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Patent code US9249085

Compile Data Set for Download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204958
PNG
(US9249085, I(r) | US9624159, Compound I(r))
Show SMILES OC(=O)COc1ccc(Cl)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1Cl
Show InChI InChI=1S/C21H15Cl2F2NO3/c22-16-5-7-18(29-11-19(27)28)20(23)21(16)26-10-14-8-13(4-6-17(14)25)12-2-1-3-15(24)9-12/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204973
PNG
(US9249085, I(ag))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-21(30-13-22(28)29)16(3)24(14)27-12-19-10-18(9-15(2)23(19)26)17-5-4-6-20(25)11-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204951
PNG
(US9249085, I(k) | US9624159, Compound I(k))
Show SMILES OC(=O)COc1ccc(Cl)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15ClF3NO3/c22-16-5-7-18(29-11-19(27)28)20(25)21(16)26-10-14-8-13(4-6-17(14)24)12-2-1-3-15(23)9-12/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204986
PNG
(US9249085, I(at) | US9624159, Compound I(at))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-9-18(17-5-4-6-20(25)11-17)10-19(15(14)2)12-27-24-16(3)22(8-7-21(24)26)30-13-23(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204970
PNG
(US9249085, I(ad) | US9624159, Compound I(ad))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(22(13)26)11-27-23-14(2)20(7-6-19(23)25)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204978
PNG
(US9249085, I(al) | US9624159, Compound I(al))
Show SMILES COc1c(C)cc(cc1CNc1c(C)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO4/c1-15-8-9-22(31-14-23(28)29)17(3)24(15)27-13-20-11-19(10-16(2)25(20)30-4)18-6-5-7-21(26)12-18/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204989
PNG
(US9249085, I(aw) | US9624159, Compound I(aw))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204967
PNG
(US9249085, I(aa) | US9624159, Compound I(aa))
Show SMILES Cc1c(F)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-15(7-14(9-18(12)25)13-3-2-4-16(23)8-13)10-27-22-17(24)5-6-19(21(22)26)30-11-20(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM204977
PNG
(US9249085, I(ak) | US9624159, Compound I(ak))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO3/c1-15-8-9-23(30-14-24(28)29)18(4)25(15)27-13-21-11-20(10-16(2)17(21)3)19-6-5-7-22(26)12-19/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
The competition reaction was initiated by incubation of membrane protein homogenate (20 μg protein) for 120 min at 22° C. with 0.5 nM [3H]PGE2 l...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204955
PNG
(US9249085, I(o))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1Cl
Show InChI InChI=1S/C21H15ClF3NO3/c22-20-18(29-11-19(27)28)7-6-17(25)21(20)26-10-14-8-13(4-5-16(14)24)12-2-1-3-15(23)9-12/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204957
PNG
(US9249085, I(q))
Show SMILES COc1cc(CNc2c(F)ccc(OCC(O)=O)c2F)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO4/c1-29-17-8-13(7-15(10-17)14-3-2-4-16(23)9-14)11-26-22-18(24)5-6-19(21(22)25)30-12-20(27)28/h2-10,26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204958
PNG
(US9249085, I(r) | US9624159, Compound I(r))
Show SMILES OC(=O)COc1ccc(Cl)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1Cl
Show InChI InChI=1S/C21H15Cl2F2NO3/c22-16-5-7-18(29-11-19(27)28)20(23)21(16)26-10-14-8-13(4-6-17(14)25)12-2-1-3-15(24)9-12/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204989
PNG
(US9249085, I(aw) | US9624159, Compound I(aw))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204941
PNG
(US9249085, I(a))
Show SMILES OC(=O)COc1cccc(NCc2cc(ccc2F)-c2cccc(F)c2)c1
Show InChI InChI=1S/C21H17F2NO3/c22-17-4-1-3-14(10-17)15-7-8-20(23)16(9-15)12-24-18-5-2-6-19(11-18)27-13-21(25)26/h1-11,24H,12-13H2,(H,25,26)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204948
PNG
(US9249085, I(h))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-7-14(13-3-2-4-16(23)9-13)8-15(20(12)25)10-27-22-17(24)5-6-18(21(22)26)30-11-19(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204950
PNG
(US9249085, I(j))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(ccc1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H21F2NO3/c1-14-6-9-21(29-13-22(27)28)15(2)23(14)26-12-18-10-17(7-8-20(18)25)16-4-3-5-19(24)11-16/h3-11,26H,12-13H2,1-2H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204961
