Found 101 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250432
(US9464044, 22)Show SMILES CN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F |r,wU:9.9,TLB:8:9:13:16.17.15,18:16:13:9.10.11,19:16:9:13.12.11,THB:18:10:13:16.17.15,17:16:9:13.12.11,17:12:9:16.18.15,(-3.29,2.5,;-3.29,.96,;-1.95,.19,;-.62,.96,;.15,2.3,;-1.39,2.3,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;-7.29,-1.35,)| Show InChI InChI=1S/C23H30FN3O4S/c1-27(32(30,31)18-5-3-2-4-17(18)24)13-22(6-7-22)21(29)26-19-15-8-14-9-16(19)12-23(10-14,11-15)20(25)28/h2-5,14-16,19H,6-13H2,1H3,(H2,25,28)(H,26,29)/t14?,15?,16?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250460
(US9464044, 62)Show SMILES CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1 |r,wU:8.8,TLB:18:15:8:12.11.10,7:8:12:15.16.14,17:15:12:8.9.10,THB:16:15:8:12.11.10,16:11:8:15.17.14,17:9:12:15.16.14,(-1.95,-1.73,;-1.95,-.19,;-.62,.58,;.15,1.91,;-1.39,1.91,;.72,-.19,;.72,-1.73,;2.05,.58,;3.38,-.19,;4.72,.58,;3.96,-.59,;3.94,-2.99,;2.55,-3.63,;3.38,-1.73,;4.72,-2.5,;6.04,-1.73,;5.15,-3.66,;6.04,-.19,;7.53,-2.13,;8.62,-1.04,;7.93,-3.62,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-7.29,1.35,;-8.62,.58,;-5.95,.58,)| Show InChI InChI=1S/C22H28ClN3O4S/c1-26(31(29,30)17-4-2-3-16(23)9-17)22(5-6-22)20(28)25-18-14-7-13-8-15(18)12-21(10-13,11-14)19(24)27/h2-4,9,13-15,18H,5-8,10-12H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250418
(US9464044, 8)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:30:3.4.31,8:3:30:9.7.6,1:3:9:30.5.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-7.95,.96,;-9.29,.19,;-6.62,.19,;-6.62,-1.35,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H27ClFN3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112152
(CHEMBL3608401 | US9464044, 84)Show SMILES CC(C)(NS(=O)(=O)c1c(F)cccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:18.18,TLB:22:23:27:26.20.21,22:21:27:18.23.24,18:19:26:23.22.24,THB:17:18:27:26.20.21,18:23:26:27.20.19,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-11.31,-2.31,;-11.14,-3.53,;-12.74,-1.74,;-12.96,-.21,;-11.75,.74,;-10.32,.17,;-9.35,.93,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| Show InChI InChI=1S/C21H27F2N3O4S/c1-20(2,26-31(29,30)17-14(22)4-3-5-15(17)23)19(28)25-16-12-6-11-7-13(16)10-21(8-11,9-12)18(24)27/h3-5,11-13,16,26H,6-10H2,1-2H3,(H2,24,27)(H,25,28)/t11?,12?,13?,16-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250453
(US9464044, 50)Show SMILES Cn1ccc2cccc(c12)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:20.22,TLB:29:27:24:20.21.22,30:27:20:24.23.22,19:20:24:27.28.26,THB:29:21:24:27.28.26,28:27:20:24.23.22,28:23:20:27.29.26,(-5.28,-2.02,;-6.37,-.93,;-7.9,-1.09,;-8.53,.32,;-7.38,1.35,;-7.38,2.89,;-6.05,3.66,;-4.71,2.89,;-4.71,1.35,;-6.05,.58,;-3.38,.58,;-2.61,1.91,;-4.15,-.76,;-2.05,-.19,;-.71,.58,;.06,1.91,;-1.48,1.91,;.62,-.19,;.62,-1.73,;1.95,.58,;3.29,-.19,;4.62,.58,;3.87,-.59,;3.85,-2.99,;2.45,-3.63,;3.29,-1.73,;4.62,-2.5,;5.95,-1.73,;5.05,-3.66,;5.95,-.19,;7.44,-2.13,;8.53,-1.04,;7.84,-3.62,)| Show InChI InChI=1S/C24H30N4O4S/c1-28-8-5-15-3-2-4-18(20(15)28)33(31,32)27-24(6-7-24)22(30)26-19-16-9-14-10-17(19)13-23(11-14,12-16)21(25)29/h2-5,8,14,16-17,19,27H,6-7,9-13H2,1H3,(H2,25,29)(H,26,30)/t14?,16?,17?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112133
(CHEMBL3609861 | US9464044, 71)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:17.17,TLB:16:17:21:23.25.24,26:24:21:19.18.17,THB:27:24:21:19.18.17,27:24:21.20.19:17,25:20:17:23.24.26,25:24:21.20.19:17,26:18:21:23.25.24,(-5.85,-2.77,;-6.03,-1.55,;-7,-2.31,;-7.46,-.97,;-8.67,-1.93,;-8.49,-3.15,;-7.53,-2.38,;-10.1,-1.35,;-11.31,-2.31,;-12.74,-1.74,;-12.96,-.21,;-11.75,.74,;-10.32,.17,;-9.35,.93,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.17,;3.58,2.29,;3.79,.17,)| Show InChI InChI=1S/C21H28FN3O4S/c1-20(2,25-30(28,29)16-6-4-3-5-15(16)22)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)26/h3-6,12-14,17,25H,7-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112143
(CHEMBL3609871 | US9464044, 73)Show SMILES CC(C)(NS(=O)(=O)c1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:17.17,TLB:21:22:26:25.19.20,21:20:26:17.22.23,17:18:25:22.21.23,THB:16:17:26:25.19.20,17:22:25:26.19.18,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-12.96,-.21,;-12.74,-1.74,;-13.71,-2.5,;-11.31,-2.31,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| Show InChI InChI=1S/C21H28ClN3O4S/c1-20(2,25-30(28,29)16-5-3-4-15(22)8-16)19(27)24-17-13-6-12-7-14(17)11-21(9-12,10-13)18(23)26/h3-5,8,12-14,17,25H,6-7,9-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250486
(US9464044, 119)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.46,;8.87,-1.55,;9.26,-3.04,;7.38,-1.15,;6.48,-3.08,;5.28,-2.41,;5.29,-.01,;6.05,1.15,;7.38,.38,;4.72,.38,;3.38,1.15,;2.05,.38,;2.05,-1.15,;.72,1.15,;.72,2.69,;-.62,3.47,;-1.95,2.69,;-1.95,1.15,;-3.29,.38,;-4.62,1.15,;-4.62,2.69,;-3.53,2.24,;-5.95,.38,;-7.29,1.15,;-8.62,.38,;-9.95,1.15,;-8.62,-1.15,;-7.29,-1.93,;-7.29,-3.47,;-5.95,-1.15,;-.62,.38,;4.72,-1.15,;3.88,-3.06,;6.05,-1.93,)| Show InChI InChI=1S/C24H25Cl2N3O4S/c25-17-7-18(26)9-20(8-17)34(32,33)29-19-3-1-2-14(6-19)22(30)28-21-15-4-13-5-16(21)12-24(10-13,11-15)23(27)31/h1-3,6-9,13,15-16,21,29H,4-5,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250474
(US9464044, 102)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccs4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:29:3.4.30,8:3:29:9.7.6,1:3:9:29.5.6,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(9.14,-.66,;8.05,-1.75,;8.45,-3.23,;6.56,-1.35,;5.67,-3.27,;4.46,-2.6,;4.48,-.2,;5.23,.96,;6.56,.19,;3.9,.19,;2.57,.96,;1.23,.19,;1.23,-1.35,;-.1,.96,;-.1,2.5,;-1.43,3.27,;-2.77,2.5,;-2.77,.96,;-4.1,.19,;-5.44,.96,;-5.44,2.5,;-4.35,2.05,;-6.77,.19,;-6.77,-1.35,;-8.23,-1.82,;-9.14,-.58,;-8.23,.67,;-1.43,.19,;3.9,-1.35,;3.07,-3.25,;5.23,-2.12,)| Show InChI InChI=1S/C22H25N3O4S2/c23-21(27)22-10-13-7-15(11-22)19(16(8-13)12-22)24-20(26)14-3-1-4-17(9-14)25-31(28,29)18-5-2-6-30-18/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H2,23,27)(H,24,26)/t13?,15?,16?,19-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250436
(US9464044, 28)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:28.5.6,10:9:28:3.4.29,8:3:28:9.7.6,THB:4:3:9:28.5.6,4:5:9:3.8.29,8:7:28:3.4.29,(8.62,-.66,;7.53,-1.75,;7.93,-3.23,;6.04,-1.35,;5.15,-3.27,;3.94,-2.6,;3.96,-.2,;4.72,.96,;6.04,.19,;3.38,.19,;2.05,.96,;.72,.19,;.72,-1.35,;-.62,.96,;-1.95,.19,;-3.29,.96,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;.15,2.3,;-1.39,2.3,;3.38,-1.35,;2.55,-3.25,;4.72,-2.12,)| Show InChI InChI=1S/C22H29N3O4S/c23-19(26)22-10-14-8-15(11-22)18(16(9-14)12-22)25-20(27)21(6-7-21)13-24-30(28,29)17-4-2-1-3-5-17/h1-5,14-16,18,24H,6-13H2,(H2,23,26)(H,25,27)/t14?,15?,16?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250435
(US9464044, 26)Show SMILES Cn1ccc2cc(ccc12)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:21.23,TLB:30:28:25:21.22.23,31:28:21:25.24.23,20:21:25:28.29.27,THB:30:22:25:28.29.27,29:28:21:25.24.23,29:24:21:28.30.27,(-9.67,3.79,;-8.9,2.46,;-9.81,1.21,;-8.9,-.03,;-7.44,.44,;-6.1,-.33,;-4.77,.44,;-4.77,1.98,;-6.1,2.75,;-7.44,1.98,;-3.43,-.33,;-4.2,-1.66,;-2.66,-1.66,;-2.1,.44,;-.77,-.33,;.57,.44,;1.34,1.78,;-.2,1.78,;1.9,-.33,;1.9,-1.87,;3.23,.44,;4.57,-.33,;5.9,.44,;5.15,-.72,;5.13,-3.12,;3.73,-3.77,;4.57,-1.87,;5.9,-2.64,;7.23,-1.87,;6.33,-3.79,;7.23,-.33,;8.72,-2.27,;9.81,-1.18,;9.12,-3.75,)| Show InChI InChI=1S/C25H32N4O4S/c1-29-7-4-16-10-19(2-3-20(16)29)34(32,33)27-14-24(5-6-24)23(31)28-21-17-8-15-9-18(21)13-25(11-15,12-17)22(26)30/h2-4,7,10,15,17-18,21,27H,5-6,8-9,11-14H2,1H3,(H2,26,30)(H,28,31)/t15?,17?,18?,21-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250466
(US9464044, 72)Show SMILES CN(C(C)(C)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F |r,wU:8.7,TLB:18:15:8:12.11.10,7:8:12:15.16.14,17:15:12:8.9.10,THB:16:15:8:12.11.10,16:11:8:15.17.14,17:9:12:15.16.14,(-2.62,-.96,;-2.62,.58,;-1.29,1.35,;-.52,2.68,;-2.06,2.68,;.05,.58,;.05,-.96,;1.38,1.35,;2.72,.58,;4.05,1.35,;3.29,.18,;3.28,-2.22,;1.88,-2.86,;2.72,-.96,;4.05,-1.73,;5.38,-.96,;4.48,-2.89,;5.38,.58,;6.86,-1.36,;7.95,-.27,;7.26,-2.85,;-3.95,1.35,;-3.95,2.89,;-3.95,-.19,;-5.29,.58,;-5.29,-.96,;-6.62,-1.73,;-7.95,-.96,;-7.95,.58,;-6.62,1.35,;-6.62,2.89,)| Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26(3)31(29,30)17-7-5-4-6-16(17)23)20(28)25-18-14-8-13-9-15(18)12-22(10-13,11-14)19(24)27/h4-7,13-15,18H,8-12H2,1-3H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250437
(US9464044, 31)Show SMILES CN(CC1(CC1)C(=O)NC12CC3CC(CC(C3)C1)C2)S(=O)(=O)c1ccccc1F |TLB:12:13:11.10.16:17,16:11:18:15.14.17,16:15:18:12.11.10,THB:12:11:18.13.14:17| Show InChI InChI=1S/C22H29FN2O3S/c1-25(29(27,28)19-5-3-2-4-18(19)23)14-21(6-7-21)20(26)24-22-11-15-8-16(12-22)10-17(9-15)13-22/h2-5,15-17H,6-14H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250438
(US9464044, 32)Show SMILES CCN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F |r,wU:10.10,TLB:20:17:10:14.13.12,9:10:14:17.18.16,19:17:14:10.11.12,THB:18:17:10:14.13.12,18:13:10:17.19.16,19:11:14:17.18.16,(-4.6,3.27,;-3.27,2.5,;-3.29,.96,;-1.95,.19,;-.62,.96,;.15,2.3,;-1.39,2.3,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;-7.29,-1.35,)| Show InChI InChI=1S/C24H32FN3O4S/c1-2-28(33(31,32)19-6-4-3-5-18(19)25)14-23(7-8-23)22(30)27-20-16-9-15-10-17(20)13-24(11-15,12-16)21(26)29/h3-6,15-17,20H,2,7-14H2,1H3,(H2,26,29)(H,27,30)/t15?,16?,17?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250439
