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Patent code US9273043

Compile Data Set for Download or QSAR
Found 82 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210894
PNG
(US9273043, A123(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(Cl)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-3-2-13(21)7-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 0.400n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210898
PNG
(US9273043, A126(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(C)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-18(7-12)31-20(24-16)25-21(30)27-6-5-26(10-13(27)2)19-15(22)8-14(9-23-19)17(29)11-28/h3-4,7-9,13,17,28-29H,5-6,10-11H2,1-2H3,(H,24,25,30)/t13-,17+/m1/s1
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n/an/a 0.400n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210896
PNG
(US9273043, A125(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(F)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-3-2-13(21)7-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 0.600n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210893
PNG
(US9273043, A122(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccccc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(18-14(21)8-13(9-22-18)16(28)11-27)6-7-26(12)20(29)24-19-23-15-4-2-3-5-17(15)30-19/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m1/s1
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n/an/a 5.80n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210894
PNG
(US9273043, A123(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(Cl)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-3-2-13(21)7-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 11.5n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210897
PNG
(US9273043, A126(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2ccc(C)cc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-18(7-12)31-20(24-16)25-21(30)27-6-5-26(10-13(27)2)19-15(22)8-14(9-23-19)17(29)11-28/h3-4,7-9,13,17,28-29H,5-6,10-11H2,1-2H3,(H,24,25,30)/t13-,17+/m0/s1
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n/an/a 12.2n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210902
PNG
(US9273043, A155(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2cc(F)ccc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-7-13(21)2-3-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 16.5n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210903
PNG
(US9273043, A158(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2cc(F)c(F)cc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(18-14(23)4-11(7-24-18)16(30)9-29)2-3-28(10)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16+/m0/s1
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n/an/a 17.1n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210917
PNG
(US9273043, C4(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(21)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(22)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 17.4n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210898
PNG
(US9273043, A126(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(C)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-18(7-12)31-20(24-16)25-21(30)27-6-5-26(10-13(27)2)19-15(22)8-14(9-23-19)17(29)11-28/h3-4,7-9,13,17,28-29H,5-6,10-11H2,1-2H3,(H,24,25,30)/t13-,17+/m1/s1
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n/an/a 18.2n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210896
PNG
(US9273043, A125(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(F)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-3-2-13(21)7-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 18.4n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210918
PNG
(US9273043, C123(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(Cl)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 20.6n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210896
PNG
(US9273043, A125(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(F)cc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-3-2-13(21)7-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m1/s1
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n/an/a 23.9n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210918
PNG
(US9273043, C123(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(Cl)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 26.9n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210921
PNG
(US9273043, C170(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3cc(C)c(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C22H26FN5O3S/c1-12-8-17-18(9-13(12)2)32-21(25-17)26-22(31)28-6-4-27(5-7-28)20-16(23)10-15(11-24-20)19(30)14(3)29/h8-11,14,19,29-30H,4-7H2,1-3H3,(H,25,26,31)/t14-,19+/m0/s1
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n/an/a 32.8n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210897
PNG
(US9273043, A126(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2ccc(C)cc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-18(7-12)31-20(24-16)25-21(30)27-6-5-26(10-13(27)2)19-15(22)8-14(9-23-19)17(29)11-28/h3-4,7-9,13,17,28-29H,5-6,10-11H2,1-2H3,(H,24,25,30)/t13-,17+/m0/s1
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n/an/a 40.2n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 40.8n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 40.8n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210917
PNG
(US9273043, C4(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(21)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(22)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 42.8n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210915
PNG
(US9273043, B158(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)c(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H22F3N5O3S/c1-10-9-28(21(32)27-20-26-16-6-13(22)14(23)7-17(16)33-20)3-4-29(10)19-15(24)5-12(8-25-19)18(31)11(2)30/h5-8,10-11,18,30-31H,3-4,9H2,1-2H3,(H,26,27,32)/t10-,11+,18-/m1/s1
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n/an/a 49n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210903
