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Patent code US9265773

Compile Data Set for Download or QSAR

Found 422 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208264
PNG
(US9265773, 209)
Show SMILES COC(=O)C(=O)N(C)C(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H26F2N4O8S/c1-39(34(43)35(44)47-3)33(42)30-22-14-21(26(40(2)50(4,45)46)16-29(22)49-32(30)18-8-10-19(36)11-9-18)24-12-13-28-31(38-24)27-15-20-23(37)6-5-7-25(20)41(27)17-48-28/h5-16H,17H2,1-4H3
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208106
PNG
(US9265773, 49)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4cccnc34)-c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H25FN4O5S/c1-34-32(38)29-24-15-22(19-8-11-27-23(13-19)26-14-20-5-4-12-35-31(20)37(26)17-41-27)25(36(2)43(3,39)40)16-28(24)42-30(29)18-6-9-21(33)10-7-18/h4-16H,17H2,1-3H3,(H,34,38)
PDB
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UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208061
PNG
(US9265773, 4)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN5O5S/c1-33-31(38)27-21-13-20(23(36(2)43(3,39)40)14-25(21)42-29(27)17-8-10-19(32)11-9-17)30-34-15-26-28(35-30)24-12-18-6-4-5-7-22(18)37(24)16-41-26/h4-15H,16H2,1-3H3,(H,33,38)
PDB
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UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208164
PNG
(US9265773, 107 | US9265773, 108)
Show SMILES CCNC(=O)C1Oc2ccc(nc2-c2cc3c(F)cccc3n12)-c1cc2c(C(=O)NC)c(oc2cc1N(C)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C35H29F2N5O6S/c1-5-39-34(44)35-42-25-8-6-7-23(37)20(25)16-27(42)31-28(48-35)14-13-24(40-31)21-15-22-29(17-26(21)41(3)49(4,45)46)47-32(30(22)33(43)38-2)18-9-11-19(36)12-10-18/h6-17,35H,5H2,1-4H3,(H,38,43)(H,39,44)
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US Patent
n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208080
PNG
(US9265773, 23)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(cccc4n3COc2cn1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)31-24-11-22(27(38(2)45(3,41)42)14-29(24)44-32(31)18-7-9-20(34)10-8-18)25-12-23-28-13-21-19(15-35)5-4-6-26(21)39(28)17-43-30(23)16-37-25/h4-14,16H,17H2,1-3H3,(H,36,40)
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US Patent
n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208162
PNG
(US9265773, 105 | US9265773, 106)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(C(N)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H25F2N5O6S/c1-37-32(42)28-20-13-19(24(39(2)47(3,43)44)15-27(20)45-30(28)16-7-9-17(34)10-8-16)22-11-12-26-29(38-22)25-14-18-21(35)5-4-6-23(18)40(25)33(46-26)31(36)41/h4-15,33H,1-3H3,(H2,36,41)(H,37,42)
PDB

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US Patent
n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208146
PNG
(US9265773, 89 | US9265773, 90)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(F)cccc4n3C(CO)Oc2cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H26F2N4O6S/c1-36-33(41)31-22-11-20(26(38(2)46(3,42)43)14-28(22)45-32(31)17-7-9-18(34)10-8-17)24-12-21-27-13-19-23(35)5-4-6-25(19)39(27)30(16-40)44-29(21)15-37-24/h4-15,30,40H,16H2,1-3H3,(H,36,41)
PDB

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UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208184
PNG
(US9265773, 128)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNS(C)(=O)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H29F2N5O7S2/c1-37-34(42)31-22-14-21(26(40(2)50(4,45)46)16-29(22)48-33(31)18-8-10-19(35)11-9-18)24-12-13-28-32(39-24)27-15-20-23(36)6-5-7-25(20)41(27)30(47-28)17-38-49(3,43)44/h5-16,30,38H,17H2,1-4H3,(H,37,42)
PDB

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UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208090
PNG
(US9265773, 33)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-31(40)28-22-11-21(25(38(2)45(3,41)42)13-27(22)44-30(28)17-7-9-19(33)10-8-17)23-15-36-32-29(37-23)26-12-20-18(14-34)5-4-6-24(20)39(26)16-43-32/h4-13,15H,16H2,1-3H3,(H,35,40)
PDB
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UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208219
PNG
(US9265773, 164)
Show SMILES CNC(=O)c1c(oc2cc(c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-n1cn[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C32H20F2N6O4/c1-35-31(41)28-20-11-19(22-9-10-26-29(37-22)25-12-18-21(34)3-2-4-23(18)40(25)15-43-26)24(39-14-36-38-32(39)42)13-27(20)44-30(28)16-5-7-17(33)8-6-16/h2-14H,15H2,1H3,(H,35,41)(H,38,42)
PDB

