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Patent code US9346810

Compile Data Set for Download or QSAR

Found 249 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228762
PNG
(US10369153, Compound 212 | US9346810, 212)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cn1
Show InChI InChI=1S/C22H22FN7O2S/c1-29(17-9-11-30(13-17)22-19-8-10-24-21(19)26-14-27-22)20-7-4-16(12-25-20)28-33(31,32)18-5-2-15(23)3-6-18/h2-8,10,12,14,17,28H,9,11,13H2,1H3,(H,24,26,27)/t17-/m1/s1
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US Patent
n/an/a 0.0550n/an/an/an/an/a25



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228676
PNG
(US10369153, Compound 121 | US9346810, 121)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(c1)C#N
Show InChI InChI=1S/C17H17N7/c1-23(13-2-5-19-12(8-13)9-18)14-4-7-24(10-14)17-15-3-6-20-16(15)21-11-22-17/h2-3,5-6,8,11,14H,4,7,10H2,1H3,(H,20,21,22)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228668
PNG
(US10369153, Compound 42 | US9346810, 42)
Show SMILES COc1nc(ccc1C#N)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H19N7O/c1-24(15-4-3-12(9-19)18(23-15)26-2)13-6-8-25(10-13)17-14-5-7-20-16(14)21-11-22-17/h3-5,7,11,13H,6,8,10H2,1-2H3,(H,20,21,22)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228672
PNG
(US10369153, Compound 86 | US9346810, 86)
Show SMILES COc1cc2ncnc(N(C)[C@@H]3CCN(C3)c3ncnc4[nH]ccc34)c2cc1OC
Show InChI InChI=1S/C21H23N7O2/c1-27(20-15-8-17(29-2)18(30-3)9-16(15)23-11-25-20)13-5-7-28(10-13)21-14-4-6-22-19(14)24-12-26-21/h4,6,8-9,11-13H,5,7,10H2,1-3H3,(H,22,24,26)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228674
PNG
(US10369153, Compound 106 | US9346810, 106)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc(F)c(C#N)c(F)c1
Show InChI InChI=1S/C18H16F2N6/c1-25(12-6-15(19)14(8-21)16(20)7-12)11-3-5-26(9-11)18-13-2-4-22-17(13)23-10-24-18/h2,4,6-7,10-11H,3,5,9H2,1H3,(H,22,23,24)/t11-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228678
PNG
(US10369153, Compound 123 | US9346810, 123)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N6/c1-25(14-3-2-11(8-22-14)17(18,19)20)12-5-7-26(9-12)16-13-4-6-21-15(13)23-10-24-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,21,23,24)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228708
PNG
(US10369153, Compound 259 | US9346810, 259)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CCOCC1
Show InChI InChI=1S/C21H27N7O3S/c1-27(16-5-9-28(13-16)21-18-4-8-22-20(18)24-14-25-21)19-3-2-17(12-23-19)32(29,30)26-15-6-10-31-11-7-15/h2-4,8,12,14-16,26H,5-7,9-11,13H2,1H3,(H,22,24,25)/t16-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228719
PNG
(US10369153, Compound 71 | US9346810, 71 | US934681...)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
Show InChI InChI=1S/C17H17N7/c1-23(15-3-2-12(8-18)9-20-15)13-5-7-24(10-13)17-14-4-6-19-16(14)21-11-22-17/h2-4,6,9,11,13H,5,7,10H2,1H3,(H,19,21,22)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228760
PNG
(US9346810, 209)
Show SMILES COC[C@@H](NC(=O)c1cc(F)c(N(C)[C@@H]2CCN(C2)c2ncnc3[nH]ccc23)c(F)c1)c1ccccc1
Show InChI InChI=1S/C27H28F2N6O2/c1-34(19-9-11-35(14-19)26-20-8-10-30-25(20)31-16-32-26)24-21(28)12-18(13-22(24)29)27(36)33-23(15-37-2)17-6-4-3-5-7-17/h3-8,10,12-13,16,19,23H,9,11,14-15H2,1-2H3,(H,33,36)(H,30,31,32)/t19-,23-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228698
