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Patent code US9273014

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209895
PNG
(US9273014, 24)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H28F6N4O3/c29-27(30,31)13-11-18(23(35)39)19(12-14-28(32,33)34)25(40)38-24-26(41)37-22-17(15-9-10-15)7-4-8-20(22)21(36-24)16-5-2-1-3-6-16/h1-8,15,18-19,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209891
PNG
(US9273014, 20)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F |r,c:32|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-7-18-19(13)39-24(43)22(38-20(18)14-5-3-6-15(12-14)27(34,35)36)40-23(42)17(9-11-26(31,32)33)16(21(37)41)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209891
PNG
(US9273014, 20)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F |r,c:32|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-7-18-19(13)39-24(43)22(38-20(18)14-5-3-6-15(12-14)27(34,35)36)40-23(42)17(9-11-26(31,32)33)16(21(37)41)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209896
PNG
(US9273014, 25)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(c2)C2CC2)c2cccc(Cl)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H27ClF6N4O3/c29-20-6-2-5-19-21(16-4-1-3-15(13-16)14-7-8-14)37-24(26(42)38-22(19)20)39-25(41)18(10-12-28(33,34)35)17(23(36)40)9-11-27(30,31)32/h1-6,13-14,17-18,24H,7-12H2,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209874
PNG
(US9273014, 3)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:34|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14(2)17-7-4-8-20-21(15-5-3-6-16(29)13-15)37-24(26(42)38-22(17)20)39-25(41)19(10-12-28(33,34)35)18(23(36)40)9-11-27(30,31)32/h3-8,13-14,18-19,24H,9-12H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209874
PNG
(US9273014, 3)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:34|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14(2)17-7-4-8-20-21(15-5-3-6-16(29)13-15)37-24(26(42)38-22(17)20)39-25(41)19(10-12-28(33,34)35)18(23(36)40)9-11-27(30,31)32/h3-8,13-14,18-19,24H,9-12H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209895
PNG
(US9273014, 24)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H28F6N4O3/c29-27(30,31)13-11-18(23(35)39)19(12-14-28(32,33)34)25(40)38-24-26(41)37-22-17(15-9-10-15)7-4-8-20(22)21(36-24)16-5-2-1-3-6-16/h1-8,15,18-19,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209876
PNG
(US9273014, 5)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14-11-15(2)13-16(12-14)21-19-5-3-7-20(29)22(19)38-26(42)24(37-21)39-25(41)18(8-10-28(33,34)35)17(23(36)40)6-4-9-27(30,31)32/h3,5,7,11-13,17-18,24H,4,6,8-10H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209888
PNG
(US9273014, 17)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-14-5-2-6-15(13-14)20-18-7-3-9-19(28)21(18)37-25(41)23(36-20)38-24(40)17(10-12-27(32,33)34)16(22(35)39)8-4-11-26(29,30)31/h2-3,5-7,9,13,16-17,23H,4,8,10-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209881
PNG
(US9273014, 10)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-13-10-14(2)12-15(11-13)20-18-4-3-5-19(28)21(18)37-25(41)23(36-20)38-24(40)17(7-9-27(32,33)34)16(22(35)39)6-8-26(29,30)31/h3-5,10-12,16-17,23H,6-9H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209898
PNG
(US9273014, 27)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cc1 |r,c:33|
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-4-2-3-17-19(13-5-7-14(27)8-6-13)35-22(24(40)36-20(17)18)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209898
PNG
(US9273014, 27)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cc1 |r,c:33|
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-4-2-3-17-19(13-5-7-14(27)8-6-13)35-22(24(40)36-20(17)18)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209902
