Found 119 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226282
(US9321790, 94)Show SMILES CC(=O)N1CCC(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:15:19:24.25:22| Show InChI InChI=1S/C21H28F3N5O3/c1-13(30)26-5-2-14(3-6-26)10-29-17(21(22,23)24)4-7-27-19(31)9-18(25-20(27)29)28-11-16-8-15(28)12-32-16/h9,14-17H,2-8,10-12H2,1H3/t15-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226283
(US9321790, 95)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCN(CC1)C=O |THB:10:14:20.19:17| Show InChI InChI=1S/C20H26F3N5O3/c21-20(22,23)16-3-6-26-18(30)8-17(27-10-15-7-14(27)11-31-15)24-19(26)28(16)9-13-1-4-25(12-29)5-2-13/h8,12-16H,1-7,9-11H2/t14-,15-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226271
(US9321790, 83)Show SMILES Oc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1 |TLB:14:18:21.22:25| Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-10-29-20(31)11-19(27-12-16-5-6-17(13-27)32-16)26-21(29)28(18)9-7-14-1-3-15(30)4-2-14/h1-4,11,16-18,30H,5-10,12-13H2/t16?,17?,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226272
(US9321790, 84)Show SMILES Cc1c(nc2N(CCCc3ccccc3)[C@@H](CCn2c1=O)C(F)(F)F)N1CC2CCC(C1)O2 |TLB:2:25:28.29:32| Show InChI InChI=1S/C24H29F3N4O2/c1-16-21(29-14-18-9-10-19(15-29)33-18)28-23-30(12-5-8-17-6-3-2-4-7-17)20(24(25,26)27)11-13-31(23)22(16)32/h2-4,6-7,18-20H,5,8-15H2,1H3/t18?,19?,20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226266
(US9321790, 78)Show SMILES CN(C)CCCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:16:28:31.32:35| Show InChI InChI=1S/C27H36F3N5O3/c1-26(27(28,29)30)18-34-24(36)15-23(33-16-21-9-10-22(17-33)38-21)31-25(34)35(26)13-11-19-5-7-20(8-6-19)37-14-4-12-32(2)3/h5-8,15,21-22H,4,9-14,16-18H2,1-3H3/t21?,22?,26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226299
(US9321790, 111)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCCN2CCOCC2)cc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C27H34F3N5O4/c28-27(29,30)23-6-8-34-25(36)16-24(35-17-22-15-20(35)18-39-22)31-26(34)33(23)7-5-19-1-3-21(4-2-19)38-14-11-32-9-12-37-13-10-32/h1-4,16,20,22-23H,5-15,17-18H2/t20-,22-,23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226270
(US9321790, 82)Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1cc2ccccc2s1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C24H25F3N4O3S/c25-24(26,27)20-7-8-30-22(33)10-21(29-11-15-5-6-16(12-29)34-15)28-23(30)31(20)13-17(32)19-9-14-3-1-2-4-18(14)35-19/h1-4,9-10,15-17,20,32H,5-8,11-13H2/t15?,16?,17-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226305
(US9321790, 117)Show SMILES CN(C)CCOc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1 |TLB:19:23:28.29:26| Show InChI InChI=1S/C25H32F3N5O3/c1-30(2)11-12-35-19-5-3-17(4-6-19)7-9-31-21(25(26,27)28)8-10-32-23(34)14-22(29-24(31)32)33-15-20-13-18(33)16-36-20/h3-6,14,18,20-21H,7-13,15-16H2,1-2H3/t18-,20-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226285
(US9321790, 97)Show SMILES OC(CCN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C(F)(F)F)C(F)(F)F |THB:11:15:21.20:18| Show InChI InChI=1S/C18H19F9N4O3/c19-16(20,21)11-1-3-30-13(32)6-12(31-7-10-5-9(31)8-34-10)28-14(30)29(11)4-2-15(33,17(22,23)24)18(25,26)27/h6,9-11,33H,1-5,7-8H2/t9-,10-,11?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226280
(US9321790, 92)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCOCC1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)16-2-6-26-18(28)10-17(27-11-15-9-14(27)12-30-15)24-19(26)25(16)5-1-13-3-7-29-8-4-13/h10,13-16H,1-9,11-12H2/t14-,15-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226289
(US9321790, 101)Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)14-3-6-24-16(27)8-15(25-9-13-7-12(25)10-29-13)23-17(24)26(14)11-18(28)4-1-2-5-18/h8,12-14,28H,1-7,9-11H2/t12-,13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226303
(US9321790, 115)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(OCC(=O)N2CCOCC2)cc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C27H32F3N5O5/c28-27(29,30)22-6-8-34-24(36)14-23(35-15-21-13-19(35)16-39-21)31-26(34)33(22)7-5-18-1-3-20(4-2-18)40-17-25(37)32-9-11-38-12-10-32/h1-4,14,19,21-22H,5-13,15-17H2/t19-,21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226260
(US9321790, 72)Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCc1ccc(O)cc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)10-18(27-11-16-6-7-17(12-27)32-16)26-20(28)29(21)9-8-14-2-4-15(30)5-3-14/h2-5,10,16-17,30H,6-9,11-13H2,1H3/t16?,17?,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226281
(US9321790, 93)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC1CCOCC1 |THB:10:14:20.19:17| Show InChI InChI=1S/C19H25F3N4O3/c20-19(21,22)15-1-4-24-17(27)8-16(25-10-14-7-13(25)11-29-14)23-18(24)26(15)9-12-2-5-28-6-3-12/h8,12-15H,1-7,9-11H2/t13-,14-,15?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226259
(US9321790, 71)Show SMILES COc1cc(F)ccc1[C@H](O)CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F |TLB:19:23:26.27:30| Show InChI InChI=1S/C23H26F4N4O4/c1-34-18-8-13(24)2-5-16(18)17(32)12-31-19(23(25,26)27)6-7-30-21(33)9-20(28-22(30)31)29-10-14-3-4-15(11-29)35-14/h2,5,8-9,14-15,17,19,32H,3-4,6-7,10-12H2,1H3/t14?,15?,17-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226265
