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Patent code US9393245

Compile Data Set for Download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235381
PNG
(BDBM287835 | US9393245, 113)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)C(=O)OC(C)(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C27H27ClN4O5/c1-27(2,3)37-26(35)30-12-11-18(15-30)31-23-19-9-6-10-21(36-4)22(19)29-14-20(23)24(33)32(25(31)34)17-8-5-7-16(28)13-17/h5-10,13-14,18H,11-12,15H2,1-4H3/t18-/m1/s1
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n/an/a 0.300n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235368
PNG
(US10085990, Example 98 | US9393245, 98)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)C(=O)NC(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C27H28ClN5O4/c1-16(2)30-26(35)31-12-10-18(11-13-31)32-24-20-8-5-9-22(37-3)23(20)29-15-21(24)25(34)33(27(32)36)19-7-4-6-17(28)14-19/h4-9,14-16,18H,10-13H2,1-3H3,(H,30,35)
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235364
PNG
(US10085990, Example 94 | US9393245, 94)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)N(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H26ClN5O5S/c1-28(2)37(34,35)29-12-10-17(11-13-29)30-23-19-8-5-9-21(36-3)22(19)27-15-20(23)24(32)31(25(30)33)18-7-4-6-16(26)14-18/h4-9,14-15,17H,10-13H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235366
PNG
(US10085990, Example 96 | US9393245, 96)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)C2CCS(=O)(=O)C2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C27H27ClN4O7S2/c1-39-23-7-3-6-21-24(23)29-15-22-25(21)31(27(34)32(26(22)33)19-5-2-4-17(28)14-19)18-8-11-30(12-9-18)41(37,38)20-10-13-40(35,36)16-20/h2-7,14-15,18,20H,8-13,16H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235363
PNG
(US10085990, Example 93 | US9393245, 93)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)C(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C26H27ClN4O5S/c1-16(2)37(34,35)29-12-10-18(11-13-29)30-24-20-8-5-9-22(36-3)23(20)28-15-21(24)25(32)31(26(30)33)19-7-4-6-17(27)14-19/h4-9,14-16,18H,10-13H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235367
PNG
(US10085990, Example 97 | US9393245, 97)
Show SMILES CCNC(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C26H26ClN5O4/c1-3-28-25(34)30-12-10-17(11-13-30)31-23-19-8-5-9-21(36-2)22(19)29-15-20(23)24(33)32(26(31)35)18-7-4-6-16(27)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3,(H,28,34)
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235370
PNG
(US10085990, Example 100 | US9393245, 100)
Show SMILES COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2ccc(Cl)cc2)c1=O |(-5.33,-5,;-4,-4.23,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-4,.38,;-2.67,-.38,;-2.67,-1.93,;-1.33,-2.69,;,-1.93,;,-.38,;-1.33,.38,;-1.33,1.93,;-2.67,2.69,;-2.67,4.23,;-4,5,;-5.33,4.23,;-6.67,5,;-5.33,2.69,;-4,1.93,;,2.69,;,4.23,;1.33,1.93,;2.67,2.69,;4,1.93,;5.33,2.69,;5.33,4.23,;6.67,5,;4,5,;2.67,4.23,;1.33,.38,;2.67,-.38,)|
Show InChI InChI=1S/C25H24ClN3O3/c1-15-6-10-17(11-7-15)28-23-19-4-3-5-21(32-2)22(19)27-14-20(23)24(30)29(25(28)31)18-12-8-16(26)9-13-18/h3-5,8-9,12-15,17H,6-7,10-11H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235365
PNG
(US10085990, Example 95 | US9393245, 95)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)c2ccccc2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C29H25ClN4O5S/c1-39-25-12-6-11-23-26(25)31-18-24-27(23)33(29(36)34(28(24)35)21-8-5-7-19(30)17-21)20-13-15-32(16-14-20)40(37,38)22-9-3-2-4-10-22/h2-12,17-18,20H,13-16H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235359
PNG
(US10085990, Example 88 | US9393245, 88)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C28H29ClN4O5/c1-28(2,3)38-27(36)31-13-11-18(12-14-31)32-24-20-9-6-10-22(37-4)23(20)30-16-21(24)25(34)33(26(32)35)19-8-5-7-17(29)15-19/h5-10,15-16,18H,11-14H2,1-4H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235350
PNG
(US10085990, Example 78 | US9393245, 78)
Show SMILES COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2cccc(C)c2)c1=O |(-5.33,-5,;-4,-4.23,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-4,.38,;-2.67,-.38,;-2.67,-1.93,;-1.33,-2.69,;,-1.93,;,-.38,;-1.33,.38,;-1.33,1.93,;-2.67,2.69,;-2.67,4.23,;-4,5,;-5.33,4.23,;-6.67,5,;-5.33,2.69,;-4,1.93,;,2.69,;,4.23,;1.33,1.93,;2.67,2.69,;2.67,4.23,;4,5,;5.33,4.23,;5.33,2.69,;6.67,1.93,;4,1.93,;1.33,.38,;2.67,-.38,)|
Show InChI InChI=1S/C26H27N3O3/c1-16-10-12-18(13-11-16)28-24-20-8-5-9-22(32-3)23(20)27-15-21(24)25(30)29(26(28)31)19-7-4-6-17(2)14-19/h4-9,14-16,18H,10-13H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235375
PNG
(US10085990, Example 107 | US9393245, 107)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C29H30N4O7/c1-29(2,3)40-28(36)31-12-10-17(11-13-31)32-25-19-6-5-7-22(37-4)24(19)30-15-20(25)26(34)33(27(32)35)18-8-9-21-23(14-18)39-16-38-21/h5-9,14-15,17H,10-13,16H2,1-4H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235355
