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Patent code US9233111

Compile Data Set for Download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200783
PNG
(US9233111, 17)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2)C2CC2)c1CO |c:8|
Show InChI InChI=1S/C31H32N6O3/c1-36(2)31(40)37-14-12-21(13-15-37)27-16-24-28(32-18-33-29(24)34-27)23-4-3-5-26(25(23)17-38)35-30(39)22-10-8-20(9-11-22)19-6-7-19/h3-5,8-12,16,18-19,38H,6-7,13-15,17H2,1-2H3,(H,35,39)(H,32,33,34)
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n/an/a 1n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200756
PNG
(US9233111, 1)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C2(F)CC2)c1C |c:8|
Show InChI InChI=1S/C31H30F2N6O2/c1-18-23(14-22(32)15-25(18)37-29(40)20-4-6-21(7-5-20)31(33)10-11-31)27-24-16-26(36-28(24)35-17-34-27)19-8-12-39(13-9-19)30(41)38(2)3/h4-8,14-17H,9-13H2,1-3H3,(H,37,40)(H,34,35,36)
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n/an/a 1n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200888
PNG
(US9233111, 63)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1ccc(F)c(NC(=O)N2CC(C2)OC(C)(C)C)c1C |c:8|
Show InChI InChI=1S/C29H36FN7O3/c1-17-20(7-8-22(30)24(17)34-27(38)37-14-19(15-37)40-29(2,3)4)25-21-13-23(33-26(21)32-16-31-25)18-9-11-36(12-10-18)28(39)35(5)6/h7-9,13,16,19H,10-12,14-15H2,1-6H3,(H,34,38)(H,31,32,33)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200778
PNG
(US9233111, 16)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2F)C(C)(C)O)c1CO |c:8|
Show InChI InChI=1S/C31H33FN6O4/c1-31(2,42)19-8-9-21(24(32)14-19)29(40)36-25-7-5-6-20(23(25)16-39)27-22-15-26(35-28(22)34-17-33-27)18-10-12-38(13-11-18)30(41)37(3)4/h5-10,14-15,17,39,42H,11-13,16H2,1-4H3,(H,36,40)(H,33,34,35)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200802
PNG
(US9233111, 25)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCS(=O)CC1 |t:34|
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200887
PNG
(US9233111, 62)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1ccc(F)c(NC(=O)N2CC(C2)OC(C)(C)C)c1 |c:8|
Show InChI InChI=1S/C28H34FN7O3/c1-28(2,3)39-19-14-36(15-19)26(37)33-23-12-18(6-7-21(23)29)24-20-13-22(32-25(20)31-16-30-24)17-8-10-35(11-9-17)27(38)34(4)5/h6-8,12-13,16,19H,9-11,14-15H2,1-5H3,(H,33,37)(H,30,31,32)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200768
PNG
(US9233111, 6)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)(C)CO)c1C |c:8|
Show InChI InChI=1S/C32H35FN6O3/c1-19-24(14-23(33)15-26(19)37-30(41)21-6-8-22(9-7-21)32(2,3)17-40)28-25-16-27(36-29(25)35-18-34-28)20-10-12-39(13-11-20)31(42)38(4)5/h6-10,14-16,18,40H,11-13,17H2,1-5H3,(H,37,41)(H,34,35,36)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200766
PNG
(US9233111, 4)
Show SMILES CC(C)N(C)c1ccc(cc1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:35|
Show InChI InChI=1S/C32H36FN7O2/c1-19(2)39(6)24-9-7-22(8-10-24)31(41)37-27-16-23(33)15-25(20(27)3)29-26-17-28(36-30(26)35-18-34-29)21-11-13-40(14-12-21)32(42)38(4)5/h7-11,15-19H,12-14H2,1-6H3,(H,37,41)(H,34,35,36)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200860
PNG
(US9233111, 47)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(N2CCc3cc(ccc3C2=O)C(C)(C)O)c1CO |c:8|
Show InChI InChI=1S/C33H36N6O4/c1-33(2,43)22-8-9-23-21(16-22)12-15-39(31(23)41)28-7-5-6-24(26(28)18-40)29-25-17-27(36-30(25)35-19-34-29)20-10-13-38(14-11-20)32(42)37(3)4/h5-10,16-17,19,40,43H,11-15,18H2,1-4H3,(H,34,35,36)
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200881
PNG
(US9233111, 56)
Show SMILES CN(C)C1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2)C(C)(C)C)c1CO |c:6|
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n/an/a 2n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200884
PNG
(US9233111, 59)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)N2Cc3ccc(F)cc3C2)c1C |c:8|
Show InChI InChI=1S/C30H29F2N7O2/c1-17-23(11-22(32)12-25(17)36-29(40)39-14-19-4-5-21(31)10-20(19)15-39)27-24-13-26(35-28(24)34-16-33-27)18-6-8-38(9-7-18)30(41)37(2)3/h4-6,10-13,16H,7-9,14-15H2,1-3H3,(H,36,40)(H,33,34,35)