(US9321790, 77)Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CCCc1ccccc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C23H27F3N4O2/c1-22(23(24,25)26)15-29-20(31)12-19(28-13-17-9-10-18(14-28)32-17)27-21(29)30(22)11-5-8-16-6-3-2-4-7-16/h2-4,6-7,12,17-18H,5,8-11,13-15H2,1H3/t17?,18?,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226262
(US9321790, 74)Show SMILES CN(C)CCOc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:15:27:30.31:34| Show InChI InChI=1S/C26H34F3N5O3/c1-25(26(27,28)29)17-33-23(35)14-22(32-15-20-8-9-21(16-32)37-20)30-24(33)34(25)11-10-18-4-6-19(7-5-18)36-13-12-31(2)3/h4-7,14,20-21H,8-13,15-17H2,1-3H3/t20?,21?,25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226291
(US9321790, 103)Show SMILES OC(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C21H27F3N4O3/c22-21(23,24)16-5-6-26-18(29)8-17(27-9-15-7-14(27)10-31-15)25-19(26)28(16)11-20(30,12-1-2-12)13-3-4-13/h8,12-16,30H,1-7,9-11H2/t14-,15-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226292
(US9321790, 104)Show SMILES OC1(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C17H21F3N4O3/c18-17(19,20)12-1-4-22-14(25)6-13(23-7-11-5-10(23)8-27-11)21-15(22)24(12)9-16(26)2-3-16/h6,10-12,26H,1-5,7-9H2/t10-,11-,12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226264
(US9321790, 76)Show SMILES COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:11:23:26.27:30| Show InChI InChI=1S/C23H27F3N4O3/c1-22(23(24,25)26)14-29-20(31)11-19(28-12-17-7-8-18(13-28)33-17)27-21(29)30(22)10-9-15-3-5-16(32-2)6-4-15/h3-6,11,17-18H,7-10,12-14H2,1-2H3/t17?,18?,22-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226213
(US9321790, 25)Show SMILES Cc1ncsc1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:15:19:24.25:22| Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)2-4-25-15(19(20,21)22)3-5-26-17(28)7-16(24-18(25)26)27-8-13-6-12(27)9-29-13/h7,10,12-13,15H,2-6,8-9H2,1H3/t12-,13-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226258
(US9321790, 70)Show SMILES CN(C)C(=O)COc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2CC3CCC(C2)O3)cc1 |TLB:16:28:31.32:35| Show InChI InChI=1S/C26H32F3N5O4/c1-25(26(27,28)29)16-33-22(35)12-21(32-13-19-8-9-20(14-32)38-19)30-24(33)34(25)11-10-17-4-6-18(7-5-17)37-15-23(36)31(2)3/h4-7,12,19-20H,8-11,13-16H2,1-3H3/t19?,20?,25-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226211
(US9321790, 23)Show SMILES CCNC(=O)Nc1ccc(CCN2C(CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)cc1 |TLB:19:23:28.29:26| Show InChI InChI=1S/C24H29F3N6O3/c1-2-28-22(35)29-16-5-3-15(4-6-16)7-9-31-19(24(25,26)27)8-10-32-21(34)12-20(30-23(31)32)33-13-18-11-17(33)14-36-18/h3-6,12,17-19H,2,7-11,13-14H2,1H3,(H2,28,29,35)/t17-,18-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226276
(US9321790, 88)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccn1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-6-8-28-19(31)9-18(27-10-13-4-5-14(11-27)32-13)26-20(28)29(17)12-16(30)15-3-1-2-7-25-15/h1-3,7,9,13-14,17H,4-6,8,10-12H2/t13?,14?,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226215
(US9321790, 27)Show SMILES Cc1n[nH]c(C)c1CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)3-5-27-16(20(21,22)23)4-6-28-18(30)8-17(24-19(27)28)29-9-14-7-13(29)10-31-14/h8,13-14,16H,3-7,9-10H2,1-2H3,(H,25,26)/t13-,14-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226267
(US9321790, 79)Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1C[C@@H](O)c1ccccc1)C(F)(F)F |TLB:6:10:13.14:17| Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(31)9-18(27-10-15-7-8-16(11-27)32-15)26-20(28)29(21)12-17(30)14-5-3-2-4-6-14/h2-6,9,15-17,30H,7-8,10-13H2,1H3/t15?,16?,17-,21+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226268
(US9321790, 80)Show SMILES O[C@H](CN1[C@@H](CCn2c1nc(cc2=O)N1CC2CCC(C1)O2)C(F)(F)F)c1ccccc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-18,30H,6-9,11-13H2/t15?,16?,17-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226293
(US9321790, 105)Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C18H23F3N4O3/c19-18(20,21)13-1-5-24-15(26)8-14(25-9-12-7-11(25)10-28-12)22-16(24)23(13)6-4-17(27)2-3-17/h8,11-13,27H,1-7,9-10H2/t11-,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226288
(US9321790, 100)Show SMILES OC1(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CCCC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C20H27F3N4O3/c21-20(22,23)15-3-7-26-17(28)10-16(27-11-14-9-13(27)12-30-14)24-18(26)25(15)8-6-19(29)4-1-2-5-19/h10,13-15,29H,1-9,11-12H2/t13-,14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226214
(US9321790, 26)Show SMILES Cc1ncsc1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:11:23:28.29:26| Show InChI InChI=1S/C19H22F3N5O2S/c1-11-14(30-10-23-11)3-4-27-17-24-15(25-7-13-5-12(25)8-29-13)6-16(28)26(17)9-18(27,2)19(20,21)22/h6,10,12-13H,3-5,7-9H2,1-2H3/t12-,13-,18?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226269
(US9321790, 81)Show SMILES COc1ccc(CCN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)cc1 |TLB:15:19:22.23:26| Show InChI InChI=1S/C23H27F3N4O3/c1-32-16-4-2-15(3-5-16)8-10-29-19(23(24,25)26)9-11-30-21(31)12-20(27-22(29)30)28-13-17-6-7-18(14-28)33-17/h2-5,12,17-19H,6-11,13-14H2,1H3/t17?,18?,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226242