PNG
(US10085990, Example 83 | US9393245, 83)
Show SMILES CCCCn1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C23H23N3O3/c1-4-5-12-25-21-17-10-7-11-19(29-3)20(17)24-14-18(21)22(27)26(23(25)28)16-9-6-8-15(2)13-16/h6-11,13-14H,4-5,12H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135819
PNG
(US10085990, Example 103 | US10568888, Example 103 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4.67,-5.78,;-3.33,-5,;-3.33,-3.47,;-4.67,-2.69,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-3.33,4.23,;-4.67,3.47,;-4.67,1.93,;-3.33,1.15,;-6,4.23,;-7.34,3.47,;-6,5.78,;.67,1.93,;.67,3.47,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,4.23,;6,3.47,;6,1.93,;7.34,1.15,;4.67,1.15,;2,-.38,;3.33,-1.15,)|
Show InChI InChI=1S/C25H22ClN3O5/c1-34-20-7-3-6-18-21(20)27-13-19-22(18)28(16-10-8-14(9-11-16)24(31)32)25(33)29(23(19)30)17-5-2-4-15(26)12-17/h2-7,12-14,16H,8-11H2,1H3,(H,31,32)/t14-,16?
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US Patent
n/an/a 1n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235362
PNG
(US10085990, Example 91 | US9393245, 91)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)C(=O)c2ccccc2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C30H25ClN4O4/c1-39-25-12-6-11-23-26(25)32-18-24-27(23)34(30(38)35(29(24)37)22-10-5-9-20(31)17-22)21-13-15-33(16-14-21)28(36)19-7-3-2-4-8-19/h2-12,17-18,21H,13-16H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235390
PNG
(US10085990, Example 126 | US9393245, 126)
Show SMILES COc1cccc2c1ncc1c2n(CC2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(15-16-9-11-28(12-10-16)36(2,33)34)25(32)30(24(20)31)18-6-3-5-17(26)13-18/h3-8,13-14,16H,9-12,15H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235358
PNG
(US10085990, Example 87 | US9393245, 87)
Show SMILES COc1cccc2c1ncc1c2n(C2CCC(F)(F)CC2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H20ClF2N3O3/c1-33-19-7-3-6-17-20(19)28-13-18-21(17)29(15-8-10-24(26,27)11-9-15)23(32)30(22(18)31)16-5-2-4-14(25)12-16/h2-7,12-13,15H,8-11H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235383
PNG
(US10085990, Example 116 | US9393245, 116)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)C(=O)OC(C)(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C27H27ClN4O5/c1-27(2,3)37-26(35)30-12-11-18(15-30)31-23-19-9-6-10-21(36-4)22(19)29-14-20(23)24(33)32(25(31)34)17-8-5-7-16(28)13-17/h5-10,13-14,18H,11-12,15H2,1-4H3/t18-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235361
PNG
(US10085990, Example 90 | US9393245, 90)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)C(C)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H23ClN4O4/c1-15(31)28-11-9-17(10-12-28)29-23-19-7-4-8-21(34-2)22(19)27-14-20(23)24(32)30(25(29)33)18-6-3-5-16(26)13-18/h3-8,13-14,17H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135817
PNG
(US10085990, Example 84 | US10568888, Example 84 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H21N3O5/c1-30-19-8-4-7-16-21(19)25-12-17-22(16)26(14-5-2-3-6-14)24(29)27(23(17)28)15-9-10-18-20(11-15)32-13-31-18/h4,7-12,14H,2-3,5-6,13H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135818
PNG
(US10085990, Example 92 | US10568888, Example 92 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235374
PNG
(US10085990, Example 106 | US9393245, 106)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCCC2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H22ClN3O3/c1-31-20-12-6-11-18-21(20)26-14-19-22(18)27(16-8-3-2-4-9-16)24(30)28(23(19)29)17-10-5-7-15(25)13-17/h5-7,10-14,16H,2-4,8-9H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235344
PNG
(US10085990, Example 72 | US9393245, 72)
Show SMILES COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2cccc(Cl)c2)c1=O |(-5.33,-5,;-4,-4.23,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-4,.38,;-2.67,-.38,;-2.67,-1.93,;-1.33,-2.69,;,-1.93,;,-.38,;-1.33,.38,;-1.33,1.93,;-2.67,2.69,;-2.67,4.23,;-4,5,;-5.33,4.23,;-6.67,5,;-5.33,2.69,;-4,1.93,;,2.69,;,4.23,;1.33,1.93,;2.67,2.69,;2.67,4.23,;4,5,;5.33,4.23,;5.33,2.69,;6.67,1.93,;4,1.93,;1.33,.38,;2.67,-.38,)|
Show InChI InChI=1S/C25H24ClN3O3/c1-15-9-11-17(12-10-15)28-23-19-7-4-8-21(32-2)22(19)27-14-20(23)24(30)29(25(28)31)18-6-3-5-16(26)13-18/h3-8,13-15,17H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235360
PNG
(US10085990, Example 89 | US9393245, 89)
Show SMILES COc1cccc2c1ncc1c2n(C2CCNCC2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H21ClN4O3/c1-31-19-7-3-6-17-20(19)26-13-18-21(17)27(15-8-10-25-11-9-15)23(30)28(22(18)29)16-5-2-4-14(24)12-16/h2-7,12-13,15,25H,8-11H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135816
PNG