PNG
(US9346810, 241)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC[C@@H]1CCCO1
Show InChI InChI=1S/C21H27N7O3S/c1-27(15-7-9-28(13-15)21-18-6-8-22-20(18)24-14-25-21)19-5-4-17(12-23-19)32(29,30)26-11-16-3-2-10-31-16/h4-6,8,12,14-16,26H,2-3,7,9-11,13H2,1H3,(H,22,24,25)/t15-,16+/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228699
PNG
(US10369153, Compound 242 | US9346810, 242)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1COC1
Show InChI InChI=1S/C19H23N7O3S/c1-25(17-3-2-15(8-21-17)30(27,28)24-13-10-29-11-13)14-5-7-26(9-14)19-16-4-6-20-18(16)22-12-23-19/h2-4,6,8,12-14,24H,5,7,9-11H2,1H3,(H,20,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228759
PNG
(US9346810, 208)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1c(F)cc(cc1F)C(=O)N[C@H](CO)c1ccccc1
Show InChI InChI=1S/C26H26F2N6O2/c1-33(18-8-10-34(13-18)25-19-7-9-29-24(19)30-15-31-25)23-20(27)11-17(12-21(23)28)26(36)32-22(14-35)16-5-3-2-4-6-16/h2-7,9,11-12,15,18,22,35H,8,10,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,22-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228661
PNG
(US10369153, Compound 1 | US9346810, 1)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C14H16N6O/c1-19(12(21)2-5-15)10-4-7-20(8-10)14-11-3-6-16-13(11)17-9-18-14/h3,6,9-10H,2,4,7-8H2,1H3,(H,16,17,18)/t10-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228671
PNG
(US10369153, Compound 77 | US9346810, 77)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cc(C)c(cn1)[N+]([O-])=O
Show InChI InChI=1S/C17H19N7O2/c1-11-7-15(19-8-14(11)24(25)26)22(2)12-4-6-23(9-12)17-13-3-5-18-16(13)20-10-21-17/h3,5,7-8,10,12H,4,6,9H2,1-2H3,(H,18,20,21)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228644
PNG
(US10111875, Compound 105 | US10369153, Compound 10...)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1 |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228676
PNG
(US10369153, Compound 121 | US9346810, 121)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(c1)C#N
Show InChI InChI=1S/C17H17N7/c1-23(13-2-5-19-12(8-13)9-18)14-4-7-24(10-14)17-15-3-6-20-16(15)21-11-22-17/h2-3,5-6,8,11,14H,4,7,10H2,1H3,(H,20,21,22)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228697
PNG
(US10369153, Compound 239 | US9346810, 239)
Show SMILES CNS(=O)(=O)c1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N7O2S/c1-18-27(25,26)13-3-4-15(20-9-13)23(2)12-6-8-24(10-12)17-14-5-7-19-16(14)21-11-22-17/h3-5,7,9,11-12,18H,6,8,10H2,1-2H3,(H,19,21,22)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228686
PNG
(US9346810, 161)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)-c1nnn[nH]1
Show InChI InChI=1S/C18H18FN9/c1-27(15-3-2-11(8-14(15)19)16-23-25-26-24-16)12-5-7-28(9-12)18-13-4-6-20-17(13)21-10-22-18/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,20,21,22)(H,23,24,25,26)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228689
PNG
(US10369153, Compound 215 | US9346810, 215)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)c2cccnc2)cn1
Show InChI InChI=1S/C21H22N8O2S/c1-28(16-7-10-29(13-16)21-18-6-9-23-20(18)25-14-26-21)19-5-4-15(11-24-19)27-32(30,31)17-3-2-8-22-12-17/h2-6,8-9,11-12,14,16,27H,7,10,13H2,1H3,(H,23,25,26)/t16-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228694
PNG
