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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247276 (US9447085, 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | 1 | -52.2 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247292 (US9447085, 8) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -50.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247278 (US9447085, 3) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -50.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247281 (US9447085, 4b) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -50.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247282 (US9447085, 4c) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | -49.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247289 (US9447085, 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | -49.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247282 (US9447085, 4c) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4 | -48.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247287 (US9447085, 10) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6 | -47.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247279 (US9447085, 4) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7 | -47.3 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247280 (US9447085, 4a) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7 | -47.3 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247277 (US9447085, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8 | -47.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247291 (US9447085, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8 | -47.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247292 (US9447085, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9 | -46.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247276 (US9447085, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.10 | -46.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247286 (US9447085, 9) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 15 | -45.4 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247289 (US9447085, 12) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 17 | -45.1 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247291 (US9447085, 14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | -44.9 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247280 (US9447085, 4a) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | -44.9 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247290 (US9447085, 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 21 | -44.6 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247281 (US9447085, 4b) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 25 | -44.1 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247288 (US9447085, 11) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 28 | -43.8 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247290 (US9447085, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 30 | -43.7 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247286 (US9447085, 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 57 | -42.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247277 (US9447085, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 57 | -42.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247284 (US9447085, 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 58 | -42.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247279 (US9447085, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 83 | -41.1 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247288 (US9447085, 11) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 95 | -40.8 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247285 (US9447085, 7) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 148 | -39.6 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247278 (US9447085, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 152 | -39.6 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247287 (US9447085, 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 188 | -39.0 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247284 (US9447085, 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 340 | -37.5 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 1 (Homo sapiens (Human)) | BDBM247285 (US9447085, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 371 | -37.3 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description This assay monitors the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY7... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Beta-secretase 2 (Homo sapiens (Human)) | BDBM247283 (US9447085, 5) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.45E+3 | -33.9 | n/a | n/a | n/a | n/a | n/a | 5.0 | 30 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0.... | US Patent US9447085 (2016) BindingDB Entry DOI: 10.7270/Q2348J9M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