(US10085990, Example 54 | US10568888, Example 54 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-7-5-10-17(13-15)27-23(28)19-14-25-21-18(11-6-12-20(21)30-2)22(19)26(24(27)29)16-8-3-4-9-16/h5-7,10-14,16H,3-4,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235347
PNG
(US10085990, Example 75 | US9393245, 75)
Show SMILES CCc1cccc(c1)-n1c(=O)n(C2CCCC2)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C25H25N3O3/c1-3-16-8-6-11-18(14-16)28-24(29)20-15-26-22-19(12-7-13-21(22)31-2)23(20)27(25(28)30)17-9-4-5-10-17/h6-8,11-15,17H,3-5,9-10H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135824
PNG
(US10085990, Example 127 | US10568888, Example 127 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4,-5.01,;-2.67,-4.24,;-2.67,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-1.33,-.39,;-1.33,-1.93,;,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5.01,;-4,4.23,;-4,2.69,;-2.67,1.92,;-5.33,5,;-6.67,4.23,;-8,5,;-7.44,2.9,;-5.9,2.9,;1.33,2.69,;1.33,4.23,;2.67,1.92,;4,2.69,;4,4.23,;5.33,5,;6.67,4.23,;6.67,2.69,;8,1.92,;5.33,1.92,;2.67,.38,;4,-.39,)|
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(17-11-9-16(10-12-17)28-36(2,33)34)25(32)30(24(20)31)18-6-3-5-15(26)13-18/h3-8,13-14,16-17,28H,9-12H2,1-2H3/t16-,17?
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235377
PNG
(US10085990, Example 109 | US9393245, 109)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C25H24N4O7S/c1-34-20-5-3-4-17-22(20)26-13-18-23(17)28(15-8-10-27(11-9-15)37(2,32)33)25(31)29(24(18)30)16-6-7-19-21(12-16)36-14-35-19/h3-7,12-13,15H,8-11,14H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235345
PNG
(US10085990, Example 73 | US9393245, 73)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C23H20ClN3O3/c1-30-19-11-5-10-17-20(19)25-13-18-21(17)26(15-7-2-3-8-15)23(29)27(22(18)28)16-9-4-6-14(24)12-16/h4-6,9-13,15H,2-3,7-8H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135819
PNG
(US10085990, Example 103 | US10568888, Example 103 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4.67,-5.78,;-3.33,-5,;-3.33,-3.47,;-4.67,-2.69,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-3.33,4.23,;-4.67,3.47,;-4.67,1.93,;-3.33,1.15,;-6,4.23,;-7.34,3.47,;-6,5.78,;.67,1.93,;.67,3.47,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,4.23,;6,3.47,;6,1.93,;7.34,1.15,;4.67,1.15,;2,-.38,;3.33,-1.15,)|
Show InChI InChI=1S/C25H22ClN3O5/c1-34-20-7-3-6-18-21(20)27-13-19-22(18)28(16-10-8-14(9-11-16)24(31)32)25(33)29(23(19)30)17-5-2-4-15(26)12-17/h2-7,12-14,16H,8-11H2,1H3,(H,31,32)/t14-,16?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235369
PNG
(US10085990, Example 99 | US9393245, 99)
Show SMILES COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2ccccc2Cl)c1=O |(-4.67,-5,;-3.33,-4.23,;-3.33,-2.69,;-4.67,-1.93,;-4.67,-.38,;-3.33,.38,;-2,-.38,;-2,-1.93,;-.67,-2.69,;.67,-1.93,;.67,-.38,;-.67,.38,;-.67,1.93,;-2,2.69,;-2,4.23,;-3.33,5,;-4.67,4.23,;-6,5,;-4.67,2.69,;-3.33,1.93,;.67,2.69,;.67,4.23,;2,1.93,;3.33,2.69,;3.33,4.23,;4.67,5,;6,4.23,;6,2.69,;4.67,1.93,;4.67,.38,;2,.38,;3.33,-.38,)|
Show InChI InChI=1S/C25H24ClN3O3/c1-15-10-12-16(13-11-15)28-23-17-6-5-9-21(32-2)22(17)27-14-18(23)24(30)29(25(28)31)20-8-4-3-7-19(20)26/h3-9,14-16H,10-13H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135824
PNG
(US10085990, Example 127 | US10568888, Example 127 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4,-5.01,;-2.67,-4.24,;-2.67,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-1.33,-.39,;-1.33,-1.93,;,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5.01,;-4,4.23,;-4,2.69,;-2.67,1.92,;-5.33,5,;-6.67,4.23,;-8,5,;-7.44,2.9,;-5.9,2.9,;1.33,2.69,;1.33,4.23,;2.67,1.92,;4,2.69,;4,4.23,;5.33,5,;6.67,4.23,;6.67,2.69,;8,1.92,;5.33,1.92,;2.67,.38,;4,-.39,)|
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(17-11-9-16(10-12-17)28-36(2,33)34)25(32)30(24(20)31)18-6-3-5-15(26)13-18/h3-8,13-14,16-17,28H,9-12H2,1-2H3/t16-,17?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135822
PNG
(US10085990, Example 121 | US10568888, Example 121 ...)
Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135821
PNG
(US10085990, Example 118 | US10568888, Example 118 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135820
PNG
(US10085990, Example 115 | US10568888, Example 115 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m1/s1
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135815
PNG
(US10085990, Example 51 | US10568888, Example 51 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O
Show InChI InChI=1S/C22H21N3O3S/c1-13-10-18(29-12-13)25-21(26)16-11-23-19-15(8-5-9-17(19)28-2)20(16)24(22(25)27)14-6-3-4-7-14/h5,8-12,14H,3-4,6-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235382
PNG