PNG
(US9249085, I(u))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1O)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO4/c1-12-7-14(13-3-2-4-16(23)9-13)8-15(22(12)29)10-26-21-17(24)5-6-18(20(21)25)30-11-19(27)28/h2-9,26,29H,10-11H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204971
PNG
(US9249085, I(ae))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H21F2NO3/c1-14-8-16(10-18(9-14)17-4-3-5-19(24)11-17)12-26-23-15(2)21(7-6-20(23)25)29-13-22(27)28/h3-11,26H,12-13H2,1-2H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204981
PNG
(US9249085, I(ao))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(O)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FNO4/c1-14-6-7-21(29-13-22(27)28)15(2)23(14)25-12-16-8-18(11-20(26)9-16)17-4-3-5-19(24)10-17/h3-11,25-26H,12-13H2,1-2H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204988
PNG
(US9249085, I(av))
Show SMILES Cc1c(F)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-17(8-16(10-20(13)26)15-4-3-5-18(24)9-15)11-27-23-14(2)21(7-6-19(23)25)30-12-22(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204992
PNG
(US9249085, CP-544326)
Show SMILES CC(C)OC(=O)COc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)c1
Show InChI InChI=1S/C27H28N4O5S/c1-21(2)36-27(32)20-35-25-7-3-6-23(16-25)19-30(37(33,34)26-8-4-13-28-17-26)18-22-9-11-24(12-10-22)31-15-5-14-29-31/h3-17,21H,18-20H2,1-2H3
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n/an/an/an/a 46n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204943
PNG
(US9249085, I(c))
Show SMILES Cc1ccc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO3/c1-13-5-6-15(14-3-2-4-17(23)10-14)9-16(13)11-26-22-18(24)7-8-19(21(22)25)29-12-20(27)28/h2-10,26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204947
PNG
(US9249085, I(g))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2F)c(F)c(c1)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-7-14(20(25)16(8-12)13-3-2-4-15(23)9-13)10-27-22-17(24)5-6-18(21(22)26)30-11-19(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204963
PNG
(US9249085, I(w))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(ccc2F)-c2ccc(F)c(F)c2)c1F
Show InChI InChI=1S/C21H14F5NO3/c22-14-3-1-11(12-2-4-15(23)17(25)8-12)7-13(14)9-27-21-16(24)5-6-18(20(21)26)30-10-19(28)29/h1-8,27H,9-10H2,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204964
PNG
(US9249085, I(x))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(cc(c2)-c2cccc(F)c2)C#N)c1F
Show InChI InChI=1S/C22H15F3N2O3/c23-17-3-1-2-15(9-17)16-7-13(10-26)6-14(8-16)11-27-22-18(24)4-5-19(21(22)25)30-12-20(28)29/h1-9,27H,11-12H2,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204969
PNG
(US9249085, I(ac))
Show SMILES Cc1cc(OCC(O)=O)c(C)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-20(30-12-21(28)29)14(2)23(22(13)26)27-11-17-9-16(6-7-19(17)25)15-4-3-5-18(24)10-15/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204976
PNG
(US9249085, I(aj))
Show SMILES Cc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H24FNO3/c1-15-9-18(11-20(10-15)19-5-4-6-21(25)12-19)13-26-24-16(2)7-8-22(17(24)3)29-14-23(27)28/h4-12,26H,13-14H2,1-3H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204978
PNG
(US9249085, I(al) | US9624159, Compound I(al))
Show SMILES COc1c(C)cc(cc1CNc1c(C)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO4/c1-15-8-9-22(31-14-23(28)29)17(3)24(15)27-13-20-11-19(10-16(2)25(20)30-4)18-6-5-7-21(26)12-18/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204980
PNG
(US9249085, I(an))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1C#N
Show InChI InChI=1S/C22H15F3N2O3/c23-16-3-1-2-13(9-16)14-4-5-18(24)15(8-14)11-27-22-17(10-26)20(7-6-19(22)25)30-12-21(28)29/h1-9,27H,11-12H2,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204986
PNG
(US9249085, I(at) | US9624159, Compound I(at))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-9-18(17-5-4-6-20(25)11-17)10-19(15(14)2)12-27-24-16(3)22(8-7-21(24)26)30-13-23(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204990
PNG
(US9249085, II(d))
Show SMILES CC(C)OC(=O)COc1ccc(F)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C24H21F4NO3/c1-14(2)32-22(30)13-31-21-9-8-20(27)24(23(21)28)29-12-17-10-16(6-7-19(17)26)15-4-3-5-18(25)11-15/h3-11,14,29H,12-13H2,1-2H3