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n/an/a 3n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200767
PNG
(US9233111, 5)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc3c(C)c[nH]c3c2)c1C |c:8|
Show InChI InChI=1S/C31H30FN7O2/c1-17-15-33-27-11-20(5-6-22(17)27)30(40)37-25-13-21(32)12-23(18(25)2)28-24-14-26(36-29(24)35-16-34-28)19-7-9-39(10-8-19)31(41)38(3)4/h5-7,11-16,33H,8-10H2,1-4H3,(H,37,40)(H,34,35,36)
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n/an/a 3n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200769
PNG
(US9233111, 7)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)N2CCCCC2)c1C |c:8|
Show InChI InChI=1S/C33H36FN7O2/c1-21-26(17-24(34)18-28(21)38-32(42)23-7-9-25(10-8-23)40-13-5-4-6-14-40)30-27-19-29(37-31(27)36-20-35-30)22-11-15-41(16-12-22)33(43)39(2)3/h7-11,17-20H,4-6,12-16H2,1-3H3,(H,38,42)(H,35,36,37)
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n/an/a 3n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200817
PNG
(US9233111, 31)
Show SMILES CC(=O)OCC(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C2CC2)c1C |c:10|
Show InChI InChI=1S/C32H30FN5O4/c1-18-25(13-24(33)14-27(18)37-32(41)23-7-5-21(6-8-23)20-3-4-20)30-26-15-28(36-31(26)35-17-34-30)22-9-11-38(12-10-22)29(40)16-42-19(2)39/h5-9,13-15,17,20H,3-4,10-12,16H2,1-2H3,(H,37,41)(H,34,35,36)
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n/an/a 3n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200770
PNG
(US9233111, 8)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)=C)c1C |c:8|
Show InChI InChI=1S/C31H31FN6O2/c1-18(2)20-6-8-22(9-7-20)30(39)36-26-15-23(32)14-24(19(26)3)28-25-16-27(35-29(25)34-17-33-28)21-10-12-38(13-11-21)31(40)37(4)5/h6-10,14-17H,1,11-13H2,2-5H3,(H,36,39)(H,33,34,35)
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n/an/a 3n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200825
PNG
(US9233111, 36)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO |t:36|
Show InChI InChI=1S/C27H23F6N5O3S/c1-15-20(10-18(28)11-22(15)37-27(41)17-2-4-19(5-3-17)42(29,30,31,32)33)25-21-12-23(36-26(21)35-14-34-25)16-6-8-38(9-7-16)24(40)13-39/h2-6,10-12,14,39H,7-9,13H2,1H3,(H,37,41)(H,34,35,36)
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200878
PNG
(US9233111, 55)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1CO)-c1ncnc2[nH]c(cc12)C1=CCC(O)CC1 |t:34|
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200775
PNG
(US9233111, 13)
Show SMILES COC(C)(C)c1ccc(cc1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:35|
Show InChI InChI=1S/C32H35FN6O3/c1-19-24(15-23(33)16-26(19)37-30(40)21-7-9-22(10-8-21)32(2,3)42-6)28-25-17-27(36-29(25)35-18-34-28)20-11-13-39(14-12-20)31(41)38(4)5/h7-11,15-18H,12-14H2,1-6H3,(H,37,40)(H,34,35,36)
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200774
PNG
(US9233111, 12)
Show SMILES COCC(C)(C)c1ccc(cc1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:36|
Show InChI InChI=1S/C33H37FN6O3/c1-20-25(15-24(34)16-27(20)38-31(41)22-7-9-23(10-8-22)33(2,3)18-43-6)29-26-17-28(37-30(26)36-19-35-29)21-11-13-40(14-12-21)32(42)39(4)5/h7-11,15-17,19H,12-14,18H2,1-6H3,(H,38,41)(H,35,36,37)
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200764
PNG
(US9233111, 2)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc3c(OCC3(C)C)c2)c1C |c:8|
Show InChI InChI=1S/C32H33FN6O3/c1-18-22(13-21(33)14-25(18)37-30(40)20-6-7-24-27(12-20)42-16-32(24,2)3)28-23-15-26(36-29(23)35-17-34-28)19-8-10-39(11-9-19)31(41)38(4)5/h6-8,12-15,17H,9-11,16H2,1-5H3,(H,37,40)(H,34,35,36)
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200819
PNG
(US9233111, 33)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C2CC2)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CC#N |t:34|
Show InChI InChI=1S/C31H27FN6O2/c1-18-24(14-23(32)15-26(18)37-31(40)22-6-4-20(5-7-22)19-2-3-19)29-25-16-27(36-30(25)35-17-34-29)21-9-12-38(13-10-21)28(39)8-11-33/h4-7,9,14-17,19H,2-3,8,10,12-13H2,1H3,(H,37,40)(H,34,35,36)
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n/an/a 4n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200773
PNG
(US9233111, 11)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)c1C |c:8|