(US10085990, Example 114 | US9393245, 114)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCNC2)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C22H19ClN4O3/c1-30-18-7-3-6-16-19(18)25-12-17-20(16)26(15-8-9-24-11-15)22(29)27(21(17)28)14-5-2-4-13(23)10-14/h2-7,10,12,15,24H,8-9,11H2,1H3/t15-/m1/s1
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135823
PNG
(US10085990, Example 122 | US10568888, Example 122 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135820
PNG
(US10085990, Example 115 | US10568888, Example 115 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m1/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135819
PNG
(US10085990, Example 103 | US10568888, Example 103 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4.67,-5.78,;-3.33,-5,;-3.33,-3.47,;-4.67,-2.69,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-3.33,4.23,;-4.67,3.47,;-4.67,1.93,;-3.33,1.15,;-6,4.23,;-7.34,3.47,;-6,5.78,;.67,1.93,;.67,3.47,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,4.23,;6,3.47,;6,1.93,;7.34,1.15,;4.67,1.15,;2,-.38,;3.33,-1.15,)|
Show InChI InChI=1S/C25H22ClN3O5/c1-34-20-7-3-6-18-21(20)27-13-19-22(18)28(16-10-8-14(9-11-16)24(31)32)25(33)29(23(19)30)17-5-2-4-15(26)12-17/h2-7,12-14,16H,8-11H2,1H3,(H,31,32)/t14-,16?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135822
PNG
(US10085990, Example 121 | US10568888, Example 121 ...)
Show SMILES CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O5S/c1-3-36(33,34)28-12-10-17(11-13-28)29-23-19-8-5-9-21(35-2)22(19)27-15-20(23)24(31)30(25(29)32)18-7-4-6-16(26)14-18/h4-9,14-15,17H,3,10-13H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135818
PNG
(US10085990, Example 92 | US10568888, Example 92 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135824
PNG
(US10085990, Example 127 | US10568888, Example 127 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)NS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4,-5.01,;-2.67,-4.24,;-2.67,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-1.33,-.39,;-1.33,-1.93,;,-2.7,;1.33,-1.93,;1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5.01,;-4,4.23,;-4,2.69,;-2.67,1.92,;-5.33,5,;-6.67,4.23,;-8,5,;-7.44,2.9,;-5.9,2.9,;1.33,2.69,;1.33,4.23,;2.67,1.92,;4,2.69,;4,4.23,;5.33,5,;6.67,4.23,;6.67,2.69,;8,1.92,;5.33,1.92,;2.67,.38,;4,-.39,)|
Show InChI InChI=1S/C25H25ClN4O5S/c1-35-21-8-4-7-19-22(21)27-14-20-23(19)29(17-11-9-16(10-12-17)28-36(2,33)34)25(32)30(24(20)31)18-6-3-5-15(26)13-18/h3-8,13-14,16-17,28H,9-12H2,1-2H3/t16-,17?
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235379
PNG
(US10085990, Example 111 | US9393245, 111)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(SC)c2)c1=O
Show InChI InChI=1S/C24H23N3O3S/c1-30-20-12-6-11-18-21(20)25-14-19-22(18)26(15-7-3-4-8-15)24(29)27(23(19)28)16-9-5-10-17(13-16)31-2/h5-6,9-15H,3-4,7-8H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135816
PNG
(US10085990, Example 54 | US10568888, Example 54 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-7-5-10-17(13-15)27-23(28)19-14-25-21-18(11-6-12-20(21)30-2)22(19)26(24(27)29)16-8-3-4-9-16/h5-7,10-14,16H,3-4,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135821
PNG
(US10085990, Example 118 | US10568888, Example 118 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135823
PNG
(US10085990, Example 122 | US10568888, Example 122 ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(=O)(=O)CS(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H25ClN4O7S2/c1-37-21-8-4-7-19-22(21)27-14-20-23(19)29(25(32)30(24(20)31)18-6-3-5-16(26)13-18)17-9-11-28(12-10-17)39(35,36)15-38(2,33)34/h3-8,13-14,17H,9-12,15H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235378
PNG
(US10085990, Example 110 | US9393245, 110)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(c2)C#N)c1=O
Show InChI InChI=1S/C24H20N4O3/c1-31-20-11-5-10-18-21(20)26-14-19-22(18)27(16-7-2-3-8-16)24(30)28(23(19)29)17-9-4-6-15(12-17)13-25/h4-6,9-12,14,16H,2-3,7-8H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135815
PNG
(US10085990, Example 51 | US10568888, Example 51 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O
Show InChI InChI=1S/C22H21N3O3S/c1-13-10-18(29-12-13)25-21(26)16-11-23-19-15(8-5-9-17(19)28-2)20(16)24(22(25)27)14-6-3-4-7-14/h5,8-12,14H,3-4,6-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135818
PNG
(US10085990, Example 92 | US10568888, Example 92 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCN(CC2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C24H23ClN4O5S/c1-34-20-8-4-7-18-21(20)26-14-19-22(18)28(16-9-11-27(12-10-16)35(2,32)33)24(31)29(23(19)30)17-6-3-5-15(25)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135820
PNG
(US10085990, Example 115 | US10568888, Example 115 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m1/s1
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n/an/a 163n/an/an/an/an/a30