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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208087
PNG
(US9265773, 30)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)c(F)ccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H22F3N5O5S/c1-35-31(40)26-19-10-18(22(38(2)45(3,41)42)12-24(19)44-29(26)15-4-6-16(32)7-5-15)30-36-13-25-28(37-30)23-11-17-21(39(23)14-43-25)9-8-20(33)27(17)34/h4-13H,14H2,1-3H3,(H,35,40)
PDB
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208062
PNG
(US9265773, 5)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)27-20-11-19(23(37(2)44(3,40)41)13-25(20)43-29(27)16-7-9-17(32)10-8-16)30-35-14-26-28(36-30)24-12-18-21(33)5-4-6-22(18)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)
PDB
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208082
PNG
(US9265773, 25)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H23F2N5O5S/c1-34-30(39)27-20-11-19(24(37(2)44(3,40)41)13-26(20)43-29(27)16-7-9-17(32)10-8-16)22-14-35-31-28(36-22)25-12-18-21(33)5-4-6-23(18)38(25)15-42-31/h4-14H,15H2,1-3H3,(H,34,39)
PDB
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208218
PNG
(US9265773, 163)
Show SMILES CNC(=O)c1c(oc2cc(N)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H20F2N4O3/c1-34-30(37)27-19-11-18(21(33)13-26(19)39-29(27)15-5-7-16(31)8-6-15)22-9-10-25-28(35-22)24-12-17-20(32)3-2-4-23(17)36(24)14-38-25/h2-13H,14,33H2,1H3,(H,34,37)
PDB
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UniChem
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208066
PNG
(US9265773, 9)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OC(C)n3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O5S/c1-17-38-23-8-6-5-7-19(23)13-25(38)29-27(42-17)16-35-31(36-29)21-14-22-26(15-24(21)37(3)44(4,40)41)43-30(28(22)32(39)34-2)18-9-11-20(33)12-10-18/h5-17H,1-4H3,(H,34,39)
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208146
PNG
(US9265773, 89 | US9265773, 90)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(F)cccc4n3C(CO)Oc2cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H26F2N4O6S/c1-36-33(41)31-22-11-20(26(38(2)46(3,42)43)14-28(22)45-32(31)17-7-9-18(34)10-8-17)24-12-21-27-13-19-23(35)5-4-6-25(19)39(27)30(16-40)44-29(21)15-37-24/h4-15,30,40H,16H2,1-3H3,(H,36,41)
PDB
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UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208083
PNG
(US9265773, 26)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)28-22-11-21(24(38(2)45(3,41)42)13-26(22)44-30(28)17-7-9-19(33)10-8-17)31-36-15-27-29(37-31)25-12-20-18(14-34)5-4-6-23(20)39(25)16-43-27/h4-13,15H,16H2,1-3H3,(H,35,40)
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208083
PNG
(US9265773, 26)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)28-22-11-21(24(38(2)45(3,41)42)13-26(22)44-30(28)17-7-9-19(33)10-8-17)31-36-15-27-29(37-31)25-12-20-18(14-34)5-4-6-23(20)39(25)16-43-27/h4-13,15H,16H2,1-3H3,(H,35,40)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208090
PNG
(US9265773, 33)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-31(40)28-22-11-21(25(38(2)45(3,41)42)13-27(22)44-30(28)17-7-9-19(33)10-8-17)23-15-36-32-29(37-23)26-12-20-18(14-34)5-4-6-24(20)39(26)16-43-32/h4-13,15H,16H2,1-3H3,(H,35,40)
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US Patent
n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208204
PNG
(US9265773, 149)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C31H22F3N5O5S/c1-35-31(40)27-19-10-18(23(38(2)45(3,41)42)12-25(19)44-29(27)16-8-7-15(32)9-21(16)34)30-36-13-26-28(37-30)24-11-17-20(33)5-4-6-22(17)39(24)14-43-26/h4-13H,14H2,1-3H3,(H,35,40)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208104
PNG
(US9265773, 47)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(nccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)29-21-12-19(25(38(2)45(3,41)42)14-28(21)44-31(29)17-4-6-18(33)7-5-17)22-8-9-27-30(37-22)26-13-20-23(15-34)36-11-10-24(20)39(26)16-43-27/h4-14H,16H2,1-3H3,(H,35,40)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208080
PNG
(US9265773, 23)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4c(cccc4n3COc2cn1)C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)31-24-11-22(27(38(2)45(3,41)42)14-29(24)44-32(31)18-7-9-20(34)10-8-18)25-12-23-28-13-21-19(15-35)5-4-6-26(21)39(28)17-43-30(23)16-37-25/h4-14,16H,17H2,1-3H3,(H,36,40)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208061
PNG
(US9265773, 4)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN5O5S/c1-33-31(38)27-21-13-20(23(36(2)43(3,39)40)14-25(21)42-29(27)17-8-10-19(32)11-9-17)30-34-15-26-28(35-30)24-12-18-6-4-5-7-22(18)37(24)16-41-26/h4-15H,16H2,1-3H3,(H,33,38)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208248
PNG
(US9265773, 193)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H24F3N5O5S/c1-36-32(41)28-21-12-20(31-37-15-27-29(38-31)25-13-19-22(35)4-3-5-23(19)39(25)16-44-27)24(40(11-10-33)46(2,42)43)14-26(21)45-30(28)17-6-8-18(34)9-7-17/h3-9,12-15H,10-11,16H2,1-2H3,(H,36,41)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208162
PNG
(US9265773, 105 | US9265773, 106)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(C(N)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H25F2N5O6S/c1-37-32(42)28-20-13-19(24(39(2)47(3,43)44)15-27(20)45-30(28)16-7-9-17(34)10-8-16)22-11-12-26-29(38-22)25-14-18-21(35)5-4-6-23(18)40(25)33(46-26)31(36)41/h4-15,33H,1-3H3,(H2,36,41)(H,37,42)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208180
PNG
(US9265773, 124 | US9265773, 126)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(=O)[C@@H]3CCCN3C(=O)OC)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C40H36F2N6O8S/c1-43-39(50)35-25-17-24(30(46(2)57(4,52)53)19-33(25)56-37(35)21-10-12-22(41)13-11-21)27-14-15-32-36(45-27)31-18-23-26(42)7-5-8-28(23)48(31)34(55-32)20-44-38(49)29-9-6-16-47(29)40(51)54-3/h5,7-8,10-15,17-19,29,34H,6,9,16,20H2,1-4H3,(H,43,50)(H,44,49)/t29-,34?/m0/s1
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208091
PNG
(US9265773, 34)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(F)cccc34)-c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H24F2N4O5S/c1-35-31(39)29-23-12-20(26(37(2)44(3,40)41)14-28(23)43-30(29)17-7-9-19(33)10-8-17)18-11-22-27-13-21-24(34)5-4-6-25(21)38(27)16-42-32(22)36-15-18/h4-15H,16H2,1-3H3,(H,35,39)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208164
PNG
(US9265773, 107 | US9265773, 108)
Show SMILES CCNC(=O)C1Oc2ccc(nc2-c2cc3c(F)cccc3n12)-c1cc2c(C(=O)NC)c(oc2cc1N(C)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C35H29F2N5O6S/c1-5-39-34(44)35-42-25-8-6-7-23(37)20(25)16-27(42)31-28(48-35)14-13-24(40-31)21-15-22-29(17-26(21)41(3)49(4,45)46)47-32(30(22)33(43)38-2)18-9-11-19(36)12-10-18/h6-17,35H,5H2,1-4H3,(H,38,43)(H,39,44)
PDB
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208063
PNG
(US9265773, 6)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4cc(F)ccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)27-21-12-20(23(37(2)44(3,40)41)13-25(21)43-29(27)16-4-6-18(32)7-5-16)30-35-14-26-28(36-30)24-11-17-10-19(33)8-9-22(17)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208103
PNG
(US9265773, 46)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cncc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H23F2N5O5S/c1-34-31(39)28-20-10-19(23(37(2)44(3,40)41)12-27(20)43-30(28)16-4-6-17(32)7-5-16)22-8-9-26-29(36-22)24-11-18-21(33)13-35-14-25(18)38(24)15-42-26/h4-14H,15H2,1-3H3,(H,34,39)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208065
PNG
(US9265773, 8)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H25F2N5O5S/c1-35-32(40)28-21-13-20(24(38(2)45(3,41)42)15-26(21)44-30(28)17-7-9-18(33)10-8-17)31-36-16-27-29(37-31)25-14-19-22(34)5-4-6-23(19)39(25)11-12-43-27/h4-10,13-16H,11-12H2,1-3H3,(H,35,40)
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n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208267
PNG
(US9265773, 2)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H24F2N4O5S/c1-35-32(39)29-21-13-20(25(37(2)44(3,40)41)15-28(21)43-31(29)17-7-9-18(33)10-8-17)23-11-12-27-30(36-23)26-14-19-22(34)5-4-6-24(19)38(26)16-42-27/h4-15H,16H2,1-3H3,(H,35,39)
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n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208181
PNG
(US9265773, 125 | US9265773, 127)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(=O)[C@@H](NC(=O)OC)C(C)C)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C40H38F2N6O8S/c1-20(2)35(46-40(51)54-5)39(50)44-19-33-48-28-9-7-8-26(42)23(28)17-30(48)36-31(55-33)15-14-27(45-36)24-16-25-32(18-29(24)47(4)57(6,52)53)56-37(34(25)38(49)43-3)21-10-12-22(41)13-11-21/h7-18,20,33,35H,19H2,1-6H3,(H,43,49)(H,44,50)(H,46,51)/t33?,35-/m0/s1
PDB

