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Patent code US9278930

Compile Data Set for Download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102350
PNG
(US10562854, No. F3 | US8536181, F3 | US9278930, F3)
Show SMILES Oc1cccn(Cc2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C12H10ClNO2/c13-10-5-3-9(4-6-10)8-14-7-1-2-11(15)12(14)16/h1-7,15H,8H2
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n/an/a 1.20E+3n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102349
PNG
(US10562854, No. E33 | US8536181, E33 | US9278930, ...)
Show SMILES CN(CC(O)=O)Cc1ccn(c(=O)c1O)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C16H18N2O6S/c1-11-3-5-13(6-4-11)25(23,24)18-8-7-12(15(21)16(18)22)9-17(2)10-14(19)20/h3-8,21H,9-10H2,1-2H3,(H,19,20)
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n/an/a 2.10E+3n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102345
PNG
(US10562854, No. D10 | US8536181, D10 | US9278930, ...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc(CN2CCC(CC2)N2CCCCC2)c(O)c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-18-5-7-21(8-6-18)31(29,30)26-16-9-19(22(27)23(26)28)17-24-14-10-20(11-15-24)25-12-3-2-4-13-25/h5-9,16,20,27H,2-4,10-15,17H2,1H3
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n/an/a 4.40E+3n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102351
PNG
(US10562854, No. F2 | US8536181, F2 | US9278930, F2)
Show SMILES Oc1cccn(Cc2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C12H10ClNO2/c13-10-4-1-3-9(7-10)8-14-6-2-5-11(15)12(14)16/h1-7,15H,8H2
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n/an/a 5.00E+3n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102350
PNG
(US10562854, No. F3 | US8536181, F3 | US9278930, F3)
Show SMILES Oc1cccn(Cc2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C12H10ClNO2/c13-10-5-3-9(4-6-10)8-14-7-1-2-11(15)12(14)16/h1-7,15H,8H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM126621
PNG
(US10562854, No. B5 | US8778412, B5 | US9278930, B5)
Show SMILES OCC[C@H]1CCCN1Cc1ccn(Cc2ccccc2)c(=O)c1O |r|
Show InChI InChI=1S/C19H24N2O3/c22-12-9-17-7-4-10-20(17)14-16-8-11-21(19(24)18(16)23)13-15-5-2-1-3-6-15/h1-3,5-6,8,11,17,22-23H,4,7,9-10,12-14H2/t17-/m1/s1
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n/an/a 9.00E+3n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102341
PNG
(US10562854, No. B14 | US8536181, B14 | US9278930, ...)
Show SMILES Oc1c(CN2CCN(CC2)c2ccc(Cl)nn2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H22ClN5O2/c22-18-6-7-19(24-23-18)26-12-10-25(11-13-26)15-17-8-9-27(21(29)20(17)28)14-16-4-2-1-3-5-16/h1-9,28H,10-15H2
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n/an/a 1.10E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102336
PNG
(US10562854, No. C17 | US8536181, C17 | US9278930, ...)
Show SMILES CC1CCC(CC1)NCc1ccn(Cc2ccccc2)c(=O)c1O |(8.08,,;6.54,,;5.78,-1.33,;4.23,-1.33,;3.47,,;4.23,1.33,;5.78,1.33,;1.93,,;1.15,1.33,;-.38,1.33,;-1.15,2.67,;-2.69,2.67,;-3.47,1.33,;-5,1.33,;-5.78,,;-7.31,,;-8.08,-1.33,;-7.31,-2.67,;-5.78,-2.67,;-5,-1.33,;-2.69,,;-3.47,-1.33,;-1.15,,;-.38,-1.33,)|
Show InChI InChI=1S/C20H26N2O2/c1-15-7-9-18(10-8-15)21-13-17-11-12-22(20(24)19(17)23)14-16-5-3-2-4-6-16/h2-6,11-12,15,18,21,23H,7-10,13-14H2,1H3
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n/an/a 1.10E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102342
PNG
(US10562854, No. C19 | US8536181, C19 | US9278930, ...)