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235327
PNG
(US10085990, Example 55 | US9393245, 55)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc(C)cc2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-10-12-17(13-11-15)27-23(28)19-14-25-21-18(8-5-9-20(21)30-2)22(19)26(24(27)29)16-6-3-4-7-16/h5,8-14,16H,3-4,6-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235278
PNG
(US10085990, Example 1 | US9393245, 1)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C19H21N3O3/c1-3-21-18(23)14-11-20-16-13(9-6-10-15(16)25-2)17(14)22(19(21)24)12-7-4-5-8-12/h6,9-12H,3-5,7-8H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235319
PNG
(US10085990, Example 45 | US9393245, 45)
Show SMILES CCn1c(=O)n(C2CCC(C)CC2)c2c3cccc(OC)c3ncc2c1=O |(5.33,1.93,;4,2.69,;2.67,1.92,;1.33,2.69,;1.33,4.23,;,1.92,;-1.33,2.69,;-1.33,4.23,;-2.67,5,;-4,4.23,;-5.33,5,;-4,2.69,;-2.67,1.93,;,.38,;-1.33,-.39,;-2.67,.38,;-4,-.39,;-4,-1.93,;-2.67,-2.7,;-2.67,-4.23,;-4,-5,;-1.33,-1.93,;,-2.7,;1.33,-1.93,;1.33,-.39,;2.67,.38,;4,-.39,)|
Show InChI InChI=1S/C21H25N3O3/c1-4-23-20(25)16-12-22-18-15(6-5-7-17(18)27-3)19(16)24(21(23)26)14-10-8-13(2)9-11-14/h5-7,12-14H,4,8-11H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135821
PNG
(US10085990, Example 118 | US10568888, Example 118 ...)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCN(C2)S(C)(=O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C23H21ClN4O5S/c1-33-19-8-4-7-17-20(19)25-12-18-21(17)27(16-9-10-26(13-16)34(2,31)32)23(30)28(22(18)29)15-6-3-5-14(24)11-15/h3-8,11-12,16H,9-10,13H2,1-2H3/t16-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235386
PNG
(US10085990, Example 120 | US9393245, 120)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCCOc3c2)c1=O
Show InChI InChI=1S/C25H23N3O5/c1-31-20-8-4-7-17-22(20)26-14-18-23(17)27(15-5-2-3-6-15)25(30)28(24(18)29)16-9-10-19-21(13-16)33-12-11-32-19/h4,7-10,13-15H,2-3,5-6,11-12H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235282
PNG
(US10085990, Example 5 | US9393245, 5)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(C(C)C)c1=O
Show InChI InChI=1S/C20H23N3O3/c1-12(2)22-19(24)15-11-21-17-14(9-6-10-16(17)26-3)18(15)23(20(22)25)13-7-4-5-8-13/h6,9-13H,4-5,7-8H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235380
PNG
(US10085990, Example 112 | US9393245, 112)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(c2)S(C)(=O)=O)c1=O
Show InChI InChI=1S/C24H23N3O5S/c1-32-20-12-6-11-18-21(20)25-14-19-22(18)26(15-7-3-4-8-15)24(29)27(23(19)28)16-9-5-10-17(13-16)33(2,30)31/h5-6,9-15H,3-4,7-8H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135816
PNG
(US10085990, Example 54 | US10568888, Example 54 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccc(C)c2)c1=O
Show InChI InChI=1S/C24H23N3O3/c1-15-7-5-10-17(13-15)27-23(28)19-14-25-21-18(11-6-12-20(21)30-2)22(19)26(24(27)29)16-8-3-4-9-16/h5-7,10-14,16H,3-4,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235294
PNG
(US10085990, Example 17 | US9393245, 17)
Show SMILES CCCCn1c2c3cccc(OC)c3ncc2c(=O)n(CC)c1=O
Show InChI InChI=1S/C18H21N3O3/c1-4-6-10-21-16-12-8-7-9-14(24-3)15(12)19-11-13(16)17(22)20(5-2)18(21)23/h7-9,11H,4-6,10H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235287
PNG
(US10085990, Example 10 | US9393245, 10)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cccs2)c1=O
Show InChI InChI=1S/C21H19N3O3S/c1-27-16-9-4-8-14-18(16)22-12-15-19(14)23(13-6-2-3-7-13)21(26)24(20(15)25)17-10-5-11-28-17/h4-5,8-13H,2-3,6-7H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235376
PNG
(US10085990, Example 108 | US9393245, 108)
Show SMILES COc1cccc2c1ncc1c2n(C2CCNCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H22N4O5/c1-31-19-4-2-3-16-21(19)26-12-17-22(16)27(14-7-9-25-10-8-14)24(30)28(23(17)29)15-5-6-18-20(11-15)33-13-32-18/h2-6,11-12,14,25H,7-10,13H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235312
PNG
(US10085990, Example 38 | US9393245, 38)
Show SMILES CCC(C)n1c(=O)n(C2CCCC2)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O3/c1-4-13(2)23-20(25)16-12-22-18-15(10-7-11-17(18)27-3)19(16)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235315
PNG
(US10085990, Example 41 | US9393245, 41)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C)c3ncc2c1=O
Show InChI InChI=1S/C19H21N3O2/c1-3-21-18(23)15-11-20-16-12(2)7-6-10-14(16)17(15)22(19(21)24)13-8-4-5-9-13/h6-7,10-11,13H,3-5,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135817
PNG
(US10085990, Example 84 | US10568888, Example 84 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H21N3O5/c1-30-19-8-4-7-16-21(19)25-12-17-22(16)26(14-5-2-3-6-14)24(29)27(23(17)28)15-9-10-18-20(11-15)32-13-31-18/h4,7-12,14H,2-3,5-6,13H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135815
PNG
(US10085990, Example 51 | US10568888, Example 51 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O
