Affinity Data by Patent

Patent code US9452985

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247405 (US9452985, THK-5125) Show SMILES CCNc1ccc(cc1)-c1ccc2cc(OCC(O)CF)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.20	-45.9	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247403 (US9452985, THK-5117) Show SMILES CNc1ccc(cc1)-c1ccc2cc(OCC(O)CF)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	10.5	-45.5	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247407 (US9452985, THK-5129) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21.4	-43.8	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247404 (US9452985, THK-5122) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	34.9	-42.6	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247402 (US9452985, THK-5116) Show SMILES Nc1ccc(cc1)-c1ccc2cc(OCC(O)CF)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	36	-42.5	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247406 (US9452985, THK-5151) Show SMILES CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	40.1	-42.2	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM247408 (US9452985, THK-523 (reference for comparison)) Show SMILES Nc1ccc(cc1)-c1ccc2cc(OCCF)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	59.3	-41.2	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair
Microtubule-associated protein tau (Homo sapiens (Human))	BDBM50185987 (2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	US Patent	256	-37.6	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
GE Healthcare Limited US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%