Affinity Data by Patent

Patent code US9394307

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM237158 (US9394307, 4-chloro-N-(2-{5-methoxy-1H,3aH,7aH-pyr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM237157 (US9394307, 4-chloro-N-(5-methyl-2-{1H-pyrazolo[3,4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM237159 (US9394307, N-(2-{1H,3aH,7aH-pyrrolo[2,3-b]pyridine...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM237160 (US9394307, 4-chloro-N-(5-chloro-2-{7H-pyrrolo[2,3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50398343 (CHEMBL2178573 \| US9394307, 4-chloro-N-(5-methyl-2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50398343 (CHEMBL2178573 \| US9394307, 4-chloro-N-(5-methyl-2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	37
ChemoCentryx, Inc. US Patent					Assay Description The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...				US Patent US9394307 (2016) BindingDB Entry DOI: 10.7270/Q2NZ86JV
ChemoCentryx, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%