PNG
(US9273043, A158(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2cc(F)c(F)cc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(18-14(23)4-11(7-24-18)16(30)9-29)2-3-28(10)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16+/m0/s1
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n/an/a 62.4n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60943
PNG
(US9273043, BB)
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN([C@@H](C)C2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(19-15(23)7-13(9-24-19)18(30)12(2)29)5-6-28(11)21(31)26-20-25-16-4-3-14(22)8-17(16)32-20/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 63.7n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60943
PNG
(US9273043, BB)
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN([C@@H](C)C2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(19-15(23)7-13(9-24-19)18(30)12(2)29)5-6-28(11)21(31)26-20-25-16-4-3-14(22)8-17(16)32-20/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 63.7n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 67n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 67n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 68n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 68n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210919
PNG
(US9273043, C125(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 69n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 71n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 71n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210893
PNG
(US9273043, A122(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccccc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(18-14(21)8-13(9-22-18)16(28)11-27)6-7-26(12)20(29)24-19-23-15-4-2-3-5-17(15)30-19/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m1/s1
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n/an/a 80.6n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210895
PNG
(US9273043, A125(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccc(F)cc2s1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(20(30)25-19-24-15-3-2-13(21)7-17(15)31-19)4-5-27(11)18-14(22)6-12(8-23-18)16(29)10-28/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m1/s1
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n/an/a 81n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210917
PNG
(US9273043, C4(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(Cl)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(21)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(22)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 87n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210921
PNG
(US9273043, C170(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3cc(C)c(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C22H26FN5O3S/c1-12-8-17-18(9-13(12)2)32-21(25-17)26-22(31)28-6-4-27(5-7-28)20-16(23)10-15(11-24-20)19(30)14(3)29/h8-11,14,19,29-30H,4-7H2,1-3H3,(H,25,26,31)/t14-,19+/m0/s1
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n/an/a 89n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210918
PNG
(US9273043, C123(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(Cl)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21ClFN5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 96n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210899
PNG
(US9273043, A155(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2cc(F)ccc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-7-13(21)2-3-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m0/s1
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n/an/a 96n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210893
PNG
(US9273043, A122(e))
Show SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccccc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(18-14(21)8-13(9-22-18)16(28)11-27)6-7-26(12)20(29)24-19-23-15-4-2-3-5-17(15)30-19/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m1/s1
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n/an/a 96n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210890
PNG
(US9273043, A122(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2ccccc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(18-14(21)8-13(9-22-18)16(28)11-27)6-7-26(12)20(29)24-19-23-15-4-2-3-5-17(15)30-19/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m0/s1
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n/an/a 98n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210919
PNG
(US9273043, C125(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 99n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 102n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60942
PNG
(US9273043, AE)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)c(F)cc2s1 |r|
Show InChI InChI=1S/C20H20F3N5O3S/c1-10-8-27(2-3-28(10)18-14(23)4-11(7-24-18)16(30)9-29)20(31)26-19-25-15-5-12(21)13(22)6-17(15)32-19/h4-7,10,16,29-30H,2-3,8-9H2,1H3,(H,25,26,31)/t10-,16-/m1/s1
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n/an/a 102n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210912
PNG
(US9273043, B155(h))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN([C@@H](C)C2)C(=O)Nc2nc3cc(F)ccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(19-15(23)7-13(9-24-19)18(30)12(2)29)5-6-28(11)21(31)26-20-25-16-8-14(22)3-4-17(16)32-20/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 107n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210895
PNG
(US9273043, A125(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccc(F)cc2s1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(20(30)25-19-24-15-3-2-13(21)7-17(15)31-19)4-5-27(11)18-14(22)6-12(8-23-18)16(29)10-28/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m1/s1
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n/an/a 112n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210900
PNG
(US9273043, A155(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)ccc2s1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(20(30)25-19-24-15-7-13(21)2-3-17(15)31-19)4-5-27(11)18-14(22)6-12(8-23-18)16(29)10-28/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m1/s1
