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Patent code US9260440

Compile Data Set for Download or QSAR
Found 123 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207586
PNG
(US10501467, Example 31 | US9260440, 31 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C22H28N4O/c1-22(2)13-16-20-18(14-22)26(12-11-25-9-4-3-5-10-25)17-8-6-7-15(19(17)20)21(27)24-23-16/h6-8H,3-5,9-14H2,1-2H3,(H,24,27)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207576
PNG
(US10501467, Example 21 | US9260440, 21 | US9617273...)
Show SMILES Fc1cc2[nH]c3CN(Cc4n[nH]c(=O)c(c1)c2c34)C(=O)OCc1ccccc1
Show InChI InChI=1S/C20H15FN4O3/c21-12-6-13-17-14(7-12)22-15-8-25(9-16(18(15)17)23-24-19(13)26)20(27)28-10-11-4-2-1-3-5-11/h1-7,22H,8-10H2,(H,24,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207588
PNG
(US10501467, Example 33 | US9260440, 33 | US9617273...)
Show SMILES CCN(CC)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C21H28N4O/c1-5-24(6-2)10-11-25-16-9-7-8-14-18(16)19-15(22-23-20(14)26)12-21(3,4)13-17(19)25/h7-9H,5-6,10-13H2,1-4H3,(H,23,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207602
PNG
(US10501467, Example 47 | US9260440, 47 | US9617273...)
Show SMILES O=C(C1CC1)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H14N4O2/c21-15-9-2-1-3-10-13(9)14-11(17-10)6-20(7-12(14)18-19-15)16(22)8-4-5-8/h1-3,8,17H,4-7H2,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207623
PNG
(US10501467, Example 68 | US9260440, 68 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cccc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H14N4O/c1-16-6-3-7-20(16)8-11-13-12-9(15(21)19-18-11)4-2-5-10(12)17-14(13)16/h2,4-5H,3,6-8H2,1H3/t16-/m1/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207624
PNG
(US10501467, Example 69 | US9260440, 69 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H13FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6H,2-4,7H2,1H3/t16-/m1/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207575
PNG
(US10501467, Example 20 | US9260440, 20 | US9617273...)
Show SMILES O=C(OCc1ccccc1)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C20H16N4O3/c25-19-13-7-4-8-14-17(13)18-15(21-14)9-24(10-16(18)22-23-19)20(26)27-11-12-5-2-1-3-6-12/h1-8,21H,9-11H2,(H,23,25)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207570
PNG
(US10501467, Example 15 | US9260440, 15 | US9617273...)
Show SMILES CC1(C)Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H15N3O/c1-15(2)6-10-13-11(7-15)17-18-14(19)8-4-3-5-9(16-10)12(8)13/h3-5,16H,6-7H2,1-2H3,(H,18,19)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207571
PNG
(US10501467, Example 16 | US9260440, 16 | US9617273...)
Show SMILES CC1(C)Cc2[nH]c3ccc(F)c4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-9-12-10(6-15)18-19-14(20)11-7(16)3-4-8(17-9)13(11)12/h3-4,17H,5-6H2,1-2H3,(H,19,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207569
PNG
(US10501467, Example 19 | US9260440, 14 | US9260440...)
Show SMILES CC1(C)CCc2[nH]c3cc(F)cc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)4-3-9-12-11-8(14(20)19-18-13(12)15)5-7(16)6-10(11)17-9/h5-6,17H,3-4H2,1-2H3,(H,19,20)
PDB

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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207569
PNG
(US10501467, Example 19 | US9260440, 14 | US9260440...)
Show SMILES CC1(C)CCc2[nH]c3cc(F)cc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)4-3-9-12-11-8(14(20)19-18-13(12)15)5-7(16)6-10(11)17-9/h5-6,17H,3-4H2,1-2H3,(H,19,20)
PDB

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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207600
PNG
(US10501467, Example 45 | US9260440, 45 | US9617273...)
Show SMILES CC(C)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H16N4O/c1-8(2)19-6-11-14-12(7-19)17-18-15(20)9-4-3-5-10(16-11)13(9)14/h3-5,8,16H,6-7H2,1-2H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207562
PNG
(US10501467, Example 7 | US9260440, 7 | US9617273, ...)
Show SMILES Fc1cc2[nH]c3CCCc4n[nH]c(=O)c(c1)c2c34
Show InChI InChI=1S/C13H10FN3O/c14-6-4-7-11-10(5-6)15-8-2-1-3-9(12(8)11)16-17-13(7)18/h4-5,15H,1-3H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207624
PNG
(US10501467, Example 69 | US9260440, 69 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H13FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6H,2-4,7H2,1H3/t16-/m1/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207581
PNG
(US10501467, Example 26 | US9260440, 26 | US9617273...)
Show SMILES CC1(C)Cc2n[nH]c(=O)c3cc(F)cc4[nH]c(C1=O)c2c34
Show InChI InChI=1S/C15H12FN3O2/c1-15(2)5-9-11-10-7(14(21)19-18-9)3-6(16)4-8(10)17-12(11)13(15)20/h3-4,17H,5H2,1-2H3,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207617
PNG
(US9260440, 62 | US9617273, Example 62)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17N5O2/c1-16(2,17)15(23)21-6-10-13-11(7-21)19-20-14(22)8-4-3-5-9(18-10)12(8)13/h3-5,18H,6-7,17H2,1-2H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207623
PNG
(US10501467, Example 68 | US9260440, 68 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cccc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H14N4O/c1-16-6-3-7-20(16)8-11-13-12-9(15(21)19-18-11)4-2-5-10(12)17-14(13)16/h2,4-5H,3,6-8H2,1H3/t16-/m1/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207557
PNG
(US9260440, 2 | US9617273, Example 2)
Show SMILES O=c1[nH]nc2CCCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C14H13N3O/c18-14-8-4-3-7-9-12(8)13-10(15-9)5-1-2-6-11(13)16-17-14/h3-4,7,15H,1-2,5-6H2,(H,17,18)
PDB