Show InChI InChI=1S/C28H26F6N6O2S/c1-16-21(12-19(29)13-23(16)38-27(41)18-4-6-20(7-5-18)43(30,31,32,33)34)25-22-14-24(37-26(22)36-15-35-25)17-8-10-40(11-9-17)28(42)39(2)3/h4-8,12-15H,9-11H2,1-3H3,(H,38,41)(H,35,36,37)
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n/an/a 5n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200765
PNG
(US9233111, 3)
Show SMILES CC1CCc2sc(cc2C1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:35|
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n/an/a 5n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200771
PNG
(US9233111, 9)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C2(CC2)C(F)(F)F)c1C |c:8|
Show InChI InChI=1S/C32H30F4N6O2/c1-18-23(27-24-16-26(39-28(24)38-17-37-27)19-8-12-42(13-9-19)30(44)41(2)3)14-22(33)15-25(18)40-29(43)20-4-6-21(7-5-20)31(10-11-31)32(34,35)36/h4-8,14-17H,9-13H2,1-3H3,(H,40,43)(H,37,38,39)
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n/an/a 5n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200816
PNG
(US9233111, 30)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C2CC2)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N1CCCC1 |t:34|
Show InChI InChI=1S/C33H33FN6O2/c1-20-26(16-25(34)17-28(20)38-32(41)24-8-6-22(7-9-24)21-4-5-21)30-27-18-29(37-31(27)36-19-35-30)23-10-14-40(15-11-23)33(42)39-12-2-3-13-39/h6-10,16-19,21H,2-5,11-15H2,1H3,(H,38,41)(H,35,36,37)
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n/an/a 6n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200784
PNG
(US9233111, 18)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)(O)C(F)(F)F)c1C |c:8|
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n/an/a 6n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200789
PNG
(US9233111, 21)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1ccc(F)c(NC(=O)c2ccc(cc2)C(C)(C)CO)c1 |c:8|
Show InChI InChI=1S/C31H33FN6O3/c1-31(2,17-39)22-8-5-20(6-9-22)29(40)36-26-15-21(7-10-24(26)32)27-23-16-25(35-28(23)34-18-33-27)19-11-13-38(14-12-19)30(41)37(3)4/h5-11,15-16,18,39H,12-14,17H2,1-4H3,(H,36,40)(H,33,34,35)
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n/an/a 6n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200786
PNG
(US9233111, 20)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1ccc(F)c(NC(=O)c2ccc(cc2)C2CC2)c1 |c:8|
Show InChI InChI=1S/C30H29FN6O2/c1-36(2)30(39)37-13-11-20(12-14-37)25-16-23-27(32-17-33-28(23)34-25)22-9-10-24(31)26(15-22)35-29(38)21-7-5-19(6-8-21)18-3-4-18/h5-11,15-18H,3-4,12-14H2,1-2H3,(H,35,38)(H,32,33,34)
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n/an/a 6n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200886
PNG
(US9233111, 61)
Show SMILES Cc1c(NC(=O)N2CC(C2)OC(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:33|
Show InChI InChI=1S/C26H30FN5O3/c1-15-19(23-20-11-22(16-5-7-34-8-6-16)30-24(20)29-14-28-23)9-17(27)10-21(15)31-25(33)32-12-18(13-32)35-26(2,3)4/h5,9-11,14,18H,6-8,12-13H2,1-4H3,(H,31,33)(H,28,29,30)
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n/an/a 6n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200818
PNG
(US9233111, 32)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C2CC2)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO |t:34|
Show InChI InChI=1S/C30H28FN5O3/c1-17-23(12-22(31)13-25(17)35-30(39)21-6-4-19(5-7-21)18-2-3-18)28-24-14-26(34-29(24)33-16-32-28)20-8-10-36(11-9-20)27(38)15-37/h4-8,12-14,16,18,37H,2-3,9-11,15H2,1H3,(H,35,39)(H,32,33,34)
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n/an/a 7n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200882
PNG
(US9233111, 57)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)N2CC(C2)OC(C)(C)C)c1C |c:8|
Show InChI InChI=1S/C29H36FN7O3/c1-17-21(11-19(30)12-23(17)34-27(38)37-14-20(15-37)40-29(2,3)4)25-22-13-24(33-26(22)32-16-31-25)18-7-9-36(10-8-18)28(39)35(5)6/h7,11-13,16,20H,8-10,14-15H2,1-6H3,(H,34,38)(H,31,32,33)
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n/an/a 7n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200866
PNG
(US9233111, 48)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1CO)-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:34|
