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Patent code US9434697

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a<0.200n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249443
PNG
(US10537571, Compound 164 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249404
PNG
(US10537571, Compound 121 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249405
PNG
(US10537571, Compound 122 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249408
PNG
(US10537571, Compound 125 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249425
PNG
(US10537571, Compound 144 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249433
PNG
(US10537571, Compound 154 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249437
PNG
(US10537571, Compound 158 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249440
PNG
(US10537571, Compound 161 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249398
PNG
(US10537571, Compound 111 | US10912774, Compound 11...)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249400
PNG
(US10537571, Compound 113 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249436
PNG
(US10537571, Compound 157 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249439
PNG
(US10537571, Compound 160 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249409
PNG
(US10537571, Compound 126 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249426
PNG
(US10537571, Compound 145 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249428
PNG
(US10537571, Compound 148 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249430
PNG
(US10537571, Compound 150 | US10912774, Compound 15...)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249434
PNG
(US10537571, Compound 155 | US10912774, Compound 15...)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249435
PNG
(US10537571, Compound 156 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249441
PNG
(US10537571, Compound 162 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249401
PNG
(US10537571, Compound 114 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249407
PNG
(US10537571, Compound 124 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl |r|
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249417
PNG
(US10537571, Compound 135 | US10912774, Compound 13...)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249423
PNG
(US10537571, Compound 142 | US10912774, Compound 14...)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249444
PNG
(US10537571, Compound 165 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249452
PNG
(US10537571, Compound 181 | US10912774, Compound 18...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249395
PNG
(US10537571, Compound 107 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249399
PNG
(US10537571, Compound 112 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249406
PNG
(US10537571, Compound 123 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249427
PNG
(US10537571, Compound 147 | US10912774, Compound 14...)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249429
PNG
(US10537571, Compound 149 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249446
PNG
(US10537571, Compound 167 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249415
PNG
(US10537571, Compound 132 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249421
PNG
(US10537571, Compound 140 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249442
PNG
(US10537571, Compound 163 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249445
PNG
(US10537571, Compound 166 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249410
PNG
(US10537571, Compound 127 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249419
PNG
(US10537571, Compound 137 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a<1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249431
PNG
(US10537571, Compound 151 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249447
PNG
(US10537571, Compound 168 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50355393
PNG
(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249403
PNG
(US10537571, Compound 120 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249414
PNG
(US10537571, Compound 131 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249418
PNG
(US10537571, Compound 136 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249438
PNG
(US10537571, Compound 159 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249413
PNG
(US10537571, Compound 130 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249422
PNG
(US10537571, Compound 141 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249448
PNG
(US10537571, Compound 170 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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n/an/a 3n/an/an/an/a7.525



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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249416
PNG
(US10537571, Compound 133 | US10912774, Compound 13...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249402
PNG
(US10537571, Compound 116 | US10912774, Compound 11...)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a 4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249420
PNG
(US10537571, Compound 139 | US10912774, Compound 13...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
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n/an/a 6n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249448
PNG
(US10537571, Compound 170 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249424
PNG
(US10537571, Compound 143 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249450
PNG
(US10537571, Compound 172 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50355393
PNG
(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 13n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249455
PNG
(US10537571, Compound 185 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249432
PNG
(US10537571, Compound 152 | US10912774, Compound 15...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249451
PNG
(US10537571, Compound 175 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249397
PNG
(US10537571, Compound 110 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249411
PNG
(US10537571, Compound 128 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249401
PNG
(US10537571, Compound 114 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249412
PNG
(US10537571, Compound 129 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249454
PNG
(US10537571, Compound 184 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249425
PNG
(US10537571, Compound 144 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249418
PNG
(US10537571, Compound 136 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249438
PNG
(US10537571, Compound 159 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249436
PNG
(US10537571, Compound 157 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249424
PNG
(US10537571, Compound 143 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 155n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249407
PNG
(US10537571, Compound 124 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl |r|
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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n/an/a 164n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 173n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 173n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249453
PNG
(US10537571, Compound 183 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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n/an/a 180n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249431
PNG
(US10537571, Compound 151 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 197n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249394
PNG
(US10537571, Compound 105 | US10912774, Compound 10...)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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n/an/a 201n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249452
PNG
(US10537571, Compound 181 | US10912774, Compound 18...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
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n/an/a 224n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249432
PNG
(US10537571, Compound 152 | US10912774, Compound 15...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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n/an/a 297n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249405
PNG
(US10537571, Compound 122 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a 324n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249456
PNG
(US10537571, Compound 186 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 345n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249415
PNG
(US10537571, Compound 132 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a 495n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 513n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249442
PNG
(US10537571, Compound 163 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 519n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249409
PNG