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204991
PNG
(US9249085, I(as) (+ isomer))
Show SMILES C[C@@H](Nc1c(F)ccc(OCC(O)=O)c1F)c1cc(ccc1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12(27-22-18(25)7-8-19(21(22)26)30-11-20(28)29)16-10-14(5-6-17(16)24)13-3-2-4-15(23)9-13/h2-10,12,27H,11H2,1H3,(H,28,29)/t12-/m1/s1
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204942
PNG
(US9249085, I(b))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15F4NO3/c22-15-3-1-2-12(9-15)13-4-5-16(23)14(8-13)10-26-21-17(24)6-7-18(20(21)25)29-11-19(27)28/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204952
PNG
(US9249085, I(l))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(ccc2Cl)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15ClF3NO3/c22-16-5-4-13(12-2-1-3-15(23)9-12)8-14(16)10-26-21-17(24)6-7-18(20(21)25)29-11-19(27)28/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204953
PNG
(US9249085, I(m))
Show SMILES Cc1c(OCC(O)=O)ccc(F)c1NCc1cc(ccc1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO3/c1-13-20(29-12-21(27)28)8-7-19(25)22(13)26-11-16-9-15(5-6-18(16)24)14-3-2-4-17(23)10-14/h2-10,26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204956
PNG
(US9249085, I(p))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(O)cc(c2)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H16F3NO4/c22-15-3-1-2-13(8-15)14-6-12(7-16(26)9-14)10-25-21-17(23)4-5-18(20(21)24)29-11-19(27)28/h1-9,25-26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204965
PNG
(US9249085, I(y))
Show SMILES Cc1c(CNc2c(F)ccc(OCC(O)=O)c2F)c(F)ccc1-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-15(13-3-2-4-14(23)9-13)5-6-17(24)16(12)10-27-22-18(25)7-8-19(21(22)26)30-11-20(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204970
PNG
(US9249085, I(ad) | US9624159, Compound I(ad))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(22(13)26)11-27-23-14(2)20(7-6-19(23)25)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204974
PNG
(US9249085, I(ah))
Show SMILES Cc1c(OCC(O)=O)ccc(F)c1NCc1cc(O)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C22H19F2NO4/c1-13-20(29-12-21(27)28)6-5-19(24)22(13)25-11-14-7-16(10-18(26)8-14)15-3-2-4-17(23)9-15/h2-10,25-26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204975
PNG
(US9249085, I(ai))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2C)c(F)c(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(22(26)18(9-13)15-4-3-5-17(24)10-15)11-27-23-14(2)20(7-6-19(23)25)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204977
PNG
(US9249085, I(ak) | US9624159, Compound I(ak))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO3/c1-15-8-9-23(30-14-24(28)29)18(4)25(15)27-13-21-11-20(10-16(2)17(21)3)19-6-5-7-22(26)12-19/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204979
PNG
(US9249085, I(am))
Show SMILES Cc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)c(F)c(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-9-18(23(26)20(10-14)17-5-4-6-19(25)11-17)12-27-24-15(2)7-8-21(16(24)3)30-13-22(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204982
PNG
(US9249085, I(ap))
Show SMILES COc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H24FNO4/c1-15-7-8-22(30-14-23(27)28)16(2)24(15)26-13-17-9-19(12-21(10-17)29-3)18-5-4-6-20(25)11-18/h4-12,26H,13-14H2,1-3H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204944
PNG
(US9249085, I(d))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2F)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO3/c1-13-7-14(9-16(8-13)15-3-2-4-17(23)10-15)11-26-22-18(24)5-6-19(21(22)25)29-12-20(27)28/h2-10,26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204951
PNG
(US9249085, I(k) | US9624159, Compound I(k))
Show SMILES OC(=O)COc1ccc(Cl)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15ClF3NO3/c22-16-5-7-18(29-11-19(27)28)20(25)21(16)26-10-14-8-13(4-6-17(14)24)12-2-1-3-15(23)9-12/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204959
PNG
(US9249085, I(s))
Show SMILES OC(=O)COc1ccc(F)c(NCc2c(F)ccc(c2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H14F5NO3/c22-12-3-1-2-11(8-12)13-4-5-15(23)14(19(13)25)9-27-21-16(24)6-7-17(20(21)26)30-10-18(28)29/h1-8,27H,9-10H2,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204960
PNG