(US9464044, 33)Show SMILES OCCC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 |r,wU:11.12,TLB:3:5:11:31.7.8,12:11:31:5.6.32,10:5:31:11.9.8,THB:6:5:11:31.7.8,6:7:11:5.10.32,10:9:31:5.6.32,(9.91,.03,;8.82,-1.06,;7.33,-.66,;6.24,-1.75,;6.64,-3.23,;4.76,-1.35,;3.86,-3.27,;2.66,-2.6,;2.67,-.2,;3.43,.96,;4.76,.19,;2.09,.19,;.76,.96,;-.57,.19,;-.57,-1.35,;-1.91,.96,;-3.24,.19,;-4.57,.96,;-5.91,.19,;-6.68,-1.14,;-5.14,-1.14,;-7.24,.96,;-7.24,2.5,;-8.58,3.27,;-9.91,2.5,;-9.91,.96,;-8.58,.19,;-8.58,-1.35,;-1.14,2.3,;-2.68,2.3,;2.09,-1.35,;1.26,-3.25,;3.43,-2.12,)| Show InChI InChI=1S/C24H31FN2O5S/c25-18-3-1-2-4-19(18)33(31,32)26-14-23(6-7-23)22(30)27-21-16-9-15-10-17(21)13-24(11-15,12-16)20(29)5-8-28/h1-4,15-17,21,26,28H,5-14H2,(H,27,30)/t15?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250444
(US9464044, 40)Show SMILES Cc1cccc(F)c1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:18.19,TLB:27:25:22:18.19.20,28:25:18:22.21.20,17:18:22:25.26.24,THB:27:19:22:25.26.24,26:25:18:22.21.20,26:21:18:25.27.24,(-3.95,3.66,;-5.29,2.89,;-6.62,3.66,;-7.95,2.89,;-7.95,1.35,;-6.62,.58,;-6.62,-.96,;-5.29,1.35,;-3.95,.58,;-3.18,1.91,;-4.72,-.76,;-2.62,-.19,;-1.29,.58,;-.52,1.91,;-2.06,1.91,;.05,-.19,;.05,-1.73,;1.38,.58,;2.72,-.19,;4.05,.58,;3.29,-.59,;3.28,-2.99,;1.88,-3.63,;2.72,-1.73,;4.05,-2.5,;5.38,-1.73,;4.48,-3.66,;5.38,-.19,;6.86,-2.13,;7.95,-1.04,;7.26,-3.62,)| Show InChI InChI=1S/C22H28FN3O4S/c1-12-3-2-4-16(23)18(12)31(29,30)26-22(5-6-22)20(28)25-17-14-7-13-8-15(17)11-21(9-13,10-14)19(24)27/h2-4,13-15,17,26H,5-11H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250472
(US9464044, 99)Show SMILES CN(c1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1C(F)(F)F |r,wU:11.11,TLB:10:11:15:18.19.17,20:18:15:11.12.13,21:18:11:15.14.13,THB:20:12:15:18.19.17,19:18:11:15.14.13,19:14:11:18.20.17,(-3.85,-1.73,;-3.85,-.19,;-2.52,.58,;-2.52,2.12,;-1.18,2.89,;.15,2.12,;.15,.58,;-1.18,-.19,;1.49,-.19,;1.49,-1.73,;2.82,.58,;4.15,-.19,;5.49,.58,;4.73,-.59,;4.71,-2.99,;3.32,-3.63,;4.15,-1.73,;5.49,-2.5,;6.81,-1.73,;5.92,-3.66,;6.81,-.19,;8.3,-2.13,;9.39,-1.04,;8.7,-3.62,;-5.18,.58,;-5.18,2.12,;-3.85,1.35,;-6.52,-.19,;-6.52,-1.73,;-7.85,-2.5,;-9.18,-1.73,;-9.18,-.19,;-7.85,.58,;-7.85,2.12,;-7.85,3.66,;-9.39,2.12,;-6.31,2.12,)| Show InChI InChI=1S/C26H28F3N3O4S/c1-32(37(35,36)21-8-3-2-7-20(21)26(27,28)29)19-6-4-5-16(11-19)23(33)31-22-17-9-15-10-18(22)14-25(12-15,13-17)24(30)34/h2-8,11,15,17-18,22H,9-10,12-14H2,1H3,(H2,30,34)(H,31,33)/t15?,17?,18?,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112142
(CHEMBL3609870 | US9464044, 81)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:16.16,TLB:20:21:25:24.18.19,20:19:25:16.21.22,16:17:24:21.20.22,THB:15:16:25:24.18.19,16:21:24:25.18.17,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-11.31,-2.31,;-12.74,-1.74,;-12.96,-.21,;-11.75,.74,;-10.32,.17,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| Show InChI InChI=1S/C21H29N3O4S/c1-20(2,24-29(27,28)16-6-4-3-5-7-16)19(26)23-17-14-8-13-9-15(17)12-21(10-13,11-14)18(22)25/h3-7,13-15,17,24H,8-12H2,1-2H3,(H2,22,25)(H,23,26)/t13?,14?,15?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112127
(CHEMBL3608407 | US9464044, 76)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(CO)(C3)C2 |r,wD:17.17,TLB:21:22:28:27.19.20,21:20:28:17.22.23,17:18:27:22.21.23,THB:16:17:28:27.19.20,17:22:27:28.19.18,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-12.96,-.21,;-12.74,-1.74,;-11.31,-2.31,;-11.14,-3.53,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;3.07,1.15,;3.59,2.27,;1.56,2.59,;.56,-.22,)| Show InChI InChI=1S/C21H29FN2O4S/c1-20(2,24-29(27,28)17-6-4-3-5-16(17)22)19(26)23-18-14-7-13-8-15(18)11-21(9-13,10-14)12-25/h3-6,13-15,18,24-25H,7-12H2,1-2H3,(H,23,26)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250420
(US9464044, 10)Show SMILES Cc1cccc(F)c1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:19.20,TLB:18:19:23:26.27.25,28:26:23:19.20.21,29:26:19:23.22.21,THB:28:20:23:26.27.25,27:26:19:23.22.21,27:22:19:26.28.25,(-4.62,3.27,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;-7.29,-1.35,;-5.95,.96,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-3.29,.96,;-1.95,.19,;-.62,.96,;.15,2.3,;-1.39,2.3,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,)| Show InChI InChI=1S/C23H30FN3O4S/c1-13-3-2-4-17(24)19(13)32(30,31)26-12-22(5-6-22)21(29)27-18-15-7-14-8-16(18)11-23(9-14,10-15)20(25)28/h2-4,14-16,18,26H,5-12H2,1H3,(H2,25,28)(H,27,29)/t14?,15?,16?,18-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250417
(US9464044, 7)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:29:9.7.6,1:3:9:29.5.6,10:9:29:3.4.30,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-7.95,.96,;-9.29,.19,;-6.62,.19,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H28ClN3O4S/c23-16-2-1-3-17(8-16)31(29,30)25-12-21(4-5-21)20(28)26-18-14-6-13-7-15(18)11-22(9-13,10-14)19(24)27/h1-3,8,13-15,18,25H,4-7,9-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112126
(CHEMBL3608406 | US9464044, 74)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C#N |r,wD:17.17,TLB:17:18:25:22.21.23,21:22:26:25.19.20,21:20:26:17.22.23,THB:16:17:26:25.19.20,17:22:25:26.19.18,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-12.96,-.21,;-12.74,-1.74,;-11.31,-2.31,;-11.14,-3.53,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;4.3,1.26,)| Show InChI InChI=1S/C21H26FN3O3S/c1-20(2,25-29(27,28)17-6-4-3-5-16(17)22)19(26)24-18-14-7-13-8-15(18)11-21(9-13,10-14)12-23/h3-6,13-15,18,25H,7-11H2,1-2H3,(H,24,26)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250480
(US9464044, 113)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc([N-]S(=O)(=O)c4cccc(Cl)c4F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.29,1.73,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-8.62,.19,;-9.95,.96,;-7.29,.96,;-7.29,2.5,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H24ClFN3O4S/c25-18-5-2-6-19(20(18)26)34(32,33)29-17-4-1-3-14(9-17)22(30)28-21-15-7-13-8-16(21)12-24(10-13,11-15)23(27)31/h1-6,9,13,15-16,21H,7-8,10-12H2,(H2,27,31)(H,28,30)/q-1/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250416
(US9464044, 5)Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:19.20,TLB:18:19:23:26.27.25,28:26:23:19.20.21,29:26:19:23.22.21,THB:28:20:23:26.27.25,27:26:19:23.22.21,27:22:19:26.28.25,(-6.62,-1.35,;-6.62,.19,;-7.95,.96,;-9.29,.19,;-7.95,2.5,;-6.62,3.27,;-5.29,2.5,;-5.29,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-2.62,.96,;-1.29,.19,;.05,.96,;.82,2.3,;-.72,2.3,;1.38,.19,;1.38,-1.35,;2.72,.96,;4.05,.19,;5.38,.96,;4.63,-.2,;4.61,-2.6,;3.22,-3.25,;4.05,-1.35,;5.38,-2.12,;6.71,-1.35,;5.81,-3.27,;6.71,.19,;8.2,-1.75,;9.29,-.66,;8.6,-3.23,)| Show InChI InChI=1S/C23H30ClN3O4S/c1-13-17(24)3-2-4-18(13)32(30,31)26-12-22(5-6-22)21(29)27-19-15-7-14-8-16(19)11-23(9-14,10-15)20(25)28/h2-4,14-16,19,26H,5-12H2,1H3,(H2,25,28)(H,27,29)/t14?,15?,16?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250423
(US9464044, 13)Show SMILES CN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1c(C)cccc1F |r,wU:9.9,TLB:8:9:13:16.17.15,18:16:13:9.10.11,19:16:9:13.12.11,THB:18:10:13:16.17.15,17:16:9:13.12.11,17:12:9:16.18.15,(-3.29,2.5,;-3.29,.96,;-1.95,.19,;-.62,.96,;.15,2.3,;-1.39,2.3,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,;-4.62,.19,;-5.39,-1.14,;-3.85,-1.14,;-5.95,.96,;-5.95,2.5,;-4.62,3.27,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;-7.29,-1.35,)| Show InChI InChI=1S/C24H32FN3O4S/c1-14-4-3-5-18(25)20(14)33(31,32)28(2)13-23(6-7-23)22(30)27-19-16-8-15-9-17(19)12-24(10-15,11-16)21(26)29/h3-5,15-17,19H,6-13H2,1-2H3,(H2,26,29)(H,27,30)/t15?,16?,17?,19-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250459
(US9464044, 61)Show SMILES CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F |r,wU:8.8,TLB:18:15:8:12.11.10,7:8:12:15.16.14,17:15:12:8.9.10,THB:16:15:8:12.11.10,16:11:8:15.17.14,17:9:12:15.16.14,(-2.62,-1.73,;-2.62,-.19,;-1.29,.58,;-.52,1.91,;-2.06,1.91,;.05,-.19,;.05,-1.73,;1.38,.58,;2.72,-.19,;4.05,.58,;3.29,-.59,;3.28,-2.99,;1.88,-3.63,;2.72,-1.73,;4.05,-2.5,;5.38,-1.73,;4.48,-3.66,;5.38,-.19,;6.86,-2.13,;7.95,-1.04,;7.26,-3.62,;-3.95,.58,;-3.18,1.91,;-4.72,-.76,;-5.29,1.35,;-5.29,2.89,;-6.62,3.66,;-7.95,2.89,;-7.95,1.35,;-6.62,.58,;-6.62,-.96,)| Show InChI InChI=1S/C22H28FN3O4S/c1-26(31(29,30)17-5-3-2-4-16(17)23)22(6-7-22)20(28)25-18-14-8-13-9-15(18)12-21(10-13,11-14)19(24)27/h2-5,13-15,18H,6-12H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250477
(US9464044, 106)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4Cl)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,1:3:9:31.5.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;.05,2.5,;-1.29,3.27,;-2.62,2.5,;-2.62,.96,;-3.95,.19,;-5.29,.96,;-5.29,2.5,;-4.2,2.05,;-6.62,.19,;-6.62,-1.35,;-7.95,-2.12,;-9.29,-1.35,;-9.29,.19,;-7.95,.96,;-7.95,2.5,;-1.29,.19,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C24H26ClN3O4S/c25-19-6-1-2-7-20(19)33(31,32)28-18-5-3-4-15(10-18)22(29)27-21-16-8-14-9-17(21)13-24(11-14,12-16)23(26)30/h1-7,10,14,16-17,21,28H,8-9,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250484