Show InChI InChI=1S/C29H30N4O3/c1-29(2,3)20-9-7-19(8-10-20)28(35)33-24-6-4-5-21(23(24)16-34)26-22-15-25(18-11-13-36-14-12-18)32-27(22)31-17-30-26/h4-11,15,17,34H,12-14,16H2,1-3H3,(H,33,35)(H,30,31,32)
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n/an/a 7n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200901
PNG
(US9233111, 67)
Show SMILES CN(C)C1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C |c:6|
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n/an/a 8n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200790
PNG
(US9233111, 22)
Show SMILES Cc1c(NC(=O)c2ccc(cc2F)C(C)(C)O)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:35|
Show InChI InChI=1S/C28H26F2N4O3/c1-15-20(25-21-13-24(16-6-8-37-9-7-16)33-26(21)32-14-31-25)11-18(29)12-23(15)34-27(35)19-5-4-17(10-22(19)30)28(2,3)36/h4-6,10-14,36H,7-9H2,1-3H3,(H,34,35)(H,31,32,33)
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n/an/a 8n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200885
PNG
(US9233111, 60)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)N2CC(C2)OC(C(F)(F)F)C(F)(F)F)c1C |c:8|
Show InChI InChI=1S/C28H28F7N7O3/c1-14-18(22-19-10-21(38-23(19)37-13-36-22)15-4-6-41(7-5-15)26(44)40(2)3)8-16(29)9-20(14)39-25(43)42-11-17(12-42)45-24(27(30,31)32)28(33,34)35/h4,8-10,13,17,24H,5-7,11-12H2,1-3H3,(H,39,43)(H,36,37,38)
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n/an/a 8n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200854
PNG
(US9233111, 45)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(N2CCc3cc(ccc3C2=O)C(C)(C)C)c1CO |c:8|
Show InChI InChI=1S/C34H38N6O3/c1-34(2,3)23-9-10-24-22(17-23)13-16-40(32(24)42)29-8-6-7-25(27(29)19-41)30-26-18-28(37-31(26)36-20-35-30)21-11-14-39(15-12-21)33(43)38(4)5/h6-11,17-18,20,41H,12-16,19H2,1-5H3,(H,35,36,37)
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n/an/a 8n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200897
PNG
(US9233111, 65)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCC2(CC1)OCCO2 |t:33|
Show InChI InChI=1S/C32H34N4O3/c1-20-24(6-5-7-26(20)36-30(37)22-8-10-23(11-9-22)31(2,3)4)28-25-18-27(35-29(25)34-19-33-28)21-12-14-32(15-13-21)38-16-17-39-32/h5-12,18-19H,13-17H2,1-4H3,(H,36,37)(H,33,34,35)
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n/an/a 9n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200898
PNG
(US9233111, 66)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCC(O)CC1 |t:33|
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US Patent
n/an/a 12n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200794
PNG
(US9233111, 23)
Show SMILES CC(C)(O)c1ccc(C(=O)Nc2cccc(c2CO)-c2ncnc3[nH]c(cc23)C2=CCOCC2)c(F)c1 |t:31|
Show InChI InChI=1S/C28H27FN4O4/c1-28(2,36)17-6-7-19(22(29)12-17)27(35)33-23-5-3-4-18(21(23)14-34)25-20-13-24(16-8-10-37-11-9-16)32-26(20)31-15-30-25/h3-8,12-13,15,34,36H,9-11,14H2,1-2H3,(H,33,35)(H,30,31,32)
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n/an/a 12n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200811
PNG
(US9233111, 29)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C2CC2)c1C |c:8|
Show InChI InChI=1S/C31H31FN6O2/c1-18-24(14-23(32)15-26(18)36-30(39)22-8-6-20(7-9-22)19-4-5-19)28-25-16-27(35-29(25)34-17-33-28)21-10-12-38(13-11-21)31(40)37(2)3/h6-10,14-17,19H,4-5,11-13H2,1-3H3,(H,36,39)(H,33,34,35)
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n/an/a 13n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200838
PNG
(US9233111, 39)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2F)C(C)(C)O)c1C |c:8|
Show InChI InChI=1S/C31H32F2N6O3/c1-17-22(13-20(32)14-25(17)37-29(40)21-7-6-19(12-24(21)33)31(2,3)42)27-23-15-26(36-28(23)35-16-34-27)18-8-10-39(11-9-18)30(41)38(4)5/h6-8,12-16,42H,9-11H2,1-5H3,(H,37,40)(H,34,35,36)
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n/an/a 13n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200824
PNG
(US9233111, 35)
Show SMILES CC(=O)OCC(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)c1C |c:10|