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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207561
PNG
(US10501467, Example 6 | US9260440, 6 | US9617273, ...)
Show SMILES CC(C)C1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H15N3O/c1-8(2)9-6-12-15-13(7-9)18-19-16(20)10-4-3-5-11(17-12)14(10)15/h3-5,8-9H,6-7H2,1-2H3
PDB

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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207606
PNG
(US10501467, Example 51 | US9260440, 51 | US9617273...)
Show SMILES CC(C)(C)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C17H18N4O2/c1-17(2,3)16(23)21-7-11-14-12(8-21)19-20-15(22)9-5-4-6-10(18-11)13(9)14/h4-6,18H,7-8H2,1-3H3,(H,20,22)
PDB

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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207560
PNG
(US9260440, 5 | US9617273, Example 5)
Show SMILES O=c1[nH]nc2CC(Cc3[nH]c4cccc1c4c23)c1ccccc1
Show InChI InChI=1S/C19H13N3O/c23-19-13-7-4-8-14-17(13)18-15(20-14)9-12(10-16(18)21-22-19)11-5-2-1-3-6-11/h1-8,12H,9-10H2
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207558
PNG
(US10501467, Example 3 | US9260440, 3 | US9617273, ...)
Show SMILES CC1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C14H11N3O/c1-7-5-10-13-11(6-7)16-17-14(18)8-3-2-4-9(15-10)12(8)13/h2-4,7H,5-6H2,1H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207556
PNG
(US10501467, Example 2 | US9260440, 1 | US9617273, ...)
Show SMILES O=c1[nH]nc2CCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C13H11N3O/c17-13-7-3-1-4-8-11(7)12-9(14-8)5-2-6-10(12)15-16-13/h1,3-4,14H,2,5-6H2,(H,16,17)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207604
PNG
(US10501467, Example 49 | US9260440, 49 | US9617273...)
Show SMILES Fc1cc2[nH]c3CN(Cc4n[nH]c(=O)c(c1)c2c34)C(=O)C1CC1
Show InChI InChI=1S/C16H13FN4O2/c17-8-3-9-13-10(4-8)18-11-5-21(16(23)7-1-2-7)6-12(14(11)13)19-20-15(9)22/h3-4,7,18H,1-2,5-6H2,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207617
PNG
(US9260440, 62 | US9617273, Example 62)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17N5O2/c1-16(2,17)15(23)21-6-10-13-11(7-21)19-20-14(22)8-4-3-5-9(18-10)12(8)13/h3-5,18H,6-7,17H2,1-2H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207586
PNG
(US10501467, Example 31 | US9260440, 31 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C22H28N4O/c1-22(2)13-16-20-18(14-22)26(12-11-25-9-4-3-5-10-25)17-8-6-7-15(19(17)20)21(27)24-23-16/h6-8H,3-5,9-14H2,1-2H3,(H,24,27)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207588
PNG
(US10501467, Example 33 | US9260440, 33 | US9617273...)
Show SMILES CCN(CC)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C21H28N4O/c1-5-24(6-2)10-11-25-16-9-7-8-14-18(16)19-15(22-23-20(14)26)12-21(3,4)13-17(19)25/h7-9H,5-6,10-13H2,1-4H3,(H,23,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207602
PNG
(US10501467, Example 47 | US9260440, 47 | US9617273...)
Show SMILES O=C(C1CC1)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H14N4O2/c21-15-9-2-1-3-10-13(9)14-11(17-10)6-20(7-12(14)18-19-15)16(22)8-4-5-8/h1-3,8,17H,4-7H2,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207566
PNG
(US10501467, Example 11 | US9260440, 11 | US9617273...)
Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207614
PNG
(US10501467, Example 59 | US9260440, 59 | US9617273...)
Show SMILES CCCCN1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17FN4O/c1-2-3-4-21-7-12-15-13(8-21)19-20-16(22)10-5-9(17)6-11(18-12)14(10)15/h5-6,18H,2-4,7-8H2,1H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207612
PNG
(US10501467, Example 57 | US9260440, 57 | US9617273...)
Show SMILES CCCN1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H15FN4O/c1-2-3-20-6-11-14-12(7-20)18-19-15(21)9-4-8(16)5-10(17-11)13(9)14/h4-5,17H,2-3,6-7H2,1H3,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207613
PNG
(US10501467, Example 58 | US9260440, 58 | US9617273...)
Show SMILES CCN1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C14H13FN4O/c1-2-19-5-10-13-11(6-19)17-18-14(20)8-3-7(15)4-9(16-10)12(8)13/h3-4,16H,2,5-6H2,1H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207601
PNG
(US10501467, Example 46 | US9260440, 46 | US9617273...)
Show SMILES CC(C)N1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H15FN4O/c1-7(2)20-5-11-14-12(6-20)18-19-15(21)9-3-8(16)4-10(17-11)13(9)14/h3-4,7,17H,5-6H2,1-2H3,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207564
PNG
(US10501467, Example 9 | US9260440, 9 | US9617273, ...)
Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)
PDB
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207569
PNG
(US10501467, Example 19 | US9260440, 14 | US9260440...)
Show SMILES CC1(C)CCc2[nH]c3cc(F)cc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)4-3-9-12-11-8(14(20)19-18-13(12)15)5-7(16)6-10(11)17-9/h5-6,17H,3-4H2,1-2H3,(H,19,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207569
PNG
(US10501467, Example 19 | US9260440, 14 | US9260440...)
Show SMILES CC1(C)CCc2[nH]c3cc(F)cc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)4-3-9-12-11-8(14(20)19-18-13(12)15)5-7(16)6-10(11)17-9/h5-6,17H,3-4H2,1-2H3,(H,19,20)
PDB
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207583
PNG
(US10501467, Example 28 | US9260440, 28 | US9617273...)
Show SMILES CN(C)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C19H24N4O/c1-19(2)10-13-17-15(11-19)23(9-8-22(3)4)14-7-5-6-12(16(14)17)18(24)21-20-13/h5-7H,8-11H2,1-4H3,(H,21,24)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207610
PNG
(US10501467, Example 55 | US9260440, 55 | US9617273...)
Show SMILES CN1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C13H11FN4O/c1-18-4-9-12-10(5-18)16-17-13(19)7-2-6(14)3-8(15-9)11(7)12/h2-3,15H,4-5H2,1H3,(H,17,19)
PDB
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207565
PNG
(US10501467, Example 10 | US9260440, 10 | US9617273...)
Show SMILES Fc1cc2[nH]c3CC(Cc4n[nH]c(=O)c(c1)c2c34)c1ccccc1
Show InChI InChI=1S/C19H12FN3O/c20-12-8-13-17-15(9-12)21-14-6-11(10-4-2-1-3-5-10)7-16(18(14)17)22-23-19(13)24/h1-5,8-9,11H,6-7H2
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207573
PNG
(US10501467, Example 18 | US9260440, 18 | US9617273...)
Show SMILES CC1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C14H10FN3O/c1-6-2-9-13-11(3-6)17-18-14(19)8-4-7(15)5-10(16-9)12(8)13/h4-6H,2-3H2,1H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207562
PNG
(US10501467, Example 7 | US9260440, 7 | US9617273, ...)
Show SMILES Fc1cc2[nH]c3CCCc4n[nH]c(=O)c(c1)c2c34
Show InChI InChI=1S/C13H10FN3O/c14-6-4-7-11-10(5-6)15-8-2-1-3-9(12(8)11)16-17-13(7)18/h4-5,15H,1-3H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207561
PNG
(US10501467, Example 6 | US9260440, 6 | US9617273, ...)
Show SMILES CC(C)C1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H15N3O/c1-8(2)9-6-12-15-13(7-9)18-19-16(20)10-4-3-5-11(17-12)14(10)15/h3-5,8-9H,6-7H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207570