(US9321790, 54)Show SMILES CCC(O)(CC)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:14:18:23.24:21| Show InChI InChI=1S/C19H27F3N4O3/c1-3-18(28,4-2)11-26-14(19(20,21)22)5-6-24-16(27)8-15(23-17(24)26)25-9-13-7-12(25)10-29-13/h8,12-14,28H,3-7,9-11H2,1-2H3/t12-,13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.21E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226216
(US9321790, 28)Show SMILES Cc1n[nH]c(C)c1CCN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:12:24:29.30:27| Show InChI InChI=1S/C20H25F3N6O2/c1-11-15(12(2)26-25-11)4-5-29-18-24-16(27-8-14-6-13(27)9-31-14)7-17(30)28(18)10-19(29,3)20(21,22)23/h7,13-14H,4-6,8-10H2,1-3H3,(H,25,26)/t13-,14-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.26E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226278
(US9321790, 90)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCC1CCN(CC1)C=O |THB:10:14:20.19:17| Show InChI InChI=1S/C21H28F3N5O3/c22-21(23,24)17-4-8-28-19(31)10-18(29-11-16-9-15(29)12-32-16)25-20(28)27(17)7-3-14-1-5-26(13-30)6-2-14/h10,13-17H,1-9,11-12H2/t15-,16-,17?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226212
(US9321790, 24)Show SMILES CCNC(=O)Nc1ccc(CCN2c3nc(cc(=O)n3C[C@@]2(C)C(F)(F)F)N2C[C@@H]3C[C@H]2CO3)cc1 |TLB:15:27:32.33:30| Show InChI InChI=1S/C24H29F3N6O3/c1-3-28-21(35)29-16-6-4-15(5-7-16)8-9-33-22-30-19(31-12-18-10-17(31)13-36-18)11-20(34)32(22)14-23(33,2)24(25,26)27/h4-7,11,17-18H,3,8-10,12-14H2,1-2H3,(H2,28,29,35)/t17-,18-,23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.44E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226261
(US9321790, 73)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccccc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C22H23F3N4O3/c23-22(24,25)18-8-9-28-20(31)10-19(27-11-15-6-7-16(12-27)32-15)26-21(28)29(18)13-17(30)14-4-2-1-3-5-14/h1-5,10,15-16,18H,6-9,11-13H2/t15?,16?,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226290
(US9321790, 102)Show SMILES OC(CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C1CC1)C1CC1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C22H29F3N4O3/c23-22(24,25)17-5-7-28-19(30)10-18(29-11-16-9-15(29)12-32-16)26-20(28)27(17)8-6-21(31,13-1-2-13)14-3-4-14/h10,13-17,31H,1-9,11-12H2/t15-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226237
(US9321790, 49)Show SMILES CCC(O)(CC)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:15:19:24.25:22| Show InChI InChI=1S/C20H29F3N4O3/c1-3-19(29,4-2)6-8-25-15(20(21,22)23)5-7-26-17(28)10-16(24-18(25)26)27-11-14-9-13(27)12-30-14/h10,13-15,29H,3-9,11-12H2,1-2H3/t13-,14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.74E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226277
(US9321790, 89)Show SMILES CC(=O)N1CCC(CCN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)CC1 |TLB:16:20:25.26:23| Show InChI InChI=1S/C22H30F3N5O3/c1-14(31)27-6-2-15(3-7-27)4-8-28-18(22(23,24)25)5-9-29-20(32)11-19(26-21(28)29)30-12-17-10-16(30)13-33-17/h11,15-18H,2-10,12-13H2,1H3/t16-,17-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226200
(US9321790, 12)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H22F3N5O2/c21-20(22,23)16-4-7-27-18(29)9-17(28-11-15-8-14(28)12-30-15)25-19(27)26(16)6-3-13-2-1-5-24-10-13/h1-2,5,9-10,14-16H,3-4,6-8,11-12H2/t14-,15-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226189
(US9321790, 1)Show SMILES CC(C)(CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)c1ccncc1 |TLB:11:15:20.21:18| Show InChI InChI=1S/C22H26F3N5O2/c1-21(2,14-3-6-26-7-4-14)13-30-17(22(23,24)25)5-8-28-19(31)10-18(27-20(28)30)29-11-16-9-15(29)12-32-16/h3-4,6-7,10,15-17H,5,8-9,11-13H2,1-2H3/t15-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.13E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226220
(US9321790, 32)Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1ccc(N)cc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C21H24F3N5O2/c1-20(21(22,23)24)12-28-18(30)9-17(27-10-16-8-15(27)11-31-16)26-19(28)29(20)7-6-13-2-4-14(25)5-3-13/h2-5,9,15-16H,6-8,10-12,25H2,1H3/t15-,16-,20?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226255
(US9321790, 67)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C18H21F3N4O3/c19-18(20,21)14-3-4-23-16(27)6-15(24-7-12-5-11(24)9-28-12)22-17(23)25(14)8-13(26)10-1-2-10/h6,10-12,14H,1-5,7-9H2/t11-,12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226229
(US9321790, 41)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(cc1)N1CCOCC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C25H28F3N5O4/c26-25(27,28)21-5-6-31-23(35)12-22(32-13-19-11-18(32)15-37-19)29-24(31)33(21)14-20(34)16-1-3-17(4-2-16)30-7-9-36-10-8-30/h1-4,12,18-19,21H,5-11,13-15H2/t18-,19-,21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226238
(US9321790, 50)Show SMILES CC(C)(O)CCN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:13:17:22.23:20| Show InChI InChI=1S/C18H25F3N4O3/c1-17(2,27)4-6-23-13(18(19,20)21)3-5-24-15(26)8-14(22-16(23)24)25-9-12-7-11(25)10-28-12/h8,11-13,27H,3-7,9-10H2,1-2H3/t11-,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226201
(US9321790, 13)Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CCc1cccnc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C20H22F3N5O2/c1-19(20(21,22)23)12-27-17(29)8-16(26-10-15-7-14(26)11-30-15)25-18(27)28(19)6-4-13-3-2-5-24-9-13/h2-3,5,8-9,14-15H,4,6-7,10-12H2,1H3/t14-,15-,19?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.75E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226226