(US10369153, Compound 236 | US9346810, 236)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C19H23N7O2S/c1-25(17-5-4-15(10-21-17)29(27,28)24-13-2-3-13)14-7-9-26(11-14)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-14,24H,2-3,7,9,11H2,1H3,(H,20,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228699
PNG
(US10369153, Compound 242 | US9346810, 242)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1COC1
Show InChI InChI=1S/C19H23N7O3S/c1-25(17-3-2-15(8-21-17)30(27,28)24-13-10-29-11-13)14-5-7-26(9-14)19-16-4-6-20-18(16)22-12-23-19/h2-4,6,8,12-14,24H,5,7,9-11H2,1H3,(H,20,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228661
PNG
(US10369153, Compound 1 | US9346810, 1)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C14H16N6O/c1-19(12(21)2-5-15)10-4-7-20(8-10)14-11-3-6-16-13(11)17-9-18-14/h3,6,9-10H,2,4,7-8H2,1H3,(H,16,17,18)/t10-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228727
PNG
(US9346810, 93)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C1NC(=CS1)C#N |c:21|
Show InChI InChI=1S/C15H17N7S/c1-21(15-20-10(6-16)8-23-15)11-3-5-22(7-11)14-12-2-4-17-13(12)18-9-19-14/h2,4,8-9,11,15,20H,3,5,7H2,1H3,(H,17,18,19)/t11-,15?/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228734
PNG
(US10369153, Compound 114 | US9346810, 114)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(Br)c1
Show InChI InChI=1S/C18H17BrN6/c1-24(13-3-2-12(9-20)16(19)8-13)14-5-7-25(10-14)18-15-4-6-21-17(15)22-11-23-18/h2-4,6,8,11,14H,5,7,10H2,1H3,(H,21,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228737
PNG
(US10369153, Compound 131 | US9346810, 131)
Show SMILES C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C20H18N6/c1-2-10-26(16-5-3-15(12-21)4-6-16)17-8-11-25(13-17)20-18-7-9-22-19(18)23-14-24-20/h1,3-7,9,14,17H,8,10-11,13H2,(H,22,23,24)/t17-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228740
PNG
(US10369153, Compound 156 | US9346810, 156)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccccn1
Show InChI InChI=1S/C16H18N6/c1-21(14-4-2-3-7-17-14)12-6-9-22(10-12)16-13-5-8-18-15(13)19-11-20-16/h2-5,7-8,11-12H,6,9-10H2,1H3,(H,18,19,20)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228750
PNG
(US10369153, Compound 179 | US9346810, 179)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)N[C@@H](CO)c1ccccc1
Show InChI InChI=1S/C26H27FN6O2/c1-32(19-10-12-33(14-19)25-20-9-11-28-24(20)29-16-30-25)23-8-7-18(13-21(23)27)26(35)31-22(15-34)17-5-3-2-4-6-17/h2-9,11,13,16,19,22,34H,10,12,14-15H2,1H3,(H,31,35)(H,28,29,30)/t19-,22+/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228752
PNG
(US10369153, Compound 184 | US9346810, 184)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC1C(O)Cc2ccccc12
Show InChI InChI=1S/C27H27FN6O2/c1-33(18-9-11-34(14-18)26-20-8-10-29-25(20)30-15-31-26)22-7-6-17(12-21(22)28)27(36)32-24-19-5-3-2-4-16(19)13-23(24)35/h2-8,10,12,15,18,23-24,35H,9,11,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,23?,24?/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228716
PNG
(US10369153, Compound 63 | US9346810, 63)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(Cl)n1
Show InChI InChI=1S/C15H16ClN7/c1-22(12-3-6-18-15(16)21-12)10-4-7-23(8-10)14-11-2-5-17-13(11)19-9-20-14/h2-3,5-6,9-10H,4,7-8H2,1H3,(H,17,19,20)/t10-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228718
PNG
