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Patent code US9242977

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204852
PNG
(US9242977, 85-226)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3S(C)(=O)=O)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C25H23F3N6O4S2/c1-3-10-29-24-32-14-20(39-24)15-4-7-18(8-5-15)38-23-30-12-17(13-31-23)33-22(35)34-19-11-16(25(26,27)28)6-9-21(19)40(2,36)37/h4-9,11-14H,3,10H2,1-2H3,(H,29,32)(H2,33,34,35)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204848
PNG
(US9242977, 85-117)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C24H20ClF3N6O2S/c1-2-9-29-23-32-13-20(37-23)14-3-6-17(7-4-14)36-22-30-11-16(12-31-22)33-21(35)34-19-10-15(24(26,27)28)5-8-18(19)25/h3-8,10-13H,2,9H2,1H3,(H,29,32)(H2,33,34,35)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204837
PNG
(US9242977, 65-1)
Show SMILES Cc1ccc(cc1C)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H34N8O3S/c1-20-8-11-24(15-21(20)2)41-28(16-27(39-41)33(3,4)5)38-30(43)37-23-17-34-31(35-18-23)44-25-12-9-22(10-13-25)26-19-36-32(45-26)40-14-6-7-29(40)42/h8-13,15-19H,6-7,14H2,1-5H3,(H2,37,38,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204842
PNG
(US9242977, 71)
Show SMILES Cn1ncc2cc(ccc12)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H32N10O3S/c1-33(2,3)27-15-28(43(40-27)23-9-12-25-21(14-23)16-37-41(25)4)39-30(45)38-22-17-34-31(35-18-22)46-24-10-7-20(8-11-24)26-19-36-32(47-26)42-13-5-6-29(42)44/h7-12,14-19H,5-6,13H2,1-4H3,(H2,38,39,45)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204849
PNG
(US9242977, 85-184)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C28H22F6N8O2S/c1-2-10-35-26-38-15-22(45-26)16-3-6-19(7-4-16)44-25-36-13-18(14-37-25)39-24(43)40-20-12-17(27(29,30)31)5-8-21(20)42-11-9-23(41-42)28(32,33)34/h3-9,11-15H,2,10H2,1H3,(H,35,38)(H2,39,40,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204835
PNG
(US9242977, 57)
Show SMILES Cc1cccc(c1)-c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C31H24F3N7O3S/c1-18-4-2-5-20(12-18)27-24(13-21(14-35-27)31(32,33)34)40-28(43)39-22-15-36-29(37-16-22)44-23-9-7-19(8-10-23)25-17-38-30(45-25)41-11-3-6-26(41)42/h2,4-5,7-10,12-17H,3,6,11H2,1H3,(H2,39,40,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204838
PNG
(US9242977, 66-19)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)n(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C33H32N8O4S/c1-33(2,3)27-16-28(41(39-27)23-8-11-25-21(15-23)12-14-44-25)38-30(43)37-22-17-34-31(35-18-22)45-24-9-6-20(7-10-24)26-19-36-32(46-26)40-13-4-5-29(40)42/h6-11,15-19H,4-5,12-14H2,1-3H3,(H2,37,38,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204850
PNG
(US9242977, 85-209)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(F)ccc3F)cn2)cc1
Show InChI InChI=1S/C23H20F2N6O2S/c1-2-9-26-23-29-13-20(34-23)14-3-6-17(7-4-14)33-22-27-11-16(12-28-22)30-21(32)31-19-10-15(24)5-8-18(19)25/h3-8,10-13H,2,9H2,1H3,(H,26,29)(H2,30,31,32)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204851
PNG
(US9242977, 85-225)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3S(=O)(=O)N(C)C)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C26H26F3N7O4S2/c1-4-11-30-25-33-15-21(41-25)16-5-8-19(9-6-16)40-24-31-13-18(14-32-24)34-23(37)35-20-12-17(26(27,28)29)7-10-22(20)42(38,39)36(2)3/h5-10,12-15H,4,11H2,1-3H3,(H,30,33)(H2,34,35,37)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204830