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n/an/a 134n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210915
PNG
(US9273043, B158(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)c(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H22F3N5O3S/c1-10-9-28(21(32)27-20-26-16-6-13(22)14(23)7-17(16)33-20)3-4-29(10)19-15(24)5-12(8-25-19)18(31)11(2)30/h5-8,10-11,18,30-31H,3-4,9H2,1-2H3,(H,26,27,32)/t10-,11+,18-/m1/s1
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n/an/a 136n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210916
PNG
(US9273043, B158(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)c(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H22F3N5O3S/c1-10-9-28(21(32)27-20-26-16-6-13(22)14(23)7-17(16)33-20)3-4-29(10)19-15(24)5-12(8-25-19)18(31)11(2)30/h5-8,10-11,18,30-31H,3-4,9H2,1-2H3,(H,26,27,32)/t10-,11-,18+/m1/s1
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n/an/a 146n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 155n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60941
PNG
(US9273043, C126(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-3-4-16-17(9-12)31-20(24-16)25-21(30)27-7-5-26(6-8-27)19-15(22)10-14(11-23-19)18(29)13(2)28/h3-4,9-11,13,18,28-29H,5-8H2,1-2H3,(H,24,25,30)/t13-,18+/m0/s1
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n/an/a 155n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210901
PNG
(US9273043, A155(d))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2cc(F)ccc2s1)c1ncc(cc1F)[C@@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-7-13(21)2-3-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m0/s1
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n/an/a 168n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210921
PNG
(US9273043, C170(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3cc(C)c(C)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C22H26FN5O3S/c1-12-8-17-18(9-13(12)2)32-21(25-17)26-22(31)28-6-4-27(5-7-28)20-16(23)10-15(11-24-20)19(30)14(3)29/h8-11,14,19,29-30H,4-7H2,1-3H3,(H,25,26,31)/t14-,19+/m0/s1
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n/an/a 170n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210911
PNG
(US9273043, B125(p))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m0/s1
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n/an/a 171n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210916
PNG
(US9273043, B158(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)c(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H22F3N5O3S/c1-10-9-28(21(32)27-20-26-16-6-13(22)14(23)7-17(16)33-20)3-4-29(10)19-15(24)5-12(8-25-19)18(31)11(2)30/h5-8,10-11,18,30-31H,3-4,9H2,1-2H3,(H,26,27,32)/t10-,11-,18+/m1/s1
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n/an/a 171n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210890
PNG
(US9273043, A122(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2ccccc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(18-14(21)8-13(9-22-18)16(28)11-27)6-7-26(12)20(29)24-19-23-15-4-2-3-5-17(15)30-19/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m0/s1
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n/an/a 177n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210892
PNG
(US9273043, A122(c))
Show SMILES C[C@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(20(29)24-19-23-15-4-2-3-5-17(15)30-19)6-7-26(12)18-14(21)8-13(9-22-18)16(28)11-27/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m0/s1
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n/an/a 178n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210909
PNG
(US9273043, B125(k))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 186n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210908
PNG
(US9273043, B125(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m1/s1
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n/an/a 194n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210906
PNG
(US9273043, B122(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13-,18+/m1/s1
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n/an/a 199n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210911
PNG
(US9273043, B125(p))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m0/s1
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n/an/a 211n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210900
PNG
(US9273043, A155(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2cc(F)ccc2s1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(20(30)25-19-24-15-7-13(21)2-3-17(15)31-19)4-5-27(11)18-14(22)6-12(8-23-18)16(29)10-28/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m1/s1
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n/an/a 216n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210914
PNG
(US9273043, B155(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)ccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-8-14(22)3-4-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m1/s1
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n/an/a 249n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210908
PNG
(US9273043, B125(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m1/s1
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n/an/a 303n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210910
PNG
(US9273043, B125(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m1/s1
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n/an/a 309n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210919
PNG
(US9273043, C125(r))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(CC2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11(28)17(29)12-8-14(22)18(23-10-12)26-4-6-27(7-5-26)20(30)25-19-24-15-3-2-13(21)9-16(15)31-19/h2-3,8-11,17,28-29H,4-7H2,1H3,(H,24,25,30)/t11-,17+/m0/s1
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n/an/a 335n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210913
PNG
(US9273043, B155(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)ccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-8-14(22)3-4-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m1/s1