(US10369153, Compound 66 | US9346810, 66)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(F)cn1
Show InChI InChI=1S/C16H17FN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228751
PNG
(US9346810, 182)
Show SMILES C[C@@H](NC(=O)c1ccc(N(C)[C@@H]2CCN(C2)c2ncnc3[nH]ccc23)c(F)c1)c1ccccc1
Show InChI InChI=1S/C26H27FN6O/c1-17(18-6-4-3-5-7-18)31-26(34)19-8-9-23(22(27)14-19)32(2)20-11-13-33(15-20)25-21-10-12-28-24(21)29-16-30-25/h3-10,12,14,16-17,20H,11,13,15H2,1-2H3,(H,31,34)(H,28,29,30)/t17-,20-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228662
PNG
(US10369153, Compound 16 | US9346810, 16)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C19H19N7O/c1-25(19(27)24-14-4-2-3-13(9-14)10-20)15-6-8-26(11-15)18-16-5-7-21-17(16)22-12-23-18/h2-5,7,9,12,15H,6,8,11H2,1H3,(H,24,27)(H,21,22,23)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228679
PNG
(US10369153, Compound 124 | US9346810, 124)
Show SMILES N#Cc1ccc(nc1)N(CC1CC1)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H21N7/c21-9-15-3-4-18(23-10-15)27(11-14-1-2-14)16-6-8-26(12-16)20-17-5-7-22-19(17)24-13-25-20/h3-5,7,10,13-14,16H,1-2,6,8,11-12H2,(H,22,24,25)/t16-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228696
PNG
(US10369153, Compound 238 | US9346810, 238)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C20H27N7O2S/c1-20(2,3)25-30(28,29)15-5-6-17(22-11-15)26(4)14-8-10-27(12-14)19-16-7-9-21-18(16)23-13-24-19/h5-7,9,11,13-14,25H,8,10,12H2,1-4H3,(H,21,23,24)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228700
PNG
(US10369153, Compound 243 | US9346810, 243)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NCCO
Show InChI InChI=1S/C18H23N7O3S/c1-24(16-3-2-14(10-20-16)29(27,28)23-7-9-26)13-5-8-25(11-13)18-15-4-6-19-17(15)21-12-22-18/h2-4,6,10,12-13,23,26H,5,7-9,11H2,1H3,(H,19,21,22)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228716
PNG
(US10369153, Compound 63 | US9346810, 63)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccnc(Cl)n1
Show InChI InChI=1S/C15H16ClN7/c1-22(12-3-6-18-15(16)21-12)10-4-7-23(8-10)14-11-2-5-17-13(11)19-9-20-14/h2-3,5-6,9-10H,4,7-8H2,1H3,(H,17,19,20)/t10-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228669
PNG
(US10369153, Compound 67 | US9346810, 67)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(Cl)cn1
Show InChI InChI=1S/C16H17ClN6/c1-22(14-3-2-11(17)8-19-14)12-5-7-23(9-12)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,18,20,21)/t12-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228723
PNG
(US10369153, Compound 84 | US9346810, 84)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)C#N
Show InChI InChI=1S/C16H16N8/c1-23(14-8-19-11(6-17)7-20-14)12-3-5-24(9-12)16-13-2-4-18-15(13)21-10-22-16/h2,4,7-8,10,12H,3,5,9H2,1H3,(H,18,21,22)/t12-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228678
PNG
(US10369153, Compound 123 | US9346810, 123)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N6/c1-25(14-3-2-11(8-22-14)17(18,19)20)12-5-7-26(9-12)16-13-4-6-21-15(13)23-10-24-16/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,21,23,24)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228682
PNG
(US10369153, Compound 128 | US9346810, 128)
Show SMILES C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H17N7/c1-2-8-26(17-4-3-14(10-20)11-22-17)15-6-9-25(12-15)19-16-5-7-21-18(16)23-13-24-19/h1,3-5,7,11,13,15H,6,8-9,12H2,(H,21,23,24)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228738