Show InChI InChI=1S/C22H21N3O3S/c1-13-10-18(29-12-13)25-21(26)16-11-23-19-15(8-5-9-17(19)28-2)20(16)24(22(25)27)14-6-3-4-7-14/h5,8-12,14H,3-4,6-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235293
PNG
(US10085990, Example 16 | US9393245, 16)
Show SMILES CCCn1c2c3cccc(OC)c3ncc2c(=O)n(CC)c1=O
Show InChI InChI=1S/C17H19N3O3/c1-4-9-20-15-11-7-6-8-13(23-3)14(11)18-10-12(15)16(21)19(5-2)17(20)22/h6-8,10H,4-5,9H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135817
PNG
(US10085990, Example 84 | US10568888, Example 84 | ...)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccc3OCOc3c2)c1=O
Show InChI InChI=1S/C24H21N3O5/c1-30-19-8-4-7-16-21(19)25-12-17-22(16)26(14-5-2-3-6-14)24(29)27(23(17)28)15-9-10-18-20(11-15)32-13-31-18/h4,7-12,14H,2-3,5-6,13H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235321
PNG
(US10085990, Example 47 | US9393245, 47)
Show SMILES CCn1c(=O)n(CCCF)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C17H18FN3O3/c1-3-20-16(22)12-10-19-14-11(6-4-7-13(14)24-2)15(12)21(17(20)23)9-5-8-18/h4,6-7,10H,3,5,8-9H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235306
PNG
(US10085990, Example 29 | US9393245, 29)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cc(F)cc(OC)c3ncc2c1=O
Show InChI InChI=1S/C19H20FN3O3/c1-3-22-18(24)14-10-21-16-13(8-11(20)9-15(16)26-2)17(14)23(19(22)25)12-6-4-5-7-12/h8-10,12H,3-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235320
PNG
(US10085990, Example 46 | US9393245, 46)
Show SMILES CCOC(=O)Cn1c(=O)n(C2CCCC2)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C21H23N3O5/c1-3-29-17(25)12-23-20(26)15-11-22-18-14(9-6-10-16(18)28-2)19(15)24(21(23)27)13-7-4-5-8-13/h6,9-11,13H,3-5,7-8,12H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235384
PNG
(US10085990, Example 117 | US9393245, 117)
Show SMILES COc1cccc2c1ncc1c2n([C@H]2CCNC2)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Show InChI InChI=1S/C22H19ClN4O3/c1-30-18-7-3-6-16-19(18)25-12-17-20(16)26(15-8-9-24-11-15)22(29)27(21(17)28)14-5-2-4-13(23)10-14/h2-7,10,12,15,24H,8-9,11H2,1H3/t15-/m0/s1
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235295
PNG
(US10085990, Example 18 | US9393245, 18)
Show SMILES CCn1c(=O)n(CC(C)C)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C18H21N3O3/c1-5-20-17(22)13-9-19-15-12(7-6-8-14(15)24-4)16(13)21(18(20)23)10-11(2)3/h6-9,11H,5,10H2,1-4H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235313
PNG
(US10085990, Example 39 | US9393245, 39)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C23H21N3O3/c1-29-19-13-7-12-17-20(19)24-14-18-21(17)25(15-10-5-6-11-15)23(28)26(22(18)27)16-8-3-2-4-9-16/h2-4,7-9,12-15H,5-6,10-11H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235322
PNG
(US10085990, Example 48 | US9393245, 48)
Show SMILES COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(C)c1=O
Show InChI InChI=1S/C18H19N3O3/c1-20-17(22)13-10-19-15-12(8-5-9-14(15)24-2)16(13)21(18(20)23)11-6-3-4-7-11/h5,8-11H,3-4,6-7H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135812
PNG
(US10085990, Example 30 | US10568888, Example 30 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135813
PNG
(US10085990, Example 32 | US10568888, Example 32 | ...)
Show SMILES CCCc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(CC)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-3-8-14-9-7-12-16-18(14)22-13-17-19(16)24(15-10-5-6-11-15)21(26)23(4-2)20(17)25/h7,9,12-13,15H,3-6,8,10-11H2,1-2H3
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n/an/a 2.60E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235305
PNG
(US10085990, Example 28 | US9393245, 28)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cc(Cl)cc(OC)c3ncc2c1=O
Show InChI InChI=1S/C19H20ClN3O3/c1-3-22-18(24)14-10-21-16-13(8-11(20)9-15(16)26-2)17(14)23(19(22)25)12-6-4-5-7-12/h8-10,12H,3-7H2,1-2H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235308
PNG
(US10085990, Example 34 | US9393245, 34)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(OC(F)(F)F)c3ncc2c1=O
Show InChI InChI=1S/C19H18F3N3O3/c1-2-24-17(26)13-10-23-15-12(8-5-9-14(15)28-19(20,21)22)16(13)25(18(24)27)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135814
PNG
(US10085990, Example 33 | US10568888, Example 33 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-23-20(25)17-12-22-18-15(13(2)3)10-7-11-16(18)19(17)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235281
PNG
(US10085990, Example 4 | US9393245, 4)
Show SMILES CCn1c(=O)n(-c2ccc(OC)c(OC)c2)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C22H21N3O5/c1-5-24-21(26)15-12-23-19-14(7-6-8-17(19)29-3)20(15)25(22(24)27)13-9-10-16(28-2)18(11-13)30-4/h6-12H,5H2,1-4H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135812
PNG
(US10085990, Example 30 | US10568888, Example 30 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/a30