Show InChI InChI=1S/C29H25F6N5O4S/c1-16-22(11-20(30)12-24(16)39-29(43)19-3-5-21(6-4-19)45(31,32,33,34)35)27-23-13-25(38-28(23)37-15-36-27)18-7-9-40(10-8-18)26(42)14-44-17(2)41/h3-7,11-13,15H,8-10,14H2,1-2H3,(H,39,43)(H,36,37,38)
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n/an/a 14n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200772
PNG
(US9233111, 10)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:34|
Show InChI InChI=1S/C31H33FN6O3/c1-18(2)41-23-8-6-21(7-9-23)30(39)36-26-15-22(32)14-24(19(26)3)28-25-16-27(35-29(25)34-17-33-28)20-10-12-38(13-11-20)31(40)37(4)5/h6-10,14-18H,11-13H2,1-5H3,(H,36,39)(H,33,34,35)
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n/an/a 15n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200891
PNG
(US9233111, 64)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:33|
Show InChI InChI=1S/C29H30N4O2/c1-18-22(26-23-16-25(19-12-14-35-15-13-19)32-27(23)31-17-30-26)6-5-7-24(18)33-28(34)20-8-10-21(11-9-20)29(2,3)4/h5-12,16-17H,13-15H2,1-4H3,(H,33,34)(H,30,31,32)
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n/an/a 15n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200776
PNG
(US9233111, 14)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc3ccn(C)c3n2)c1C |c:8|
Show InChI InChI=1S/C30H29FN8O2/c1-17-21(13-20(31)14-24(17)36-29(40)23-6-5-19-7-10-38(4)28(19)35-23)26-22-15-25(34-27(22)33-16-32-26)18-8-11-39(12-9-18)30(41)37(2)3/h5-8,10,13-16H,9,11-12H2,1-4H3,(H,36,40)(H,32,33,34)
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n/an/a 16n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200883
PNG
(US9233111, 58)
Show SMILES CC(C)OC1CN(C1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:32|
Show InChI InChI=1S/C28H34FN7O3/c1-16(2)39-20-13-36(14-20)27(37)33-23-11-19(29)10-21(17(23)3)25-22-12-24(32-26(22)31-15-30-25)18-6-8-35(9-7-18)28(38)34(4)5/h6,10-12,15-16,20H,7-9,13-14H2,1-5H3,(H,33,37)(H,30,31,32)
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n/an/a 16n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200851
PNG
(US9233111, 44)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O |t:33|
Show InChI InChI=1S/C30H33N5O3S/c1-19-23(7-6-8-25(19)34-29(36)21-9-11-22(12-10-21)30(2,3)4)27-24-17-26(33-28(24)32-18-31-27)20-13-15-35(16-14-20)39(5,37)38/h6-13,17-18H,14-16H2,1-5H3,(H,34,36)(H,31,32,33)
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n/an/a 17n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200777
PNG
(US9233111, 15)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)N(C)C)c1C |c:8|
Show InChI InChI=1S/C30H32FN7O2/c1-18-23(14-21(31)15-25(18)35-29(39)20-6-8-22(9-7-20)36(2)3)27-24-16-26(34-28(24)33-17-32-27)19-10-12-38(13-11-19)30(40)37(4)5/h6-10,14-17H,11-13H2,1-5H3,(H,35,39)(H,32,33,34)
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n/an/a 17n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200857
PNG
(US9233111, 46)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(N2CCc3cc(ccc3C2=O)C2CC2)c1CO |c:8|
Show InChI InChI=1S/C33H34N6O3/c1-37(2)33(42)38-13-10-21(11-14-38)28-17-26-30(34-19-35-31(26)36-28)25-4-3-5-29(27(25)18-40)39-15-12-23-16-22(20-6-7-20)8-9-24(23)32(39)41/h3-5,8-10,16-17,19-20,40H,6-7,11-15,18H2,1-2H3,(H,34,35,36)
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n/an/a 17n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200844
PNG
(US9233111, 40)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCNCC1 |t:34|
Show InChI InChI=1S/C29H30FN5O/c1-17-22(26-23-15-25(18-9-11-31-12-10-18)34-27(23)33-16-32-26)13-21(30)14-24(17)35-28(36)19-5-7-20(8-6-19)29(2,3)4/h5-9,13-16,31H,10-12H2,1-4H3,(H,35,36)(H,32,33,34)
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n/an/a 19n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200835
PNG
(US9233111, 38)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1CO)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CF |t:34|
Show InChI InChI=1S/C31H32FN5O3/c1-31(2,3)21-9-7-20(8-10-21)30(40)36-25-6-4-5-22(24(25)17-38)28-23-15-26(35-29(23)34-18-33-28)19-11-13-37(14-12-19)27(39)16-32/h4-11,15,18,38H,12-14,16-17H2,1-3H3,(H,36,40)(H,33,34,35)
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n/an/a 20n/an/an/an/an/a4