(US9464044, 117)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4c(Cl)cc(Cl)cc4Cl)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:33:3.4.34,8:3:33:9.7.6,1:3:9:33.5.6,THB:8:7:33:3.4.34,4:3:9:33.5.6,4:5:9:3.8.34,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-7.29,.96,;-7.29,2.5,;-8.62,.19,;-8.62,-1.35,;-9.95,-2.12,;-7.29,-2.12,;-5.95,-1.35,;-4.62,-2.12,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H24Cl3N3O4S/c25-16-7-18(26)21(19(27)8-16)35(33,34)30-17-3-1-2-13(6-17)22(31)29-20-14-4-12-5-15(20)11-24(9-12,10-14)23(28)32/h1-3,6-8,12,14-15,20,30H,4-5,9-11H2,(H2,28,32)(H,29,31)/t12?,14?,15?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250426
(US9464044, 16)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(Cl)c(Cl)cc4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,1:3:9:31.5.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,(9.29,-1.43,;8.2,-2.52,;8.6,-4,;6.71,-2.12,;5.81,-4.04,;4.61,-3.37,;4.63,-.97,;5.38,.19,;6.71,-.58,;4.05,-.58,;2.72,.19,;1.38,-.58,;1.38,-2.12,;.05,.19,;-1.29,-.58,;-2.62,.19,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-5.29,.19,;-5.29,1.73,;-6.62,2.5,;-6.62,4.04,;-7.95,1.73,;-9.29,2.5,;-7.95,.19,;-6.62,-.58,;-6.62,-2.12,;.82,1.53,;-.72,1.53,;4.05,-2.12,;3.22,-4.02,;5.38,-2.89,)| Show InChI InChI=1S/C22H26Cl2FN3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112141
(CHEMBL3609869 | US9464044, 3)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 |r,wD:9.10,TLB:10:9:29:3.4.30,8:3:29:9.7.6,THB:1:3:29:9.7.6,9:28:4:8.7.6,9:7:4:29.30.28,8:7:29:3.4.30,(3.79,.16,;3.07,1.16,;3.58,2.29,;1.56,1.02,;1.56,2.59,;.12,3.07,;-1,2.05,;-.95,.32,;.56,-.22,;-2.19,-.22,;-3.39,-1.17,;-4.82,-.59,;-4.99,.63,;-6.03,-1.55,;-5.81,-3.07,;-7.02,-4.02,;-6.8,-5.55,;-5.66,-6.01,;-5.83,-4.79,;-8.01,-6.5,;-9.44,-5.93,;-10.65,-6.88,;-10.43,-8.41,;-9,-8.98,;-7.79,-8.03,;-6.65,-8.48,;-6.85,-.39,;-7.43,-1.82,;-1.2,1.02,;-1.2,2.69,;.34,.44,)| Show InChI InChI=1S/C22H28FN3O4S/c23-16-3-1-2-4-17(16)31(29,30)25-12-21(5-6-21)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h1-4,13-15,18,25H,5-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250465
(US9464044, 70)Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC(C)(C)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:19.19,TLB:29:26:19:23.22.21,18:19:23:26.27.25,28:26:23:19.20.21,THB:28:20:23:26.27.25,27:26:19:23.22.21,27:22:19:26.28.25,(-6.62,-1.35,;-6.62,.19,;-7.95,.96,;-9.29,.19,;-7.95,2.5,;-6.62,3.27,;-5.29,2.5,;-5.29,.96,;-3.95,.19,;-3.95,-1.35,;-3.95,1.73,;-2.62,.96,;-1.29,.19,;.05,.96,;.82,2.3,;-.72,2.3,;1.38,.19,;1.38,-1.35,;2.72,.96,;4.05,.19,;5.38,.96,;4.63,-.2,;4.61,-2.6,;3.22,-3.25,;4.05,-1.35,;5.38,-2.12,;6.71,-1.35,;5.81,-3.27,;6.71,.19,;8.2,-1.75,;9.29,-.66,;8.6,-3.23,)| Show InChI InChI=1S/C23H32ClN3O4S/c1-13-17(24)5-4-6-18(13)32(30,31)26-12-22(2,3)21(29)27-19-15-7-14-8-16(19)11-23(9-14,10-15)20(25)28/h4-6,14-16,19,26H,7-12H2,1-3H3,(H2,25,28)(H,27,29)/t14?,15?,16?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250446
(US9464044, 42)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)cc1)C(C3)C2 |r,wU:9.10,TLB:8:3:28:9.7.6,1:3:9:28.5.6,10:9:28:3.4.29,THB:8:7:28:3.4.29,4:3:9:28.5.6,4:5:9:3.8.29,(8.62,-1.04,;7.53,-2.13,;7.93,-3.62,;6.04,-1.73,;5.15,-3.66,;3.94,-2.99,;3.96,-.59,;4.72,.58,;6.04,-.19,;3.38,-.19,;2.05,.58,;.72,-.19,;.72,-1.73,;-.62,.58,;.15,1.91,;-1.39,1.91,;-1.95,-.19,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-5.95,.58,;-7.29,1.35,;-7.29,2.89,;-8.62,3.66,;-5.95,3.66,;-4.62,2.89,;3.38,-1.73,;2.55,-3.63,;4.72,-2.5,)| Show InChI InChI=1S/C21H26FN3O4S/c22-15-1-3-16(4-2-15)30(28,29)25-21(5-6-21)19(27)24-17-13-7-12-8-14(17)11-20(9-12,10-13)18(23)26/h1-4,12-14,17,25H,5-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250443
(US9464044, 38)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccc(Cl)c1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:28.5.6,10:9:28:3.4.29,8:3:28:9.7.6,THB:8:7:28:3.4.29,4:3:9:28.5.6,4:5:9:3.8.29,(8.61,-1.04,;7.52,-2.13,;7.92,-3.62,;6.04,-1.73,;5.14,-3.66,;3.94,-2.99,;3.95,-.59,;4.71,.58,;6.04,-.19,;3.38,-.19,;2.04,.58,;.71,-.19,;.71,-1.73,;-.63,.58,;.14,1.91,;-1.4,1.91,;-1.96,-.19,;-3.28,.58,;-2.51,1.91,;-4.05,-.75,;-4.61,1.35,;-4.61,2.89,;-5.95,3.66,;-7.28,2.89,;-7.28,1.35,;-8.61,.58,;-5.95,.58,;3.38,-1.73,;2.54,-3.63,;4.71,-2.5,)| Show InChI InChI=1S/C21H26ClN3O4S/c22-15-2-1-3-16(8-15)30(28,29)25-21(4-5-21)19(27)24-17-13-6-12-7-14(17)11-20(9-12,10-13)18(23)26/h1-3,8,12-14,17,25H,4-7,9-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250463
(US9464044, 67)Show SMILES CC(C)(CNS(=O)(=O)c1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:18.18,TLB:28:25:18:22.21.20,17:18:22:25.26.24,27:25:22:18.19.20,THB:27:19:22:25.26.24,26:25:18:22.21.20,26:21:18:25.27.24,(.72,1.73,;-.62,.96,;-1.39,2.3,;-1.95,.19,;-3.29,.96,;-4.62,.19,;-4.62,-1.35,;-4.62,1.73,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-10.03,.34,;-7.29,.19,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,)| Show InChI InChI=1S/C22H30ClN3O4S/c1-21(2,12-25-31(29,30)17-5-3-4-16(23)8-17)20(28)26-18-14-6-13-7-15(18)11-22(9-13,10-14)19(24)27/h3-5,8,13-15,18,25H,6-7,9-12H2,1-2H3,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250488
(US9464044, 121)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-9.95,-2.12,;-8.62,.19,;-7.29,.96,;-7.29,2.5,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25F2N3O4S/c25-17-4-5-20(19(26)9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250454
(US9464044, 55)Show SMILES Clc1cccc(c1)S(=O)(=O)NC1(CC1)C(=O)NC1CC2CCC1C2 Show InChI InChI=1S/C17H21ClN2O3S/c18-13-2-1-3-14(10-13)24(22,23)20-17(6-7-17)16(21)19-15-9-11-4-5-12(15)8-11/h1-3,10-12,15,20H,4-9H2,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112140
(CHEMBL3609868 | US9464044, 68)Show SMILES CC(C)(CNS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:18.18,TLB:17:18:22:25.26.24,18:19:26:22.24.23,27:25:22:18.19.20,THB:28:25:22:18.19.20,18:23:26:27.19.20,27:19:22:25.26.24,(-5.85,-2.77,;-6.03,-1.55,;-7,-2.31,;-7.46,-.97,;-8.67,-1.93,;-10.1,-1.35,;-10.28,-.14,;-9.13,-.59,;-11.31,-2.31,;-12.74,-1.73,;-13.95,-2.69,;-13.73,-4.21,;-12.3,-4.78,;-11.09,-3.83,;-9.95,-4.29,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.16,;3.79,.16,;3.58,2.29,)| Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,12-25-31(29,30)17-6-4-3-5-16(17)23)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h3-6,13-15,18,25H,7-12H2,1-2H3,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250455
(US9464044, 57)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccc(F)c(F)c1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:28.5.6,10:9:28:3.4.29,8:3:28:9.7.6,THB:8:7:28:3.4.29,4:3:9:28.5.6,4:5:9:3.8.29,(8.62,-.27,;7.53,-1.36,;7.93,-2.85,;6.04,-.96,;5.15,-2.89,;3.94,-2.22,;3.96,.18,;4.72,1.35,;6.04,.58,;3.38,.58,;2.05,1.35,;.72,.58,;.72,-.96,;-.62,1.35,;.15,2.68,;-1.39,2.68,;-1.95,.58,;-3.29,1.35,;-3.29,2.89,;-4.62,.58,;-4.62,-.96,;-5.95,-1.73,;-7.29,-.96,;-8.62,-1.73,;-7.29,.58,;-8.62,1.35,;-5.95,1.35,;3.38,-.96,;2.55,-2.86,;4.72,-1.73,)| Show InChI InChI=1S/C22H25F2N3O3/c23-15-2-1-12(7-16(15)24)18(28)27-22(3-4-22)20(30)26-17-13-5-11-6-14(17)10-21(8-11,9-13)19(25)29/h1-2,7,11,13-14,17H,3-6,8-10H2,(H2,25,29)(H,26,30)(H,27,28)/t11?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250422
(US9464044, 12)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4c(F)cc(F)cc4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,1:3:9:31.5.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-6.62,.19,;-6.62,-1.35,;-7.95,.96,;-7.95,2.5,;-9.29,3.27,;-6.62,3.27,;-5.29,2.5,;-3.95,3.27,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-15(24)18(16(25)6-14)33(31,32)27-10-21(1-2-21)20(30)28-17-12-3-11-4-13(17)9-22(7-11,8-12)19(26)29/h5-6,11-13,17,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,17-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250434
(US9464044, 25)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:29:9.7.6,1:3:9:29.5.6,10:9:29:3.4.30,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-3.95,-1.35,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-9.29,3.27,;-7.95,.96,;-9.29,.19,;-6.62,.19,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C23H27F2N3O3/c24-16-2-1-13(7-17(16)25)19(29)27-11-22(3-4-22)21(31)28-18-14-5-12-6-15(18)10-23(8-12,9-14)20(26)30/h1-2,7,12,14-15,18H,3-6,8-11H2,(H2,26,30)(H,27,29)(H,28,31)/t12?,14?,15?,18-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112153
(CHEMBL3608402 | US9464044, 83)Show SMILES CC(C)(NS(=O)(=O)c1cc(F)cc(F)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:18.18,TLB:22:23:27:26.20.21,22:21:27:18.23.24,18:19:26:23.22.24,THB:17:18:27:26.20.21,18:23:26:27.20.19,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-11.93,1.96,;-12.96,-.21,;-12.74,-1.74,;-13.71,-2.5,;-11.31,-2.31,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| Show InChI InChI=1S/C21H27F2N3O4S/c1-20(2,26-31(29,30)16-6-14(22)5-15(23)7-16)19(28)25-17-12-3-11-4-13(17)10-21(8-11,9-12)18(24)27/h5-7,11-13,17,26H,3-4,8-10H2,1-2H3,(H2,24,27)(H,25,28)/t11?,12?,13?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250445