(US9321790, 38)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cnc2NCCOc2c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C22H23F3N6O4/c23-22(24,25)17-1-3-29-19(33)7-18(30-9-14-6-13(30)11-35-14)28-21(29)31(17)10-15(32)12-5-16-20(27-8-12)26-2-4-34-16/h5,7-8,13-14,17H,1-4,6,9-11H2,(H,26,27)/t13-,14-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.77E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226219
(US9321790, 31)Show SMILES Cc1cc(cnc1N)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H23F3N6O3/c1-11-4-12(7-26-19(11)25)15(31)9-30-16(21(22,23)24)2-3-28-18(32)6-17(27-20(28)30)29-8-14-5-13(29)10-33-14/h4,6-7,13-14,16H,2-3,5,8-10H2,1H3,(H2,25,26)/t13-,14-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.35E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226246
(US9321790, 58)Show SMILES COC(=O)Nc1ccc(cn1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:21:25:30.31:28| Show InChI InChI=1S/C22H23F3N6O5/c1-35-21(34)27-17-3-2-12(8-26-17)15(32)10-31-16(22(23,24)25)4-5-29-19(33)7-18(28-20(29)31)30-9-14-6-13(30)11-36-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3,(H,26,27,34)/t13-,14-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226256
(US9321790, 68)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccccn1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-4-6-26-18(30)8-17(27-9-13-7-12(27)11-31-13)25-19(26)28(16)10-15(29)14-3-1-2-5-24-14/h1-3,5,8,12-13,16H,4,6-7,9-11H2/t12-,13-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226251
(US9321790, 63)Show SMILES FCCOc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:20:24:29.30:27| Show InChI InChI=1S/C22H23F4N5O4/c23-4-6-34-19-2-1-13(9-27-19)16(32)11-31-17(22(24,25)26)3-5-29-20(33)8-18(28-21(29)31)30-10-15-7-14(30)12-35-15/h1-2,8-9,14-15,17H,3-7,10-12H2/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >7.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226198
(US9321790, 10)Show SMILES COc1ccc(CCN2c3nc(cc(=O)n3CC2(C)C(F)(F)F)N2C[C@@H]3C[C@H]2CO3)cc1 |TLB:11:23:28.29:26| Show InChI InChI=1S/C22H25F3N4O3/c1-21(22(23,24)25)13-28-19(30)10-18(27-11-17-9-15(27)12-32-17)26-20(28)29(21)8-7-14-3-5-16(31-2)6-4-14/h3-6,10,15,17H,7-9,11-13H2,1-2H3/t15-,17-,21?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226191
(US9321790, 3)Show SMILES Nc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C20H21F3N6O3/c21-20(22,23)15-3-4-27-18(31)6-17(28-8-13-5-12(28)10-32-13)26-19(27)29(15)9-14(30)11-1-2-16(24)25-7-11/h1-2,6-7,12-13,15H,3-5,8-10H2,(H2,24,25)/t12-,13-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226203
(US9321790, 15)Show SMILES Cc1cncc(c1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C21H22F3N5O3/c1-12-4-13(8-25-7-12)16(30)10-29-17(21(22,23)24)2-3-27-19(31)6-18(26-20(27)29)28-9-15-5-14(28)11-32-15/h4,6-8,14-15,17H,2-3,5,9-11H2,1H3/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >7.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226204
(US9321790, 16)Show SMILES Cc1cncc(c1)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:13:25:30.31:28| Show InChI InChI=1S/C21H22F3N5O3/c1-12-3-13(7-25-6-12)16(30)9-29-19-26-17(27-8-15-4-14(27)10-32-15)5-18(31)28(19)11-20(29,2)21(22,23)24/h3,5-7,14-15H,4,8-11H2,1-2H3/t14-,15-,20?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >7.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226274
(US9321790, 86)Show SMILES FC(F)n1ccc(CN2[C@@H](CCn3c2nc(cc3=O)N2CC3CCC(C2)O3)C(F)(F)F)n1 |TLB:15:19:22.23:26| Show InChI InChI=1S/C19H21F5N6O2/c20-17(21)30-6-3-11(26-30)8-29-14(19(22,23)24)4-5-28-16(31)7-15(25-18(28)29)27-9-12-1-2-13(10-27)32-12/h3,6-7,12-14,17H,1-2,4-5,8-10H2/t12?,13?,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226297
(US9321790, 109)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1Cc1cccc2cnccc12 |TLB:10:14:19.20:17| Show InChI InChI=1S/C23H22F3N5O2/c24-23(25,26)19-5-7-29-21(32)9-20(30-12-17-8-16(30)13-33-17)28-22(29)31(19)11-15-3-1-2-14-10-27-6-4-18(14)15/h1-4,6,9-10,16-17,19H,5,7-8,11-13H2/t16-,17-,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226217
(US9321790, 29)Show SMILES CC(C)(C)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:14:18:23.24:21| Show InChI InChI=1S/C19H25F3N4O3/c1-18(2,3)14(27)9-26-13(19(20,21)22)4-5-24-16(28)7-15(23-17(24)26)25-8-12-6-11(25)10-29-12/h7,11-13H,4-6,8-10H2,1-3H3/t11-,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 7.93E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226193
(US9321790, 5)Show SMILES CNc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H23F3N6O3/c1-25-17-3-2-12(8-26-17)15(31)10-30-16(21(22,23)24)4-5-28-19(32)7-18(27-20(28)30)29-9-14-6-13(29)11-33-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3,(H,25,26)/t13-,14-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226284
(US9321790, 96)Show SMILES OC(CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F)(C(F)(F)F)C(F)(F)F |THB:10:14:20.19:17| Show InChI InChI=1S/C17H17F9N4O3/c18-15(19,20)10-1-2-28-12(31)4-11(29-5-9-3-8(29)6-33-9)27-13(28)30(10)7-14(32,16(21,22)23)17(24,25)26/h4,8-10,32H,1-3,5-7H2/t8-,9-,10?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226190