PNG
(US10501467, Example 15 | US9260440, 15 | US9617273...)
Show SMILES CC1(C)Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H15N3O/c1-15(2)6-10-13-11(7-15)17-18-14(19)8-4-3-5-9(16-10)12(8)13/h3-5,16H,6-7H2,1-2H3,(H,18,19)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207560
PNG
(US9260440, 5 | US9617273, Example 5)
Show SMILES O=c1[nH]nc2CC(Cc3[nH]c4cccc1c4c23)c1ccccc1
Show InChI InChI=1S/C19H13N3O/c23-19-13-7-4-8-14-17(13)18-15(20-14)9-12(10-16(18)21-22-19)11-5-2-1-3-6-11/h1-8,12H,9-10H2
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207563
PNG
(US10501467, Example 8 | US9260440, 8 | US9617273, ...)
Show SMILES Fc1cc2[nH]c3CCCCc4n[nH]c(=O)c(c1)c2c34
Show InChI InChI=1S/C14H12FN3O/c15-7-5-8-12-11(6-7)16-9-3-1-2-4-10(13(9)12)17-18-14(8)19/h5-6,16H,1-4H2,(H,18,19)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207595
PNG
(US10501467, Example 40 | US9260440, 40 | US9617273...)
Show SMILES CN(C)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cc(F)cc1c4c23
Show InChI InChI=1S/C19H23FN4O/c1-19(2)9-13-17-15(10-19)24(6-5-23(3)4)14-8-11(20)7-12(16(14)17)18(25)22-21-13/h7-8H,5-6,9-10H2,1-4H3,(H,22,25)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207585
PNG
(US10501467, Example 34 | US9260440, 30 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C21H26N4O/c1-21(2)12-15-19-17(13-21)25(11-10-24-8-3-4-9-24)16-7-5-6-14(18(16)19)20(26)23-22-15/h5-7H,3-4,8-13H2,1-2H3,(H,23,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207557
PNG
(US9260440, 2 | US9617273, Example 2)
Show SMILES O=c1[nH]nc2CCCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C14H13N3O/c18-14-8-4-3-7-9-12(8)13-10(15-9)5-1-2-6-11(13)16-17-14/h3-4,7,15H,1-2,5-6H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207576
PNG
(US10501467, Example 21 | US9260440, 21 | US9617273...)
Show SMILES Fc1cc2[nH]c3CN(Cc4n[nH]c(=O)c(c1)c2c34)C(=O)OCc1ccccc1
Show InChI InChI=1S/C20H15FN4O3/c21-12-6-13-17-14(7-12)22-15-8-25(9-16(18(15)17)23-24-19(13)26)20(27)28-10-11-4-2-1-3-5-11/h1-7,22H,8-10H2,(H,24,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207600
PNG
(US10501467, Example 45 | US9260440, 45 | US9617273...)
Show SMILES CC(C)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H16N4O/c1-8(2)19-6-11-14-12(7-19)17-18-15(20)9-4-3-5-10(16-11)13(9)14/h3-5,8,16H,6-7H2,1-2H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207617
PNG
(US9260440, 62 | US9617273, Example 62)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17N5O2/c1-16(2,17)15(23)21-6-10-13-11(7-21)19-20-14(22)8-4-3-5-9(18-10)12(8)13/h3-5,18H,6-7,17H2,1-2H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207607
PNG
(US10501467, Example 52 | US9260440, 52 | US9617273...)
Show SMILES CC(C)(C)C(=O)N1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C17H17FN4O2/c1-17(2,3)16(24)22-6-11-14-12(7-22)20-21-15(23)9-4-8(18)5-10(19-11)13(9)14/h4-5,19H,6-7H2,1-3H3,(H,21,23)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207558
PNG
(US10501467, Example 3 | US9260440, 3 | US9617273, ...)
Show SMILES CC1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C14H11N3O/c1-7-5-10-13-11(6-7)16-17-14(18)8-3-2-4-9(15-10)12(8)13/h2-4,7H,5-6H2,1H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207611
PNG
(US10501467, Example 56 | US9260440, 56 | US9617273...)
Show SMILES CCCN1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H16N4O/c1-2-6-19-7-11-14-12(8-19)17-18-15(20)9-4-3-5-10(16-11)13(9)14/h3-5,16H,2,6-8H2,1H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207598
PNG
(US10501467, Example 43 | US9260440, 43 | US9617273...)
Show SMILES Fc1cc2[nH]c3CNCc4n[nH]c(=O)c(c1)c2c34
Show InChI InChI=1S/C12H9FN4O/c13-5-1-6-10-7(2-5)15-8-3-14-4-9(11(8)10)16-17-12(6)18/h1-2,14-15H,3-4H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207575
PNG
(US10501467, Example 20 | US9260440, 20 | US9617273...)
Show SMILES O=C(OCc1ccccc1)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C20H16N4O3/c25-19-13-7-4-8-14-17(13)18-15(21-14)9-24(10-16(18)22-23-19)20(26)27-11-12-5-2-1-3-6-12/h1-8,21H,9-11H2,(H,23,25)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207571
PNG
(US10501467, Example 16 | US9260440, 16 | US9617273...)
Show SMILES CC1(C)Cc2[nH]c3ccc(F)c4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-9-12-10(6-15)18-19-14(20)11-7(16)3-4-8(17-9)13(11)12/h3-4,17H,5-6H2,1-2H3,(H,19,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207608
PNG
(US10501467, Example 53 | US9260440, 53 | US9617273...)
Show SMILES O=c1[nH]nc2CN(Cc3[nH]c4cccc1c4c23)C1CCCCC1
Show InChI InChI=1S/C18H20N4O/c23-18-12-7-4-8-13-16(12)17-14(19-13)9-22(10-15(17)20-21-18)11-5-2-1-3-6-11/h4,7-8,11,19H,1-3,5-6,9-10H2,(H,21,23)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207590
PNG
(US10501467, Example 35 | US9260440, 35 | US9617273...)
Show SMILES O=c1[nH]nc2CCCc3n(CCN4CCCCC4)c4cccc1c4c23
Show InChI InChI=1S/C20H24N4O/c25-20-14-6-4-8-16-18(14)19-15(21-22-20)7-5-9-17(19)24(16)13-12-23-10-2-1-3-11-23/h4,6,8H,1-3,5,7,9-13H2,(H,22,25)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207556
PNG
(US10501467, Example 2 | US9260440, 1 | US9617273, ...)
Show SMILES O=c1[nH]nc2CCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C13H11N3O/c17-13-7-3-1-4-8-11(7)12-9(14-8)5-2-6-10(12)15-16-13/h1,3-4,14H,2,5-6H2,(H,16,17)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207582
PNG
(US10501467, Example 27 | US9260440, 27 | US9617273...)
Show SMILES CC1(C)Cc2n[nH]c(=O)c3cc(F)cc4[nH]c(C1O)c2c34 |w:17.18|
Show InChI InChI=1S/C15H12FN3O2/c1-15(2)5-9-11-10-7(14(21)19-18-9)3-6(16)4-8(10)17-12(11)13(15)20/h3-4,13,20H,5H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207603
PNG
(US10501467, Example 48 | US9260440, 48 | US9617273...)
Show SMILES CN(C)CCn1c2CN(Cc3n[nH]c(=O)c4cccc1c4c23)C(=O)C1CC1
Show InChI InChI=1S/C20H23N5O2/c1-23(2)8-9-25-15-5-3-4-13-17(15)18-14(21-22-19(13)26)10-24(11-16(18)25)20(27)12-6-7-12/h3-5,12H,6-11H2,1-2H3,(H,22,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207589
PNG
(US9260440, 34 | US9617273, Example 34)
Show SMILES O=c1[nH]nc2CCCc3n(CCN4CCCC4)c4cccc1c4c23
Show InChI InChI=1S/C19H22N4O/c24-19-13-5-3-7-15-17(13)18-14(20-21-19)6-4-8-16(18)23(15)12-11-22-9-1-2-10-22/h3,5,7H,1-2,4,6,8-12H2,(H,21,24)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207606
PNG
(US10501467, Example 51 | US9260440, 51 | US9617273...)
Show SMILES CC(C)(C)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C17H18N4O2/c1-17(2,3)16(23)21-7-11-14-12(8-21)19-20-15(22)9-5-4-6-10(18-11)13(9)14/h4-6,18H,7-8H2,1-3H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207581
PNG
(US10501467, Example 26 | US9260440, 26 | US9617273...)
Show SMILES CC1(C)Cc2n[nH]c(=O)c3cc(F)cc4[nH]c(C1=O)c2c34
Show InChI InChI=1S/C15H12FN3O2/c1-15(2)5-9-11-10-7(14(21)19-18-9)3-6(16)4-8(10)17-12(11)13(15)20/h3-4,17H,5H2,1-2H3,(H,19,21)
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n/an/a 11.4n/an/an/an/a8.0n/a



BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207620
PNG
(US10501467, Example 65 | US9260440, 65 | US9617273...)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H16FN5O2/c1-16(2,18)15(24)22-5-10-13-11(6-22)20-21-14(23)8-3-7(17)4-9(19-10)12(8)13/h3-4,19H,5-6,18H2,1-2H3,(H,21,23)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207609
PNG
(US10501467, Example 54 | US9260440, 54 | US9617273...)
Show SMILES CC(C)(C)CCN1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C18H22N4O/c1-18(2,3)7-8-22-9-13-16-14(10-22)20-21-17(23)11-5-4-6-12(19-13)15(11)16/h4-6,19H,7-10H2,1-3H3,(H,21,23)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207592
PNG
(US10501467, Example 37 | US9260440, 37 | US9617273...)
Show SMILES CN(C)CCn1c2CCCc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C17H20N4O/c1-20(2)9-10-21-13-7-3-5-11-15(13)16-12(18-19-17(11)22)6-4-8-14(16)21/h3,5,7H,4,6,8-10H2,1-2H3,(H,19,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207578
PNG
(US10501467, Example 23 | US9260440, 23 | US9617273...)
Show SMILES Cn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C16H17N3O/c1-16(2)7-10-14-12(8-16)19(3)11-6-4-5-9(13(11)14)15(20)18-17-10/h4-6H,7-8H2,1-3H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207577
PNG
(US9260440, 22 | US9617273, Example 22)
Show SMILES Cn1c2CCCc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C14H13N3O/c1-17-10-6-2-4-8-12(10)13-9(15-16-14(8)18)5-3-7-11(13)17/h2,4,6H,3,5,7H2,1H3,(H,16,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207599
PNG
(US10501467, Example 44 | US9260440, 44 | US9617273...)
Show SMILES CN1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C13H12N4O/c1-17-5-9-12-10(6-17)15-16-13(18)7-3-2-4-8(14-9)11(7)12/h2-4,14H,5-6H2,1H3,(H,16,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207593
PNG
(US10501467, Example 38 | US9260440, 38 | US9617273...)
Show SMILES CCN(CC)CCn1c2CCCc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C19H24N4O/c1-3-22(4-2)11-12-23-15-9-5-7-13-17(15)18-14(20-21-19(13)24)8-6-10-16(18)23/h5,7,9H,3-4,6,8,10-12H2,1-2H3,(H,21,24)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207597
PNG
(US10501467, Example 42 | US9260440, 42 | US9617273...)
Show SMILES O=c1[nH]nc2CNCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C12H10N4O/c17-12-6-2-1-3-7-10(6)11-8(14-7)4-13-5-9(11)15-16-12/h1-3,13-14H,4-5H2,(H,16,17)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207617
PNG
(US9260440, 62 | US9617273, Example 62)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17N5O2/c1-16(2,17)15(23)21-6-10-13-11(7-21)19-20-14(22)8-4-3-5-9(18-10)12(8)13/h3-5,18H,6-7,17H2,1-2H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207605
PNG
(US10501467, Example 50 | US9260440, 50 | US9617273...)
Show SMILES CN(C)CCn1c2CN(Cc3n[nH]c(=O)c4cc(F)cc1c4c23)C(=O)C1CC1
Show InChI InChI=1S/C20H22FN5O2/c1-24(2)5-6-26-15-8-12(21)7-13-17(15)18-14(22-23-19(13)27)9-25(10-16(18)26)20(28)11-3-4-11/h7-8,11H,3-6,9-10H2,1-2H3,(H,23,27)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207559
PNG
(US10501467, Example 4 | US9260440, 4 | US9617273, ...)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H15N3O/c1-15(2)7-6-10-12-11-8(4-3-5-9(11)16-10)14(19)18-17-13(12)15/h3-5,16H,6-7H2,1-2H3,(H,18,19)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207568
PNG
(US10501467, Example 13 | US9260440, 13 | US9617273...)
Show SMILES CN(C)c1ccc(cc1)C1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C21H18N4O/c1-25(2)14-8-6-12(7-9-14)13-10-17-20-18(11-13)23-24-21(26)15-4-3-5-16(22-17)19(15)20/h3-9,13H,10-11H2,1-2H3
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n/an/a 19.8n/an/an/an/a8.0n/a



BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))		BDBM207596
PNG
(US10501467, Example 41 | US9260440, 41 | US9617273...)
Show SMILES CC1(C)Cc2n(CC3CO3)c3cccc4c3c2c(C1)n[nH]c4=O
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207622
PNG
(US10501467, Example 67 | US9260440, 67)
Show SMILES CC1(C)Cc2n(CCO)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C17H19N3O2/c1-17(2)8-11-15-13(9-17)20(6-7-21)12-5-3-4-10(14(12)15)16(22)19-18-11/h3-5,21H,6-9H2,1-2H3,(H,19,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207572
PNG
(US10501467, Example 17 | US9260440, 17 | US9617273...)
Show SMILES Fc1ccc2c3c1[nH]c1CCCc(n[nH]c2=O)c31
Show InChI InChI=1S/C13H10FN3O/c14-7-5-4-6-10-11-8(15-12(7)10)2-1-3-9(11)16-17-13(6)18/h4-5,15H,1-3H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207567
PNG
(US9260440, 12 | US9617273, Example 12)
Show SMILES CN(C)c1ccc(cc1)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C21H17FN4O/c1-26(2)14-5-3-11(4-6-14)12-7-16-20-18(8-12)24-25-21(27)15-9-13(22)10-17(23-16)19(15)20/h3-6,9-10,12H,7-8H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207596
PNG
(US10501467, Example 41 | US9260440, 41 | US9617273...)
Show SMILES CC1(C)Cc2n(CC3CO3)c3cccc4c3c2c(C1)n[nH]c4=O
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207615
PNG
(US10501467, Example 60 | US9260440, 60 | US9617273...)
Show SMILES CN(C)CCN1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H19N5O/c1-20(2)6-7-21-8-12-15-13(9-21)18-19-16(22)10-4-3-5-11(17-12)14(10)15/h3-5,17H,6-9H2,1-2H3,(H,19,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207566
PNG
(US10501467, Example 11 | US9260440, 11 | US9617273...)
Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207619
PNG
(US10501467, Example 64 | US9260440, 64 | US9617273...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O |r|
Show InChI InChI=1S/C21H17N5O2/c22-14(9-12-5-2-1-3-6-12)21(28)26-10-16-19-17(11-26)24-25-20(27)13-7-4-8-15(23-16)18(13)19/h1-8,14H,9-11,22H2/t14-/m0/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207616
PNG
(US10501467, Example 61 | US9260440, 61 | US9617273...)
Show SMILES CN(C)CCN1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H18FN5O/c1-21(2)3-4-22-7-12-15-13(8-22)19-20-16(23)10-5-9(17)6-11(18-12)14(10)15/h5-6,18H,3-4,7-8H2,1-2H3,(H,20,23)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207561
PNG
(US10501467, Example 6 | US9260440, 6 | US9617273, ...)
Show SMILES CC(C)C1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H15N3O/c1-8(2)9-6-12-15-13(7-9)18-19-16(20)10-4-3-5-11(17-12)14(10)15/h3-5,8-9H,6-7H2,1-2H3
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207618
PNG
(US10501467, Example 63 | US9260440, 63)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O |r|
Show InChI InChI=1S/C26H25N5O4/c1-26(2,3)35-25(34)28-18(12-15-8-5-4-6-9-15)24(33)31-13-19-22-20(14-31)29-30-23(32)16-10-7-11-17(27-19)21(16)22/h4-11,18H,12-14H2,1-3H3,(H,28,34)/t18-/m0/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207562
PNG
(US10501467, Example 7 | US9260440, 7 | US9617273, ...)
Show SMILES Fc1cc2[nH]c3CCCc4n[nH]c(=O)c(c1)c2c34
Show InChI InChI=1S/C13H10FN3O/c14-6-4-7-11-10(5-6)15-8-2-1-3-9(12(8)11)16-17-13(7)18/h4-5,15H,1-3H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207590
PNG
(US10501467, Example 35 | US9260440, 35 | US9617273...)
Show SMILES O=c1[nH]nc2CCCc3n(CCN4CCCCC4)c4cccc1c4c23
Show InChI InChI=1S/C20H24N4O/c25-20-14-6-4-8-16-18(14)19-15(21-22-20)7-5-9-17(19)24(16)13-12-23-10-2-1-3-11-23/h4,6,8H,1-3,5,7,9-13H2,(H,22,25)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207564
PNG
(US10501467, Example 9 | US9260440, 9 | US9617273, ...)
Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207556
PNG
(US10501467, Example 2 | US9260440, 1 | US9617273, ...)
Show SMILES O=c1[nH]nc2CCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C13H11N3O/c17-13-7-3-1-4-8-11(7)12-9(14-8)5-2-6-10(12)15-16-13/h1,3-4,14H,2,5-6H2,(H,16,17)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207558
PNG
(US10501467, Example 3 | US9260440, 3 | US9617273, ...)
Show SMILES CC1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C14H11N3O/c1-7-5-10-13-11(6-7)16-17-14(18)8-3-2-4-9(15-10)12(8)13/h2-4,7H,5-6H2,1H3
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207589
PNG
(US9260440, 34 | US9617273, Example 34)
Show SMILES O=c1[nH]nc2CCCc3n(CCN4CCCC4)c4cccc1c4c23
Show InChI InChI=1S/C19H22N4O/c24-19-13-5-3-7-15-17(13)18-14(20-21-19)6-4-8-16(18)23(15)12-11-22-9-1-2-10-22/h3,5,7H,1-2,4,6,8-12H2,(H,21,24)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207557
PNG
(US9260440, 2 | US9617273, Example 2)
Show SMILES O=c1[nH]nc2CCCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C14H13N3O/c18-14-8-4-3-7-9-12(8)13-10(15-9)5-1-2-6-11(13)16-17-14/h3-4,7,15H,1-2,5-6H2,(H,17,18)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207560
PNG
(US9260440, 5 | US9617273, Example 5)
Show SMILES O=c1[nH]nc2CC(Cc3[nH]c4cccc1c4c23)c1ccccc1
Show InChI InChI=1S/C19H13N3O/c23-19-13-7-4-8-14-17(13)18-15(20-14)9-12(10-16(18)21-22-19)11-5-2-1-3-6-11/h1-8,12H,9-10H2
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207602
PNG
(US10501467, Example 47 | US9260440, 47 | US9617273...)
Show SMILES O=C(C1CC1)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H14N4O2/c21-15-9-2-1-3-10-13(9)14-11(17-10)6-20(7-12(14)18-19-15)16(22)8-4-5-8/h1-3,8,17H,4-7H2,(H,19,21)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207624