NOVARTIS AG

US Patent


Assay Description
Alternatively, the present compounds might also be assessed for their capacity to inhibit Btk-dependent FcG receptor-induced IL-8 secretion in human ...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200785
PNG
(US9233111, 19)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)=O)c1C |c:8|
Show InChI InChI=1S/C30H29FN6O3/c1-17-23(13-22(31)14-25(17)35-29(39)21-7-5-19(6-8-21)18(2)38)27-24-15-26(34-28(24)33-16-32-27)20-9-11-37(12-10-20)30(40)36(3)4/h5-9,13-16H,10-12H2,1-4H3,(H,35,39)(H,32,33,34)
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n/an/a 23n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200848
PNG
(US9233111, 41)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C |c:8|
Show InChI InChI=1S/C32H35FN6O2/c1-19-24(15-23(33)16-26(19)37-30(40)21-7-9-22(10-8-21)32(2,3)4)28-25-17-27(36-29(25)35-18-34-28)20-11-13-39(14-12-20)31(41)38(5)6/h7-11,15-18H,12-14H2,1-6H3,(H,37,40)(H,34,35,36)
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n/an/a 23n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200798
PNG
(US9233111, 24)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCSCC1 |t:34|
Show InChI InChI=1S/C29H29FN4OS/c1-17-22(26-23-15-25(18-9-11-36-12-10-18)33-27(23)32-16-31-26)13-21(30)14-24(17)34-28(35)19-5-7-20(8-6-19)29(2,3)4/h5-9,13-16H,10-12H2,1-4H3,(H,34,35)(H,31,32,33)
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n/an/a 23n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200875
PNG
(US9233111, 52)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCS(=O)CC1 |t:33|
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n/an/a 24n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200877
PNG
(US9233111, 54)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1CO)-c1ncnc2[nH]c(cc12)C1=CCC2(CC1)OCCO2 |t:34|
Show InChI InChI=1S/C32H34N4O4/c1-31(2,3)22-9-7-21(8-10-22)30(38)36-26-6-4-5-23(25(26)18-37)28-24-17-27(35-29(24)34-19-33-28)20-11-13-32(14-12-20)39-15-16-40-32/h4-11,17,19,37H,12-16,18H2,1-3H3,(H,36,38)(H,33,34,35)
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n/an/a 24n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200826
PNG
(US9233111, 37)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2)C(C)(C)C)c1CO |c:8|
Show InChI InChI=1S/C32H36N6O3/c1-32(2,3)22-11-9-21(10-12-22)30(40)36-26-8-6-7-23(25(26)18-39)28-24-17-27(35-29(24)34-19-33-28)20-13-15-38(16-14-20)31(41)37(4)5/h6-13,17,19,39H,14-16,18H2,1-5H3,(H,36,40)(H,33,34,35)
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n/an/a 26n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200835
PNG
(US9233111, 38)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc(c1CO)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CF |t:34|
Show InChI InChI=1S/C31H32FN5O3/c1-31(2,3)21-9-7-20(8-10-21)30(40)36-25-6-4-5-22(24(25)17-38)28-23-15-26(35-29(23)34-18-33-28)19-11-13-37(14-12-19)27(39)16-32/h4-11,15,18,38H,12-14,16-17H2,1-3H3,(H,36,40)(H,33,34,35)
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n/an/a 27n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200765
PNG
(US9233111, 3)
Show SMILES CC1CCc2sc(cc2C1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N(C)C |t:35|
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n/an/a 27n/an/an/an/an/a4