(US9249085, I(t))
Show SMILES COc1c(C)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO4/c1-13-8-15(14-4-3-5-17(24)10-14)9-16(23(13)30-2)11-27-22-18(25)6-7-19(21(22)26)31-12-20(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204962
PNG
(US9249085, I(v))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(14(13)2)11-27-23-19(25)6-7-20(22(23)26)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204966
PNG
(US9249085, I(z))
Show SMILES NC(=O)c1cc(CNc2c(F)ccc(OCC(O)=O)c2F)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F3N2O4/c23-16-3-1-2-13(9-16)14-6-12(7-15(8-14)22(26)30)10-27-21-17(24)4-5-18(20(21)25)31-11-19(28)29/h1-9,27H,10-11H2,(H2,26,30)(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204972
PNG
(US9249085, I(af))
Show SMILES COc1c(C)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO4/c1-14-9-17(16-5-4-6-19(25)11-16)10-18(24(14)30-3)12-27-23-15(2)21(8-7-20(23)26)31-13-22(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204983
PNG
(US9249085, I(aq))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H19F4NO3/c1-12-7-15(14-3-4-17(24)19(26)9-14)8-16(13(12)2)10-28-23-18(25)5-6-20(22(23)27)31-11-21(29)30/h3-9,28H,10-11H2,1-2H3,(H,29,30)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204949
PNG
(US9249085, I(i))
Show SMILES Cc1ccc(OCC(O)=O)c(F)c1NCc1cc(ccc1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H18F3NO3/c1-13-5-8-19(29-12-20(27)28)21(25)22(13)26-11-16-9-15(6-7-18(16)24)14-3-2-4-17(23)10-14/h2-10,26H,11-12H2,1H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204945
PNG
(US9249085, I(e))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cccc(c2)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H16F3NO3/c22-16-6-2-5-15(10-16)14-4-1-3-13(9-14)11-25-21-17(23)7-8-18(20(21)24)28-12-19(26)27/h1-10,25H,11-12H2,(H,26,27)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204985
PNG
(US9249085, I(as))
Show SMILES CC(Nc1c(F)ccc(OCC(O)=O)c1F)c1cc(ccc1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12(27-22-18(25)7-8-19(21(22)26)30-11-20(28)29)16-10-14(5-6-17(16)24)13-3-2-4-15(23)9-13/h2-10,12,27H,11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204984
PNG
(US9249085, I(ar))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H19F4NO3/c1-12-5-14(15-7-17(24)9-18(25)8-15)6-16(13(12)2)10-28-23-19(26)3-4-20(22(23)27)31-11-21(29)30/h3-9,28H,10-11H2,1-2H3,(H,29,30)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204973
PNG
(US9249085, I(ag))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-21(30-13-22(28)29)16(3)24(14)27-12-19-10-18(9-15(2)23(19)26)17-5-4-6-20(25)11-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204968
PNG
(US9249085, I(ab))
Show SMILES Cc1cc(OCC(O)=O)c(F)c(NCc2cc(ccc2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C22H17F4NO3/c1-12-7-18(30-11-19(28)29)21(26)22(20(12)25)27-10-15-8-14(5-6-17(15)24)13-3-2-4-16(23)9-13/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204967
PNG
(US9249085, I(aa) | US9624159, Compound I(aa))
Show SMILES Cc1c(F)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-15(7-14(9-18(12)25)13-3-2-4-16(23)8-13)10-27-22-17(24)5-6-19(21(22)26)30-11-20(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204987
PNG
(US9249085, I(au))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1ccccc1
Show InChI InChI=1S/C23H21F2NO3/c1-14-10-17(16-6-4-3-5-7-16)11-18(15(14)2)12-26-23-19(24)8-9-20(22(23)25)29-13-21(27)28/h3-11,26H,12-13H2,1-2H3,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204946
PNG
(US9249085, I(f))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(O)cc(c2F)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15F4NO4/c22-13-3-1-2-11(6-13)15-8-14(27)7-12(19(15)24)9-26-21-16(23)4-5-17(20(21)25)30-10-18(28)29/h1-8,26-27H,9-10H2,(H,28,29)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))		BDBM204954
PNG
(US9249085, I(n))
Show SMILES OC(=O)COc1ccc(F)c(NCc2cc(F)cc(c2)-c2cccc(F)c2)c1F
Show InChI InChI=1S/C21H15F4NO3/c22-15-3-1-2-13(8-15)14-6-12(7-16(23)9-14)10-26-21-17(24)4-5-18(20(21)25)29-11-19(27)28/h1-9,26H,10-11H2,(H,27,28)
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FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...

US Patent US9249085 (2016)


BindingDB Entry DOI: 10.7270/Q2WQ02N8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%