PNG
(US9242977, 23)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3-c3ccc(C)cc3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C29H24F3N7O2S/c1-3-33-28-37-16-24(42-28)18-8-10-22(11-9-18)41-27-35-14-21(15-36-27)38-26(40)39-23-12-20(29(30,31)32)13-34-25(23)19-6-4-17(2)5-7-19/h4-16H,3H2,1-2H3,(H,33,37)(H2,38,39,40)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204834
PNG
(US9242977, 54)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H22F3N7O3S/c31-30(32,33)20-13-23(26(34-14-20)19-5-2-1-3-6-19)39-27(42)38-21-15-35-28(36-16-21)43-22-10-8-18(9-11-22)24-17-37-29(44-24)40-12-4-7-25(40)41/h1-3,5-6,8-11,13-17H,4,7,12H2,(H2,38,39,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204831
PNG
(US9242977, 34)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ccc(NC(=O)Nc3cc(cnc3-c3ccc(C)c(C)c3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C31H27F3N6O2S/c1-4-35-30-38-17-26(43-30)20-7-10-24(11-8-20)42-27-12-9-23(16-36-27)39-29(41)40-25-14-22(31(32,33)34)15-37-28(25)21-6-5-18(2)19(3)13-21/h5-17H,4H2,1-3H3,(H,35,38)(H2,39,40,41)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204839
PNG
(US9242977, 66-27)
Show SMILES COC(=O)c1cccc(c1)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H32N8O5S/c1-33(2,3)26-16-27(41(39-26)23-8-5-7-21(15-23)29(43)45-4)38-30(44)37-22-17-34-31(35-18-22)46-24-12-10-20(11-13-24)25-19-36-32(47-25)40-14-6-9-28(40)42/h5,7-8,10-13,15-19H,6,9,14H2,1-4H3,(H2,37,38,44)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204832
PNG
(US9242977, 48)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3Oc3ccccc3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C28H22F3N7O3S/c1-2-32-27-36-16-23(42-27)17-8-10-21(11-9-17)41-26-34-14-19(15-35-26)37-25(39)38-22-12-18(28(29,30)31)13-33-24(22)40-20-6-4-3-5-7-20/h3-16H,2H2,1H3,(H,32,36)(H2,37,38,39)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204843
PNG
(US9242977, 72-1)
Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C29H23F3N8O3S/c1-17-5-2-3-6-21(17)40-24(13-23(38-40)29(30,31)32)37-26(42)36-19-14-33-27(34-15-19)43-20-10-8-18(9-11-20)22-16-35-28(44-22)39-12-4-7-25(39)41/h2-3,5-6,8-11,13-16H,4,7,12H2,1H3,(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204833
PNG
(US9242977, 50)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)c1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C30H20F6N8O3S/c31-29(32,33)18-10-21(25(38-12-18)17-5-8-23(37-11-17)30(34,35)36)43-26(46)42-19-13-39-27(40-14-19)47-20-6-3-16(4-7-20)22-15-41-28(48-22)44-9-1-2-24(44)45/h3-8,10-15H,1-2,9H2,(H2,42,43,46)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204840
PNG
(US9242977, 66-28)
Show SMILES CC(=O)Nc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H33N9O4S/c1-20(43)37-22-9-11-24(12-10-22)42-28(16-27(40-42)33(2,3)4)39-30(45)38-23-17-34-31(35-18-23)46-25-13-7-21(8-14-25)26-19-36-32(47-26)41-15-5-6-29(41)44/h7-14,16-19H,5-6,15H2,1-4H3,(H,37,43)(H2,38,39,45)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204844
PNG
(US9242977, 72-3)
Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(F)F