(US9464044, 41)Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:18.19,TLB:27:25:22:18.19.20,28:25:18:22.21.20,17:18:22:25.26.24,THB:27:19:22:25.26.24,26:25:18:22.21.20,26:21:18:25.27.24,(-5.95,-.96,;-5.95,.58,;-7.29,1.35,;-8.62,.58,;-7.29,2.89,;-5.95,3.66,;-4.62,2.89,;-4.62,1.35,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-1.95,-.19,;-.62,.58,;.15,1.91,;-1.39,1.91,;.72,-.19,;.72,-1.73,;2.05,.58,;3.38,-.19,;4.72,.58,;3.96,-.59,;3.94,-2.99,;2.55,-3.63,;3.38,-1.73,;4.72,-2.5,;6.04,-1.73,;5.15,-3.66,;6.04,-.19,;7.53,-2.13,;8.62,-1.04,;7.93,-3.62,)| Show InChI InChI=1S/C22H28ClN3O4S/c1-12-16(23)3-2-4-17(12)31(29,30)26-22(5-6-22)20(28)25-18-14-7-13-8-15(18)11-21(9-13,10-14)19(24)27/h2-4,13-15,18,26H,5-11H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250421
(US9464044, 11 | US9464044, 24)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(F)c4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:30:3.4.31,8:3:30:9.7.6,1:3:9:30.5.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-7.95,.96,;-9.29,.19,;-6.62,.19,;-6.62,-1.35,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H27F2N3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250457
(US9464044, 59)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1cccc(F)c1F)C(C3)C2 |r,wU:9.10,TLB:1:3:9:28.5.6,10:9:28:3.4.29,8:3:28:9.7.6,THB:8:7:28:3.4.29,4:3:9:28.5.6,4:5:9:3.8.29,(8.62,-.27,;7.53,-1.36,;7.93,-2.85,;6.04,-.96,;5.15,-2.89,;3.94,-2.22,;3.96,.18,;4.72,1.35,;6.04,.58,;3.38,.58,;2.05,1.35,;.72,.58,;.72,-.96,;-.62,1.35,;.15,2.68,;-1.39,2.68,;-1.95,.58,;-3.29,1.35,;-3.29,2.89,;-4.62,.58,;-4.62,-.96,;-5.95,-1.73,;-7.29,-.96,;-7.29,.58,;-8.62,1.35,;-5.95,1.35,;-5.95,2.89,;3.38,-.96,;2.55,-2.86,;4.72,-1.73,)| Show InChI InChI=1S/C22H25F2N3O3/c23-15-3-1-2-14(16(15)24)18(28)27-22(4-5-22)20(30)26-17-12-6-11-7-13(17)10-21(8-11,9-12)19(25)29/h1-3,11-13,17H,4-10H2,(H2,25,29)(H,26,30)(H,27,28)/t11?,12?,13?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.2 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250491
(US9464044, 125)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4C(F)(F)F)c1F)C(C3)C2 |r,wU:9.10,TLB:10:9:35:3.4.36,8:3:35:9.7.6,1:3:9:35.5.6,THB:8:7:35:3.4.36,4:3:9:35.5.6,4:5:9:3.8.36,(9.39,-1.04,;8.3,-2.13,;8.7,-3.62,;6.81,-1.73,;5.92,-3.66,;4.71,-2.99,;4.73,-.59,;5.49,.58,;6.81,-.19,;4.15,-.19,;2.82,.58,;1.49,-.19,;1.49,-1.73,;.15,.58,;.15,2.12,;-1.18,2.89,;-2.52,2.12,;-2.52,.58,;-3.85,-.19,;-5.18,.58,;-5.18,2.12,;-5.18,-.96,;-6.52,-.19,;-6.52,-1.73,;-7.85,-2.5,;-9.18,-1.73,;-9.18,-.19,;-7.85,.58,;-7.85,2.12,;-7.85,3.66,;-9.39,2.12,;-6.31,2.12,;-1.18,-.19,;-1.18,-1.73,;4.15,-1.73,;3.32,-3.63,;5.49,-2.5,)| Show InChI InChI=1S/C25H25F4N3O4S/c26-20-16(22(33)31-21-14-8-13-9-15(21)12-24(10-13,11-14)23(30)34)4-3-6-18(20)32-37(35,36)19-7-2-1-5-17(19)25(27,28)29/h1-7,13-15,21,32H,8-12H2,(H2,30,34)(H,31,33)/t13?,14?,15?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250458
(US9464044, 60)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccccc1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:27.5.6,10:9:27:3.4.28,8:3:27:9.7.6,THB:4:3:9:27.5.6,4:5:9:3.8.28,8:7:27:3.4.28,(7.95,-1.04,;6.86,-2.13,;7.26,-3.62,;5.38,-1.73,;4.48,-3.66,;3.28,-2.99,;3.29,-.59,;4.05,.58,;5.38,-.19,;2.72,-.19,;1.38,.58,;.05,-.19,;.05,-1.73,;-1.29,.58,;-.52,1.91,;-2.06,1.91,;-2.62,-.19,;-3.95,.58,;-3.18,1.91,;-4.72,-.76,;-5.29,1.35,;-5.29,2.89,;-6.62,3.66,;-7.95,2.89,;-7.95,1.35,;-6.62,.58,;2.72,-1.73,;1.88,-3.63,;4.05,-2.5,)| Show InChI InChI=1S/C21H27N3O4S/c22-18(25)20-10-13-8-14(11-20)17(15(9-13)12-20)23-19(26)21(6-7-21)24-29(27,28)16-4-2-1-3-5-16/h1-5,13-15,17,24H,6-12H2,(H2,22,25)(H,23,26)/t13?,14?,15?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250490
(US9464044, 123)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4c(F)cccc4F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;.05,2.5,;-1.29,3.27,;-2.62,2.5,;-2.62,.96,;-3.95,.19,;-5.29,.96,;-5.29,2.5,;-4.2,2.05,;-6.62,.19,;-6.62,-1.35,;-5.29,-2.12,;-7.95,-2.12,;-9.29,-1.35,;-9.29,.19,;-7.95,.96,;-7.95,2.5,;-1.29,.19,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C24H25F2N3O4S/c25-18-5-2-6-19(26)21(18)34(32,33)29-17-4-1-3-14(9-17)22(30)28-20-15-7-13-8-16(20)12-24(10-13,11-15)23(27)31/h1-6,9,13,15-16,20,29H,7-8,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,20-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250470
(US9464044, 95)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(Cl)c4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:4.32.3,8:3:31:9.7.6,THB:8:7:31:4.32.3,4:5:9:8.32.3,4:3:9:31.5.6,1:3:31:9.7.6,(10,-1.15,;8.67,-1.93,;8.67,-3.47,;7.33,-1.15,;6.44,-3.08,;5.23,-2.41,;5.25,-.01,;6,1.15,;7.33,.38,;4.67,.38,;3.34,1.15,;2,.38,;2,-1.15,;.67,1.15,;.67,2.69,;-.66,3.47,;-2,2.69,;-2,1.15,;-3.33,.38,;-4.66,1.15,;-5.75,2.24,;-3.58,2.24,;-6,.38,;-6,-1.15,;-7.33,-1.93,;-8.67,-1.15,;-8.67,.38,;-10,1.15,;-7.33,1.15,;-.66,.38,;4.67,-1.15,;3.69,-2.41,;6,-1.93,)| Show InChI InChI=1S/C24H26ClN3O4S/c25-18-4-2-6-20(10-18)33(31,32)28-19-5-1-3-15(9-19)22(29)27-21-16-7-14-8-17(21)13-24(11-14,12-16)23(26)30/h1-6,9-10,14,16-17,21,28H,7-8,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250424
(US9464044, 14)Show SMILES Cc1cc(c(Cl)cc1Cl)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:20.21,TLB:19:20:24:27.28.26,29:27:24:20.21.22,30:27:20:24.23.22,THB:29:21:24:27.28.26,28:27:20:24.23.22,28:23:20:27.29.26,(-6.62,4.04,;-6.62,2.5,;-5.29,1.73,;-5.29,.19,;-6.62,-.58,;-6.62,-2.12,;-7.95,.19,;-7.95,1.73,;-9.29,2.5,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-2.62,.19,;-1.29,-.58,;.05,.19,;.82,1.53,;-.72,1.53,;1.38,-.58,;1.38,-2.12,;2.72,.19,;4.05,-.58,;5.38,.19,;4.63,-.97,;4.61,-3.37,;3.22,-4.02,;4.05,-2.12,;5.38,-2.89,;6.71,-2.12,;5.81,-4.04,;6.71,-.58,;8.2,-2.52,;9.29,-1.43,;8.6,-4,)| Show InChI InChI=1S/C23H29Cl2N3O4S/c1-12-4-18(17(25)7-16(12)24)33(31,32)27-11-22(2-3-22)21(30)28-19-14-5-13-6-15(19)10-23(8-13,9-14)20(26)29/h4,7,13-15,19,27H,2-3,5-6,8-11H2,1H3,(H2,26,29)(H,28,30)/t13?,14?,15?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250414
(US9464044, 1)Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC(C2)CC1C3 |r,wU:19.20,TLB:21:22:26:19.20.25,18:19:26:22.23.28,THB:21:20:26:22.23.28,23:22:19:26.24.25,23:24:19:22.21.28,(-5.33,-1.35,;-5.33,.19,;-6.67,.96,;-8,.19,;-6.67,2.5,;-5.33,3.27,;-4,2.5,;-4,.96,;-2.66,.19,;-3.43,-1.14,;-1.89,-1.14,;-1.33,.96,;0,.19,;1.34,.96,;2.11,2.3,;.57,2.3,;2.67,.19,;2.67,-1.35,;4,.96,;5.34,.19,;6.67,.96,;8,.19,;8,-1.35,;7.1,-3.27,;5.9,-2.6,;5.92,-.2,;4.5,-3.25,;5.34,-1.35,;6.67,-2.12,)| Show InChI InChI=1S/C22H29ClN2O3S/c1-13-18(23)3-2-4-19(13)29(27,28)24-12-22(5-6-22)21(26)25-20-16-8-14-7-15(10-16)11-17(20)9-14/h2-4,14-17,20,24H,5-12H2,1H3,(H,25,26)/t14?,15?,16?,17?,20- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14.2 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250483
(US9464044, 116)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(Br)cc4Cl)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-9.95,-2.12,;-8.62,.19,;-7.29,.96,;-7.29,2.5,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25BrClN3O4S/c25-17-4-5-20(19(26)9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250496
(US9464044, 133)Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1ccc(Cl)c(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:23.24,TLB:22:23:27:30.31.29,32:30:27:23.24.25,33:30:23:27.26.25,THB:32:24:27:30.31.29,31:30:23:27.26.25,31:26:23:30.32.29,(-10.62,-1.35,;-9.29,-2.12,;-7.95,-1.35,;-6.62,-2.12,;-5.29,-1.35,;-5.29,.19,;-6.62,.96,;-7.95,.19,;-9.29,.96,;-3.95,.96,;-3.95,2.5,;-3.95,-.58,;-2.62,.19,;-1.29,.96,;-1.29,2.5,;.05,3.27,;1.38,2.5,;2.72,3.27,;1.38,.96,;.05,.19,;2.72,.19,;2.72,-1.35,;4.05,.96,;5.38,.19,;6.72,.96,;5.96,-.2,;5.95,-2.6,;4.55,-3.25,;5.38,-1.35,;6.72,-2.12,;8.04,-1.35,;7.15,-3.27,;8.04,.19,;9.53,-1.75,;10.62,-.66,;9.93,-3.23,)| Show InChI InChI=1S/C25H27Cl2N3O5S/c1-35-21-5-3-17(9-20(21)27)36(33,34)30-16-2-4-19(26)18(8-16)23(31)29-22-14-6-13-7-15(22)12-25(10-13,11-14)24(28)32/h2-5,8-9,13-15,22,30H,6-7,10-12H2,1H3,(H2,28,32)(H,29,31)/t13?,14?,15?,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112131
(CHEMBL3608411 | US9464044, 80)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(CC(N)=O)(C3)C2 |r,wD:17.17,TLB:17:18:29:22.21.23,21:22:30:29.19.20,21:20:30:17.22.23,THB:16:17:30:29.19.20,17:22:29:30.19.18,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-12.96,-.21,;-12.74,-1.74,;-11.31,-2.31,;-11.14,-3.53,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;3.07,1.15,;3.72,2.55,;3.01,3.56,;4.95,2.66,;1.56,2.59,;.56,-.22,)| Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-6-4-3-5-16(17)23)20(28)25-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(24)27/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,27)(H,25,28)/t13?,14?,15?,19-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 14.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250489
(US9464044, 122)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(F)ccc4F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-7.29,.96,;-8.62,.19,;-9.95,.96,;-8.62,-1.35,;-7.29,-2.12,;-5.95,-1.35,;-4.62,-2.12,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25F2N3O4S/c25-17-4-5-19(26)20(9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 15.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250473
