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Patent code US9247759

Compile Data Set for Download or QSAR

Found 464 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211386
PNG
(US9247759, 12-37)
Show SMILES C[C@H]1N(Cc2ccccc2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Show InChI InChI=1S/C20H21N5O3/c1-13-18(15(3)28-22-13)12-23-11-17(9-21-23)25-19(26)14(2)24(20(25)27)10-16-7-5-4-6-8-16/h4-9,11,14H,10,12H2,1-3H3/t14-/m1/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211368
PNG
(US9247759, 12-19)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2ccc(F)c(O)c2)C(C)(C)C1=O
Show InChI InChI=1S/C21H22FN5O4/c1-12-16(13(2)31-24-12)11-25-10-15(8-23-25)27-19(29)21(3,4)26(20(27)30)9-14-5-6-17(22)18(28)7-14/h5-8,10,28H,9,11H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211336
PNG
(US9247759, 10-84)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(CCc2ccc(F)cc2)C1=O
Show InChI InChI=1S/C20H20FN5O3/c1-13-18(14(2)29-23-13)11-25-10-17(9-22-25)26-19(27)12-24(20(26)28)8-7-15-3-5-16(21)6-4-15/h3-6,9-10H,7-8,11-12H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211352
PNG
(US9247759, 12-3)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cc(O)cc(O)c2)C(C)(C)C1=O
Show InChI InChI=1S/C21H23N5O5/c1-12-18(13(2)31-23-12)11-24-10-15(8-22-24)26-19(29)21(3,4)25(20(26)30)9-14-5-16(27)7-17(28)6-14/h5-8,10,27-28H,9,11H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211360
PNG
(US9247759, 12-11)
Show SMILES C[C@@H]1N(Cc2ccccc2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Show InChI InChI=1S/C20H21N5O3/c1-13-18(15(3)28-22-13)12-23-11-17(9-21-23)25-19(26)14(2)24(20(25)27)10-16-7-5-4-6-8-16/h4-9,11,14H,10,12H2,1-3H3/t14-/m0/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211318
PNG
(US9247759, 10-66)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)-n1c(=O)n(C)n(CCc2ccc(F)cc2)c1=O
Show InChI InChI=1S/C20H21FN6O3/c1-13-18(14(2)30-23-13)12-25-11-17(10-22-25)27-19(28)24(3)26(20(27)29)9-8-15-4-6-16(21)7-5-15/h4-7,10-11H,8-9,12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 14


(Homo sapiens (Human))		BDBM211090
PNG
(US9247759, 5-11)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(CC1CCC(CC1)C(O)=O)Cc1ccccc1 |(-5.26,1,;-3.93,.23,;-3.93,-1.31,;-2.59,-2.08,;-1.26,-1.31,;-1.26,.23,;-2.59,1,;.08,-2.08,;-.69,-3.41,;.85,-3.41,;1.41,-1.31,;.64,.03,;1.41,1.36,;2.95,1.36,;3.72,2.69,;2.95,4.03,;1.41,4.03,;.64,2.7,;3.72,5.36,;5.26,5.36,;2.95,6.7,;2.74,-2.08,;2.74,-3.62,;1.41,-4.39,;1.41,-5.93,;2.74,-6.7,;4.08,-5.93,;4.08,-4.39,)|
Show InChI InChI=1S/C22H27NO4S/c1-17-7-13-21(14-8-17)28(26,27)23(15-18-5-3-2-4-6-18)16-19-9-11-20(12-10-19)22(24)25/h2-8,13-14,19-20H,9-12,15-16H2,1H3,(H,24,25)
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211356
PNG
(US9247759, 12-7)
Show SMILES C[C@H]1N(Cc2cccc(O)c2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Show InChI InChI=1S/C20H21N5O4/c1-12-18(14(3)29-22-12)11-23-10-16(8-21-23)25-19(27)13(2)24(20(25)28)9-15-5-4-6-17(26)7-15/h4-8,10,13,26H,9,11H2,1-3H3/t13-/m1/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211341
PNG
(US9247759, 10-89)
Show SMILES COCn1n(Cc2ccccc2)c(=O)n(-c2cnn(Cc3c(C)noc3C)c2)c1=O
Show InChI InChI=1S/C20H22N6O4/c1-14-18(15(2)30-22-14)12-23-11-17(9-21-23)26-19(27)24(25(13-29-3)20(26)28)10-16-7-5-4-6-8-16/h4-9,11H,10,12-13H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211366