PNG
(US10501467, Example 69 | US9260440, 69 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H13FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6H,2-4,7H2,1H3/t16-/m1/s1
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207587
PNG
(US10501467, Example 32 | US9260440, 32 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCOCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C21H26N4O2/c1-21(2)12-15-19-17(13-21)25(7-6-24-8-10-27-11-9-24)16-5-3-4-14(18(16)19)20(26)23-22-15/h3-5H,6-13H2,1-2H3,(H,23,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207556
PNG
(US10501467, Example 2 | US9260440, 1 | US9617273, ...)
Show SMILES O=c1[nH]nc2CCCc3[nH]c4cccc1c4c23
Show InChI InChI=1S/C13H11N3O/c17-13-7-3-1-4-8-11(7)12-9(14-8)5-2-6-10(12)15-16-13/h1,3-4,14H,2,5-6H2,(H,16,17)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207564
PNG
(US10501467, Example 9 | US9260440, 9 | US9617273, ...)
Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207591
PNG
(US10501467, Example 36 | US9260440, 36 | US9617273...)
Show SMILES O=c1[nH]nc2CCCc3n(CCN4CCOCC4)c4cccc1c4c23
Show InChI InChI=1S/C19H22N4O2/c24-19-13-3-1-5-15-17(13)18-14(20-21-19)4-2-6-16(18)23(15)8-7-22-9-11-25-12-10-22/h1,3,5H,2,4,6-12H2,(H,21,24)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207595
PNG
(US10501467, Example 40 | US9260440, 40 | US9617273...)
Show SMILES CN(C)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cc(F)cc1c4c23
Show InChI InChI=1S/C19H23FN4O/c1-19(2)9-13-17-15(10-19)24(6-5-23(3)4)14-8-11(20)7-12(16(14)17)18(25)22-21-13/h7-8H,5-6,9-10H2,1-4H3,(H,22,25)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207606
PNG
(US10501467, Example 51 | US9260440, 51 | US9617273...)
Show SMILES CC(C)(C)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C17H18N4O2/c1-17(2,3)16(23)21-7-11-14-12(8-21)19-20-15(22)9-5-4-6-10(18-11)13(9)14/h4-6,18H,7-8H2,1-3H3,(H,20,22)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207586
PNG
(US10501467, Example 31 | US9260440, 31 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C22H28N4O/c1-22(2)13-16-20-18(14-22)26(12-11-25-9-4-3-5-10-25)17-8-6-7-15(19(17)20)21(27)24-23-16/h6-8H,3-5,9-14H2,1-2H3,(H,24,27)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207600
PNG
(US10501467, Example 45 | US9260440, 45 | US9617273...)
Show SMILES CC(C)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H16N4O/c1-8(2)19-6-11-14-12(7-19)17-18-15(20)9-4-3-5-10(16-11)13(9)14/h3-5,8,16H,6-7H2,1-2H3,(H,18,20)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207624
PNG
(US10501467, Example 69 | US9260440, 69 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H13FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6H,2-4,7H2,1H3/t16-/m1/s1
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n/an/a 766n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207594
PNG
(US10501467, Example 39 | US9260440, 39 | US9617273...)
Show SMILES O=c1[nH]nc2CCCc3n(CCN(Cc4ccccc4)Cc4ccccc4)c4cccc1c4c23
Show InChI InChI=1S/C29H28N4O/c34-29-23-13-7-15-25-27(23)28-24(30-31-29)14-8-16-26(28)33(25)18-17-32(19-21-9-3-1-4-10-21)20-22-11-5-2-6-12-22/h1-7,9-13,15H,8,14,16-20H2,(H,31,34)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207570
PNG
(US10501467, Example 15 | US9260440, 15 | US9617273...)
Show SMILES CC1(C)Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H15N3O/c1-15(2)6-10-13-11(7-15)17-18-14(19)8-4-3-5-9(16-10)12(8)13/h3-5,16H,6-7H2,1-2H3,(H,18,19)
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BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207580
PNG
(US10501467, Example 25 | US9260440, 25 | US9617273...)
Show SMILES Cn1c2CC(C)(C)Cc3nn(C)c(=O)c4cccc1c4c23
Show InChI InChI=1S/C17H19N3O/c1-17(2)8-11-15-13(9-17)19(3)12-7-5-6-10(14(12)15)16(21)20(4)18-11/h5-7H,8-9H2,1-4H3
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207579
PNG
(US10501467, Example 24 | US9260440, 24 | US9617273...)
Show SMILES CC1(C)Cc2n(Cc3ccccc3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C22H21N3O/c1-22(2)11-16-20-18(12-22)25(13-14-7-4-3-5-8-14)17-10-6-9-15(19(17)20)21(26)24-23-16/h3-10H,11-13H2,1-2H3,(H,24,26)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207596
PNG
(US10501467, Example 41 | US9260440, 41 | US9617273...)
Show SMILES CC1(C)Cc2n(CC3CO3)c3cccc4c3c2c(C1)n[nH]c4=O
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n/an/a 1.00E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207584
PNG
(US10501467, Example 29 | US9260440, 29 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN(Cc3ccccc3)Cc3ccccc3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C31H32N4O/c1-31(2)18-25-29-27(19-31)35(26-15-9-14-24(28(26)29)30(36)33-32-25)17-16-34(20-22-10-5-3-6-11-22)21-23-12-7-4-8-13-23/h3-15H,16-21H2,1-2H3,(H,33,36)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207559
PNG
(US10501467, Example 4 | US9260440, 4 | US9617273, ...)
Show SMILES CC1(C)CCc2[nH]c3cccc4c3c2c1n[nH]c4=O
Show InChI InChI=1S/C15H15N3O/c1-15(2)7-6-10-12-11-8(4-3-5-9(11)16-10)14(19)18-17-13(12)15/h3-5,16H,6-7H2,1-2H3,(H,18,19)
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n/an/a 1.05E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207600
PNG
(US10501467, Example 45 | US9260440, 45 | US9617273...)
Show SMILES CC(C)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C15H16N4O/c1-8(2)19-6-11-14-12(7-19)17-18-15(20)9-4-3-5-10(16-11)13(9)14/h3-5,8,16H,6-7H2,1-2H3,(H,18,20)
PDB