(US9464044, 100)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc([N-]S(=O)(=O)c4ccccc4C(F)(F)F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:34:3.4.35,8:3:34:9.7.6,1:3:9:34.5.6,THB:8:7:34:3.4.35,4:3:9:34.5.6,4:5:9:3.8.35,(9.39,-1.04,;8.3,-2.13,;8.7,-3.62,;6.81,-1.73,;5.92,-3.66,;4.71,-2.99,;4.73,-.59,;5.49,.58,;6.81,-.19,;4.15,-.19,;2.82,.58,;1.49,-.19,;1.49,-1.73,;.15,.58,;.15,2.12,;-1.18,2.89,;-2.52,2.12,;-2.52,.58,;-3.85,-.19,;-5.18,.58,;-5.18,2.12,;-3.85,1.35,;-6.52,-.19,;-6.52,-1.73,;-7.85,-2.5,;-9.18,-1.73,;-9.18,-.19,;-7.85,.58,;-7.85,2.12,;-7.85,3.66,;-9.39,2.12,;-6.31,2.12,;-1.18,-.19,;4.15,-1.73,;3.32,-3.63,;5.49,-2.5,)| Show InChI InChI=1S/C25H25F3N3O4S/c26-25(27,28)19-6-1-2-7-20(19)36(34,35)31-18-5-3-4-15(10-18)22(32)30-21-16-8-14-9-17(21)13-24(11-14,12-16)23(29)33/h1-7,10,14,16-17,21H,8-9,11-13H2,(H2,29,33)(H,30,32)/q-1/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 15.3 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250441
(US9464044, 36)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)c(F)cc4F)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:31.5.6,10:9:31:3.4.32,8:3:31:9.7.6,THB:4:3:9:31.5.6,4:5:9:3.8.32,8:7:31:3.4.32,(9.29,-1.43,;8.2,-2.52,;8.6,-4,;6.71,-2.12,;5.81,-4.04,;4.61,-3.37,;4.63,-.97,;5.38,.19,;6.71,-.58,;4.05,-.58,;2.72,.19,;1.38,-.58,;1.38,-2.12,;.05,.19,;-1.29,-.58,;-2.62,.19,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-5.29,.19,;-5.29,1.73,;-6.62,2.5,;-6.62,4.04,;-7.95,1.73,;-9.29,2.5,;-7.95,.19,;-6.62,-.58,;-6.62,-2.12,;.82,1.53,;-.72,1.53,;4.05,-2.12,;3.22,-4.02,;5.38,-2.89,)| Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 15.4 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250471
(US9464044, 97)Show SMILES CN(c1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1 |r,wU:11.11,TLB:10:11:15:19.17.18,20:18:15:11.12.13,THB:20:12:15:19.17.18,19:14:11:20.17.18,19:18:11:15.14.13,21:18:15:11.12.13,(-3.33,-1.15,;-3.33,.38,;-2,1.15,;-2,2.69,;-.66,3.47,;.67,2.69,;.67,1.15,;-.66,.38,;2,.38,;2,-1.15,;3.34,1.15,;4.67,.38,;6,1.15,;5.25,-.01,;5.23,-2.41,;3.69,-2.41,;4.67,-1.15,;6,-1.93,;7.33,-1.15,;6.44,-3.08,;7.33,.38,;8.67,-1.93,;10,-1.15,;8.67,-3.47,;-4.66,1.15,;-5.75,2.24,;-3.58,2.24,;-6,.38,;-6,-1.15,;-7.33,-1.93,;-8.67,-1.15,;-8.67,.38,;-10,1.15,;-7.33,1.15,)| Show InChI InChI=1S/C25H28ClN3O4S/c1-29(34(32,33)21-7-3-5-19(26)11-21)20-6-2-4-16(10-20)23(30)28-22-17-8-15-9-18(22)14-25(12-15,13-17)24(27)31/h2-7,10-11,15,17-18,22H,8-9,12-14H2,1H3,(H2,27,31)(H,28,30)/t15?,17?,18?,22-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 15.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250442
(US9464044, 37)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(Cl)cc4)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:29.5.6,10:9:29:3.4.30,8:3:29:9.7.6,THB:4:3:9:29.5.6,4:5:9:3.8.30,8:7:29:3.4.30,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-9.29,3.27,;-7.95,.96,;-6.62,.19,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H28ClN3O4S/c23-16-1-3-17(4-2-16)31(29,30)25-12-21(5-6-21)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h1-4,13-15,18,25H,5-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250456
(US9464044, 58)Show SMILES Cn1nccc1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:16.17,TLB:26:23:16:20.19.18,15:16:20:23.24.22,25:23:20:16.17.18,THB:24:23:16:20.19.18,24:19:16:23.25.22,25:17:20:23.24.22,(-4.1,3.66,;-5.44,2.89,;-6.9,3.36,;-7.8,2.12,;-6.9,.87,;-5.44,1.35,;-4.1,.58,;-3.33,1.91,;-4.87,-.76,;-2.77,-.19,;-1.43,.58,;-.66,1.91,;-2.2,1.91,;-.1,-.19,;-.1,-1.73,;1.23,.58,;2.57,-.19,;3.9,.58,;3.15,-.59,;3.13,-2.99,;1.73,-3.63,;2.57,-1.73,;3.9,-2.5,;5.23,-1.73,;4.33,-3.66,;5.23,-.19,;6.72,-2.13,;7.8,-1.04,;7.11,-3.62,)| Show InChI InChI=1S/C19H27N5O4S/c1-24-14(2-5-21-24)29(27,28)23-19(3-4-19)17(26)22-15-12-6-11-7-13(15)10-18(8-11,9-12)16(20)25/h2,5,11-13,15,23H,3-4,6-10H2,1H3,(H2,20,25)(H,22,26)/t11?,12?,13?,15-,18? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250429
(US9464044, 19)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccs4)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:27.5.6,10:9:27:3.4.28,8:3:27:9.7.6,THB:4:3:9:27.5.6,4:5:9:3.8.28,8:7:27:3.4.28,(8.47,-.51,;7.38,-1.6,;7.78,-3.09,;5.9,-1.2,;5,-3.13,;3.8,-2.46,;3.81,-.06,;4.57,1.11,;5.9,.34,;3.23,.34,;1.9,1.11,;.57,.34,;.57,-1.2,;-.77,1.11,;-2.1,.34,;-3.43,1.11,;-4.77,.34,;-5.54,-.99,;-4,-.99,;-6.1,1.11,;-6.1,2.65,;-7.57,3.13,;-8.47,1.88,;-7.57,.63,;0,2.44,;-1.54,2.44,;3.23,-1.2,;2.4,-3.1,;4.57,-1.97,)| Show InChI InChI=1S/C20H27N3O4S2/c21-17(24)20-8-12-6-13(9-20)16(14(7-12)10-20)23-18(25)19(3-4-19)11-22-29(26,27)15-2-1-5-28-15/h1-2,5,12-14,16,22H,3-4,6-11H2,(H2,21,24)(H,23,25)/t12?,13?,14?,16-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250482
(US9464044, 115)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4C(F)(F)F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:34:3.4.35,8:3:34:9.7.6,1:3:9:34.5.6,THB:8:7:34:3.4.35,4:3:9:34.5.6,4:5:9:3.8.35,(9.39,-1.04,;8.3,-2.13,;8.7,-3.62,;6.81,-1.73,;5.92,-3.66,;4.71,-2.99,;4.73,-.59,;5.49,.58,;6.81,-.19,;4.15,-.19,;2.82,.58,;1.49,-.19,;1.49,-1.73,;.15,.58,;.15,2.12,;-1.18,2.89,;-2.52,2.12,;-2.52,.58,;-3.85,-.19,;-5.18,.58,;-5.18,2.12,;-3.85,1.35,;-6.52,-.19,;-6.52,-1.73,;-7.85,-2.5,;-9.18,-1.73,;-9.18,-.19,;-7.85,.58,;-7.85,2.12,;-7.85,3.66,;-9.39,2.12,;-6.31,2.12,;-1.18,-.19,;4.15,-1.73,;3.32,-3.63,;5.49,-2.5,)| Show InChI InChI=1S/C25H26F3N3O4S/c26-25(27,28)19-6-1-2-7-20(19)36(34,35)31-18-5-3-4-15(10-18)22(32)30-21-16-8-14-9-17(21)13-24(11-14,12-16)23(29)33/h1-7,10,14,16-17,21,31H,8-9,11-13H2,(H2,29,33)(H,30,32)/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 19.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250485
(US9464044, 118)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(F)cc(Cl)c4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.46,;8.87,-1.55,;9.26,-3.04,;7.38,-1.15,;6.48,-3.08,;5.28,-2.41,;5.29,-.01,;6.05,1.15,;7.38,.38,;4.72,.38,;3.38,1.15,;2.05,.38,;2.05,-1.15,;.72,1.15,;.72,2.69,;-.62,3.47,;-1.95,2.69,;-1.95,1.15,;-3.29,.38,;-4.62,1.15,;-4.62,2.69,;-3.53,2.24,;-5.95,.38,;-5.95,-1.15,;-7.29,-1.93,;-7.29,-3.47,;-8.62,-1.15,;-8.62,.38,;-9.95,1.15,;-7.29,1.15,;-.62,.38,;4.72,-1.15,;3.88,-3.06,;6.05,-1.93,)| Show InChI InChI=1S/C24H25ClFN3O4S/c25-17-7-18(26)9-20(8-17)34(32,33)29-19-3-1-2-14(6-19)22(30)28-21-15-4-13-5-16(21)12-24(10-13,11-15)23(27)31/h1-3,6-9,13,15-16,21,29H,4-5,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20.4 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250475
(US9464044, 103)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccco4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:29:3.4.30,8:3:29:9.7.6,1:3:9:29.5.6,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(9.14,-.66,;8.05,-1.75,;8.45,-3.23,;6.56,-1.35,;5.67,-3.27,;4.46,-2.6,;4.48,-.2,;5.23,.96,;6.56,.19,;3.9,.19,;2.57,.96,;1.23,.19,;1.23,-1.35,;-.1,.96,;-.1,2.5,;-1.43,3.27,;-2.77,2.5,;-2.77,.96,;-4.1,.19,;-5.44,.96,;-5.44,2.5,;-4.35,2.05,;-6.77,.19,;-6.77,-1.35,;-8.23,-1.82,;-9.14,-.58,;-8.23,.67,;-1.43,.19,;3.9,-1.35,;3.07,-3.25,;5.23,-2.12,)| Show InChI InChI=1S/C22H25N3O5S/c23-21(27)22-10-13-7-15(11-22)19(16(8-13)12-22)24-20(26)14-3-1-4-17(9-14)25-31(28,29)18-5-2-6-30-18/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H2,23,27)(H,24,26)/t13?,15?,16?,19-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250428
(US9464044, 18)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(Cl)cc(Cl)c4)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-1.43,;8.2,-2.52,;8.6,-4,;6.71,-2.12,;5.81,-4.04,;4.61,-3.37,;4.63,-.97,;5.38,.19,;6.71,-.58,;4.05,-.58,;2.72,.19,;1.38,-.58,;1.38,-2.12,;.05,.19,;-1.29,-.58,;-2.62,.19,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-5.29,.19,;-5.29,1.73,;-6.62,2.5,;-6.62,4.04,;-7.95,1.73,;-7.95,.19,;-9.29,-.58,;-6.62,-.58,;.82,1.53,;-.72,1.53,;4.05,-2.12,;3.22,-4.02,;5.38,-2.89,)| Show InChI InChI=1S/C22H27Cl2N3O4S/c23-15-5-16(24)7-17(6-15)32(30,31)26-11-21(1-2-21)20(29)27-18-13-3-12-4-14(18)10-22(8-12,9-13)19(25)28/h5-7,12-14,18,26H,1-4,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23.9 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112136
(CHEMBL3609864 | US9464044, 39)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccccc1F)C(C3)C2 |r,wD:9.10,TLB:28:27:8:4.6.5,THB:28:5:8:9.27.29,10:9:8:4.6.5,9:27:4:8.6.7,9:7:4:27.28.29,(3.78,.15,;3.07,1.15,;3.59,2.27,;1.56,1.02,;1.56,2.59,;.12,3.07,;-1,2.05,;-.95,.32,;.56,-.22,;-2.19,-.22,;-3.39,-1.17,;-4.82,-.59,;-4.99,.63,;-6.03,-1.55,;-5.1,-2.62,;-6.62,-2.84,;-7.46,-.97,;-7.68,.55,;-6.54,.09,;-6.71,1.31,;-9.11,1.12,;-9.33,2.65,;-10.76,3.22,;-11.97,2.27,;-11.75,.74,;-10.32,.17,;-10.15,-1.05,;-1.2,1.02,;-1.2,2.69,;.34,.44,)| Show InChI InChI=1S/C21H26FN3O4S/c22-15-3-1-2-4-16(15)30(28,29)25-21(5-6-21)19(27)24-17-13-7-12-8-14(17)11-20(9-12,10-13)18(23)26/h1-4,12-14,17,25H,5-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 24.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250415