(US9321790, 2)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccncc1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-3-6-26-18(30)8-17(27-9-14-7-13(27)11-31-14)25-19(26)28(16)10-15(29)12-1-4-24-5-2-12/h1-2,4-5,8,13-14,16H,3,6-7,9-11H2/t13-,14-,16?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226197
(US9321790, 9)Show SMILES CNc1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2C[C@@]1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:14:26:31.32:29| Show InChI InChI=1S/C21H23F3N6O3/c1-20(21(22,23)24)11-29-18(32)6-17(28-8-14-5-13(28)10-33-14)27-19(29)30(20)9-15(31)12-3-4-16(25-2)26-7-12/h3-4,6-7,13-14H,5,8-11H2,1-2H3,(H,25,26)/t13-,14-,20-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226306
(US9321790, 118)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CCN(CC1)C=O |THB:10:14:20.19:17| Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)17-3-6-27-19(32)8-18(28-9-15-7-14(28)11-33-15)25-20(27)29(17)10-16(31)13-1-4-26(12-30)5-2-13/h8,12-15,17H,1-7,9-11H2/t14-,15-,17?/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226225
(US9321790, 37)Show SMILES FC(F)Oc1ccc(cc1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:20:24:29.30:27| Show InChI InChI=1S/C22H21F5N4O4/c23-20(24)35-14-3-1-12(2-4-14)16(32)10-31-17(22(25,26)27)5-6-29-19(33)8-18(28-21(29)31)30-9-15-7-13(30)11-34-15/h1-4,8,13,15,17,20H,5-7,9-11H2/t13-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226235
(US9321790, 47)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2snnc2c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C21H19F3N6O3S/c22-21(23,24)17-3-4-28-19(32)7-18(29-8-13-6-12(29)10-33-13)25-20(28)30(17)9-15(31)11-1-2-16-14(5-11)26-27-34-16/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226287
(US9321790, 99)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2CC3C[C@H]2CO3)N1CC(=O)N1C2CC[C@H]1COC2 |THB:10:14:20.19:17| Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)16-3-4-26-18(30)6-17(27-7-15-5-14(27)11-33-15)25-20(26)28(16)8-19(31)29-12-1-2-13(29)10-32-9-12/h6,12-16H,1-5,7-11H2/t12-,13?,14-,15?,16?/m0/s1 | PDB
UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226192
(US9321790, 4)Show SMILES Cc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C21H22F3N5O3/c1-12-2-3-13(8-25-12)16(30)10-29-17(21(22,23)24)4-5-27-19(31)7-18(26-20(27)29)28-9-15-6-14(28)11-32-15/h2-3,7-8,14-15,17H,4-6,9-11H2,1H3/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226209
(US9321790, 21)Show SMILES CC1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C20H20F3N5O3/c1-19(20(21,22)23)11-27-17(30)6-16(26-8-14-5-13(26)10-31-14)25-18(27)28(19)9-15(29)12-3-2-4-24-7-12/h2-4,6-7,13-14H,5,8-11H2,1H3/t13-,14-,19?/m0/s1 | PDB
UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226231
(US9321790, 43)Show SMILES Cc1ncsc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H20F3N5O3S/c1-10-17(31-9-23-10)13(28)7-27-14(19(20,21)22)2-3-25-16(29)5-15(24-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,14H,2-4,6-8H2,1H3/t11-,12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226239
(US9321790, 51)Show SMILES Cn1nc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c2ccccc12 |TLB:12:16:21.22:19| Show InChI InChI=1S/C22H23F3N6O2/c1-28-17-5-3-2-4-15(17)16(27-28)11-31-18(22(23,24)25)6-7-29-20(32)9-19(26-21(29)31)30-10-14-8-13(30)12-33-14/h2-5,9,13-14,18H,6-8,10-12H2,1H3/t13-,14-,18-/m0/s1 | PDB
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226243
(US9321790, 55)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccc(c1)C#N |THB:10:14:20.19:17| Show InChI InChI=1S/C22H20F3N5O3/c23-22(24,25)18-4-5-28-20(32)8-19(29-10-16-7-15(29)12-33-16)27-21(28)30(18)11-17(31)14-3-1-2-13(6-14)9-26/h1-3,6,8,15-16,18H,4-5,7,10-12H2/t15-,16-,18?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226245
(US9321790, 57)Show SMILES CCOC(=O)Nc1ccc(cn1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:22:26:31.32:29| Show InChI InChI=1S/C23H25F3N6O5/c1-2-36-22(35)28-18-4-3-13(9-27-18)16(33)11-32-17(23(24,25)26)5-6-30-20(34)8-19(29-21(30)32)31-10-15-7-14(31)12-37-15/h3-4,8-9,14-15,17H,2,5-7,10-12H2,1H3,(H,27,28,35)/t14-,15-,17?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226202
(US9321790, 14)Show SMILES OCCNc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:20:24:29.30:27| Show InChI InChI=1S/C22H25F3N6O4/c23-22(24,25)17-3-5-29-20(34)8-19(30-10-15-7-14(30)12-35-15)28-21(29)31(17)11-16(33)13-1-2-18(27-9-13)26-4-6-32/h1-2,8-9,14-15,17,32H,3-7,10-12H2,(H,26,27)/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226208
(US9321790, 20)Show SMILES Cc1ccncc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C21H22F3N5O3/c1-12-2-4-25-8-15(12)16(30)10-29-17(21(22,23)24)3-5-27-19(31)7-18(26-20(27)29)28-9-14-6-13(28)11-32-14/h2,4,7-8,13-14,17H,3,5-6,9-11H2,1H3/t13-,14-,17-/m0/s1 | PDB
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226230
(US9321790, 42)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(cc1)C#N |THB:10:14:20.19:17| Show InChI InChI=1S/C22H20F3N5O3/c23-22(24,25)18-5-6-28-20(32)8-19(29-10-16-7-15(29)12-33-16)27-21(28)30(18)11-17(31)14-3-1-13(9-26)2-4-14/h1-4,8,15-16,18H,5-7,10-12H2/t15-,16-,18?/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226233
(US9321790, 45)Show SMILES COc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H22F3N5O4/c1-32-18-3-2-12(8-25-18)15(30)10-29-16(21(22,23)24)4-5-27-19(31)7-17(26-20(27)29)28-9-14-6-13(28)11-33-14/h2-3,7-8,13-14,16H,4-6,9-11H2,1H3/t13-,14-,16-/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226196