NOVARTIS AG

US Patent


Assay Description
Alternatively, the present compounds might also be assessed for their capacity to inhibit Btk-dependent FcG receptor-induced IL-8 secretion in human ...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200849
PNG
(US9233111, 42)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O |t:34|
Show InChI InChI=1S/C30H32FN5O3S/c1-18-23(14-22(31)15-25(18)35-29(37)20-6-8-21(9-7-20)30(2,3)4)27-24-16-26(34-28(24)33-17-32-27)19-10-12-36(13-11-19)40(5,38)39/h6-10,14-17H,11-13H2,1-5H3,(H,35,37)(H,32,33,34)
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n/an/a 30n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200820
PNG
(US9233111, 34)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)N1CCCC1 |t:36|
Show InChI InChI=1S/C30H28F6N6O2S/c1-18-23(14-21(31)15-25(18)40-29(43)20-4-6-22(7-5-20)45(32,33,34,35)36)27-24-16-26(39-28(24)38-17-37-27)19-8-12-42(13-9-19)30(44)41-10-2-3-11-41/h4-8,14-17H,2-3,9-13H2,1H3,(H,40,43)(H,37,38,39)
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n/an/a 34n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200803
PNG
(US9233111, 26)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCS(=O)(=O)CC1 |t:34|
Show InChI InChI=1S/C29H29FN4O3S/c1-17-22(13-21(30)14-24(17)34-28(35)19-5-7-20(8-6-19)29(2,3)4)26-23-15-25(33-27(23)32-16-31-26)18-9-11-38(36,37)12-10-18/h5-9,13-16H,10-12H2,1-4H3,(H,34,35)(H,31,32,33)
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n/an/a 35n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200808
PNG
(US9233111, 28)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCC(O)CC1 |t:34|
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n/an/a 46n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200868
PNG
(US9233111, 50)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cc(F)cc(c1C)-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:33|
Show InChI InChI=1S/C27H26FN5O2/c1-16-21(25-22-14-24(17-8-10-35-11-9-17)31-26(22)30-15-29-25)12-19(28)13-23(16)32-27(34)18-4-6-20(7-5-18)33(2)3/h4-8,12-15H,9-11H2,1-3H3,(H,32,34)(H,29,30,31)
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n/an/a 47n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200872
PNG
(US9233111, 51)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCSCC1 |t:33|
Show InChI InChI=1S/C29H30N4OS/c1-18-22(26-23-16-25(19-12-14-35-15-13-19)32-27(23)31-17-30-26)6-5-7-24(18)33-28(34)20-8-10-21(11-9-20)29(2,3)4/h5-12,16-17H,13-15H2,1-4H3,(H,33,34)(H,30,31,32)
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n/an/a 47n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200876
PNG
(US9233111, 53)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1ncnc2[nH]c(cc12)C1=CCS(=O)(=O)CC1 |t:33|
Show InChI InChI=1S/C29H30N4O3S/c1-18-22(6-5-7-24(18)33-28(34)20-8-10-21(11-9-20)29(2,3)4)26-23-16-25(32-27(23)31-17-30-26)19-12-14-37(35,36)15-13-19/h5-12,16-17H,13-15H2,1-4H3,(H,33,34)(H,30,31,32)
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n/an/a 64n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200778
PNG
(US9233111, 16)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cccc(NC(=O)c2ccc(cc2F)C(C)(C)O)c1CO |c:8|
Show InChI InChI=1S/C31H33FN6O4/c1-31(2,42)19-8-9-21(24(32)14-19)29(40)36-25-7-5-6-20(23(25)16-39)27-22-15-26(35-28(22)34-17-33-27)18-10-12-38(13-11-18)30(41)37(3)4/h5-10,14-15,17,39,42H,11-13,16H2,1-4H3,(H,36,40)(H,33,34,35)
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n/an/a 69n/an/an/an/an/a4