(US9464044, 2)Show SMILES OC12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 |r,wU:7.8,TLB:6:1:27:7.5.4,8:7:27:1.2.28,THB:6:5:27:1.2.28,2:1:7:27.3.4,2:3:7:1.6.28,0:1:27:7.5.4,(8,-2.12,;6.67,-1.35,;5.77,-3.27,;4.57,-2.6,;4.58,-.2,;5.34,.96,;6.67,.19,;4,.19,;2.67,.96,;1.34,.19,;1.34,-1.35,;0,.96,;-1.33,.19,;-2.66,.96,;-4,.19,;-4.77,-1.14,;-3.23,-1.14,;-5.33,.96,;-5.33,2.5,;-6.67,3.27,;-8,2.5,;-8,.96,;-6.67,.19,;-6.67,-1.35,;.77,2.3,;-.77,2.3,;4,-1.35,;3.17,-3.25,;5.34,-2.12,)| Show InChI InChI=1S/C21H27FN2O4S/c22-16-3-1-2-4-17(16)29(27,28)23-12-20(5-6-20)19(25)24-18-14-7-13-8-15(18)11-21(26,9-13)10-14/h1-4,13-15,18,23,26H,5-12H2,(H,24,25)/t13?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 26.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250487
(US9464044, 120)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(F)c4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,1:3:9:31.5.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-8.62,.19,;-9.95,.96,;-7.29,.96,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H26FN3O4S/c25-18-4-2-6-20(10-18)33(31,32)28-19-5-1-3-15(9-19)22(29)27-21-16-7-14-8-17(21)13-24(11-14,12-16)23(26)30/h1-6,9-10,14,16-17,21,28H,7-8,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 27.2 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250425
(US9464044, 15)Show SMILES Cc1cc(c(F)cc1Cl)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:20.21,TLB:19:20:24:27.28.26,29:27:24:20.21.22,30:27:20:24.23.22,THB:29:21:24:27.28.26,28:27:20:24.23.22,28:23:20:27.29.26,(-6.62,4.04,;-6.62,2.5,;-5.29,1.73,;-5.29,.19,;-6.62,-.58,;-6.62,-2.12,;-7.95,.19,;-7.95,1.73,;-9.29,2.5,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-2.62,.19,;-1.29,-.58,;.05,.19,;.82,1.53,;-.72,1.53,;1.38,-.58,;1.38,-2.12,;2.72,.19,;4.05,-.58,;5.38,.19,;4.63,-.97,;4.61,-3.37,;3.22,-4.02,;4.05,-2.12,;5.38,-2.89,;6.71,-2.12,;5.81,-4.04,;6.71,-.58,;8.2,-2.52,;9.29,-1.43,;8.6,-4,)| Show InChI InChI=1S/C23H29ClFN3O4S/c1-12-4-18(17(25)7-16(12)24)33(31,32)27-11-22(2-3-22)21(30)28-19-14-5-13-6-15(19)10-23(8-13,9-14)20(26)29/h4,7,13-15,19,27H,2-3,5-6,8-11H2,1H3,(H2,26,29)(H,28,30)/t13?,14?,15?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250464
(US9464044, 69)Show SMILES CC(C)(CNS(=O)(=O)c1ccccc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:17.17,TLB:27:24:17:21.20.19,16:17:21:24.25.23,26:24:21:17.18.19,THB:26:18:21:24.25.23,25:24:17:21.20.19,25:20:17:24.26.23,(.72,1.73,;-.62,.96,;-1.39,2.3,;-1.95,.19,;-3.29,.96,;-4.62,.19,;-4.62,-1.35,;-4.62,1.73,;-5.95,.96,;-5.95,2.5,;-7.29,3.27,;-8.62,2.5,;-8.62,.96,;-7.29,.19,;.72,.19,;.72,-1.35,;2.05,.96,;3.38,.19,;4.72,.96,;3.96,-.2,;3.94,-2.6,;2.55,-3.25,;3.38,-1.35,;4.72,-2.12,;6.04,-1.35,;5.15,-3.27,;6.04,.19,;7.53,-1.75,;8.62,-.66,;7.93,-3.23,)| Show InChI InChI=1S/C22H31N3O4S/c1-21(2,13-24-30(28,29)17-6-4-3-5-7-17)20(27)25-18-15-8-14-9-16(18)12-22(10-14,11-15)19(23)26/h3-7,14-16,18,24H,8-13H2,1-2H3,(H2,23,26)(H,25,27)/t14?,15?,16?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250447
(US9464044, 43)Show SMILES Cc1cc(c(Cl)cc1Cl)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:19.20,TLB:28:26:23:19.20.21,29:26:19:23.22.21,18:19:23:26.27.25,THB:28:20:23:26.27.25,27:26:19:23.22.21,27:22:19:26.28.25,(-5.95,4.43,;-5.95,2.89,;-4.62,2.12,;-4.62,.58,;-5.95,-.19,;-5.95,-1.73,;-7.29,.58,;-7.29,2.12,;-8.62,2.89,;-3.29,-.19,;-2.52,1.14,;-4.06,-1.53,;-1.95,-.96,;-.62,-.19,;.15,1.14,;-1.39,1.14,;.72,-.96,;.72,-2.5,;2.05,-.19,;3.38,-.96,;4.72,-.19,;3.96,-1.36,;3.94,-3.76,;2.55,-4.4,;3.38,-2.5,;4.72,-3.27,;6.04,-2.5,;5.15,-4.43,;6.04,-.96,;7.53,-2.9,;8.62,-1.81,;7.93,-4.39,)| Show InChI InChI=1S/C22H27Cl2N3O4S/c1-11-4-17(16(24)7-15(11)23)32(30,31)27-22(2-3-22)20(29)26-18-13-5-12-6-14(18)10-21(8-12,9-13)19(25)28/h4,7,12-14,18,27H,2-3,5-6,8-10H2,1H3,(H2,25,28)(H,26,29)/t12?,13?,14?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 29.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250440
(US9464044, 34)Show SMILES NC(=O)CCC12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2 |r,wU:11.12,TLB:4:5:11:31.7.8,12:11:31:5.6.32,10:5:31:11.9.8,THB:6:5:11:31.7.8,6:7:11:5.10.32,10:9:31:5.6.32,(9.91,.03,;8.82,-1.06,;9.22,-2.54,;7.33,-.66,;6.24,-1.75,;4.76,-1.35,;3.86,-3.27,;2.66,-2.6,;2.67,-.2,;3.43,.96,;4.76,.19,;2.09,.19,;.76,.96,;-.57,.19,;-.57,-1.35,;-1.91,.96,;-3.24,.19,;-4.57,.96,;-5.91,.19,;-6.68,-1.14,;-5.14,-1.14,;-7.24,.96,;-7.24,2.5,;-8.58,3.27,;-9.91,2.5,;-9.91,.96,;-8.58,.19,;-8.58,-1.35,;-1.14,2.3,;-2.68,2.3,;2.09,-1.35,;1.26,-3.25,;3.43,-2.12,)| Show InChI InChI=1S/C24H32FN3O4S/c25-18-3-1-2-4-19(18)33(31,32)27-14-24(7-8-24)22(30)28-21-16-9-15-10-17(21)13-23(11-15,12-16)6-5-20(26)29/h1-4,15-17,21,27H,5-14H2,(H2,26,29)(H,28,30)/t15?,16?,17?,21-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 29.9 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250481
(US9464044, 114)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(c(Cl)c4)C(F)(F)F)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:35:3.4.36,8:3:35:9.7.6,1:3:9:35.5.6,THB:8:7:35:3.4.36,4:3:9:35.5.6,4:5:9:3.8.36,(10.62,-.57,;9.53,-1.66,;9.93,-3.14,;8.04,-1.26,;7.15,-3.18,;5.95,-2.52,;5.96,-.11,;6.72,1.05,;8.04,.28,;5.38,.28,;4.05,1.05,;2.72,.28,;2.72,-1.26,;1.38,1.05,;1.38,2.59,;.05,3.36,;-1.29,2.59,;-1.29,1.05,;-2.62,.28,;-3.95,1.05,;-3.95,2.59,;-2.86,2.14,;-5.29,.28,;-5.29,-1.26,;-6.62,-2.03,;-8.08,-1.32,;-7.95,.28,;-9.29,1.05,;-6.62,1.05,;-9.42,-2.08,;-10.75,-2.85,;-10.18,-.75,;-8.65,-3.42,;.05,.28,;5.38,-1.26,;4.55,-3.16,;6.72,-2.03,)| Show InChI InChI=1S/C25H25ClF3N3O4S/c26-20-9-18(4-5-19(20)25(27,28)29)37(35,36)32-17-3-1-2-14(8-17)22(33)31-21-15-6-13-7-16(21)12-24(10-13,11-15)23(30)34/h1-5,8-9,13,15-16,21,32H,6-7,10-12H2,(H2,30,34)(H,31,33)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250431
(US9464044, 21)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-9.29,3.27,;-7.95,.96,;-9.29,.19,;-6.62,.19,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H27F2N3O4S/c23-16-2-1-15(7-17(16)24)32(30,31)26-11-21(3-4-21)20(29)27-18-13-5-12-6-14(18)10-22(8-12,9-13)19(25)28/h1-2,7,12-14,18,26H,3-6,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250449
(US9464044, 45)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cc(Cl)c(Cl)cc1F)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(8.62,-1.81,;7.53,-2.9,;7.93,-4.39,;6.04,-2.5,;5.15,-4.43,;3.94,-3.76,;3.96,-1.36,;4.72,-.19,;6.04,-.96,;3.38,-.96,;2.05,-.19,;.72,-.96,;.72,-2.5,;-.62,-.19,;.15,1.14,;-1.39,1.14,;-1.95,-.96,;-3.29,-.19,;-2.52,1.14,;-4.06,-1.53,;-4.62,.58,;-4.62,2.12,;-5.95,2.89,;-5.95,4.43,;-7.29,2.12,;-8.62,2.89,;-7.29,.58,;-5.95,-.19,;-5.95,-1.73,;3.38,-2.5,;2.55,-4.4,;4.72,-3.27,)| Show InChI InChI=1S/C21H24Cl2FN3O4S/c22-13-5-15(24)16(6-14(13)23)32(30,31)27-21(1-2-21)19(29)26-17-11-3-10-4-12(17)9-20(7-10,8-11)18(25)28/h5-6,10-12,17,27H,1-4,7-9H2,(H2,25,28)(H,26,29)/t10?,11?,12?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 32.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50112144
(CHEMBL3609872 | US9464044, 88)Show SMILES CC(C)(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:17.17,TLB:21:22:26:25.19.20,21:20:26:17.22.23,17:18:25:22.21.23,THB:16:17:26:25.19.20,17:22:25:26.19.18,(-7,-2.31,;-6.03,-1.55,;-5.85,-2.77,;-7.46,-.97,;-8.67,-1.93,;-7.53,-2.38,;-8.49,-3.15,;-10.1,-1.35,;-11.31,-2.31,;-12.74,-1.74,;-12.96,-.21,;-14.11,.25,;-11.75,.74,;-10.32,.17,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| Show InChI InChI=1S/C21H28ClN3O4S/c1-20(2,25-30(28,29)16-5-3-15(22)4-6-16)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)26/h3-6,12-14,17,25H,7-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 33.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250450
(US9464044, 46)Show SMILES Cc1cc(c(F)cc1Cl)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:19.20,TLB:28:26:23:19.20.21,29:26:19:23.22.21,18:19:23:26.27.25,THB:28:20:23:26.27.25,27:26:19:23.22.21,27:22:19:26.28.25,(-5.95,4.43,;-5.95,2.89,;-4.62,2.12,;-4.62,.58,;-5.95,-.19,;-5.95,-1.73,;-7.29,.58,;-7.29,2.12,;-8.62,2.89,;-3.29,-.19,;-2.52,1.14,;-4.06,-1.53,;-1.95,-.96,;-.62,-.19,;.15,1.14,;-1.39,1.14,;.72,-.96,;.72,-2.5,;2.05,-.19,;3.38,-.96,;4.72,-.19,;3.96,-1.36,;3.94,-3.76,;2.55,-4.4,;3.38,-2.5,;4.72,-3.27,;6.04,-2.5,;5.15,-4.43,;6.04,-.96,;7.53,-2.9,;8.62,-1.81,;7.93,-4.39,)| Show InChI InChI=1S/C22H27ClFN3O4S/c1-11-4-17(16(24)7-15(11)23)32(30,31)27-22(2-3-22)20(29)26-18-13-5-12-6-14(18)10-21(8-12,9-13)19(25)28/h4,7,12-14,18,27H,2-3,5-6,8-10H2,1H3,(H2,25,28)(H,26,29)/t12?,13?,14?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 34.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250494
(US9464044, 129)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)ccc1Cl)C(C3)C2 |r,wU:9.10,TLB:10:9:33:3.4.34,8:3:33:9.7.6,1:3:9:33.5.6,THB:8:7:33:3.4.34,4:3:9:33.5.6,4:5:9:3.8.34,(9.95,-.46,;8.87,-1.55,;9.26,-3.04,;7.38,-1.16,;6.48,-3.08,;5.28,-2.41,;5.29,-.01,;6.05,1.15,;7.38,.38,;4.72,.38,;3.38,1.15,;2.05,.38,;2.05,-1.16,;.72,1.15,;-.62,.38,;-1.95,1.15,;-3.29,.38,;-4.62,1.15,;-4.62,2.69,;-3.53,2.24,;-5.95,.38,;-7.29,1.15,;-8.62,.38,;-9.95,1.16,;-8.62,-1.16,;-7.29,-1.93,;-7.29,-3.46,;-5.95,-1.16,;-1.95,2.69,;-.62,3.46,;.72,2.69,;2.05,3.46,;4.72,-1.16,;3.88,-3.06,;6.05,-1.93,)| Show InChI InChI=1S/C24H24Cl3N3O4S/c25-15-5-16(26)7-18(6-15)35(33,34)30-17-1-2-20(27)19(8-17)22(31)29-21-13-3-12-4-14(21)11-24(9-12,10-13)23(28)32/h1-2,5-8,12-14,21,30H,3-4,9-11H2,(H2,28,32)(H,29,31)/t12?,13?,14?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 41.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250476