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235311
PNG
(US10085990, Example 37 | US9393245, 37)
Show SMILES CCn1c(=O)n(C(C)C)c2c3cccc(OC)c3ncc2c1=O
Show InChI InChI=1S/C17H19N3O3/c1-5-19-16(21)12-9-18-14-11(7-6-8-13(14)23-4)15(12)20(10(2)3)17(19)22/h6-10H,5H2,1-4H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM135814
PNG
(US10085990, Example 33 | US10568888, Example 33 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-23-20(25)17-12-22-18-15(13(2)3)10-7-11-16(18)19(17)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135814
PNG
(US10085990, Example 33 | US10568888, Example 33 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(C(C)C)c3ncc2c1=O
Show InChI InChI=1S/C21H25N3O2/c1-4-23-20(25)17-12-22-18-15(13(2)3)10-7-11-16(18)19(17)24(21(23)26)14-8-5-6-9-14/h7,10-14H,4-6,8-9H2,1-3H3
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n/an/a 2.50E+4n/an/an/an/an/a30



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)


(Homo sapiens (Human))		BDBM135813
PNG
(US10085990, Example 32 | US10568888, Example 32 | ...)
Show SMILES CCCc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(CC)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-3-8-14-9-7-12-16-18(14)22-13-17-19(16)24(15-10-5-6-11-15)21(26)23(4-2)20(17)25/h7,9,12-13,15H,3-6,8,10-11H2,1-2H3
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n/an/a 2.50E+4n/an/an/an/an/a30