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n/an/a 1.20E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207623
PNG
(US10501467, Example 68 | US9260440, 68 | US9617273...)
Show SMILES C[C@]12CCCN1Cc1n[nH]c(=O)c3cccc4[nH]c2c1c34 |r|
Show InChI InChI=1S/C16H14N4O/c1-16-6-3-7-20(16)8-11-13-12-9(15(21)19-18-11)4-2-5-10(12)17-14(13)16/h2,4-5H,3,6-8H2,1H3/t16-/m1/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207583
PNG
(US10501467, Example 28 | US9260440, 28 | US9617273...)
Show SMILES CN(C)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C19H24N4O/c1-19(2)10-13-17-15(11-19)23(9-8-22(3)4)14-7-5-6-12(16(14)17)18(24)21-20-13/h5-7H,8-11H2,1-4H3,(H,21,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207585
PNG
(US10501467, Example 34 | US9260440, 30 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C21H26N4O/c1-21(2)12-15-19-17(13-21)25(11-10-24-8-3-4-9-24)16-7-5-6-14(18(16)19)20(26)23-22-15/h5-7H,3-4,8-13H2,1-2H3,(H,23,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))		BDBM207621
PNG
(US10501467, Example 66 | US9260440, 66 | US9617273...)
Show SMILES CC1(C)Cc2n(CCO)c3cccc4c3c2c(C1)nn(CCO)c4=O
Show InChI InChI=1S/C19H23N3O3/c1-19(2)10-13-17-15(11-19)21(6-8-23)14-5-3-4-12(16(14)17)18(25)22(20-13)7-9-24/h3-5,23-24H,6-11H2,1-2H3
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n/an/a 1.90E+3n/an/an/an/a8.0n/a