(US9464044, 105)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:30:3.4.31,8:3:30:9.7.6,1:3:9:30.5.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;.05,2.5,;-1.29,3.27,;-2.62,2.5,;-2.62,.96,;-3.95,.19,;-5.29,.96,;-5.29,2.5,;-4.2,2.05,;-6.62,.19,;-7.95,.96,;-9.29,.19,;-9.29,-1.35,;-7.95,-2.12,;-6.62,-1.35,;-1.29,.19,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C24H27N3O4S/c25-23(29)24-12-15-9-17(13-24)21(18(10-15)14-24)26-22(28)16-5-4-6-19(11-16)27-32(30,31)20-7-2-1-3-8-20/h1-8,11,15,17-18,21,27H,9-10,12-14H2,(H2,25,29)(H,26,28)/t15?,17?,18?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 42.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250479
(US9464044, 108)Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)Nc1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:20.21,TLB:19:20:24:27.28.26,29:27:24:20.21.22,30:27:20:24.23.22,THB:29:21:24:27.28.26,28:27:20:24.23.22,28:23:20:27.29.26,(-5.44,-2.12,;-6.77,-1.35,;-8.23,-1.82,;-9.14,-.58,;-8.23,.67,;-8.63,2.16,;-6.77,.19,;-5.44,.96,;-5.44,2.5,;-4.35,2.05,;-4.1,.19,;-2.77,.96,;-2.77,2.5,;-1.43,3.27,;-.1,2.5,;-.1,.96,;-1.43,.19,;1.23,.19,;1.23,-1.35,;2.57,.96,;3.9,.19,;5.23,.96,;4.48,-.2,;4.46,-2.6,;3.07,-3.25,;3.9,-1.35,;5.23,-2.12,;6.56,-1.35,;5.67,-3.27,;6.56,.19,;8.05,-1.75,;9.14,-.66,;8.45,-3.23,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 51.2 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250499
(US9464044, 141)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCCc5ccccc45)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,1:3:31:9.7.6,(9.33,-1.26,;8,-2.03,;8.77,-3.36,;6.67,-1.26,;5.77,-3.18,;4.57,-2.52,;4.58,-.11,;5.34,1.05,;6.67,.28,;4,.28,;2.67,1.05,;1.34,.28,;1.34,-1.26,;0,1.05,;-1.33,.28,;-2.66,1.05,;-4,.28,;-4,-1.26,;-5.33,1.05,;-5.33,2.59,;-6.67,3.36,;-8,2.59,;-8,1.05,;-9.33,.28,;-9.33,-1.26,;-8,-2.03,;-6.67,-1.26,;-6.67,.28,;.77,2.39,;-.77,2.39,;4,-1.26,;3.17,-3.16,;5.34,-2.03,)| Show InChI InChI=1S/C26H34N4O3/c27-22(31)26-12-16-10-18(13-26)21(19(11-16)14-26)29-23(32)25(7-8-25)15-28-24(33)30-9-3-5-17-4-1-2-6-20(17)30/h1-2,4,6,16,18-19,21H,3,5,7-15H2,(H2,27,31)(H,28,33)(H,29,32)/t16?,18?,19?,21-,26? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 52.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250467
(US9464044, 75)Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(\N)=N/O |r,wU:17.17,TLB:27:24:17:21.20.19,16:17:21:24.25.23,26:24:21:17.18.19,THB:25:24:17:21.20.19,25:20:17:24.26.23,26:18:21:24.25.23,(-.52,3.21,;-1.29,1.87,;-2.06,3.21,;-2.62,1.1,;-3.95,1.87,;-3.95,3.41,;-3.95,.33,;-5.29,1.1,;-5.29,-.44,;-6.62,-1.21,;-7.95,-.44,;-7.95,1.1,;-6.62,1.87,;-6.62,3.41,;.05,1.1,;.05,-.44,;1.38,1.87,;2.72,1.1,;4.05,1.87,;3.29,.71,;3.28,-1.69,;1.88,-2.34,;2.72,-.44,;4.05,-1.21,;5.38,-.44,;4.48,-2.36,;5.38,1.1,;6.86,-.84,;7.95,.25,;7.26,-2.32,;6.17,-3.41,)| Show InChI InChI=1S/C21H29FN4O4S/c1-20(2,26-31(29,30)16-6-4-3-5-15(16)22)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-28/h3-6,12-14,17,26,28H,7-11H2,1-2H3,(H2,23,25)(H,24,27)/t12?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 54.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250443
(US9464044, 38)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccc(Cl)c1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:28.5.6,10:9:28:3.4.29,8:3:28:9.7.6,THB:8:7:28:3.4.29,4:3:9:28.5.6,4:5:9:3.8.29,(8.61,-1.04,;7.52,-2.13,;7.92,-3.62,;6.04,-1.73,;5.14,-3.66,;3.94,-2.99,;3.95,-.59,;4.71,.58,;6.04,-.19,;3.38,-.19,;2.04,.58,;.71,-.19,;.71,-1.73,;-.63,.58,;.14,1.91,;-1.4,1.91,;-1.96,-.19,;-3.28,.58,;-2.51,1.91,;-4.05,-.75,;-4.61,1.35,;-4.61,2.89,;-5.95,3.66,;-7.28,2.89,;-7.28,1.35,;-8.61,.58,;-5.95,.58,;3.38,-1.73,;2.54,-3.63,;4.71,-2.5,)| Show InChI InChI=1S/C21H26ClN3O4S/c22-15-2-1-3-16(8-15)30(28,29)25-21(4-5-21)19(27)24-17-13-6-12-7-14(17)11-20(9-12,10-13)18(23)26/h1-3,8,12-14,17,25H,4-7,9-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 58.6 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250478
(US9464044, 107)Show SMILES Cc1nc(C)c(s1)S(=O)(=O)Nc1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wU:20.21,TLB:19:20:24:27.28.26,29:27:24:20.21.22,30:27:20:24.23.22,THB:29:21:24:27.28.26,28:27:20:24.23.22,28:23:20:27.29.26,(-9.91,-.58,;-8.37,-.58,;-7.46,-1.82,;-6,-1.35,;-4.67,-2.12,;-6,.19,;-7.46,.67,;-4.67,.96,;-4.67,2.5,;-3.58,2.05,;-3.33,.19,;-2,.96,;-2,2.5,;-.66,3.27,;.67,2.5,;.67,.96,;-.66,.19,;2,.19,;2,-1.35,;3.34,.96,;4.67,.19,;6,.96,;5.25,-.2,;5.23,-2.6,;3.84,-3.25,;4.67,-1.35,;6,-2.12,;7.33,-1.35,;6.44,-3.27,;7.33,.19,;8.82,-1.75,;9.91,-.66,;9.22,-3.23,)| Show InChI InChI=1S/C23H28N4O4S2/c1-12-21(32-13(2)25-12)33(30,31)27-18-5-3-4-15(8-18)20(28)26-19-16-6-14-7-17(19)11-23(9-14,10-16)22(24)29/h3-5,8,14,16-17,19,27H,6-7,9-11H2,1-2H3,(H2,24,29)(H,26,28)/t14?,16?,17?,19-,23? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 60.3 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250497
(US9464044, 138)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)C4CC4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:27:3.4.28,8:3:27:9.7.6,1:3:9:27.5.6,THB:8:7:27:3.4.28,4:3:9:27.5.6,4:5:9:3.8.28,(8.72,-.66,;7.63,-1.75,;8.03,-3.23,;6.15,-1.35,;5.25,-3.27,;4.05,-2.6,;4.06,-.2,;4.82,.96,;6.15,.19,;3.49,.19,;2.15,.96,;.82,.19,;.82,-1.35,;-.52,.96,;-.52,2.5,;-1.85,3.27,;-3.18,2.5,;-3.18,.96,;-4.52,.19,;-5.85,.96,;-5.85,2.5,;-7.18,1.73,;-7.18,.19,;-8.72,.19,;-7.95,-1.14,;-1.85,.19,;3.49,-1.35,;2.65,-3.25,;4.82,-2.12,)| Show InChI InChI=1S/C21H27N3O4S/c22-20(26)21-9-12-6-14(10-21)18(15(7-12)11-21)23-19(25)13-2-1-3-16(8-13)24-29(27,28)17-4-5-17/h1-3,8,12,14-15,17-18,24H,4-7,9-11H2,(H2,22,26)(H,23,25)/t12?,14?,15?,18-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 62.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250452
(US9464044, 48)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccs1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:26.5.6,10:9:26:3.4.27,8:3:26:9.7.6,THB:4:3:9:26.5.6,4:5:9:3.8.27,8:7:26:3.4.27,(7.8,-.89,;6.72,-1.98,;7.11,-3.47,;5.23,-1.59,;4.33,-3.51,;3.13,-2.84,;3.15,-.44,;3.9,.72,;5.23,-.05,;2.57,-.05,;1.23,.72,;-.1,-.05,;-.1,-1.59,;-1.43,.72,;-.66,2.06,;-2.2,2.06,;-2.77,-.05,;-4.1,.72,;-3.33,2.06,;-4.87,-.61,;-5.44,1.49,;-5.44,3.03,;-6.9,3.51,;-7.8,2.26,;-6.9,1.02,;2.57,-1.59,;1.73,-3.49,;3.9,-2.36,)| Show InChI InChI=1S/C19H25N3O4S2/c20-16(23)18-8-11-6-12(9-18)15(13(7-11)10-18)21-17(24)19(3-4-19)22-28(25,26)14-2-1-5-27-14/h1-2,5,11-13,15,22H,3-4,6-10H2,(H2,20,23)(H,21,24)/t11?,12?,13?,15-,18? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 62.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250492
(US9464044, 126)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cc(NS(=O)(=O)c4cccc(Cl)c4)ccc1Cl)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;-.62,.19,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-8.62,.19,;-9.95,.96,;-7.29,.96,;-1.95,2.5,;-.62,3.27,;.72,2.5,;2.05,3.27,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25Cl2N3O4S/c25-16-2-1-3-18(8-16)34(32,33)29-17-4-5-20(26)19(9-17)22(30)28-21-14-6-13-7-15(21)12-24(10-13,11-14)23(27)31/h1-5,8-9,13-15,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,14?,15?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 67.5 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250441
(US9464044, 36)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)c(F)cc4F)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:31.5.6,10:9:31:3.4.32,8:3:31:9.7.6,THB:4:3:9:31.5.6,4:5:9:3.8.32,8:7:31:3.4.32,(9.29,-1.43,;8.2,-2.52,;8.6,-4,;6.71,-2.12,;5.81,-4.04,;4.61,-3.37,;4.63,-.97,;5.38,.19,;6.71,-.58,;4.05,-.58,;2.72,.19,;1.38,-.58,;1.38,-2.12,;.05,.19,;-1.29,-.58,;-2.62,.19,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-5.29,.19,;-5.29,1.73,;-6.62,2.5,;-6.62,4.04,;-7.95,1.73,;-9.29,2.5,;-7.95,.19,;-6.62,-.58,;-6.62,-2.12,;.82,1.53,;-.72,1.53,;4.05,-2.12,;3.22,-4.02,;5.38,-2.89,)| Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250469
(US9464044, 94)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:4.32.3,8:3:31:9.7.6,THB:8:7:31:4.32.3,4:5:9:8.32.3,4:3:9:31.5.6,1:3:31:9.7.6,(10,-1.15,;8.67,-1.93,;8.67,-3.47,;7.33,-1.15,;6.44,-3.08,;5.23,-2.41,;5.25,-.01,;6,1.15,;7.33,.38,;4.67,.38,;3.34,1.15,;2,.38,;2,-1.15,;.67,1.15,;.67,2.69,;-.66,3.47,;-2,2.69,;-2,1.15,;-3.33,.38,;-4.66,1.15,;-5.75,2.24,;-3.58,2.24,;-6,.38,;-7.33,1.15,;-8.67,.38,;-8.67,-1.15,;-10,-1.93,;-7.33,-1.93,;-6,-1.15,;-.66,.38,;4.67,-1.15,;3.69,-2.41,;6,-1.93,)| Show InChI InChI=1S/C24H26FN3O4S/c25-18-4-6-20(7-5-18)33(31,32)28-19-3-1-2-15(10-19)22(29)27-21-16-8-14-9-17(21)13-24(11-14,12-16)23(26)30/h1-7,10,14,16-17,21,28H,8-9,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 75.7 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250493
(US9464044, 127)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1ccc(F)c(NS(=O)(=O)c4cccc(Cl)c4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-3.29,3.27,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-8.62,.19,;-9.95,.96,;-7.29,.96,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25ClFN3O4S/c25-17-2-1-3-18(9-17)34(32,33)29-20-8-14(4-5-19(20)26)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 78.3 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250448