PNG
(US9273014, 31)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-2-3-7-15(14)20-18-8-4-5-9-19(18)34-24(39)22(35-20)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209896
PNG
(US9273014, 25)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(c2)C2CC2)c2cccc(Cl)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H27ClF6N4O3/c29-20-6-2-5-19-21(16-4-1-3-15(13-16)14-7-8-14)37-24(26(42)38-22(19)20)39-25(41)18(10-12-28(33,34)35)17(23(36)40)9-11-27(30,31)32/h1-6,13-14,17-18,24H,7-12H2,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209907
PNG
(US9273014, 36)
Show SMILES Cc1ccc(cc1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-8-15(9-7-14)20-18-4-2-3-5-19(18)34-24(39)22(35-20)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F |r,t:8|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27(34,35)36)20(17)39-24(43)22(38-19)40-23(42)16(9-11-26(31,32)33)15(21(37)41)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209883
PNG
(US9273014, 12)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:34|
Show InChI InChI=1S/C29H32F6N4O3/c1-15(2)18-8-5-9-21-22(17-7-4-6-16(3)14-17)37-25(27(42)38-23(18)21)39-26(41)20(11-13-29(33,34)35)19(24(36)40)10-12-28(30,31)32/h4-9,14-15,19-20,25H,10-13H2,1-3H3,(H2,36,40)(H,38,42)(H,39,41)/t19-,20+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209893
PNG
(US9273014, 22)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1 |r,c:32|
Show InChI InChI=1S/C26H25F7N4O3/c1-13-3-2-4-18-19(13)36-24(40)22(35-20(18)14-5-7-15(27)8-6-14)37-23(39)17(10-12-26(31,32)33)16(21(34)38)9-11-25(28,29)30/h2-8,16-17,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209883
PNG
(US9273014, 12)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:34|
Show InChI InChI=1S/C29H32F6N4O3/c1-15(2)18-8-5-9-21-22(17-7-4-6-16(3)14-17)37-25(27(42)38-23(18)21)39-26(41)20(11-13-29(33,34)35)19(24(36)40)10-12-28(30,31)32/h4-9,14-15,19-20,25H,10-13H2,1-3H3,(H2,36,40)(H,38,42)(H,39,41)/t19-,20+,25+/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209892
PNG
(US9273014, 21)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-5-2-3-6-14(13)19-17-7-4-8-18(27)20(17)36-24(40)22(35-19)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209897
PNG
(US9273014, 26)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-7-3-6-17-19(13-4-2-5-14(27)12-13)35-22(24(40)36-20(17)18)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209884
PNG
(US9273014, 13)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 |r,c:34|
Show InChI InChI=1S/C28H30F6N4O3/c1-15(2)17-9-6-10-20-21(16-7-4-3-5-8-16)36-24(26(41)37-22(17)20)38-25(40)19(12-14-28(32,33)34)18(23(35)39)11-13-27(29,30)31/h3-10,15,18-19,24H,11-14H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209897
PNG
(US9273014, 26)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C26H25ClF6N4O4/c1-41-18-7-3-6-17-19(13-4-2-5-14(27)12-13)35-22(24(40)36-20(17)18)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209887
PNG
(US9273014, 16)
Show SMILES NC(=O)[C@@H](CCCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:22|
Show InChI InChI=1S/C29H30F6N4O4/c30-28(31,32)14-5-9-18(24(36)40)19(13-15-29(33,34)35)26(41)39-25-27(42)38-23-20(8-4-10-21(23)43-17-11-12-17)22(37-25)16-6-2-1-3-7-16/h1-4,6-8,10,17-19,25H,5,9,11-15H2,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F |r,t:8|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27(34,35)36)20(17)39-24(43)22(38-19)40-23(42)16(9-11-26(31,32)33)15(21(37)41)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209900
PNG
(US9273014, 29)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:33|
Show InChI InChI=1S/C27H28F6N4O4/c1-14-5-3-6-15(13-14)20-18-7-4-8-19(41-2)21(18)36-25(40)23(35-20)37-24(39)17(10-12-27(31,32)33)16(22(34)38)9-11-26(28,29)30/h3-8,13,16-17,23H,9-12H2,1-2H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,23+/m0/s1