Show InChI InChI=1S/C30H26F2N8O3S/c1-18-6-3-4-7-22(18)40-25(14-24(38-40)30(2,31)32)37-27(42)36-20-15-33-28(34-16-20)43-21-11-9-19(10-12-21)23-17-35-29(44-23)39-13-5-8-26(39)41/h3-4,6-7,9-12,14-17H,5,8,13H2,1-2H3,(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204838
PNG
(US9242977, 66-19)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)n(n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C33H32N8O4S/c1-33(2,3)27-16-28(41(39-27)23-8-11-25-21(15-23)12-14-44-25)38-30(43)37-22-17-34-31(35-18-22)45-24-9-6-20(7-10-24)26-19-36-32(46-26)40-13-4-5-29(40)42/h6-11,15-19H,4-5,12-14H2,1-3H3,(H2,37,38,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204848
PNG
(US9242977, 85-117)
Show SMILES CCCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C24H20ClF3N6O2S/c1-2-9-29-23-32-13-20(37-23)14-3-6-17(7-4-14)36-22-30-11-16(12-31-22)33-21(35)34-19-10-15(24(26,27)28)5-8-18(19)25/h3-8,10-13H,2,9H2,1H3,(H,29,32)(H2,33,34,35)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204842
PNG
(US9242977, 71)
Show SMILES Cn1ncc2cc(ccc12)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H32N10O3S/c1-33(2,3)27-15-28(43(40-27)23-9-12-25-21(14-23)16-37-41(25)4)39-30(45)38-22-17-34-31(35-18-22)46-24-10-7-20(8-11-24)26-19-36-32(47-26)42-13-5-6-29(42)44/h7-12,14-19H,5-6,13H2,1-4H3,(H2,38,39,45)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204835
PNG
(US9242977, 57)
Show SMILES Cc1cccc(c1)-c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C31H24F3N7O3S/c1-18-4-2-5-20(12-18)27-24(13-21(14-35-27)31(32,33)34)40-28(43)39-22-15-36-29(37-16-22)44-23-9-7-19(8-10-23)25-17-38-30(45-25)41-11-3-6-26(41)42/h2,4-5,7-10,12-17H,3,6,11H2,1H3,(H2,39,40,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204845
PNG
(US9242977, 72-7)
Show SMILES O=C(Nc1cc(nn1-c1ccccc1)C1CC1)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1
Show InChI InChI=1S/C30H26N8O3S/c39-27-7-4-14-37(27)30-33-18-25(42-30)20-10-12-23(13-11-20)41-29-31-16-21(17-32-29)34-28(40)35-26-15-24(19-8-9-19)36-38(26)22-5-2-1-3-6-22/h1-3,5-6,10-13,15-19H,4,7-9,14H2,(H2,34,35,40)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204841
PNG
(US9242977, 66-72)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C31H31N9O5S2/c1-31(2,3)25-15-26(40(38-25)21-8-12-23(13-9-21)47(32,43)44)37-28(42)36-20-16-33-29(34-17-20)45-22-10-6-19(7-11-22)24-18-35-30(46-24)39-14-4-5-27(39)41/h6-13,15-18H,4-5,14H2,1-3H3,(H2,32,43,44)(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204845
PNG
(US9242977, 72-7)
Show SMILES O=C(Nc1cc(nn1-c1ccccc1)C1CC1)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1
Show InChI InChI=1S/C30H26N8O3S/c39-27-7-4-14-37(27)30-33-18-25(42-30)20-10-12-23(13-11-20)41-29-31-16-21(17-32-29)34-28(40)35-26-15-24(19-8-9-19)36-38(26)22-5-2-1-3-6-22/h1-3,5-6,10-13,15-19H,4,7-9,14H2,(H2,34,35,40)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204833
PNG
(US9242977, 50)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)c1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C30H20F6N8O3S/c31-29(32,33)18-10-21(25(38-12-18)17-5-8-23(37-11-17)30(34,35)36)43-26(46)42-19-13-39-27(40-14-19)47-20-6-3-16(4-7-20)22-15-41-28(48-22)44-9-1-2-24(44)45/h3-8,10-15H,1-2,9H2,(H2,42,43,46)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204834
PNG
(US9242977, 54)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)c1)-c1ccccc1