PNG
(US9247759, 12-17)
Show SMILES COc1cc(O)cc(CN2C(=O)N(C(=O)C2(C)C)c2cnn(Cc3c(C)noc3C)c2)c1
Show InChI InChI=1S/C22H25N5O5/c1-13-19(14(2)32-24-13)12-25-11-16(9-23-25)27-20(29)22(3,4)26(21(27)30)10-15-6-17(28)8-18(7-15)31-5/h6-9,11,28H,10,12H2,1-5H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211295
PNG
(US9247759, 10-43)
Show SMILES CC1N(Cc2ccccc2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1
Show InChI InChI=1S/C20H21N5O3/c1-13-18(15(3)28-22-13)12-23-11-17(9-21-23)25-19(26)14(2)24(20(25)27)10-16-7-5-4-6-8-16/h4-9,11,14H,10,12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211361
PNG
(US9247759, 12-12)
Show SMILES COc1ccc(CN2C(=O)N(C(=O)C22CC2)c2cnn(Cc3c(C)noc3C)c2)cc1O
Show InChI InChI=1S/C22H23N5O5/c1-13-17(14(2)32-24-13)12-25-11-16(9-23-25)27-20(29)22(6-7-22)26(21(27)30)10-15-4-5-19(31-3)18(28)8-15/h4-5,8-9,11,28H,6-7,10,12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211442
PNG
(US9247759, 13-1)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)[C@@H]2Cc3ccc(O)cc3CN2C1=O |r|
Show InChI InChI=1S/C20H19N5O4/c1-11-17(12(2)29-22-11)10-23-9-15(7-21-23)25-19(27)18-6-13-3-4-16(26)5-14(13)8-24(18)20(25)28/h3-5,7,9,18,26H,6,8,10H2,1-2H3/t18-/m0/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211364
PNG
(US9247759, 12-15)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CC2)C1=O
Show InChI InChI=1S/C21H21N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(6-7-21)25(20(26)29)10-15-4-3-5-17(27)8-15/h3-5,8-9,11,27H,6-7,10,12H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211286
PNG
(US9247759, 10-34)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2N)C1=O
Show InChI InChI=1S/C19H20N6O3/c1-12-16(13(2)28-22-12)10-24-9-15(7-21-24)25-18(26)11-23(19(25)27)8-14-5-3-4-6-17(14)20/h3-7,9H,8,10-11,20H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211362
PNG
(US9247759, 12-13)
Show SMILES COc1ccc(CN2C(=O)N(C(=O)C22CC2)c2cnn(Cc3c(C)noc3C)c2)cc1OC
Show InChI InChI=1S/C23H25N5O5/c1-14-18(15(2)33-25-14)13-26-12-17(10-24-26)28-21(29)23(7-8-23)27(22(28)30)11-16-5-6-19(31-3)20(9-16)32-4/h5-6,9-10,12H,7-8,11,13H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211355
PNG
(US9247759, 12-6)
Show SMILES C[C@@H]1N(Cc2cccc(O)c2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Show InChI InChI=1S/C20H21N5O4/c1-12-18(14(3)29-22-12)11-23-10-16(8-21-23)25-19(27)13(2)24(20(25)28)9-15-5-4-6-17(26)7-15/h4-8,10,13,26H,9,11H2,1-3H3/t13-/m0/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211317
PNG
(US9247759, 10-65)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)-n1c(=O)n(C)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H20N6O3/c1-13-17(14(2)28-21-13)12-23-11-16(9-20-23)25-18(26)22(3)24(19(25)27)10-15-7-5-4-6-8-15/h4-9,11H,10,12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211267
PNG
(US9247759, 10-15)
Show SMILES CSc1ccccc1CN1CC(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1
Show InChI InChI=1S/C20H21N5O3S/c1-13-17(14(2)28-22-13)11-24-10-16(8-21-24)25-19(26)12-23(20(25)27)9-15-6-4-5-7-18(15)29-3/h4-8,10H,9,11-12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211363
PNG
(US9247759, 12-14)
Show SMILES COCc1cccc(CN2C(=O)N(C(=O)C22CC2)c2cnn(Cc3c(C)noc3C)c2)c1