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n/an/a 3.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209876
PNG
(US9273014, 5)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14-11-15(2)13-16(12-14)21-19-5-3-7-20(29)22(19)38-26(42)24(37-21)39-25(41)18(8-10-28(33,34)35)17(23(36)40)6-4-9-27(30,31)32/h3,5,7,11-13,17-18,24H,4,6,8-10H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209890
PNG
(US9273014, 19)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H28F6N4O4/c29-27(30,31)13-11-17(23(35)39)18(12-14-28(32,33)34)25(40)38-24-26(41)37-22-19(7-4-8-20(22)42-16-9-10-16)21(36-24)15-5-2-1-3-6-15/h1-8,16-18,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21|
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21|
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209871
PNG
(US9273014, 2)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-2-14-5-4-8-19-20(14)37-25(41)23(36-21(19)15-6-3-7-16(28)13-15)38-24(40)18(10-12-27(32,33)34)17(22(35)39)9-11-26(29,30)31/h3-8,13,17-18,23H,2,9-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209904
PNG
(US9273014, 33)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(cn1)C(F)(F)F |r,c:33|
Show InChI InChI=1S/C26H24F9N5O4/c1-44-17-4-2-3-15-18(16-6-5-12(11-37-16)26(33,34)35)38-21(23(43)39-19(15)17)40-22(42)14(8-10-25(30,31)32)13(20(36)41)7-9-24(27,28)29/h2-6,11,13-14,21H,7-10H2,1H3,(H2,36,41)(H,39,43)(H,40,42)/t13-,14+,21+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209878
PNG
(US9273014, 7)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:32|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209878
PNG
(US9273014, 7)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:32|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209886
PNG
(US9273014, 15)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12 |r,t:8|
Show InChI InChI=1S/C29H30F6N4O4/c1-15-4-2-5-16(14-15)22-20-6-3-7-21(43-17-8-9-17)23(20)38-27(42)25(37-22)39-26(41)19(11-13-29(33,34)35)18(24(36)40)10-12-28(30,31)32/h2-7,14,17-19,25H,8-13H2,1H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209886
PNG
(US9273014, 15)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12 |r,t:8|
Show InChI InChI=1S/C29H30F6N4O4/c1-15-4-2-5-16(14-15)22-20-6-3-7-21(43-17-8-9-17)23(20)38-27(42)25(37-22)39-26(41)19(11-13-29(33,34)35)18(24(36)40)10-12-28(30,31)32/h2-7,14,17-19,25H,8-13H2,1H3,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209877
PNG
(US9273014, 6)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:33|
Show InChI InChI=1S/C28H30F6N4O3/c1-3-16-7-5-9-20-21(16)37-26(41)24(36-22(20)17-8-4-6-15(2)14-17)38-25(40)19(11-13-28(32,33)34)18(23(35)39)10-12-27(29,30)31/h4-9,14,18-19,24H,3,10-13H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209889
PNG
(US9273014, 18)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F |r,c:33|
Show InChI InChI=1S/C28H27F9N4O3/c1-14-5-2-8-19-20(14)40-25(44)23(39-21(19)15-6-3-7-16(13-15)28(35,36)37)41-24(43)18(10-12-27(32,33)34)17(22(38)42)9-4-11-26(29,30)31/h2-3,5-8,13,17-18,23H,4,9-12H2,1H3,(H2,38,42)(H,40,44)(H,41,43)/t17-,18+,23+/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209902
PNG
(US9273014, 31)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-2-3-7-15(14)20-18-8-4-5-9-19(18)34-24(39)22(35-20)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209894
PNG
(US9273014, 23)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 |r,c:32|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-5-9-18-19(14)35-24(39)22(34-20(18)15-7-3-2-4-8-15)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209890
PNG