Show SMILES Oc1c(CNC2CCCCNC2=O)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H23N3O3/c23-17-15(12-21-16-8-4-5-10-20-18(16)24)9-11-22(19(17)25)13-14-6-2-1-3-7-14/h1-3,6-7,9,11,16,21,23H,4-5,8,10,12-13H2,(H,20,24)
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n/an/a 1.20E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102337
PNG
(US10562854, No. C35 | US8536181, C35 | US9278930, ...)
Show SMILES Oc1c(CNCCCn2ccnc2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H22N4O2/c24-18-17(13-20-8-4-10-22-12-9-21-15-22)7-11-23(19(18)25)14-16-5-2-1-3-6-16/h1-3,5-7,9,11-12,15,20,24H,4,8,10,13-14H2
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n/an/a 1.20E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102338
PNG
(US10562854, No. C14 | US8536181, C14 | US9278930, ...)
Show SMILES CC(NCc1ccn(Cc2ccccc2)c(=O)c1O)c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-16(18-10-6-3-7-11-18)22-14-19-12-13-23(21(25)20(19)24)15-17-8-4-2-5-9-17/h2-13,16,22,24H,14-15H2,1H3
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n/an/a 1.20E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102347
PNG
(US10562854, No. C1 | US8536181, C1 | US9278930, C1)
Show SMILES Oc1c(CNCc2ccccc2)ccn(Cc2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C20H19ClN2O2/c21-18-8-6-16(7-9-18)14-23-11-10-17(19(24)20(23)25)13-22-12-15-4-2-1-3-5-15/h1-11,22,24H,12-14H2
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102346
PNG
(US10562854, No. D14 | US8536181, D14 | US9278930, ...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc(CN2CCN(CC2)c2ccc(Cl)nn2)c(O)c1=O
Show InChI InChI=1S/C21H22ClN5O4S/c1-15-2-4-17(5-3-15)32(30,31)27-9-8-16(20(28)21(27)29)14-25-10-12-26(13-11-25)19-7-6-18(22)23-24-19/h2-9,28H,10-14H2,1H3
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n/an/a 1.20E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102343
PNG
(US10562854, No. B9 | US8536181, B9 | US9278930, B9)
Show SMILES Oc1c(CN2CCN(Cc3ccccc3)CC2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H27N3O2/c28-23-22(11-12-27(24(23)29)18-21-9-5-2-6-10-21)19-26-15-13-25(14-16-26)17-20-7-3-1-4-8-20/h1-12,28H,13-19H2
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n/an/a 1.26E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102348
PNG
(US10562854, No. A41 | US8536181, A41 | US9278930, ...)
Show SMILES CC(C)(C)OC(=O)N1CCN(Cc2ccn(Cc3ccc(Cl)cc3)c(=O)c2O)CC1
Show InChI InChI=1S/C22H28ClN3O4/c1-22(2,3)30-21(29)25-12-10-24(11-13-25)15-17-8-9-26(20(28)19(17)27)14-16-4-6-18(23)7-5-16/h4-9,27H,10-15H2,1-3H3
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n/an/a 1.40E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102340
PNG
(US10562854, No. C33 | US8536181, C33 | US9278930, ...)
Show SMILES CSCCNCc1ccn(Cc2ccccc2)c(=O)c1O
Show InChI InChI=1S/C16H20N2O2S/c1-21-10-8-17-11-14-7-9-18(16(20)15(14)19)12-13-5-3-2-4-6-13/h2-7,9,17,19H,8,10-12H2,1H3
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n/an/a 1.60E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102348
PNG
(US10562854, No. A41 | US8536181, A41 | US9278930, ...)