Show InChI InChI=1S/C23H25N5O4/c1-15-20(16(2)32-25-15)13-26-12-19(10-24-26)28-21(29)23(7-8-23)27(22(28)30)11-17-5-4-6-18(9-17)14-31-3/h4-6,9-10,12H,7-8,11,13-14H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211443
PNG
(US9247759, 13-2)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)[C@H]2Cc3ccc(O)cc3CN2C1=O |r|
Show InChI InChI=1S/C20H19N5O4/c1-11-17(12(2)29-22-11)10-23-9-15(7-21-23)25-19(27)18-6-13-3-4-16(26)5-14(13)8-24(18)20(25)28/h3-5,7,9,18,26H,6,8,10H2,1-2H3/t18-/m1/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211262
PNG
(US9247759, 10-10)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(O)c2)C1=O
Show InChI InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-4-3-5-16(25)6-14/h3-7,9,25H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
To determine the effectiveness of an individual antagonist, taste tests were performed with a T2R8 specific agonist, the compound of interest and a r...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211353
PNG
(US9247759, 12-4)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CCC2)C1=O
Show InChI InChI=1S/C22H23N5O4/c1-14-19(15(2)31-24-14)13-25-12-17(10-23-25)27-20(29)22(7-4-8-22)26(21(27)30)11-16-5-3-6-18(28)9-16/h3,5-6,9-10,12,28H,4,7-8,11,13H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211444
PNG
(US9247759, 13-3)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)C2Cc3cc(O)ccc3CN2C1=O
Show InChI InChI=1S/C20H19N5O4/c1-11-17(12(2)29-22-11)10-23-9-15(7-21-23)25-19(27)18-6-14-5-16(26)4-3-13(14)8-24(18)20(25)28/h3-5,7,9,18,26H,6,8,10H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211319
PNG
(US9247759, 10-67)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)-n1c(=O)n(C)n(CCOc2ccccc2)c1=O
Show InChI InChI=1S/C20H22N6O4/c1-14-18(15(2)30-22-14)13-24-12-16(11-21-24)26-19(27)23(3)25(20(26)28)9-10-29-17-7-5-4-6-8-17/h4-8,11-12H,9-10,13H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211262
PNG
(US9247759, 10-10)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(O)c2)C1=O
Show InChI InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-4-3-5-16(25)6-14/h3-7,9,25H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 14


(Homo sapiens (Human))		BDBM211181
PNG
(US9247759, 5-128)
Show SMILES COc1cccc(CN(CC2CCC(CC2)C(O)=O)S(=O)(=O)c2ccc(C)cc2)c1 |(4,-6.54,;4,-5,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;1.33,-1.93,;1.33,-.38,;,.38,;,1.93,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4,2.69,;2.67,1.93,;5.33,5,;6.67,4.24,;5.33,6.54,;-1.33,-.38,;-2.1,-1.72,;-.56,-1.72,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-6.67,2.69,;-4,2.69,;-2.67,1.93,;2.67,-2.69,)|
Show InChI InChI=1S/C23H29NO5S/c1-17-6-12-22(13-7-17)30(27,28)24(16-19-4-3-5-21(14-19)29-2)15-18-8-10-20(11-9-18)23(25)26/h3-7,12-14,18,20H,8-11,15-16H2,1-2H3,(H,25,26)
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211307
PNG
(US9247759, 10-55)
Show SMILES Cc1noc(C)c1CN1CC(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1
Show InChI InChI=1S/C18H20N6O4/c1-10-15(12(3)27-20-10)7-22-9-17(25)24(18(22)26)14-5-19-23(6-14)8-16-11(2)21-28-13(16)4/h5-6H,7-9H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211365
PNG
(US9247759, 12-16 | US9247759, 12-79)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2ccc(cc2)C#N)C(C)(C)C1=O