PNG
(US9346810, 134)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)N1CCOCC1
Show InChI InChI=1S/C19H24N8O/c1-25(16-10-22-17(11-21-16)26-6-8-28-9-7-26)14-3-5-27(12-14)19-15-2-4-20-18(15)23-13-24-19/h2,4,10-11,13-14H,3,5-9,12H2,1H3,(H,20,23,24)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228738
PNG
(US9346810, 134)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1cnc(cn1)N1CCOCC1
Show InChI InChI=1S/C19H24N8O/c1-25(16-10-22-17(11-21-16)26-6-8-28-9-7-26)14-3-5-27(12-14)19-15-2-4-20-18(15)23-13-24-19/h2,4,10-11,13-14H,3,5-9,12H2,1H3,(H,20,23,24)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM228694
PNG
(US10369153, Compound 236 | US9346810, 236)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C19H23N7O2S/c1-25(17-5-4-15(10-21-17)29(27,28)24-13-2-3-13)14-7-9-26(11-14)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-14,24H,2-3,7,9,11H2,1H3,(H,20,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228673
PNG
(US10369153, Compound 104 | US9346810, 104)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C18H18N6/c1-23(14-4-2-13(10-19)3-5-14)15-7-9-24(11-15)18-16-6-8-20-17(16)21-12-22-18/h2-6,8,12,15H,7,9,11H2,1H3,(H,20,21,22)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228687
PNG
(US10369153, Compound 202 | US9346810, 202)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC[C@H](O)c1ccccc1
Show InChI InChI=1S/C26H27FN6O2/c1-32(19-10-12-33(15-19)25-20-9-11-28-24(20)30-16-31-25)22-8-7-18(13-21(22)27)26(35)29-14-23(34)17-5-3-2-4-6-17/h2-9,11,13,16,19,23,34H,10,12,14-15H2,1H3,(H,29,35)(H,28,30,31)/t19-,23+/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228640
PNG
(US10111875, Compound 234 | US10369153, Compound 23...)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(N)(=O)=O |r|
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154]


(Homo sapiens (Human))		BDBM228685
PNG
(US10369153, Compound 155 | US9346810, 155)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(C)n1
Show InChI InChI=1S/C18H19N7/c1-12-13(9-19)3-4-16(23-12)24(2)14-6-8-25(10-14)18-15-5-7-20-17(15)21-11-22-18/h3-5,7,11,14H,6,8,10H2,1-2H3,(H,20,21,22)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228714
PNG
(US10369153, Compound 61 | US9346810, 61)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C17H20N6O2S/c1-22(15-4-3-13(9-19-15)26(2,24)25)12-6-8-23(10-12)17-14-5-7-18-16(14)20-11-21-17/h3-5,7,9,11-12H,6,8,10H2,1-2H3,(H,18,20,21)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228672
PNG
(US10369153, Compound 86 | US9346810, 86)
Show SMILES COc1cc2ncnc(N(C)[C@@H]3CCN(C3)c3ncnc4[nH]ccc34)c2cc1OC
Show InChI InChI=1S/C21H23N7O2/c1-27(20-15-8-17(29-2)18(30-3)9-16(15)23-11-25-20)13-5-7-28(10-13)21-14-4-6-22-19(14)24-12-26-21/h4,6,8-9,11-13H,5,7,10H2,1-3H3,(H,22,24,26)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM228728
PNG
(US10111875, Compound 142 | US10369153, Compound 14...)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(Br)cn1
Show InChI InChI=1S/C15H16BrN7/c1-22(15-18-6-10(16)7-19-15)11-3-5-23(8-11)14-12-2-4-17-13(12)20-9-21-14/h2,4,6-7,9,11H,3,5,8H2,1H3,(H,17,20,21)/t11-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...

US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%