Show SMILES CC(C)(C)OC(=O)N1CCN(Cc2ccn(Cc3ccc(Cl)cc3)c(=O)c2O)CC1
Show InChI InChI=1S/C22H28ClN3O4/c1-22(2,3)30-21(29)25-12-10-24(11-13-25)15-17-8-9-26(20(28)19(17)27)14-16-4-6-18(23)7-5-16/h4-9,27H,10-15H2,1-3H3
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AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102343
PNG
(US10562854, No. B9 | US8536181, B9 | US9278930, B9)
Show SMILES Oc1c(CN2CCN(Cc3ccccc3)CC2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C24H27N3O2/c28-23-22(11-12-27(24(23)29)18-21-9-5-2-6-10-21)19-26-15-13-25(14-16-26)17-20-7-3-1-4-8-20/h1-12,28H,13-19H2
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n/an/a 1.70E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102344
PNG
(US10562854, No. A18 | US8536181, A18 | US9278930, ...)
Show SMILES OCc1ccccc1Cn1ccc(CN2CCCCCC2)c(O)c1=O
Show InChI InChI=1S/C20H26N2O3/c23-15-18-8-4-3-7-16(18)14-22-12-9-17(19(24)20(22)25)13-21-10-5-1-2-6-11-21/h3-4,7-9,12,23-24H,1-2,5-6,10-11,13-15H2
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n/an/a 1.80E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102346
PNG
(US10562854, No. D14 | US8536181, D14 | US9278930, ...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc(CN2CCN(CC2)c2ccc(Cl)nn2)c(O)c1=O
Show InChI InChI=1S/C21H22ClN5O4S/c1-15-2-4-17(5-3-15)32(30,31)27-9-8-16(20(28)21(27)29)14-25-10-12-26(13-11-25)19-7-6-18(22)23-24-19/h2-9,28H,10-14H2,1H3
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US Patent
n/an/a 1.90E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102338
PNG
(US10562854, No. C14 | US8536181, C14 | US9278930, ...)
Show SMILES CC(NCc1ccn(Cc2ccccc2)c(=O)c1O)c1ccccc1
Show InChI InChI=1S/C21H22N2O2/c1-16(18-10-6-3-7-11-18)22-14-19-12-13-23(21(25)20(19)24)15-17-8-4-2-5-9-17/h2-13,16,22,24H,14-15H2,1H3
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n/an/a 2.06E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Egl nine homolog 1 [179-426]


(Homo sapiens (Human))		BDBM102349
PNG
(US10562854, No. E33 | US8536181, E33 | US9278930, ...)
Show SMILES CN(CC(O)=O)Cc1ccn(c(=O)c1O)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C16H18N2O6S/c1-11-3-5-13(6-4-11)25(23,24)18-8-7-12(15(21)16(18)22)9-17(2)10-14(19)20/h3-8,21H,9-10H2,1-2H3,(H,19,20)
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n/an/a 2.10E+4n/an/an/an/a7.525



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102345
PNG
(US10562854, No. D10 | US8536181, D10 | US9278930, ...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc(CN2CCC(CC2)N2CCCCC2)c(O)c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-18-5-7-21(8-6-18)31(29,30)26-16-9-19(22(27)23(26)28)17-24-14-10-20(11-15-24)25-12-3-2-4-13-25/h5-9,16,20,27H,2-4,10-15,17H2,1H3
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n/an/a 2.70E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102336
PNG
(US10562854, No. C17 | US8536181, C17 | US9278930, ...)
Show SMILES CC1CCC(CC1)NCc1ccn(Cc2ccccc2)c(=O)c1O |(8.08,,;6.54,,;5.78,-1.33,;4.23,-1.33,;3.47,,;4.23,1.33,;5.78,1.33,;1.93,,;1.15,1.33,;-.38,1.33,;-1.15,2.67,;-2.69,2.67,;-3.47,1.33,;-5,1.33,;-5.78,,;-7.31,,;-8.08,-1.33,;-7.31,-2.67,;-5.78,-2.67,;-5,-1.33,;-2.69,,;-3.47,-1.33,;-1.15,,;-.38,-1.33,)|
Show InChI InChI=1S/C20H26N2O2/c1-15-7-9-18(10-8-15)21-13-17-11-12-22(20(24)19(17)23)14-16-5-3-2-4-6-16/h2-6,11-12,15,18,21,23H,7-10,13-14H2,1H3
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n/an/a 2.74E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102344
PNG
(US10562854, No. A18 | US8536181, A18 | US9278930, ...)