Show InChI InChI=1S/C22H22N6O3/c1-14-19(15(2)31-25-14)13-26-12-18(10-24-26)28-20(29)22(3,4)27(21(28)30)11-17-7-5-16(9-23)6-8-17/h5-8,10,12H,11,13H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211343
PNG
(US9247759, 10-91)
Show SMILES CCn1n(Cc2ccccc2)c(=O)n(-c2cnn(Cc3c(C)noc3C)c2)c1=O
Show InChI InChI=1S/C20H22N6O3/c1-4-24-19(27)26(20(28)25(24)11-16-8-6-5-7-9-16)17-10-21-23(12-17)13-18-14(2)22-29-15(18)3/h5-10,12H,4,11,13H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211358
PNG
(US9247759, 12-9)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)[C@H](CO)N(Cc2cccc(O)c2)C1=O |r|
Show InChI InChI=1S/C20H21N5O5/c1-12-17(13(2)30-22-12)10-23-9-15(7-21-23)25-19(28)18(11-26)24(20(25)29)8-14-4-3-5-16(27)6-14/h3-7,9,18,26-27H,8,10-11H2,1-2H3/t18-/m0/s1
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211331
PNG
(US9247759, 10-79)
Show SMILES COc1ccc(CCN2CC(=O)N(C2=O)c2cnn(Cc3c(C)noc3C)c2)cc1
Show InChI InChI=1S/C21H23N5O4/c1-14-19(15(2)30-23-14)12-25-11-17(10-22-25)26-20(27)13-24(21(26)28)9-8-16-4-6-18(29-3)7-5-16/h4-7,10-11H,8-9,12-13H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211350
PNG
(US9247759, 12-1)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C(C)(C)C1=O
Show InChI InChI=1S/C21H23N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(3,4)25(20(26)29)10-15-6-5-7-17(27)8-15/h5-9,11,27H,10,12H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211284
PNG
(US9247759, 10-23)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccc(cc2)C#N)C1=O
Show InChI InChI=1S/C20H18N6O3/c1-13-18(14(2)29-23-13)11-25-10-17(8-22-25)26-19(27)12-24(20(26)28)9-16-5-3-15(7-21)4-6-16/h3-6,8,10H,9,11-12H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211365
PNG
(US9247759, 12-16 | US9247759, 12-79)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2ccc(cc2)C#N)C(C)(C)C1=O
Show InChI InChI=1S/C22H22N6O3/c1-14-19(15(2)31-25-14)13-26-12-18(10-24-26)28-20(29)22(3,4)27(21(28)30)11-17-7-5-16(9-23)6-8-17/h5-8,10,12H,11,13H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211283
PNG
(US9247759, 10-31)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccc(F)cc2)C1=O
Show InChI InChI=1S/C19H18FN5O3/c1-12-17(13(2)28-22-12)10-24-9-16(7-21-24)25-18(26)11-23(19(25)27)8-14-3-5-15(20)6-4-14/h3-7,9H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 14


(Homo sapiens (Human))		BDBM211114
PNG
(US9247759, 5-37)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)cc1)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H20FNO4S/c1-16-2-12-21(13-3-16)29(27,28)24(15-18-6-10-20(23)11-7-18)14-17-4-8-19(9-5-17)22(25)26/h2-13H,14-15H2,1H3,(H,25,26)
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211351
PNG
(US9247759, 12-2)
Show SMILES COc1ccc(CN2C(=O)N(C(=O)C2(C)C)c2cnn(Cc3c(C)noc3C)c2)cc1O
Show InChI InChI=1S/C22H25N5O5/c1-13-17(14(2)32-24-13)12-25-11-16(9-23-25)27-20(29)22(3,4)26(21(27)30)10-15-6-7-19(31-5)18(28)8-15/h6-9,11,28H,10,12H2,1-5H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211345
PNG
(US9247759, 10-93)
Show SMILES CCCn1n(Cc2ccccc2)c(=O)n(-c2cnn(Cc3c(C)noc3C)c2)c1=O
Show InChI InChI=1S/C21H24N6O3/c1-4-10-25-20(28)27(21(29)26(25)12-17-8-6-5-7-9-17)18-11-22-24(13-18)14-19-15(2)23-30-16(19)3/h5-9,11,13H,4,10,12,14H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211270
PNG
(US9247759, 10-18)
Show SMILES COc1ccccc1CN1CC(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1