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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208064
PNG
(US9265773, 7)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H26FN5O5S/c1-34-32(39)28-22-15-21(24(37(2)44(3,40)41)16-26(22)43-30(28)18-8-10-20(33)11-9-18)31-35-17-27-29(36-31)25-14-19-6-4-5-7-23(19)38(25)12-13-42-27/h4-11,14-17H,12-13H2,1-3H3,(H,34,39)
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n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208069
PNG
(US9265773, 12)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)30-23-13-22(26(38(2)45(3,41)42)15-29(23)44-32(30)18-7-9-20(34)10-8-18)24-11-12-28-31(37-24)27-14-21-19(16-35)5-4-6-25(21)39(27)17-43-28/h4-15H,17H2,1-3H3,(H,36,40)
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Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208067
PNG
(US9265773, 10)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4ccccc34)-c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H26FN3O5S/c1-35-33(38)31-25-16-23(20-10-13-29-24(14-20)28-15-21-6-4-5-7-26(21)37(28)18-41-29)27(36(2)43(3,39)40)17-30(25)42-32(31)19-8-11-22(34)12-9-19/h4-17H,18H2,1-3H3,(H,35,38)
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208093
PNG
(US9265773, 36)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1nc2-c3cc4c(F)cccc4n3COc2cc1OC)-c1ccc(F)cc1
Show InChI InChI=1S/C33H26F2N4O6S/c1-36-33(40)29-21-12-20(24(38(2)46(4,41)42)14-26(21)45-32(29)17-8-10-18(34)11-9-17)30-27(43-3)15-28-31(37-30)25-13-19-22(35)6-5-7-23(19)39(25)16-44-28/h5-15H,16H2,1-4H3,(H,36,40)
PDB
MMDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208106
PNG
(US9265773, 49)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4cccnc34)-c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H25FN4O5S/c1-34-32(38)29-24-15-22(19-8-11-27-23(13-19)26-14-20-5-4-12-35-31(20)37(26)17-41-27)25(36(2)43(3,39)40)16-28(24)42-30(29)18-6-9-21(33)10-7-18/h4-16H,17H2,1-3H3,(H,34,38)
PDB

