-9-7-16-32-18-24)28-25-10-6-5-8-21(25)15-17-33-28/h5-6,8,10-15,17,19-20,24,32H,4,7,9,16,18H2,1-3H3/t20?,24-/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 1.17E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
PDB

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n/an/a 1.18E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200370
PNG
(US9227956, 54 | US9227956, 55)
Show SMILES CC(C)C(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O3/c1-19(2)30(43-31(42)20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

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n/an/a 1.28E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200343
PNG
(US9227956, 27)
Show SMILES Cn1ncc(c1C(=O)NS(C)(=O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H25ClN6O4S/c1-29-20(22(31)28-35(2,33)34)18(14-27-29)15-7-9-16(10-8-15)23(32)30(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3,(H,28,31)/t17-/m1/s1
PDB

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n/an/a 1.43E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200356
PNG
(US9227956, 40 | US9227956, 41)
Show SMILES CCC(OC(=O)OC(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-25(43-30(41)42-19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

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n/an/a 1.54E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200364
PNG
(US9227956, 48 | US9227956, 49)
Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 1.54E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200346
PNG
(US9227956, 30)
Show SMILES CCOC(=O)O[C@@H](C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O4/c1-5-40-28(39)41-19(3)37-33-25(32-34-37)24-23(17-31-35(24)4)20-10-12-21(13-11-20)27(38)36(22-9-7-14-29-16-22)26-18(2)8-6-15-30-26/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19-,22+/m0/s1
PDB

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n/an/a>1.67E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200344
PNG
(US9227956, 28)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1S/C24H28N6O4S/c1-16-6-4-13-26-22(16)30(19-7-5-12-25-14-19)24(32)18-10-8-17(9-11-18)20-15-27-29(2)21(20)23(31)28-35(3,33)34/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3,(H,28,31)/t19-/m1/s1
PDB

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n/an/a 1.68E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200322
PNG
(US9227956, 7)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C22H22ClN5O3/c1-27-19(22(30)31)17(13-26-27)14-6-8-15(9-7-14)21(29)28(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24H,2,4,10,12H2,1H3,(H,30,31)/t16-/m1/s1
PDB

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n/an/a 1.80E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200356
PNG
(US9227956, 40 | US9227956, 41)
Show SMILES CCC(OC(=O)OC(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-25(43-30(41)42-19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 1.82E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200370
PNG
(US9227956, 54 | US9227956, 55)
Show SMILES CC(C)C(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O3/c1-19(2)30(43-31(42)20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

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n/an/a>1.92E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200354
PNG
(US9227956, 38 | US9227956, 39)
Show SMILES CC(C)OC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-18(2)41-29(40)42-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
PDB

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n/an/a>1.94E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200356
PNG
(US9227956, 40 | US9227956, 41)
Show SMILES CCC(OC(=O)OC(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-25(43-30(41)42-19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a>1.94E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200370
PNG
(US9227956, 54 | US9227956, 55)
Show SMILES CC(C)C(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O3/c1-19(2)30(43-31(42)20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