(US9273014, 19)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:21|
Show InChI InChI=1S/C28H28F6N4O4/c29-27(30,31)13-11-17(23(35)39)18(12-14-28(32,33)34)25(40)38-24-26(41)37-22-19(7-4-8-20(22)42-16-9-10-16)21(36-24)15-5-2-1-3-6-15/h1-8,16-18,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21|
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209899
PNG
(US9273014, 28)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27)20(17)36-24(40)22(35-19)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209905
PNG
(US9273014, 34)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cn1 |r,c:33|
Show InChI InChI=1S/C25H24ClF6N5O4/c1-41-17-4-2-3-15-18(16-6-5-12(26)11-34-16)35-21(23(40)36-19(15)17)37-22(39)14(8-10-25(30,31)32)13(20(33)38)7-9-24(27,28)29/h2-6,11,13-14,21H,7-10H2,1H3,(H2,33,38)(H,36,40)(H,37,39)/t13-,14+,21+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209871
PNG
(US9273014, 2)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-2-14-5-4-8-19-20(14)37-25(41)23(36-21(19)15-6-3-7-16(28)13-15)38-24(40)18(10-12-27(32,33)34)17(22(35)39)9-11-26(29,30)31/h3-8,13,17-18,23H,2,9-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209884
PNG
(US9273014, 13)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 |r,c:34|
Show InChI InChI=1S/C28H30F6N4O3/c1-15(2)17-9-6-10-20-21(16-7-4-3-5-8-16)36-24(26(41)37-22(17)20)38-25(40)19(12-14-28(32,33)34)18(23(35)39)11-13-27(29,30)31/h3-10,15,18-19,24H,11-14H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209911
PNG
(US9273014, Comparative Compound 47 | US9427442, Co...)
Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:14|
Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209881
PNG
(US9273014, 10)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-13-10-14(2)12-15(11-13)20-18-4-3-5-19(28)21(18)37-25(41)23(36-20)38-24(40)17(7-9-27(32,33)34)16(22(35)39)6-8-26(29,30)31/h3-5,10-12,16-17,23H,6-9H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209888
PNG
(US9273014, 17)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-14-5-2-6-15(13-14)20-18-7-3-9-19(28)21(18)37-25(41)23(36-20)38-24(40)17(10-12-27(32,33)34)16(22(35)39)8-4-11-26(29,30)31/h2-3,5-7,9,13,16-17,23H,4,8,10-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209900
PNG
(US9273014, 29)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:33|
Show InChI InChI=1S/C27H28F6N4O4/c1-14-5-3-6-15(13-14)20-18-7-4-8-19(41-2)21(18)36-25(40)23(35-20)37-24(39)17(10-12-27(31,32)33)16(22(34)38)9-11-26(28,29)30/h3-8,13,16-17,23H,9-12H2,1-2H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209887
PNG
(US9273014, 16)
Show SMILES NC(=O)[C@@H](CCCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O |r,t:22|
Show InChI InChI=1S/C29H30F6N4O4/c30-28(31,32)14-5-9-18(24(36)40)19(13-15-29(33,34)35)26(41)39-25-27(42)38-23-20(8-4-10-21(23)43-17-11-12-17)22(37-25)16-6-2-1-3-7-16/h1-4,6-8,10,17-19,25H,5,9,11-15H2,(H2,36,40)(H,38,42)(H,39,41)/t18-,19+,25+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209879
PNG
(US9273014, 8)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-14-5-2-8-19-20(14)37-25(41)23(36-21(19)15-6-3-7-16(28)13-15)38-24(40)18(10-12-27(32,33)34)17(22(35)39)9-4-11-26(29,30)31/h2-3,5-8,13,17-18,23H,4,9-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209903
PNG
(US9273014, 32)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-5-4-6-15(13-14)20-18-7-2-3-8-19(18)34-24(39)22(35-20)36-23(38)17(10-12-26(30,31)32)16(21(33)37)9-11-25(27,28)29/h2-8,13,16-17,22H,9-12H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209892
PNG
(US9273014, 21)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-5-2-3-6-14(13)19-17-7-4-8-18(27)20(17)36-24(40)22(35-19)37-23(39)16(10-12-26(31,32)33)15(21(34)38)9-11-25(28,29)30/h2-8,15-16,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209908