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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208069
PNG
(US9265773, 12)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H24FN5O5S/c1-36-33(40)30-23-13-22(26(38(2)45(3,41)42)15-29(23)44-32(30)18-7-9-20(34)10-8-18)24-11-12-28-31(37-24)27-14-21-19(16-35)5-4-6-25(21)39(27)17-43-28/h4-15H,17H2,1-3H3,(H,36,40)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208109
PNG
(US9265773, 52)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCc3c([nH]c4ncccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN5O5S/c1-33-31(38)26-20-13-19(22-10-11-24-28(35-22)27-21(15-41-24)18-5-4-12-34-30(18)36-27)23(37(2)43(3,39)40)14-25(20)42-29(26)16-6-8-17(32)9-7-16/h4-14H,15H2,1-3H3,(H,33,38)(H,34,36)
PDB
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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208219
PNG
(US9265773, 164)
Show SMILES CNC(=O)c1c(oc2cc(c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-n1cn[nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C32H20F2N6O4/c1-35-31(41)28-20-11-19(22-9-10-26-29(37-22)25-12-18-21(34)3-2-4-23(18)40(25)15-43-26)24(39-14-36-38-32(39)42)13-27(20)44-30(28)16-5-7-17(33)8-6-16/h2-14H,15H2,1H3,(H,35,41)(H,38,42)
PDB
MMDB

