Affinity Data by Patent

Patent code US9464103

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM250505 (US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfo...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM250501 (US9464103, (6'S,6aR,7s,10aS)-10a-(4-chlorobenz...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129277 (CHEMBL3629739 \| US9464103, (6aR,10aS)-10a-(4-chlor...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	10.1	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129269 (CHEMBL3629738 \| US9464103, (6aR,7S,10aS)-10a-(4-ch...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	13.9	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129272 (CHEMBL3629743 \| US9464103, (6aR,7S,10aS)-10a-(4-ch...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	23.3	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129278 (CHEMBL3629742 \| US9464103, (6aR,10aS)-10a-(4-chlor...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	26.4	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129271 (CHEMBL3629741 \| US9464103, (6aR,10aS)-10a-(4-chlor...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	57.7	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129276 (CHEMBL3629737 \| US9464103, (6aR,10aS)-10a-(4-chlor...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	66.6	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM250504 (US9464103, (6'S,6aR,7s,10aS)-1,4-difluoro-6'-methy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	79	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129270 (CHEMBL3629740 \| US9464103, (6aR,7S,10aS)-10a-(4-ch...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	228	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM250503 (US9464103, (6'R,6aR,7r,10aS)-1,4-difluoro-6'-methy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	397	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM250502 (US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenz...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	421	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37� C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
MERCK SHARP & DOHME CORP. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%