UniProtKB/SwissProt

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n/an/a 1.98E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200348
PNG
(US9227956, 32 | US9227956, 33)
Show SMILES CCOC(=O)OC(CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-5-24(42-29(40)41-6-2)38-34-26(33-35-38)25-23(18-32-36(25)4)20-11-13-21(14-12-20)28(39)37(22-10-8-15-30-17-22)27-19(3)9-7-16-31-27/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200358
PNG
(US9227956, 42 | US9227956, 43)
Show SMILES CC(C)OC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O4/c1-19(2)30(44-31(42)43-20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200362
PNG
(US9227956, 46 | US9227956, 47)
Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200368
PNG
(US9227956, 52 | US9227956, 53)
Show SMILES CCC(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(42-30(41)19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200368
PNG
(US9227956, 52 | US9227956, 53)
Show SMILES CCC(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(42-30(41)19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200370
PNG
(US9227956, 54 | US9227956, 55)
Show SMILES CC(C)C(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O3/c1-19(2)30(43-31(42)20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200340
PNG
(US9227956, 24)
Show SMILES Cn1ncc(c1C(=O)Nc1nnn[nH]1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200341
PNG
(US9227956, 25)
Show SMILES Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C22H23ClN6O3/c1-28-19(21(30)27-32)17(13-26-28)14-6-8-15(9-7-14)22(31)29(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24,32H,2,4,10,12H2,1H3,(H,27,30)/t16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200348
PNG
(US9227956, 32 | US9227956, 33)
Show SMILES CCOC(=O)OC(CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-5-24(42-29(40)41-6-2)38-34-26(33-35-38)25-23(18-32-36(25)4)20-11-13-21(14-12-20)28(39)37(22-10-8-15-30-17-22)27-19(3)9-7-16-31-27/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200356
PNG
(US9227956, 40 | US9227956, 41)
Show SMILES CCC(OC(=O)OC(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-25(43-30(41)42-19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200343
PNG
(US9227956, 27)
Show SMILES Cn1ncc(c1C(=O)NS(C)(=O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H25ClN6O4S/c1-29-20(22(31)28-35(2,33)34)18(14-27-29)15-7-9-16(10-8-15)23(32)30(17-5-3-11-25-13-17)21-19(24)6-4-12-26-21/h4,6-10,12,14,17,25H,3,5,11,13H2,1-2H3,(H,28,31)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200345
PNG
(US9227956, 29)
Show SMILES CCOC(=O)OC(C)N(C(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)S(C)(=O)=O |r|
Show InChI InChI=1S/C29H36N6O7S/c1-6-41-29(38)42-20(3)35(43(5,39)40)28(37)25-24(18-32-33(25)4)21-11-13-22(14-12-21)27(36)34(23-10-8-15-30-17-23)26-19(2)9-7-16-31-26/h7,9,11-14,16,18,20,23,30H,6,8,10,15,17H2,1-5H3/t20?,23-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200352
PNG
(US9227956, 36 | US9227956, 37)
Show SMILES CCOC(=O)OC(n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)C(C)(C)C |r|
Show InChI InChI=1S/C31H39N9O4/c1-7-43-30(42)44-29(31(3,4)5)40-36-26(35-37-40)25-24(19-34-38(25)6)21-12-14-22(15-13-21)28(41)39(23-11-9-16-32-18-23)27-20(2)10-8-17-33-27/h8,10,12-15,17,19,23,29,32H,7,9,11,16,18H2,1-6H3/t23-,29?/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200364
PNG
(US9227956, 48 | US9227956, 49)
Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200352
PNG
(US9227956, 36 | US9227956, 37)
Show SMILES CCOC(=O)OC(n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)C(C)(C)C |r|
Show InChI InChI=1S/C31H39N9O4/c1-7-43-30(42)44-29(31(3,4)5)40-36-26(35-37-40)25-24(19-34-38(25)6)21-12-14-22(15-13-21)28(41)39(23-11-9-16-32-18-23)27-20(2)10-8-17-33-27/h8,10,12-15,17,19,23,29,32H,7,9,11,16,18H2,1-6H3/t23-,29?/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200333
PNG
(US9227956, 17)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1nn[nH]n1 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200319
PNG
(US9227956, 4)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccccc12 |r|
Show InChI InChI=1S/C26H25N5O3/c1-30-23(26(33)34)22(16-29-30)18-8-10-19(11-9-18)25(32)31(20-6-4-13-27-15-20)24-21-7-3-2-5-17(21)12-14-28-24/h2-3,5,7-12,14,16,20,27H,4,6,13,15H2,1H3,(H,33,34)/t20-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200358
PNG
(US9227956, 42 | US9227956, 43)
Show SMILES CC(C)OC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O4/c1-19(2)30(44-31(42)43-20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200350
PNG
(US9227956, 34 | US9227956, 35)
Show SMILES CCOC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O4/c1-6-42-30(41)43-29(19(2)3)39-35-26(34-36-39)25-24(18-33-37(25)5)21-11-13-22(14-12-21)28(40)38(23-10-8-15-31-17-23)27-20(4)9-7-16-32-27/h7,9,11-14,16,18-19,23,29,31H,6,8,10,15,17H2,1-5H3/t23-,29?/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200342
PNG
(US9227956, 26)
Show SMILES Cn1ncc(c1-c1nn[nH]n1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
PDB