Show InChI InChI=1S/C30H22F3N7O3S/c31-30(32,33)20-13-23(26(34-14-20)19-5-2-1-3-6-19)39-27(42)38-21-15-35-28(36-16-21)43-22-10-8-18(9-11-22)24-17-37-29(44-24)40-12-4-7-25(40)41/h1-3,5-6,8-11,13-17H,4,7,12H2,(H2,38,39,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204843
PNG
(US9242977, 72-1)
Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C29H23F3N8O3S/c1-17-5-2-3-6-21(17)40-24(13-23(38-40)29(30,31)32)37-26(42)36-19-14-33-27(34-15-19)43-20-10-8-18(9-11-20)22-16-35-28(44-22)39-12-4-7-25(39)41/h2-3,5-6,8-11,13-16H,4,7,12H2,1H3,(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204841
PNG
(US9242977, 66-72)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C31H31N9O5S2/c1-31(2,3)25-15-26(40(38-25)21-8-12-23(13-9-21)47(32,43)44)37-28(42)36-20-16-33-29(34-17-20)45-22-10-6-19(7-11-22)24-18-35-30(46-24)39-14-4-5-27(39)41/h6-13,15-18H,4-5,14H2,1-3H3,(H2,32,43,44)(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204844
PNG
(US9242977, 72-3)
Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(F)F
Show InChI InChI=1S/C30H26F2N8O3S/c1-18-6-3-4-7-22(18)40-25(14-24(38-40)30(2,31)32)37-27(42)36-20-15-33-28(34-16-20)43-21-11-9-19(10-12-21)23-17-35-29(44-23)39-13-5-8-26(39)41/h3-4,6-7,9-12,14-17H,5,8,13H2,1-2H3,(H2,36,37,42)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204836
PNG
(US9242977, 59)
Show SMILES Cc1ccc(cc1C)-c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C34H30F3N7O3S/c1-20-7-8-23(14-21(20)2)30-27(15-24(16-38-30)34(35,36)37)43-31(46)42-25-17-39-32(40-18-25)47-26-11-9-22(10-12-26)28-19-41-33(48-28)44-13-5-3-4-6-29(44)45/h7-12,14-19H,3-6,13H2,1-2H3,(H2,42,43,46)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204846
PNG
(US9242977, 80-2)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)n(n1)C1CCOCC1
Show InChI InChI=1S/C30H34N8O4S/c1-30(2,3)24-15-25(38(36-24)21-10-13-41-14-11-21)35-27(40)34-20-16-31-28(32-17-20)42-22-8-6-19(7-9-22)23-18-33-29(43-23)37-12-4-5-26(37)39/h6-9,15-18,21H,4-5,10-14H2,1-3H3,(H2,34,35,40)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204840
PNG
(US9242977, 66-28)
Show SMILES CC(=O)Nc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H33N9O4S/c1-20(43)37-22-9-11-24(12-10-22)42-28(16-27(40-42)33(2,3)4)39-30(45)38-23-17-34-31(35-18-23)46-25-13-7-21(8-14-25)26-19-36-32(47-26)41-15-5-6-29(41)44/h7-14,16-19H,5-6,15H2,1-4H3,(H,37,43)(H2,38,39,45)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204837
PNG
(US9242977, 65-1)
Show SMILES Cc1ccc(cc1C)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H34N8O3S/c1-20-8-11-24(15-21(20)2)41-28(16-27(39-41)33(3,4)5)38-30(43)37-23-17-34-31(35-18-23)44-25-12-9-22(10-13-25)26-19-36-32(45-26)40-14-6-7-29(40)42/h8-13,15-19H,6-7,14H2,1-5H3,(H2,37,38,43)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204830
PNG
(US9242977, 23)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3-c3ccc(C)cc3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C29H24F3N7O2S/c1-3-33-28-37-16-24(42-28)18-8-10-22(11-9-18)41-27-35-14-21(15-36-27)38-26(40)39-23-12-20(29(30,31)32)13-34-25(23)19-6-4-17(2)5-7-19/h4-16H,3H2,1-2H3,(H,33,37)(H2,38,39,40)
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ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204847
PNG
(US9242977, 84-41)