(US9321790, 8)Show SMILES CN(C)c1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2C[C@@]1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:15:27:32.33:30| Show InChI InChI=1S/C22H25F3N6O3/c1-21(22(23,24)25)12-30-19(33)7-18(29-9-15-6-14(29)11-34-15)27-20(30)31(21)10-16(32)13-4-5-17(26-8-13)28(2)3/h4-5,7-8,14-15H,6,9-12H2,1-3H3/t14-,15-,21-/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226221
(US9321790, 33)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(nc1)C(F)(F)F |THB:10:14:20.19:17| Show InChI InChI=1S/C21H19F6N5O3/c22-20(23,24)15-2-1-11(7-28-15)14(33)9-32-16(21(25,26)27)3-4-30-18(34)6-17(29-19(30)32)31-8-13-5-12(31)10-35-13/h1-2,6-7,12-13,16H,3-5,8-10H2/t12-,13-,16?/m0/s1 | PDB
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226234
(US9321790, 46)Show SMILES Cc1nocc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H20F3N5O4/c1-10-13(9-31-24-10)14(28)7-27-15(19(20,21)22)2-3-25-17(29)5-16(23-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,15H,2-4,6-8H2,1H3/t11-,12-,15-/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226286
(US9321790, 98)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2CC3C[C@H]2CO3)N1CC(=O)N1CC2CC[C@@H](C1)O2 |TLB:23:25:29.28:32,THB:10:14:20.19:17| Show InChI InChI=1S/C21H26F3N5O4/c22-21(23,24)16-3-4-27-18(30)6-17(28-9-15-5-12(28)11-32-15)25-20(27)29(16)10-19(31)26-7-13-1-2-14(8-26)33-13/h6,12-16H,1-5,7-11H2/t12-,13-,14?,15?,16?/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226296
(US9321790, 108)Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:20:24:29.30:27| Show InChI InChI=1S/C22H23F3N4O5S/c1-35(32,33)16-4-2-13(3-5-16)17(30)11-29-18(22(23,24)25)6-7-27-20(31)9-19(26-21(27)29)28-10-15-8-14(28)12-34-15/h2-5,9,14-15,18H,6-8,10-12H2,1H3/t14-,15-,18-/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226207
(US9321790, 19)Show SMILES Cc1ncccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C21H22F3N5O3/c1-12-15(3-2-5-25-12)16(30)10-29-17(21(22,23)24)4-6-27-19(31)8-18(26-20(27)29)28-9-14-7-13(28)11-32-14/h2-3,5,8,13-14,17H,4,6-7,9-11H2,1H3/t13-,14-,17-/m0/s1 | PDB
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226307
(US9321790, 119)Show SMILES CC(=O)N1CCC(CC1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:19:23:28.29:26| Show InChI InChI=1S/C22H28F3N5O4/c1-13(31)27-5-2-14(3-6-27)17(32)11-30-18(22(23,24)25)4-7-28-20(33)9-19(26-21(28)30)29-10-16-8-15(29)12-34-16/h9,14-16,18H,2-8,10-12H2,1H3/t15-,16-,18-/m0/s1 | PDB
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226206
(US9321790, 18)Show SMILES Cc1ncccc1C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:13:25:30.31:28| Show InChI InChI=1S/C21H22F3N5O3/c1-12-15(4-3-5-25-12)16(30)9-29-19-26-17(27-8-14-6-13(27)10-32-14)7-18(31)28(19)11-20(29,2)21(22,23)24/h3-5,7,13-14H,6,8-11H2,1-2H3/t13-,14-,20?/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226236
(US9321790, 48)Show SMILES Fc1ccc(C(=O)CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c(F)c1 |TLB:15:19:24.25:22| Show InChI InChI=1S/C21H19F5N4O3/c22-11-1-2-14(15(23)5-11)16(31)9-30-17(21(24,25)26)3-4-28-19(32)7-18(27-20(28)30)29-8-13-6-12(29)10-33-13/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1 | PDB
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226273
(US9321790, 85)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C3CCC2COC3)N1CC(=O)c1cccnc1 Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-7-27-19(31)8-18(29-14-3-4-15(29)12-32-11-14)26-20(27)28(17)10-16(30)13-2-1-6-25-9-13/h1-2,6,8-9,14-15,17H,3-5,7,10-12H2/t14?,15?,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
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Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226210
(US9321790, 22)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(NC2CC2)nc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C23H25F3N6O3/c24-23(25,26)18-5-6-30-21(34)8-20(31-10-16-7-15(31)12-35-16)29-22(30)32(18)11-17(33)13-1-4-19(27-9-13)28-14-2-3-14/h1,4,8-9,14-16,18H,2-3,5-7,10-12H2,(H,27,28)/t15-,16-,18-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226248
(US9321790, 60)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1C(F)(F)F |THB:10:14:20.19:17| Show InChI InChI=1S/C21H19F6N5O3/c22-20(23,24)15-3-5-30-17(34)7-16(31-8-12-6-11(31)10-35-12)29-19(30)32(15)9-14(33)13-2-1-4-28-18(13)21(25,26)27/h1-2,4,7,11-12,15H,3,5-6,8-10H2/t11-,12-,15?/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226253
(US9321790, 65)Show SMILES COc1ncccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H22F3N5O4/c1-32-19-14(3-2-5-25-19)15(30)10-29-16(21(22,23)24)4-6-27-18(31)8-17(26-20(27)29)28-9-13-7-12(28)11-33-13/h2-3,5,8,12-13,16H,4,6-7,9-11H2,1H3/t12-,13-,16-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226263
(US9321790, 75)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1ccncc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-8-28-19(31)9-18(27-10-14-1-2-15(11-27)32-14)26-20(28)29(17)12-16(30)13-3-6-25-7-4-13/h3-4,6-7,9,14-15,17H,1-2,5,8,10-12H2/t14?,15?,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226300