PNG
(US9273014, 37)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(CO)c2NC1=O |r,t:21|
Show InChI InChI=1S/C26H25F7N4O4/c27-15-5-1-3-13(11-15)19-18-6-2-4-14(12-38)20(18)36-24(41)22(35-19)37-23(40)17(8-10-26(31,32)33)16(21(34)39)7-9-25(28,29)30/h1-6,11,16-17,22,38H,7-10,12H2,(H2,34,39)(H,36,41)(H,37,40)/t16-,17+,22+/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209893
PNG
(US9273014, 22)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1 |r,c:32|
Show InChI InChI=1S/C26H25F7N4O3/c1-13-3-2-4-18-19(13)36-24(40)22(35-20(18)14-5-7-15(27)8-6-14)37-23(39)17(10-12-26(31,32)33)16(21(34)38)9-11-25(28,29)30/h2-8,16-17,22H,9-12H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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n/an/a 6.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209903
PNG
(US9273014, 32)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-5-4-6-15(13-14)20-18-7-2-3-8-19(18)34-24(39)22(35-20)36-23(38)17(10-12-26(30,31)32)16(21(33)37)9-11-25(27,28)29/h2-8,13,16-17,22H,9-12H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209877
PNG
(US9273014, 6)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1 |r,c:33|
Show InChI InChI=1S/C28H30F6N4O3/c1-3-16-7-5-9-20-21(16)37-26(41)24(36-22(20)17-8-4-6-15(2)14-17)38-25(40)19(11-13-28(32,33)34)18(23(35)39)10-12-27(29,30)31/h4-9,14,18-19,24H,3,10-13H2,1-2H3,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209899
PNG
(US9273014, 28)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8|
Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27)20(17)36-24(40)22(35-19)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209875
PNG
(US9273014, 4)
Show SMILES Cc1ccc(cc1C)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14-8-9-16(13-15(14)2)21-19-5-3-7-20(29)22(19)38-26(42)24(37-21)39-25(41)18(10-12-28(33,34)35)17(23(36)40)6-4-11-27(30,31)32/h3,5,7-9,13,17-18,24H,4,6,10-12H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209904
PNG
(US9273014, 33)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(cn1)C(F)(F)F |r,c:33|
Show InChI InChI=1S/C26H24F9N5O4/c1-44-17-4-2-3-15-18(16-6-5-12(11-37-16)26(33,34)35)38-21(23(43)39-19(15)17)40-22(42)14(8-10-25(30,31)32)13(20(36)41)7-9-24(27,28)29/h2-6,11,13-14,21H,7-10H2,1H3,(H2,36,41)(H,39,43)(H,40,42)/t13-,14+,21+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209885
PNG
(US9273014, 14)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12 |r,t:8|
Show InChI InChI=1S/C30H32F6N4O4/c1-16-5-2-6-17(15-16)23-21-7-3-9-22(44-18-10-11-18)24(21)39-28(43)26(38-23)40-27(42)20(12-14-30(34,35)36)19(25(37)41)8-4-13-29(31,32)33/h2-3,5-7,9,15,18-20,26H,4,8,10-14H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t19-,20+,26+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209889
PNG
(US9273014, 18)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F |r,c:33|
Show InChI InChI=1S/C28H27F9N4O3/c1-14-5-2-8-19-20(14)40-25(44)23(39-21(19)15-6-3-7-16(13-15)28(35,36)37)41-24(43)18(10-12-27(32,33)34)17(22(38)42)9-4-11-26(29,30)31/h2-3,5-8,13,17-18,23H,4,9-12H2,1H3,(H2,38,42)(H,40,44)(H,41,43)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209870
PNG
(US9273014, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(F)c1 |r,c:32|
Show InChI InChI=1S/C26H25F7N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21|
Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F |r,t:8|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27(34,35)36)20(17)39-24(43)22(38-19)40-23(42)16(9-11-26(31,32)33)15(21(37)41)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209894
PNG