(US10537571, Compound 126 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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n/an/a 601n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249400
PNG
(US10537571, Compound 113 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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n/an/a 621n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249439
PNG
(US10537571, Compound 160 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a 660n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249393
PNG
(US10537571, Compound 103 | US10912774, Compound 10...)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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n/an/a 673n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249395
PNG
(US10537571, Compound 107 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a 720n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249433
PNG
(US10537571, Compound 154 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
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n/an/a 777n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249392
PNG
(US10537571, Compound 102 | US10912774, Compound 10...)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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n/an/a 853n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249404
PNG
(US10537571, Compound 121 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 1.02E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249447
PNG
(US10537571, Compound 168 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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n/an/a 1.03E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249414
PNG
(US10537571, Compound 131 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a 1.17E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249403
PNG
(US10537571, Compound 120 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 1.19E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249398
PNG
(US10537571, Compound 111 | US10912774, Compound 11...)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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n/an/a 1.28E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249411
PNG
(US10537571, Compound 128 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 1.68E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249435
PNG
(US10537571, Compound 156 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 1.95E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a 1.98E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 1.98E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249417
PNG
(US10537571, Compound 135 | US10912774, Compound 13...)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 2.03E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249437
PNG
(US10537571, Compound 158 | US10912774, Compound 15...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
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n/an/a 2.15E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249426
PNG
(US10537571, Compound 145 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
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n/an/a 2.19E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249430
PNG
(US10537571, Compound 150 | US10912774, Compound 15...)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
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n/an/a 2.29E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249399
PNG
(US10537571, Compound 112 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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n/an/a 2.60E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249440
PNG
(US10537571, Compound 161 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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n/an/a 2.69E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249408
PNG
(US10537571, Compound 125 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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n/an/a 2.86E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249410
PNG
(US10537571, Compound 127 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 3.20E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249443
PNG
(US10537571, Compound 164 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 3.51E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249406
PNG
(US10537571, Compound 123 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 3.89E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249448
PNG
(US10537571, Compound 170 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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n/an/a 3.92E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 4.18E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249445
PNG
(US10537571, Compound 166 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a 4.92E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249427
PNG
(US10537571, Compound 147 | US10912774, Compound 14...)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a 5.94E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249453
PNG
(US10537571, Compound 183 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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n/an/a 6.21E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249428
PNG
(US10537571, Compound 148 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
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n/an/a 6.44E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249454
PNG
(US10537571, Compound 184 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 6.48E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249444
PNG
(US10537571, Compound 165 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a 7.37E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249450
PNG
(US10537571, Compound 172 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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n/an/a 7.37E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249429
PNG
(US10537571, Compound 149 | US10912774, Compound 14...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
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n/an/a 7.70E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249434
PNG
(US10537571, Compound 155 | US10912774, Compound 15...)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a 8.03E+3n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249419
PNG
(US10537571, Compound 137 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249393
PNG
(US10537571, Compound 103 | US10912774, Compound 10...)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249446
PNG
(US10537571, Compound 167 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249392
PNG
(US10537571, Compound 102 | US10912774, Compound 10...)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249441
PNG
(US10537571, Compound 162 | US10912774, Compound 16...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249412
PNG
(US10537571, Compound 129 | US10912774, Compound 12...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249413
PNG
(US10537571, Compound 130 | US10912774, Compound 13...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249456
PNG
(US10537571, Compound 186 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249451
PNG
(US10537571, Compound 175 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249416
PNG
(US10537571, Compound 133 | US10912774, Compound 13...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249423
PNG
(US10537571, Compound 142 | US10912774, Compound 14...)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249448
PNG
(US10537571, Compound 170 | US10912774, Compound 17...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249394
PNG
(US10537571, Compound 105 | US10912774, Compound 10...)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249455
PNG
(US10537571, Compound 185 | US10912774, Compound 18...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a>1.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249391
PNG
(US10537571, Compound 100 | US10912774, Compound 10...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a>1.01E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249402
PNG
(US10537571, Compound 116 | US10912774, Compound 11...)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a>2.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249422
PNG
(US10537571, Compound 141 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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n/an/a>2.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249420
PNG
(US10537571, Compound 139 | US10912774, Compound 13...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
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n/an/a>2.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249421
PNG
(US10537571, Compound 140 | US10912774, Compound 14...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
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n/an/a>2.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249397
PNG
(US10537571, Compound 110 | US10912774, Compound 11...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%