Show InChI InChI=1S/C20H21N5O4/c1-13-17(14(2)29-22-13)11-24-10-16(8-21-24)25-19(26)12-23(20(25)27)9-15-6-4-5-7-18(15)28-3/h4-8,10H,9,11-12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211282
PNG
(US9247759, 10-30)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccc(C)cc2)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-13-4-6-16(7-5-13)9-23-12-19(26)25(20(23)27)17-8-21-24(10-17)11-18-14(2)22-28-15(18)3/h4-8,10H,9,11-12H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211279
PNG
(US9247759, 10-27)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(F)c2)C1=O
Show InChI InChI=1S/C19H18FN5O3/c1-12-17(13(2)28-22-12)10-24-9-16(7-21-24)25-18(26)11-23(19(25)27)8-14-4-3-5-15(20)6-14/h3-7,9H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211329
PNG
(US9247759, 10-77)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(CCc2cccc(F)c2)C1=O
Show InChI InChI=1S/C20H20FN5O3/c1-13-18(14(2)29-23-13)11-25-10-17(9-22-25)26-19(27)12-24(20(26)28)7-6-15-4-3-5-16(21)8-15/h3-5,8-10H,6-7,11-12H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211287
PNG
(US9247759, 10-35)
Show SMILES COc1ccc(CN2CC(=O)N(C2=O)c2cnn(Cc3c(C)noc3C)c2)cc1OC
Show InChI InChI=1S/C21H23N5O5/c1-13-17(14(2)31-23-13)11-25-10-16(8-22-25)26-20(27)12-24(21(26)28)9-15-5-6-18(29-3)19(7-15)30-4/h5-8,10H,9,11-12H2,1-4H3
UniProtKB/SwissProt

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n/an/a 60n/an/an/an/an/an/a



Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211264
PNG
(US9247759, 10-12)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccc(O)cc2)C1=O
Show InChI InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-3-5-16(25)6-4-14/h3-7,9,25H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211344
PNG
(US9247759, 10-92)
Show SMILES COCCn1n(Cc2ccccc2)c(=O)n(-c2cnn(Cc3c(C)noc3C)c2)c1=O
Show InChI InChI=1S/C21H24N6O4/c1-15-19(16(2)31-23-15)14-24-13-18(11-22-24)27-20(28)25(9-10-30-3)26(21(27)29)12-17-7-5-4-6-8-17/h4-8,11,13H,9-10,12,14H2,1-3H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211257
PNG
(US9247759, 10-5)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(CCOc2ccccc2)C1=O
Show InChI InChI=1S/C20H21N5O4/c1-14-18(15(2)29-22-14)12-24-11-16(10-21-24)25-19(26)13-23(20(25)27)8-9-28-17-6-4-3-5-7-17/h3-7,10-11H,8-9,12-13H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211263
PNG
(US9247759, 10-11)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2O)C1=O
Show InChI InChI=1S/C19H19N5O4/c1-12-16(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-5-3-4-6-17(14)25/h3-7,9,25H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211275
PNG
(US9247759, 10-23)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2[N+]([O-])=O)C1=O
Show InChI InChI=1S/C19H18N6O5/c1-12-16(13(2)30-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-5-3-4-6-17(14)25(28)29/h3-7,9H,8,10-11H2,1-2H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211388
PNG
(US9247759, 12-39)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2ccccc2O)C(C)(C)C1=O
Show InChI InChI=1S/C21H23N5O4/c1-13-17(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(3,4)25(20(26)29)10-15-7-5-6-8-18(15)27/h5-9,11,27H,10,12H2,1-4H3
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Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%