(US9464044, 44)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)cc1F)C(C3)C2 |r,wU:9.10,TLB:8:3:29:9.7.6,1:3:9:29.5.6,10:9:29:3.4.30,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(8.62,-1.04,;7.53,-2.13,;7.93,-3.62,;6.04,-1.73,;5.15,-3.66,;3.94,-2.99,;3.96,-.59,;4.72,.58,;6.04,-.19,;3.38,-.19,;2.05,.58,;.72,-.19,;.72,-1.73,;-.62,.58,;.15,1.91,;-1.39,1.91,;-1.95,-.19,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-8.62,3.66,;-7.29,1.35,;-5.95,.58,;-5.95,-.96,;3.38,-1.73,;2.55,-3.63,;4.72,-2.5,)| Show InChI InChI=1S/C21H25F2N3O4S/c22-14-1-2-16(15(23)7-14)31(29,30)26-21(3-4-21)19(28)25-17-12-5-11-6-13(17)10-20(8-11,9-12)18(24)27/h1-2,7,11-13,17,26H,3-6,8-10H2,(H2,24,27)(H,25,28)/t11?,12?,13?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 79.1 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250498
(US9464044, 140)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCc5ccccc5C4)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:31.5.6,10:9:31:3.4.32,8:3:31:9.7.6,THB:4:3:9:31.5.6,4:5:9:3.8.32,8:7:31:3.4.32,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;-.62,.19,;-1.95,.96,;-3.29,.19,;-3.29,-1.35,;-4.62,.96,;-4.62,2.5,;-5.95,3.27,;-7.29,2.5,;-8.62,3.27,;-9.95,2.5,;-9.95,.96,;-8.62,.19,;-7.29,.96,;-5.95,.19,;1.49,2.3,;-.05,2.3,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C26H34N4O3/c27-22(31)26-11-16-9-19(12-26)21(20(10-16)13-26)29-23(32)25(6-7-25)15-28-24(33)30-8-5-17-3-1-2-4-18(17)14-30/h1-4,16,19-21H,5-15H2,(H2,27,31)(H,28,33)(H,29,32)/t16?,19?,20?,21-,26? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 97.8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250430
(US9464044, 20)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(F)cc4C(F)(F)F)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:33:9.7.6,1:3:9:33.5.6,10:9:33:3.4.34,THB:8:7:33:3.4.34,4:3:9:33.5.6,4:5:9:3.8.34,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-9.29,3.27,;-7.95,.96,;-6.62,.14,;-6.62,-1.4,;-6.62,-2.94,;-5.16,-1.88,;-8.16,-1.4,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C23H27F4N3O4S/c24-15-1-2-17(16(7-15)23(25,26)27)35(33,34)29-11-21(3-4-21)20(32)30-18-13-5-12-6-14(18)10-22(8-12,9-13)19(28)31/h1-2,7,12-14,18,29H,3-6,8-11H2,(H2,28,31)(H,30,32)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250462
(US9464044, 64)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccc(cn1)C(F)(F)F)C(C3)C2 |r,wU:9.10,TLB:1:3:9:30.5.6,10:9:30:3.4.31,8:3:30:9.7.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.18,;8.2,-1.27,;8.6,-2.76,;6.71,-.87,;5.81,-2.8,;4.61,-2.13,;4.63,.27,;5.38,1.44,;6.71,.67,;4.05,.67,;2.72,1.44,;1.38,.67,;1.38,-.87,;.05,1.44,;.82,2.77,;-.72,2.77,;-1.29,.67,;-2.62,1.44,;-2.62,2.98,;-3.95,.67,;-5.29,1.44,;-6.62,.67,;-6.62,-.87,;-5.29,-1.64,;-3.95,-.87,;-7.95,-1.64,;-9.29,-2.41,;-8.72,-.31,;-7.18,-2.98,;4.05,-.87,;3.22,-2.77,;5.38,-1.64,)| Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)14-1-2-15(27-10-14)17(30)29-21(3-4-21)19(32)28-16-12-5-11-6-13(16)9-20(7-11,8-12)18(26)31/h1-2,10-13,16H,3-9H2,(H2,26,31)(H,28,32)(H,29,30)/t11?,12?,13?,16-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250500
(US9464044, 146)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCNc5ccccc45)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,1:3:31:9.7.6,(9.33,-1.26,;8,-2.03,;8.77,-3.36,;6.67,-1.26,;5.77,-3.18,;4.57,-2.52,;4.58,-.11,;5.34,1.05,;6.67,.28,;4,.28,;2.67,1.05,;1.34,.28,;1.34,-1.26,;0,1.05,;-1.33,.28,;-2.66,1.05,;-4,.28,;-4,-1.26,;-5.33,1.05,;-5.33,2.59,;-6.67,3.36,;-8,2.59,;-8,1.05,;-9.33,.28,;-9.33,-1.26,;-8,-2.03,;-6.67,-1.26,;-6.67,.28,;.77,2.39,;-.77,2.39,;4,-1.26,;3.17,-3.16,;5.34,-2.03,)| Show InChI InChI=1S/C25H33N5O3/c26-21(31)25-11-15-9-16(12-25)20(17(10-15)13-25)29-22(32)24(5-6-24)14-28-23(33)30-8-7-27-18-3-1-2-4-19(18)30/h1-4,15-17,20,27H,5-14H2,(H2,26,31)(H,28,33)(H,29,32)/t15?,16?,17?,20-,25? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250427
(US9464044, 17)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccco4)CC1)C(C3)C2 |r,wU:9.10,TLB:1:3:9:27.5.6,10:9:27:3.4.28,8:3:27:9.7.6,THB:4:3:9:27.5.6,4:5:9:3.8.28,8:7:27:3.4.28,(8.47,-.51,;7.38,-1.6,;7.78,-3.09,;5.9,-1.2,;5,-3.13,;3.8,-2.46,;3.81,-.06,;4.57,1.11,;5.9,.34,;3.23,.34,;1.9,1.11,;.57,.34,;.57,-1.2,;-.77,1.11,;-2.1,.34,;-3.43,1.11,;-4.77,.34,;-5.54,-.99,;-4,-.99,;-6.1,1.11,;-6.1,2.65,;-7.57,3.13,;-8.47,1.88,;-7.57,.63,;0,2.44,;-1.54,2.44,;3.23,-1.2,;2.4,-3.1,;4.57,-1.97,)| Show InChI InChI=1S/C20H27N3O5S/c21-17(24)20-8-12-6-13(9-20)16(14(7-12)10-20)23-18(25)19(3-4-19)11-22-29(26,27)15-2-1-5-28-15/h1-2,5,12-14,16,22H,3-4,6-11H2,(H2,21,24)(H,23,25)/t12?,13?,14?,16-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250468
(US9464044, 92)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccccc1F)C(C3)C2 |r,wU:9.10,TLB:10:9:31:3.4.32,8:3:31:9.7.6,1:3:9:31.5.6,THB:8:7:31:3.4.32,4:3:9:31.5.6,4:5:9:3.8.32,(7.95,-.46,;6.86,-1.55,;7.26,-3.04,;5.38,-1.15,;4.48,-3.08,;3.28,-2.41,;3.29,-.01,;4.05,1.15,;5.38,.38,;2.72,.38,;1.38,1.15,;.05,.38,;.05,-1.15,;-1.29,1.15,;-1.29,2.69,;-2.62,3.47,;-3.95,2.69,;-3.95,1.15,;-2.62,.38,;-2.62,-1.15,;-3.95,-1.93,;-3.95,-3.47,;-5.04,-3.01,;-5.29,-1.15,;-5.29,.38,;-6.62,1.15,;-7.95,.38,;-7.95,-1.15,;-6.62,-1.93,;-6.62,-3.47,;2.72,-1.15,;1.88,-3.06,;4.05,-1.93,)| Show InChI InChI=1S/C24H26FN3O4S/c25-18-6-2-4-8-20(18)33(31,32)28-19-7-3-1-5-17(19)22(29)27-21-15-9-14-10-16(21)13-24(11-14,12-15)23(26)30/h1-8,14-16,21,28H,9-13H2,(H2,26,30)(H,27,29)/t14?,15?,16?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250495
(US9464044, 132)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(Cl)c4)c1F)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-4.62,-.58,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-8.62,.19,;-9.95,.96,;-7.29,.96,;-.62,.19,;-.62,-1.35,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25ClFN3O4S/c25-16-3-1-4-17(9-16)34(32,33)29-19-6-2-5-18(20(19)26)22(30)28-21-14-7-13-8-15(21)12-24(10-13,11-14)23(27)31/h1-6,9,13-15,21,29H,7-8,10-12H2,(H2,27,31)(H,28,30)/t13?,14?,15?,21-,24? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250421
(US9464044, 11 | US9464044, 24)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(F)c4F)CC1)C(C3)C2 |r,wU:9.10,TLB:10:9:30:3.4.31,8:3:30:9.7.6,1:3:9:30.5.6,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-.66,;8.2,-1.75,;8.6,-3.23,;6.71,-1.35,;5.81,-3.27,;4.61,-2.6,;4.63,-.2,;5.38,.96,;6.71,.19,;4.05,.19,;2.72,.96,;1.38,.19,;1.38,-1.35,;.05,.96,;-1.29,.19,;-2.62,.96,;-3.95,.19,;-4.72,-1.14,;-3.18,-1.14,;-5.29,.96,;-5.29,2.5,;-6.62,3.27,;-7.95,2.5,;-7.95,.96,;-9.29,.19,;-6.62,.19,;-6.62,-1.35,;.82,2.3,;-.72,2.3,;4.05,-1.35,;3.22,-3.25,;5.38,-2.12,)| Show InChI InChI=1S/C22H27F2N3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 156 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250451
(US9464044, 47)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)c(F)c1F)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(8.62,-1.04,;7.53,-2.13,;7.93,-3.62,;6.04,-1.73,;5.15,-3.66,;3.94,-2.99,;3.96,-.59,;4.72,.58,;6.04,-.19,;3.38,-.19,;2.05,.58,;.72,-.19,;.72,-1.73,;-.62,.58,;.15,1.91,;-1.39,1.91,;-1.95,-.19,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-8.62,3.66,;-7.29,1.35,;-8.62,.58,;-5.95,.58,;-5.95,-.96,;3.38,-1.73,;2.55,-3.63,;4.72,-2.5,)| Show InChI InChI=1S/C21H24F3N3O4S/c22-13-1-2-14(16(24)15(13)23)32(30,31)27-21(3-4-21)19(29)26-17-11-5-10-6-12(17)9-20(7-10,8-11)18(25)28/h1-2,10-12,17,27H,3-9H2,(H2,25,28)(H,26,29)/t10?,11?,12?,17-,20? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 495 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250419
(US9464044, 9)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)cc(F)c4)CC1)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(9.29,-1.43,;8.2,-2.52,;8.6,-4,;6.71,-2.12,;5.81,-4.04,;4.61,-3.37,;4.63,-.97,;5.38,.19,;6.71,-.58,;4.05,-.58,;2.72,.19,;1.38,-.58,;1.38,-2.12,;.05,.19,;-1.29,-.58,;-2.62,.19,;-3.95,-.58,;-4.72,-1.91,;-3.18,-1.91,;-5.29,.19,;-6.62,-.58,;-7.95,.19,;-9.29,-.58,;-7.95,1.73,;-6.62,2.5,;-6.62,4.04,;-5.29,1.73,;.82,1.53,;-.72,1.53,;4.05,-2.12,;3.22,-4.02,;5.38,-2.89,)| Show InChI InChI=1S/C22H27F2N3O4S/c23-15-5-16(24)7-17(6-15)32(30,31)26-11-21(1-2-21)20(29)27-18-13-3-12-4-14(18)10-22(8-12,9-13)19(25)28/h5-7,12-14,18,26H,1-4,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 608 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM250461
(US9464044, 63)Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccccc1F)C(C3)C2 |r,wU:9.10,TLB:1:3:9:27.5.6,10:9:27:3.4.28,8:3:27:9.7.6,THB:8:7:27:3.4.28,4:3:9:27.5.6,4:5:9:3.8.28,(7.95,-.27,;6.86,-1.36,;7.26,-2.85,;5.38,-.96,;4.48,-2.89,;3.28,-2.22,;3.29,.18,;4.05,1.35,;5.38,.58,;2.72,.58,;1.38,1.35,;.05,.58,;.05,-.96,;-1.29,1.35,;-.52,2.68,;-2.06,2.68,;-2.62,.58,;-3.95,1.35,;-3.95,2.89,;-5.29,.58,;-5.29,-.96,;-6.62,-1.73,;-7.95,-.96,;-7.95,.58,;-6.62,1.35,;-6.62,2.89,;2.72,-.96,;1.88,-2.86,;4.05,-1.73,)| Show InChI InChI=1S/C22H26FN3O3/c23-16-4-2-1-3-15(16)18(27)26-22(5-6-22)20(29)25-17-13-7-12-8-14(17)11-21(9-12,10-13)19(24)28/h1-4,12-14,17H,5-11H2,(H2,24,28)(H,25,29)(H,26,27)/t12?,13?,14?,17-,21? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 672 | n/a | n/a | n/a | n/a | 6.0 | 25 |
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
US Patent
| Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat... |
US Patent US9464044 (2016)
BindingDB Entry DOI: 10.7270/Q2SJ1JH0 |
More data for this
Ligand-Target Pair | |
Search and Browse