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n/an/a 344n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210895
PNG
(US9273043, A125(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccc(F)cc2s1 |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(20(30)25-19-24-15-3-2-13(21)7-17(15)31-19)4-5-27(11)18-14(22)6-12(8-23-18)16(29)10-28/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16-/m1/s1
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n/an/a 389n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210910
PNG
(US9273043, B125(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m1/s1
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n/an/a 398n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210909
PNG
(US9273043, B125(k))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-4-3-14(22)8-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 415n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210913
PNG
(US9273043, B155(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)ccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-8-14(22)3-4-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12+,18-/m1/s1
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n/an/a 439n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210891
PNG
(US9273043, A122(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(20(29)24-19-23-15-4-2-3-5-17(15)30-19)6-7-26(12)18-14(21)8-13(9-22-18)16(28)11-27/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16-/m1/s1
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n/an/a 444n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60943
PNG
(US9273043, BB)
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN([C@@H](C)C2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(19-15(23)7-13(9-24-19)18(30)12(2)29)5-6-28(11)21(31)26-20-25-16-4-3-14(22)8-17(16)32-20/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 490n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM60943
PNG
(US9273043, BB)
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN([C@@H](C)C2)C(=O)Nc2nc3ccc(F)cc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(19-15(23)7-13(9-24-19)18(30)12(2)29)5-6-28(11)21(31)26-20-25-16-4-3-14(22)8-17(16)32-20/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m0/s1
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n/an/a 490n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210905
PNG
(US9273043, B122(k))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13-,18+/m0/s1
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n/an/a 502n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210907
PNG
(US9273043, B122(p))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13+,18-/m0/s1
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n/an/a 506n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210892
PNG
(US9273043, A122(c))
Show SMILES C[C@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(20(29)24-19-23-15-4-2-3-5-17(15)30-19)6-7-26(12)18-14(21)8-13(9-22-18)16(28)11-27/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16+/m0/s1
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n/an/a 553n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210904
PNG
(US9273043, B122(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13+,18-/m1/s1
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n/an/a 586n/an/an/an/a7.4n/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210891
PNG
(US9273043, A122(b))
Show SMILES C[C@@H]1CN(CCN1c1ncc(cc1F)[C@H](O)CO)C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H22FN5O3S/c1-12-10-25(20(29)24-19-23-15-4-2-3-5-17(15)30-19)6-7-26(12)18-14(21)8-13(9-22-18)16(28)11-27/h2-5,8-9,12,16,27-28H,6-7,10-11H2,1H3,(H,23,24,29)/t12-,16-/m1/s1
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n/an/a 670n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210899
PNG
(US9273043, A155(a))
Show SMILES C[C@H]1CN(CCN1C(=O)Nc1nc2cc(F)ccc2s1)c1ncc(cc1F)[C@H](O)CO |r|
Show InChI InChI=1S/C20H21F2N5O3S/c1-11-9-26(18-14(22)6-12(8-23-18)16(29)10-28)4-5-27(11)20(30)25-19-24-15-7-13(21)2-3-17(15)31-19/h2-3,6-8,11,16,28-29H,4-5,9-10H2,1H3,(H,24,25,30)/t11-,16+/m0/s1
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n/an/a 700n/an/an/an/an/a37



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210907
PNG
(US9273043, B122(p))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13+,18-/m0/s1
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n/an/a 1.02E+3n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210914
PNG
(US9273043, B155(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3cc(F)ccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H23F2N5O3S/c1-11-10-27(21(31)26-20-25-16-8-14(22)3-4-17(16)32-20)5-6-28(11)19-15(23)7-13(9-24-19)18(30)12(2)29/h3-4,7-9,11-12,18,29-30H,5-6,10H2,1-2H3,(H,25,26,31)/t11-,12-,18+/m1/s1
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n/an/a 1.23E+3n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210904
PNG
(US9273043, B122(j))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13+,18-/m1/s1
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n/an/a 1.72E+3n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210905
PNG
(US9273043, B122(k))
Show SMILES C[C@H](O)[C@@H](O)c1cnc(N2CCN(C[C@@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13-,18+/m0/s1
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n/an/a 2.05E+3n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM210906
PNG
(US9273043, B122(o))
Show SMILES C[C@@H](O)[C@H](O)c1cnc(N2CCN(C[C@H]2C)C(=O)Nc2nc3ccccc3s2)c(F)c1 |r|
Show InChI InChI=1S/C21H24FN5O3S/c1-12-11-26(21(30)25-20-24-16-5-3-4-6-17(16)31-20)7-8-27(12)19-15(22)9-14(10-23-19)18(29)13(2)28/h3-6,9-10,12-13,18,28-29H,7-8,11H2,1-2H3,(H,24,25,30)/t12-,13-,18+/m1/s1
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n/an/a 6.88E+3n/an/an/an/a7.237



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...

US Patent US9273043 (2016)


BindingDB Entry DOI: 10.7270/Q2D7998G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%