(US9321790, 112)Show SMILES CON(C)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:14:18:23.24:21| Show InChI InChI=1S/C17H22F3N5O4/c1-22(28-2)15(27)8-25-12(17(18,19)20)3-4-23-14(26)6-13(21-16(23)25)24-7-11-5-10(24)9-29-11/h6,10-12H,3-5,7-9H2,1-2H3/t10-,11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226194
(US9321790, 6)Show SMILES CN(C)c1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:19:23:28.29:26| Show InChI InChI=1S/C22H25F3N6O3/c1-28(2)18-4-3-13(9-26-18)16(32)11-31-17(22(23,24)25)5-6-29-20(33)8-19(27-21(29)31)30-10-15-7-14(30)12-34-15/h3-4,8-9,14-15,17H,5-7,10-12H2,1-2H3/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226224
(US9321790, 36)Show SMILES Cc1c(N)ncc(C(=O)CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c1C |TLB:17:21:26.27:24| Show InChI InChI=1S/C22H25F3N6O3/c1-11-12(2)20(26)27-7-15(11)16(32)9-31-17(22(23,24)25)3-4-29-19(33)6-18(28-21(29)31)30-8-14-5-13(30)10-34-14/h6-7,13-14,17H,3-5,8-10H2,1-2H3,(H2,26,27)/t13-,14-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226241
(US9321790, 53)Show SMILES Cc1noc(C)c1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:17:21:26.27:24| Show InChI InChI=1S/C20H22F3N5O4/c1-10-18(11(2)32-25-10)14(29)8-28-15(20(21,22)23)3-4-26-17(30)6-16(24-19(26)28)27-7-13-5-12(27)9-31-13/h6,12-13,15H,3-5,7-9H2,1-2H3/t12-,13-,15-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226250
(US9321790, 62)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)C1CCOCC1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H25F3N4O4/c21-20(22,23)16-1-4-25-18(29)8-17(26-9-14-7-13(26)11-31-14)24-19(25)27(16)10-15(28)12-2-5-30-6-3-12/h8,12-14,16H,1-7,9-11H2/t13-,14-,16?/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226252
(US9321790, 64)Show SMILES FCCOc1ccc(cc1F)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:21:25:30.31:28| Show InChI InChI=1S/C23H23F5N4O4/c24-4-6-35-18-2-1-13(7-16(18)25)17(33)11-32-19(23(26,27)28)3-5-30-21(34)9-20(29-22(30)32)31-10-15-8-14(31)12-36-15/h1-2,7,9,14-15,19H,3-6,8,10-12H2/t14-,15-,19-/m0/s1 | PDB
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226279
(US9321790, 91)Show SMILES CCOC(=O)N1CCC(CC1)C(=O)CN1C(CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:21:25:30.31:28| Show InChI InChI=1S/C23H30F3N5O5/c1-2-35-22(34)28-6-3-14(4-7-28)17(32)12-31-18(23(24,25)26)5-8-29-20(33)10-19(27-21(29)31)30-11-16-9-15(30)13-36-16/h10,14-16,18H,2-9,11-13H2,1H3/t15-,16-,18?/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226222
(US9321790, 34)Show SMILES CN(CCO)c1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:21:25:30.31:28| Show InChI InChI=1S/C23H27F3N6O4/c1-29(6-7-33)19-3-2-14(10-27-19)17(34)12-32-18(23(24,25)26)4-5-30-21(35)9-20(28-22(30)32)31-11-16-8-15(31)13-36-16/h2-3,9-10,15-16,18,33H,4-8,11-13H2,1H3/t15-,16-,18-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226223
(US9321790, 35)Show SMILES CCOc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:19:23:28.29:26| Show InChI InChI=1S/C22H24F3N5O4/c1-2-33-19-4-3-13(9-26-19)16(31)11-30-17(22(23,24)25)5-6-28-20(32)8-18(27-21(28)30)29-10-15-7-14(29)12-34-15/h3-4,8-9,14-15,17H,2,5-7,10-12H2,1H3/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226227
(US9321790, 39)Show SMILES Cc1ncoc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H20F3N5O4/c1-10-17(31-9-23-10)13(28)7-27-14(19(20,21)22)2-3-25-16(29)5-15(24-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,14H,2-4,6-8H2,1H3/t11-,12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
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| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226294
(US9321790, 106)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1Cc1cccc2ncccc12 |THB:10:14:20.19:17| Show InChI InChI=1S/C23H22F3N5O2/c24-23(25,26)19-6-8-29-21(32)10-20(30-12-16-9-15(30)13-33-16)28-22(29)31(19)11-14-3-1-5-18-17(14)4-2-7-27-18/h1-5,7,10,15-16,19H,6,8-9,11-13H2/t15-,16-,19?/m0/s1 | PDB
UniProtKB/SwissProt
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226295
(US9321790, 107)Show SMILES Cc1nscc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H20F3N5O3S/c1-10-13(9-31-24-10)14(28)7-27-15(19(20,21)22)2-3-25-17(29)5-16(23-18(25)27)26-6-12-4-11(26)8-30-12/h5,9,11-12,15H,2-4,6-8H2,1H3/t11-,12-,15-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
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UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226302
(US9321790, 114)Show SMILES FC(F)Oc1ccc(cn1)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:20:24:29.30:27| Show InChI InChI=1S/C21H20F5N5O4/c22-19(23)35-17-2-1-11(7-27-17)14(32)9-31-15(21(24,25)26)3-4-29-18(33)6-16(28-20(29)31)30-8-13-5-12(30)10-34-13/h1-2,6-7,12-13,15,19H,3-5,8-10H2/t12-,13-,15-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226195
(US9321790, 7)Show SMILES FC(F)(F)C1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cccnc1 |THB:10:14:20.19:17| Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)16-3-5-26-18(30)7-17(27-9-14-6-13(27)11-31-14)25-19(26)28(16)10-15(29)12-2-1-4-24-8-12/h1-2,4,7-8,13-14,16H,3,5-6,9-11H2/t13-,14-,16?/m0/s1 | PDB
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226199
(US9321790, 11)Show SMILES C[C@]1(Cn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc(N)nc1)C(F)(F)F |TLB:6:10:15.16:13| Show InChI InChI=1S/C20H21F3N6O3/c1-19(20(21,22)23)10-28-17(31)5-16(27-7-13-4-12(27)9-32-13)26-18(28)29(19)8-14(30)11-2-3-15(24)25-6-11/h2-3,5-6,12-13H,4,7-10H2,1H3,(H2,24,25)/t12-,13-,19-/m0/s1 | PDB
