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Patent code US9422263

Compile Data Set for Download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F |c:19,t:15|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:22,t:15|
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US Patent
n/an/a 2n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM62337
PNG
(Synthetic Example 4 (WO2008/071451))
Show SMILES CC1=C(C#N)C(C(C#N)=C(C)N1)c1cccc2[nH]ncc12 |c:1,t:8|
Show InChI InChI=1S/C16H13N5/c1-9-12(6-17)16(13(7-18)10(2)20-9)11-4-3-5-15-14(11)8-19-21-15/h3-5,8,16,20H,1-2H3,(H,19,21)
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US Patent
n/an/a 2n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:22,t:15|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 2n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM240737
PNG
(US9422263, 14)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(NC(C(F)F)=C1C#N)C(F)F |c:16,22|
Show InChI InChI=1S/C17H10F5N5/c1-6-7-2-8(11(18)3-12(7)27-26-6)13-9(4-23)14(16(19)20)25-15(17(21)22)10(13)5-24/h2-3,13,16-17,25H,1H3,(H,26,27)
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US Patent
n/an/a 3n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor [960-1390]


(Homo sapiens (Human))		BDBM240741
PNG
(US9422263, 30)
Show SMILES CCC(F)(F)C1=C(C#N)C(C(C#N)=C(C)N1)c1ccc2[nH]nc(C)c2c1 |c:5,t:12|
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3n/an/an/an/a7.522



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:22,t:15|
PDB
MMDB

KEGG

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US Patent
n/an/a 6n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:22,t:15|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 6n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM62337
PNG
(Synthetic Example 4 (WO2008/071451))
Show SMILES CC1=C(C#N)C(C(C#N)=C(C)N1)c1cccc2[nH]ncc12 |c:1,t:8|
Show InChI InChI=1S/C16H13N5/c1-9-12(6-17)16(13(7-18)10(2)20-9)11-4-3-5-15-14(11)8-19-21-15/h3-5,8,16,20H,1-2H3,(H,19,21)
PDB
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KEGG

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US Patent
n/an/a 8n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240742
PNG
(US9422263, 43 | US9422263, 44)
Show SMILES CN1C(C)=C(C#N)C(C(C#N)=C1C(F)(F)F)c1ccc2[nH]nc(C)c2c1 |c:10,t:3|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 8n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240742
PNG
(US9422263, 43 | US9422263, 44)
Show SMILES CN1C(C)=C(C#N)C(C(C#N)=C1C(F)(F)F)c1ccc2[nH]nc(C)c2c1 |c:10,t:3|
PDB
MMDB

KEGG

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UniChem
US Patent
n/an/a 9n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240736
PNG
(US9422263, 8)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:23,t:16|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 9n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240738
PNG
(US9422263, 17)
Show SMILES CC1=C(C#N)C(C(C#N)=C(N1)C(F)F)c1cc2cn[nH]c2cc1F |c:1,8|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 11n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F |c:19,t:15|
PDB
MMDB

KEGG

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US Patent
n/an/a 12n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F |c:19,t:15|
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 12n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240741
PNG
(US9422263, 30)
Show SMILES CCC(F)(F)C1=C(C#N)C(C(C#N)=C(C)N1)c1ccc2[nH]nc(C)c2c1 |c:5,t:12|
PDB
MMDB

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US Patent
n/an/a 21n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240737
PNG
(US9422263, 14)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(NC(C(F)F)=C1C#N)C(F)F |c:16,22|
Show InChI InChI=1S/C17H10F5N5/c1-6-7-2-8(11(18)3-12(7)27-26-6)13-9(4-23)14(16(19)20)25-15(17(21)22)10(13)5-24/h2-3,13,16-17,25H,1H3,(H,26,27)
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n/an/a 26n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240739
PNG
(US9422263, 20)
Show SMILES CC1=C(C#N)C(C(C#N)=C(N1)C(F)(F)F)c1ccc2[nH]ncc2c1 |c:1,8|
PDB
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US Patent
n/an/a 27n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM240740
PNG
(US9422263, 24)
Show SMILES FC(F)C1=C(C#N)C(C(C#N)=C(N1)C(F)F)c1ccc2[nH]ncc2c1 |c:3,10|
Show InChI InChI=1S/C16H9F4N5/c17-15(18)13-9(4-21)12(10(5-22)14(24-13)16(19)20)7-1-2-11-8(3-7)6-23-25-11/h1-3,6,12,15-16,24H,(H,23,25)
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n/an/a 28n/an/an/an/a7.032



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...

US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%