NOVARTIS AG

US Patent


Assay Description
Alternatively, the present compounds might also be assessed for their capacity to inhibit Btk-dependent FcG receptor-induced IL-8 secretion in human ...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200887
PNG
(US9233111, 62)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1ccc(F)c(NC(=O)N2CC(C2)OC(C)(C)C)c1 |c:8|
Show InChI InChI=1S/C28H34FN7O3/c1-28(2,3)39-19-14-36(15-19)26(37)33-23-12-18(6-7-21(23)29)24-20-13-22(32-25(20)31-16-30-24)17-8-10-35(11-9-17)27(38)34(4)5/h6-8,12-13,16,19H,9-11,14-15H2,1-5H3,(H,33,37)(H,30,31,32)
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n/an/a 71n/an/an/an/an/a4



NOVARTIS AG

US Patent


Assay Description
Alternatively, the present compounds might also be assessed for their capacity to inhibit Btk-dependent FcG receptor-induced IL-8 secretion in human ...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200798
PNG
(US9233111, 24)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCSCC1 |t:34|
Show InChI InChI=1S/C29H29FN4OS/c1-17-22(26-23-15-25(18-9-11-36-12-10-18)33-27(23)32-16-31-26)13-21(30)14-24(17)34-28(35)19-5-7-20(8-6-19)29(2,3)4/h5-9,13-16H,10-12H2,1-4H3,(H,34,35)(H,31,32,33)
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n/an/a 94n/an/an/an/an/a4



NOVARTIS AG

US Patent


Assay Description
Alternatively, the present compounds might also be assessed for their capacity to inhibit Btk-dependent FcG receptor-induced IL-8 secretion in human ...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200867
PNG
(US9233111, 49)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCOCC1 |t:34|
Show InChI InChI=1S/C29H29FN4O2/c1-17-22(26-23-15-25(18-9-11-36-12-10-18)33-27(23)32-16-31-26)13-21(30)14-24(17)34-28(35)19-5-7-20(8-6-19)29(2,3)4/h5-9,13-16H,10-12H2,1-4H3,(H,34,35)(H,31,32,33)
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n/an/a 99n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200804
PNG
(US9233111, 27)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCC2(CC1)OCCO2 |t:34|
Show InChI InChI=1S/C32H33FN4O3/c1-19-24(15-23(33)16-26(19)37-30(38)21-5-7-22(8-6-21)31(2,3)4)28-25-17-27(36-29(25)35-18-34-28)20-9-11-32(12-10-20)39-13-14-40-32/h5-9,15-18H,10-14H2,1-4H3,(H,37,38)(H,34,35,36)
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n/an/a 110n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM200850
PNG
(US9233111, 43)
Show SMILES CN(C)S(=O)(=O)N1CCC(=CC1)c1cc2c(ncnc2[nH]1)-c1cc(F)cc(NC(=O)c2ccc(cc2)C(C)(C)C)c1C |c:9|
Show InChI InChI=1S/C31H35FN6O3S/c1-19-24(15-23(32)16-26(19)36-30(39)21-7-9-22(10-8-21)31(2,3)4)28-25-17-27(35-29(25)34-18-33-28)20-11-13-38(14-12-20)42(40,41)37(5)6/h7-11,15-18H,12-14H2,1-6H3,(H,36,39)(H,33,34,35)
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n/an/a 140n/an/an/an/a7.530



NOVARTIS AG

US Patent


Assay Description
The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...

US Patent US9233111 (2016)


BindingDB Entry DOI: 10.7270/Q2ZS2V9C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%