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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200337
PNG
(US9227956, 21)
Show SMILES CCOC(=O)OC(C)n1nnnc1-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r,wD:28.30,(7.91,-7.27,;6.58,-6.5,;5.25,-7.27,;3.91,-6.5,;3.91,-4.96,;2.58,-7.27,;1.25,-6.5,;-.09,-7.27,;1.25,-4.96,;2.49,-4.06,;2.02,-2.59,;.48,-2.59,;,-4.06,;-1.33,-4.83,;-2.58,-3.92,;-3.83,-4.83,;-3.35,-6.29,;-1.81,-6.29,;-1.04,-7.63,;-2.58,-2.38,;-3.91,-1.61,;-3.91,-.07,;-2.58,.7,;-1.25,-.07,;-1.25,-1.61,;-2.58,2.24,;-1.25,3.01,;-3.91,3.01,;-5.25,2.24,;-5.25,.7,;-6.58,-.07,;-7.91,.7,;-7.91,2.24,;-6.58,3.01,;-3.91,4.55,;-5.25,5.32,;-5.25,6.86,;-3.91,7.63,;-2.58,6.86,;-2.58,5.32,;-1.25,4.55,)|
Show InChI InChI=1S/C28H33N9O4/c1-5-40-28(39)41-19(3)37-26(32-33-34-37)24-23(17-31-35(24)4)20-10-12-21(13-11-20)27(38)36(22-9-7-14-29-16-22)25-18(2)8-6-15-30-25/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200322
PNG
(US9227956, 7)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C22H22ClN5O3/c1-27-19(22(30)31)17(13-26-27)14-6-8-15(9-7-14)21(29)28(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24H,2,4,10,12H2,1H3,(H,30,31)/t16-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200366
PNG
(US9227956, 50 | US9227956, 51)
Show SMILES CC(C)C(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-18(2)29(40)41-20(4)38-34-26(33-35-38)25-24(17-32-36(25)5)21-10-12-22(13-11-21)28(39)37(23-9-7-14-30-16-23)27-19(3)8-6-15-31-27/h6,8,10-13,15,17-18,20,23,30H,7,9,14,16H2,1-5H3/t20?,23-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200364
PNG
(US9227956, 48 | US9227956, 49)
Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200327
PNG
(US9227956, 12)
Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r|
Show InChI InChI=1S/C25H26N6O3/c1-29-13-10-17-9-12-27-23(21(17)29)31(19-4-3-11-26-14-19)24(32)18-7-5-16(6-8-18)20-15-28-30(2)22(20)25(33)34/h5-10,12-13,15,19,26H,3-4,11,14H2,1-2H3,(H,33,34)/t19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200347
PNG
(US9227956, 31)
Show SMILES CCOC(=O)O[C@H](C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O4/c1-5-40-28(39)41-19(3)37-33-25(32-34-37)24-23(17-31-35(24)4)20-10-12-21(13-11-20)27(38)36(22-9-7-14-29-16-22)26-18(2)8-6-15-30-26/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19-,22-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200362
PNG
(US9227956, 46 | US9227956, 47)
Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200344
PNG
(US9227956, 28)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1C(=O)NS(C)(=O)=O |r|
Show InChI InChI=1S/C24H28N6O4S/c1-16-6-4-13-26-22(16)30(19-7-5-12-25-14-19)24(32)18-10-8-17(9-11-18)20-15-27-29(2)21(20)23(31)28-35(3,33)34/h4,6,8-11,13,15,19,25H,5,7,12,14H2,1-3H3,(H,28,31)/t19-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200338
PNG
(US9227956, 22)
Show SMILES Cn1ncc(c1C(=O)NS(=O)(=O)C(F)(F)F)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
Show InChI InChI=1S/C23H22ClF3N6O4S/c1-32-19(21(34)31-38(36,37)23(25,26)27)17(13-30-32)14-6-8-15(9-7-14)22(35)33(16-4-2-10-28-12-16)20-18(24)5-3-11-29-20/h3,5-9,11,13,16,28H,2,4,10,12H2,1H3,(H,31,34)/t16-/m1/s1
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200334
PNG
(US9227956, 18)
Show SMILES Cc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-c1cnn(C)c1-c1noc(=O)[nH]1 |r|
PDB

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Pfizer Inc.

US Patent


Assay Description
An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200352
PNG
(US9227956, 36 | US9227956, 37)
Show SMILES CCOC(=O)OC(n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C)C(C)(C)C |r|
Show InChI InChI=1S/C31H39N9O4/c1-7-43-30(42)44-29(31(3,4)5)40-36-26(35-37-40)25-24(19-34-38(25)6)21-12-14-22(15-13-21)28(41)39(23-11-9-16-32-18-23)27-20(2)10-8-17-33-27/h8,10,12-15,17,19,23,29,32H,7,9,11,16,18H2,1-6H3/t23-,29?/m1/s1
PDB

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n/an/a 2.29E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200348
PNG
(US9227956, 32 | US9227956, 33)
Show SMILES CCOC(=O)OC(CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O4/c1-5-24(42-29(40)41-6-2)38-34-26(33-35-38)25-23(18-32-36(25)4)20-11-13-21(14-12-20)28(39)37(22-10-8-15-30-17-22)27-19(3)9-7-16-31-27/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
PDB

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n/an/a 2.37E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200360
PNG
(US9227956, 44 | US9227956, 45)
Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.51E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200340
PNG
(US9227956, 24)
Show SMILES Cn1ncc(c1C(=O)Nc1nnn[nH]1)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.53E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200368
PNG
(US9227956, 52 | US9227956, 53)
Show SMILES CCC(OC(=O)C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C30H37N9O3/c1-6-25(42-30(41)19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(40)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,25,31H,6,8,10,15,17H2,1-5H3/t23-,25?/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.18E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200358
PNG
(US9227956, 42 | US9227956, 43)
Show SMILES CC(C)OC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C31H39N9O4/c1-19(2)30(44-31(42)43-20(3)4)40-36-27(35-37-40)26-25(18-34-38(26)6)22-11-13-23(14-12-22)29(41)39(24-10-8-15-32-17-24)28-21(5)9-7-16-33-28/h7,9,11-14,16,18-20,24,30,32H,8,10,15,17H2,1-6H3/t24-,30?/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.19E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM200362
PNG
(US9227956, 46 | US9227956, 47)
Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r|
Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.34E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...

US Patent US9227956 (2016)


BindingDB Entry DOI: 10.7270/Q20R9N7M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%