Show SMILES CC(C)c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C27H24F3N7O3S/c1-15(2)23-20(10-17(11-31-23)27(28,29)30)36-24(39)35-18-12-32-25(33-13-18)40-19-7-5-16(6-8-19)21-14-34-26(41-21)37-9-3-4-22(37)38/h5-8,10-15H,3-4,9H2,1-2H3,(H2,35,36,39)
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n/an/a 90n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204829
PNG
(US9242977, 9)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCCC3=O)nc2)c1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H22F6N8O3S/c32-30(33,34)19-11-22(26(39-13-19)18-6-9-24(38-12-18)31(35,36)37)44-27(47)43-20-14-40-28(41-15-20)48-21-7-4-17(5-8-21)23-16-42-29(49-23)45-10-2-1-3-25(45)46/h4-9,11-16H,1-3,10H2,(H2,43,44,47)
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n/an/a 93n/an/an/an/an/an/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204832
PNG
(US9242977, 48)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3Oc3ccccc3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C28H22F3N7O3S/c1-2-32-27-36-16-23(42-27)17-8-10-21(11-9-17)41-26-34-14-19(15-35-26)37-25(39)38-22-12-18(28(29,30)31)13-33-24(22)40-20-6-4-3-5-7-20/h3-16H,2H2,1H3,(H,32,36)(H2,37,38,39)
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n/an/a 120n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204839
PNG
(US9242977, 66-27)
Show SMILES COC(=O)c1cccc(c1)-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(C)C
Show InChI InChI=1S/C33H32N8O5S/c1-33(2,3)26-16-27(41(39-26)23-8-5-7-21(15-23)29(43)45-4)38-30(44)37-22-17-34-31(35-18-22)46-24-12-10-20(11-13-24)25-19-36-32(47-25)40-14-6-9-28(40)42/h5,7-8,10-13,15-19H,6,9,14H2,1-4H3,(H2,37,38,44)
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n/an/a 130n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204829
PNG
(US9242977, 9)
Show SMILES FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCCC3=O)nc2)c1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C31H22F6N8O3S/c32-30(33,34)19-11-22(26(39-13-19)18-6-9-24(38-12-18)31(35,36)37)44-27(47)43-20-14-40-28(41-15-20)48-21-7-4-17(5-8-21)23-16-42-29(49-23)45-10-2-1-3-25(45)46/h4-9,11-16H,1-3,10H2,(H2,43,44,47)
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n/an/a 160n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204831
PNG
(US9242977, 34)
Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ccc(NC(=O)Nc3cc(cnc3-c3ccc(C)c(C)c3)C(F)(F)F)cn2)cc1
Show InChI InChI=1S/C31H27F3N6O2S/c1-4-35-30-38-17-26(43-30)20-7-10-24(11-8-20)42-27-12-9-23(16-36-27)39-29(41)40-25-14-22(31(32,33)34)15-37-28(25)21-6-5-18(2)19(3)13-21/h5-17H,4H2,1-3H3,(H,35,38)(H2,39,40,41)
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n/an/a 180n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI)


(Homo sapiens (Human))		BDBM204836
PNG
(US9242977, 59)
Show SMILES Cc1ccc(cc1C)-c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCCCC2=O)nc1)C(F)(F)F
Show InChI InChI=1S/C34H30F3N7O3S/c1-20-7-8-23(14-21(20)2)30-27(15-24(16-38-30)34(35,36)37)43-31(46)42-25-17-39-32(40-18-25)47-26-11-9-22(10-12-26)28-19-41-33(48-28)44-13-5-3-4-6-29(44)45/h7-12,14-19H,3-6,13H2,1-2H3,(H2,42,43,46)
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n/an/a 190n/an/an/an/a7.5n/a



ONO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...

US Patent US9242977 (2016)


BindingDB Entry DOI: 10.7270/Q2639NJZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%