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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208185
PNG
(US9265773, 129 | US9265773, 130)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OC(CNC(C)=O)n3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C35H29F2N5O6S/c1-18(43)39-17-31-42-26-7-5-6-24(37)21(26)15-28(42)33-29(47-31)13-12-25(40-33)22-14-23-30(16-27(22)41(3)49(4,45)46)48-34(32(23)35(44)38-2)19-8-10-20(36)11-9-19/h5-16,31H,17H2,1-4H3,(H,38,44)(H,39,43)
PDB
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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208248
PNG
(US9265773, 193)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H24F3N5O5S/c1-36-32(41)28-21-12-20(31-37-15-27-29(38-31)25-13-19-22(35)4-3-5-23(19)39(25)16-44-27)24(40(11-10-33)46(2,42)43)14-26(21)45-30(28)17-6-8-18(34)9-7-17/h3-9,12-15H,10-11,16H2,1-2H3,(H,36,41)
PDB

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n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208246
PNG
(US9265773, 191)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(cccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H25F2N5O5S/c1-38-34(42)31-24-14-23(25-10-11-29-32(39-25)28-15-22-20(17-37)4-3-5-26(22)40(28)18-45-29)27(41(13-12-35)47(2,43)44)16-30(24)46-33(31)19-6-8-21(36)9-7-19/h3-11,14-16H,12-13,18H2,1-2H3,(H,38,42)
PDB
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US Patent
n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208096
PNG
(US9265773, 39)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ncc2OCCCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H28FN5O5S/c1-35-33(40)29-23-16-22(25(38(2)45(3,41)42)17-27(23)44-31(29)19-9-11-21(34)12-10-19)32-36-18-28-30(37-32)26-15-20-7-4-5-8-24(20)39(26)13-6-14-43-28/h4-5,7-12,15-18H,6,13-14H2,1-3H3,(H,35,40)
PDB

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US Patent
n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208082
PNG
(US9265773, 25)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H23F2N5O5S/c1-34-30(39)27-20-11-19(24(37(2)44(3,40)41)13-26(20)43-29(27)16-7-9-17(32)10-8-16)22-14-35-31-28(36-22)25-12-18-21(33)5-4-6-23(18)38(25)15-42-31/h4-14H,15H2,1-3H3,(H,34,39)
PDB

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US Patent
n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208104
PNG
(US9265773, 47)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(nccc34)C#N)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H23FN6O5S/c1-35-32(40)29-21-12-19(25(38(2)45(3,41)42)14-28(21)44-31(29)17-4-6-18(33)7-5-17)22-8-9-27-30(37-22)26-13-20-23(15-34)36-11-10-24(20)39(26)16-43-27/h4-14H,16H2,1-3H3,(H,35,40)
PDB

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n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208068
PNG
(US9265773, 11)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc2-c3cc4ccccc4n3COc2cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H25FN4O5S/c1-34-32(38)30-23-13-21(24-14-22-27-12-19-6-4-5-7-25(19)37(27)17-41-29(22)16-35-24)26(36(2)43(3,39)40)15-28(23)42-31(30)18-8-10-20(33)11-9-18/h4-16H,17H2,1-3H3,(H,34,38)
PDB

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n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM208251
PNG
(US9265773, 196)
Show SMILES CNC(=O)c1c(oc2cc(N(CCF)S(C)(=O)=O)c(cc12)-c1ncc2OCn3c(cc4ccccc34)-c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C32H25F2N5O5S/c1-35-32(40)28-22-14-21(31-36-16-27-29(37-31)25-13-19-5-3-4-6-23(19)38(25)17-43-27)24(39(12-11-33)45(2,41)42)15-26(22)44-30(28)18-7-9-20(34)10-8-18/h3-10,13-16H,11-12,17H2,1-2H3,(H,35,40)
PDB
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n/an/a 1.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
Genome polyprotein


(Hepatitis C Virus (Virus))		BDBM208199
PNG
(US9265773, 144 | US9265773, 145)
Show SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cnc2OCc3c(nc4ccccn34)-c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN5O5S/c1-33-30(38)27-21-13-20(18-12-22-28-24(16-41-31(22)34-15-18)37-11-5-4-6-26(37)35-28)23(36(2)43(3,39)40)14-25(21)42-29(27)17-7-9-19(32)10-8-17/h4-15H,16H2,1-3H3,(H,33,38)
PDB

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n/an/a 1.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.; MSD Italia S.R.L.

US Patent


Assay Description
Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...

US Patent US9265773 (2016)


BindingDB Entry DOI: 10.7270/Q2XD10H7
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%