(US9273014, 23)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1 |r,c:32|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-5-9-18-19(14)35-24(39)22(34-20(18)15-7-3-2-4-8-15)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,35,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209875
PNG
(US9273014, 4)
Show SMILES Cc1ccc(cc1C)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:9|
Show InChI InChI=1S/C28H29ClF6N4O3/c1-14-8-9-16(13-15(14)2)21-19-5-3-7-20(29)22(19)38-26(42)24(37-21)39-25(41)18(10-12-28(33,34)35)17(23(36)40)6-4-11-27(30,31)32/h3,5,7-9,13,17-18,24H,4,6,10-12H2,1-2H3,(H2,36,40)(H,38,42)(H,39,41)/t17-,18+,24+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209870
PNG
(US9273014, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(F)c1 |r,c:32|
Show InChI InChI=1S/C26H25F7N4O3/c1-13-4-2-7-18-19(13)36-24(40)22(35-20(18)14-5-3-6-15(27)12-14)37-23(39)17(9-11-26(31,32)33)16(21(34)38)8-10-25(28,29)30/h2-7,12,16-17,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209908
PNG
(US9273014, 37)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(CO)c2NC1=O |r,t:21|
Show InChI InChI=1S/C26H25F7N4O4/c27-15-5-1-3-13(11-15)19-18-6-2-4-14(12-38)20(18)36-24(41)22(35-19)37-23(40)17(8-10-26(31,32)33)16(21(34)39)7-9-25(28,29)30/h1-6,11,16-17,22,38H,7-10,12H2,(H2,34,39)(H,36,41)(H,37,40)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209879
PNG
(US9273014, 8)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1 |r,c:33|
Show InChI InChI=1S/C27H27ClF6N4O3/c1-14-5-2-8-19-20(14)37-25(41)23(36-21(19)15-6-3-7-16(28)13-15)38-24(40)18(10-12-27(32,33)34)17(22(35)39)9-4-11-26(29,30)31/h2-3,5-8,13,17-18,23H,4,9-12H2,1H3,(H2,35,39)(H,37,41)(H,38,40)/t17-,18+,23+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1


(Homo sapiens (Human))		BDBM209907
PNG
(US9273014, 36)
Show SMILES Cc1ccc(cc1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12 |r,t:8|
Show InChI InChI=1S/C26H26F6N4O3/c1-14-6-8-15(9-7-14)20-18-4-2-3-5-19(18)34-24(39)22(35-20)36-23(38)17(11-13-26(30,31)32)16(21(33)37)10-12-25(27,28)29/h2-9,16-17,22H,10-13H2,1H3,(H2,33,37)(H,34,39)(H,36,38)/t16-,17+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1 |r,c:11|
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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n/an/a 12.3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209912
PNG
(US9273014, Comparative Compound 48 | US9427442, Co...)
Show SMILES CCCN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CC(C)C)[C@H](CC=C)C(N)=O)C1=O)c1ccccc1 |r,c:11|
Show InChI InChI=1S/C29H36N4O3/c1-5-12-21(26(30)34)23(18-19(3)4)28(35)32-27-29(36)33(17-6-2)24-16-11-10-15-22(24)25(31-27)20-13-8-7-9-14-20/h5,7-11,13-16,19,21,23,27H,1,6,12,17-18H2,2-4H3,(H2,30,34)(H,32,35)/t21-,23+,27+/m0/s1
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n/an/a 12.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209885
PNG
(US9273014, 14)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12 |r,t:8|
Show InChI InChI=1S/C30H32F6N4O4/c1-16-5-2-6-17(15-16)23-21-7-3-9-22(44-18-10-11-18)24(21)39-28(43)26(38-23)40-27(42)20(12-14-30(34,35)36)19(25(37)41)8-4-13-29(31,32)33/h2-3,5-7,9,15,18-20,26H,4,8,10-14H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t19-,20+,26+/m0/s1
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n/an/a 12.6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209905
PNG
(US9273014, 34)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cn1 |r,c:33|
Show InChI InChI=1S/C25H24ClF6N5O4/c1-41-17-4-2-3-15-18(16-6-5-12(26)11-34-16)35-21(23(40)36-19(15)17)37-22(39)14(8-10-25(30,31)32)13(20(33)38)7-9-24(27,28)29/h2-6,11,13-14,21H,7-10H2,1H3,(H2,33,38)(H,36,40)(H,37,39)/t13-,14+,21+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209911
PNG
(US9273014, Comparative Compound 47 | US9427442, Co...)
