Affinity Data by Patent

Patent code US9428476

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM244046 (US9428476, 1b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-52.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244045 (US9428476, 1a) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-52.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244051 (US9428476, 4b) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-52.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244046 (US9428476, 1b) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-52.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244051 (US9428476, 4b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2	-50.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244050 (US9428476, 4a) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2	-50.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244052 (US9428476, 5) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	-49.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244048 (US9428476, 2b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	-49.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244053 (US9428476, 6) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	-49.5	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244045 (US9428476, 1a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	-48.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244052 (US9428476, 5) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	-47.0	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244050 (US9428476, 4a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10	-46.4	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244053 (US9428476, 6) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10	-46.4	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244047 (US9428476, 2a) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	-46.0	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244047 (US9428476, 2a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	-44.8	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 2 (Homo sapiens (Human))	BDBM244049 (US9428476, 3a) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23	-44.3	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description BACE-mediated hydrolysis of this peptide results in an increase in relative fluorescence (RFU) at 620 nm after excitation with 320 nm light Inhibitor...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM244049 (US9428476, 3a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	189	-39.0	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7...				US Patent US9428476 (2016) BindingDB Entry DOI: 10.7270/Q2WQ02Q5
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%