Show SMILES OCc1ccccc1Cn1ccc(CN2CCCCCC2)c(O)c1=O
Show InChI InChI=1S/C20H26N2O3/c23-15-18-8-4-3-7-16(18)14-22-12-9-17(19(24)20(22)25)13-21-10-5-1-2-6-11-21/h3-4,7-9,12,23-24H,1-2,5-6,10-11,13-15H2
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n/an/a 2.92E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102347
PNG
(US10562854, No. C1 | US8536181, C1 | US9278930, C1)
Show SMILES Oc1c(CNCc2ccccc2)ccn(Cc2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C20H19ClN2O2/c21-18-8-6-16(7-9-18)14-23-11-10-17(19(24)20(23)25)13-22-12-15-4-2-1-3-5-15/h1-11,22,24H,12-14H2
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n/an/a 4.20E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102337
PNG
(US10562854, No. C35 | US8536181, C35 | US9278930, ...)
Show SMILES Oc1c(CNCCCn2ccnc2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H22N4O2/c24-18-17(13-20-8-4-10-22-12-9-21-15-22)7-11-23(19(18)25)14-16-5-2-1-3-6-16/h1-3,5-7,9,11-12,15,20,24H,4,8,10,13-14H2
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n/an/a 4.25E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM126621
PNG
(US10562854, No. B5 | US8778412, B5 | US9278930, B5)
Show SMILES OCC[C@H]1CCCN1Cc1ccn(Cc2ccccc2)c(=O)c1O |r|
Show InChI InChI=1S/C19H24N2O3/c22-12-9-17-7-4-10-20(17)14-16-8-11-21(19(24)18(16)23)13-15-5-2-1-3-6-15/h1-3,5-6,8,11,17,22-23H,4,7,9-10,12-14H2/t17-/m1/s1
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US Patent
n/an/a 5.30E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102340
PNG
(US10562854, No. C33 | US8536181, C33 | US9278930, ...)
Show SMILES CSCCNCc1ccn(Cc2ccccc2)c(=O)c1O
Show InChI InChI=1S/C16H20N2O2S/c1-21-10-8-17-11-14-7-9-18(16(20)15(14)19)12-13-5-3-2-4-6-13/h2-7,9,17,19H,8,10-12H2,1H3
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n/an/a 5.30E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102342
PNG
(US10562854, No. C19 | US8536181, C19 | US9278930, ...)
Show SMILES Oc1c(CNC2CCCCNC2=O)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C19H23N3O3/c23-17-15(12-21-16-8-4-5-10-20-18(16)24)9-11-22(19(17)25)13-14-6-2-1-3-7-14/h1-3,6-7,9,11,16,21,23H,4-5,8,10,12-13H2,(H,20,24)
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n/an/a 6.29E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102341
PNG
(US10562854, No. B14 | US8536181, B14 | US9278930, ...)
Show SMILES Oc1c(CN2CCN(CC2)c2ccc(Cl)nn2)ccn(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H22ClN5O2/c22-18-6-7-19(24-23-18)26-12-10-25(11-13-26)15-17-8-9-27(21(29)20(17)28)14-16-4-2-1-3-5-16/h1-9,28H,10-15H2
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n/an/a 7.80E+4n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))		BDBM102351
PNG
(US10562854, No. F2 | US8536181, F2 | US9278930, F2)
Show SMILES Oc1cccn(Cc2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C12H10ClNO2/c13-10-4-1-3-9(7-10)8-14-6-2-5-11(15)12(14)16/h1-7,15H,8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



AERPIO THERAPEUTICS, INC.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...

US Patent US9278930 (2016)


BindingDB Entry DOI: 10.7270/Q24J0CZG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%