Show SMILES CCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccc(Cl)cc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:14|
Show InChI InChI=1S/C28H35ClN4O3/c1-5-6-9-20(25(30)34)22(16-17(2)3)27(35)32-26-28(36)33(4)23-11-8-7-10-21(23)24(31-26)18-12-14-19(29)15-13-18/h7-8,10-15,17,20,22,26H,5-6,9,16H2,1-4H3,(H2,30,34)(H,32,35)/t20-,22+,26+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3


(Homo sapiens (Human))		BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F |r,t:8|
Show InChI InChI=1S/C27H25F9N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27(34,35)36)20(17)39-24(43)22(38-19)40-23(42)16(9-11-26(31,32)33)15(21(37)41)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,37,41)(H,39,43)(H,40,42)/t15-,16+,22+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209910
PNG
(US9273014, Comparative Compound 46 | US9427442, Co...)
Show SMILES CC(C)C[C@H]([C@H](CC=C)C(N)=O)C(=O)N[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O |r,t:16|
Show InChI InChI=1S/C27H31ClN4O3/c1-5-9-19(24(29)33)20(14-16(2)3)26(34)31-25-27(35)32(4)22-13-12-18(28)15-21(22)23(30-25)17-10-7-6-8-11-17/h5-8,10-13,15-16,19-20,25H,1,9,14H2,2-4H3,(H2,29,33)(H,31,34)/t19-,20+,25+/m0/s1
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n/an/a 42.4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209909
PNG
(US9273014, Comparative Compound 45 | US9427442, Co...)
Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:13|
Show InChI InChI=1S/C27H34N4O3/c1-5-11-19(24(28)32)21(16-17(2)3)26(33)30-25-27(34)31(4)22-15-10-9-14-20(22)23(29-25)18-12-7-6-8-13-18/h6-10,12-15,17,19,21,25H,5,11,16H2,1-4H3,(H2,28,32)(H,30,33)/t19-,21+,25+/m0/s1
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n/an/a 48.3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209909
PNG
(US9273014, Comparative Compound 45 | US9427442, Co...)
Show SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O |r,t:13|
Show InChI InChI=1S/C27H34N4O3/c1-5-11-19(24(28)32)21(16-17(2)3)26(33)30-25-27(34)31(4)22-15-10-9-14-20(22)23(29-25)18-12-7-6-8-13-18/h6-10,12-15,17,19,21,25H,5,11,16H2,1-4H3,(H2,28,32)(H,30,33)/t19-,21+,25+/m0/s1
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n/an/a 64.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
Neurogenic locus notch homolog protein 3/Recombining binding protein suppressor of hairless


(Homo sapiens (Human))		BDBM209910
PNG
(US9273014, Comparative Compound 46 | US9427442, Co...)
Show SMILES CC(C)C[C@H]([C@H](CC=C)C(N)=O)C(=O)N[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O |r,t:16|
Show InChI InChI=1S/C27H31ClN4O3/c1-5-9-19(24(29)33)20(14-16(2)3)26(34)31-25-27(35)32(4)22-13-12-18(28)15-21(22)23(30-25)17-10-7-6-8-11-17/h5-8,10-13,15-16,19-20,25H,1,9,14H2,2-4H3,(H2,29,33)(H,31,34)/t19-,20+,25+/m0/s1
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n/an/a 74.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...

US Patent US9273014 (2016)


BindingDB Entry DOI: 10.7270/Q2KW5DVX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%