UniProtKB/SwissProt
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226244
(US9321790, 56)Show SMILES CC(C)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:13:17:22.23:20| Show InChI InChI=1S/C18H23F3N4O3/c1-10(2)13(26)8-25-14(18(19,20)21)3-4-23-16(27)6-15(22-17(23)25)24-7-12-5-11(24)9-28-12/h6,10-12,14H,3-5,7-9H2,1-2H3/t11-,12-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226247
(US9321790, 59)Show SMILES Cc1nc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)no1 |TLB:12:16:21.22:19| Show InChI InChI=1S/C17H19F3N6O3/c1-9-21-13(23-29-9)7-26-12(17(18,19)20)2-3-24-15(27)5-14(22-16(24)26)25-6-11-4-10(25)8-28-11/h5,10-12H,2-4,6-8H2,1H3/t10-,11-,12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226257
(US9321790, 69)Show SMILES Cn1nccc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H21F3N6O3/c1-25-13(2-4-23-25)14(29)9-28-15(19(20,21)22)3-5-26-17(30)7-16(24-18(26)28)27-8-12-6-11(27)10-31-12/h2,4,7,11-12,15H,3,5-6,8-10H2,1H3/t11-,12-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226301
(US9321790, 113)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2nccn2c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C22H21F3N6O3/c23-22(24,25)17-3-5-29-20(33)8-19(30-10-15-7-14(30)12-34-15)27-21(29)31(17)11-16(32)13-1-2-18-26-4-6-28(18)9-13/h1-2,4,6,8-9,14-15,17H,3,5,7,10-12H2/t14-,15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226205
(US9321790, 17)Show SMILES Cc1ccc(cn1)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:13:25:30.31:28| Show InChI InChI=1S/C21H22F3N5O3/c1-12-3-4-13(7-25-12)16(30)9-29-19-26-17(27-8-15-5-14(27)10-32-15)6-18(31)28(19)11-20(29,2)21(22,23)24/h3-4,6-7,14-15H,5,8-11H2,1-2H3/t14-,15-,20?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226218
(US9321790, 30)Show SMILES CC(C)(C)C(=O)CN1c2nc(cc(=O)n2CC1(C)C(F)(F)F)N1C[C@@H]2C[C@H]1CO2 |TLB:10:22:27.28:25| Show InChI InChI=1S/C19H25F3N4O3/c1-17(2,3)13(27)8-26-16-23-14(24-7-12-5-11(24)9-29-12)6-15(28)25(16)10-18(26,4)19(20,21)22/h6,11-12H,5,7-10H2,1-4H3/t11-,12-,18?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226228
(US9321790, 40)Show SMILES Fc1ccc(cc1F)C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:18:22:27.28:25| Show InChI InChI=1S/C21H19F5N4O3/c22-14-2-1-11(5-15(14)23)16(31)9-30-17(21(24,25)26)3-4-28-19(32)7-18(27-20(28)30)29-8-13-6-12(29)10-33-13/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226232
(US9321790, 44)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cncc(Cl)c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C20H19ClF3N5O3/c21-12-3-11(6-25-7-12)15(30)9-29-16(20(22,23)24)1-2-27-18(31)5-17(26-19(27)29)28-8-14-4-13(28)10-32-14/h3,5-7,13-14,16H,1-2,4,8-10H2/t13-,14-,16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226249
(US9321790, 61)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1ccc2nsnc2c1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C21H19F3N6O3S/c22-21(23,24)17-3-4-28-19(32)7-18(29-8-13-6-12(29)10-33-13)25-20(28)30(17)9-16(31)11-1-2-14-15(5-11)27-34-26-14/h1-2,5,7,12-13,17H,3-4,6,8-10H2/t12-,13-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226240
(US9321790, 52)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)c1cnc(OCC2CC2)nc1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)18-3-4-30-20(34)6-19(31-9-16-5-15(31)12-35-16)29-22(30)32(18)10-17(33)14-7-27-21(28-8-14)36-11-13-1-2-13/h6-8,13,15-16,18H,1-5,9-12H2/t15-,16-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226275
(US9321790, 87)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2CC3CCC(C2)O3)N1CC(=O)c1cccnc1 |TLB:10:14:17.18:21| Show InChI InChI=1S/C21H22F3N5O3/c22-21(23,24)17-5-7-28-19(31)8-18(27-10-14-3-4-15(11-27)32-14)26-20(28)29(17)12-16(30)13-2-1-6-25-9-13/h1-2,6,8-9,14-15,17H,3-5,7,10-12H2/t14?,15?,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226298
(US9321790, 110)Show SMILES FC(F)(F)[C@@H]1CCn2c(nc(cc2=O)N2C[C@@H]3C[C@H]2CO3)N1CC(=O)N1CCOCC1 |TLB:10:14:19.20:17| Show InChI InChI=1S/C19H24F3N5O4/c20-19(21,22)14-1-2-25-16(28)8-15(26-9-13-7-12(26)11-31-13)23-18(25)27(14)10-17(29)24-3-5-30-6-4-24/h8,12-14H,1-7,9-11H2/t12-,13-,14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226254
(US9321790, 66)Show SMILES Cn1cncc1C(=O)CN1[C@@H](CCn2c1nc(cc2=O)N1C[C@@H]2C[C@H]1CO2)C(F)(F)F |TLB:16:20:25.26:23| Show InChI InChI=1S/C19H21F3N6O3/c1-25-10-23-6-13(25)14(29)8-28-15(19(20,21)22)2-3-26-17(30)5-16(24-18(26)28)27-7-12-4-11(27)9-31-12/h5-6,10-12,15H,2-4,7-9H2,1H3/t11-,12-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM226304
(US9321790, 116)Show SMILES Cn1cc(CN2[C@@H](CCn3c2nc(cc3=O)N2C[C@@H]3C[C@H]2CO3)C(F)(F)F)c(n1)C(F)(F)F |TLB:12:16:21.22:19| Show InChI InChI=1S/C19H20F6N6O2/c1-28-6-10(16(27-28)19(23,24)25)7-31-13(18(20,21)22)2-3-29-15(32)5-14(26-17(29)31)30-8-12-4-11(30)9-33-12/h5-6,11-13H,2-4,7-9H2,1H3/t11-,12-,13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Sanofi
US Patent
| Assay Description
The compounds according to the invention underwent pharmacological trials to measure the selectivity toward human lipid kinases and especially human ... |
US Patent US9321790 (2016)
BindingDB Entry DOI: 10.7270/Q2KD1WSG |
More data for this
Ligand-Target Pair | |
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