BeiGene, Ltd.

US Patent


Assay Description
PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207588
PNG
(US10501467, Example 33 | US9260440, 33 | US9617273...)
Show SMILES CCN(CC)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C21H28N4O/c1-5-24(6-2)10-11-25-16-9-7-8-14-18(16)19-15(22-23-20(14)26)12-21(3,4)13-17(19)25/h7-9H,5-6,10-13H2,1-4H3,(H,23,26)
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n/an/a 2.40E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))		BDBM207617
PNG
(US9260440, 62 | US9617273, Example 62)
Show SMILES CC(C)(N)C(=O)N1Cc2[nH]c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C16H17N5O2/c1-16(2,17)15(23)21-6-10-13-11(7-21)19-20-14(22)8-4-3-5-9(18-10)12(8)13/h3-5,18H,6-7,17H2,1-2H3,(H,20,22)
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n/an/a 3.80E+3n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207588
PNG
(US10501467, Example 33 | US9260440, 33 | US9617273...)
Show SMILES CCN(CC)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23
Show InChI InChI=1S/C21H28N4O/c1-5-24(6-2)10-11-25-16-9-7-8-14-18(16)19-15(22-23-20(14)26)12-21(3,4)13-17(19)25/h7-9H,5-6,10-13H2,1-4H3,(H,23,26)
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n/an/a 1.10E+4n/an/an/an/an/an/a



BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)


(Homo sapiens (Human))		BDBM207586
PNG
(US10501467, Example 31 | US9260440, 31 | US9617273...)
Show SMILES CC1(C)Cc2n(CCN3CCCCC3)c3cccc4c3c2c(C1)n[nH]c4=O
Show InChI InChI=1S/C22H28N4O/c1-22(2)13-16-20-18(14-22)26(12-11-25-9-4-3-5-10-25)17-8-6-7-15(19(17)20)21(27)24-23-16/h6-8H,3-5,9-14H2,1-2H3,(H,24,27)
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BeiGene, Ltd.

US Patent


Assay Description
PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...

US Patent US9260440 (2016)


BindingDB Entry DOI: 10.7270/Q2QV3KBD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%