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135812
PNG
(US10085990, Example 30 | US10568888, Example 30 | ...)
Show SMILES CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O
Show InChI InChI=1S/C18H18ClN3O2/c1-2-21-17(23)13-10-20-15-12(8-5-9-14(15)19)16(13)22(18(21)24)11-6-3-4-7-11/h5,8-11H,2-4,6-7H2,1H3
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vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)


(Homo sapiens (Human))		BDBM135813
PNG
(US10085990, Example 32 | US10568888, Example 32 | ...)
Show SMILES CCCc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(CC)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-3-8-14-9-7-12-16-18(14)22-13-17-19(16)24(15-10-5-6-11-15)21(26)23(4-2)20(17)25/h7,9,12-13,15H,3-6,8,10-11H2,1-2H3
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n/an/a 2.50E+4n/an/an/an/an/a30



vTv Therapeutics LLC

US Patent


Assay Description
The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM235388
PNG
(US10085990, Example 124 | US9393245, 124)
Show SMILES COC(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O
Show InChI InChI=1S/C25H23ClN4O5/c1-34-20-8-4-7-18-21(20)27-14-19-22(18)29(16-9-11-28(12-10-16)25(33)35-2)24(32)30(23(19)31)17-6-3-5-15(26)13-17/h3-8,13-14,16H,9-12H2,1-2H3
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n/an/a 5.00E+4n/an/an/an/an/a25



vTv Therapeutics LLC

US Patent


Assay Description
Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...

US Patent US9393245 (2016)


BindingDB Entry DOI: 10.7270/Q2JH3K2T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%