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Patent code US9527851

Compile Data Set for Download or QSAR

Found 260 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r|
PDB

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US Patent
n/an/a 0.200n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.200n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.200n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.200n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.200n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US10428074, Example 125 | US9527851, 125 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.200n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.300n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260502
PNG
(US9527851, 99)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.300n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202489
PNG
(US9527851, example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Oc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.300n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.300n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260479
PNG
(US9527851, 50)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r|
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n/an/a 0.5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202338
PNG
((3ar,5s,6as)-n-(3-(hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES COC(=O)c1nsc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
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n/an/a 0.5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 1n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202503
PNG
(US9527851, example 121)
Show SMILES CCc1nsc(OC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 1n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 1n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
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n/an/a 1n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
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n/an/a 1n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US10428074, Example 121 | US9527851, 121 | US95278...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 1n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r|
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n/an/a 2n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260518
PNG
(US10428074, Example 135 | US9527851, 135 | US95278...)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12 |r|
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n/an/a 2n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
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n/an/a 2n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260518
PNG
(US10428074, Example 135 | US9527851, 135 | US95278...)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 2n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US10428074, Example 114 | US9527851, 114 | US95278...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r|
PDB

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n/an/a 2n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 2n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202320
PNG
(1-((4as,7ar)-6-(methyl(7h-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES CN(Cc1ccccc1)C1C[C@H]2CCN(C[C@H]2C1)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C21H32N2O2/c1-21(2,3)25-20(24)23-11-10-17-12-19(13-18(17)15-23)22(4)14-16-8-6-5-7-9-16/h5-9,17-19H,10-15H2,1-4H3/t17-,18-,19?/m1/s1
PDB

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n/an/a 3n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260470
PNG
(US10428074, Example 35 | US9527851, 35)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12 |r|
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US Patent
n/an/a 3n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
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n/an/a 3n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US10428074, Example 17 | US9527851, 17 | US9527851...)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 3n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r|
PDB

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n/an/a 4n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r|
PDB

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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260523
PNG
(US9527851, 155 | US9527851, example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1 |r|
PDB

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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260489
PNG
(US10428074, Example 74 | US9527851, 74 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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US Patent
n/an/a 4n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 4n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260489
PNG
(US10428074, Example 74 | US9527851, 74 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 4n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260523
PNG
(US9527851, 155 | US9527851, example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1 |r|
PDB

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n/an/a 4n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260485
PNG
(US10428074, Example 69 | US9527851, 69 | US9527851...)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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US Patent
n/an/a 5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260502
PNG
(US9527851, 99)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260469
PNG
(US10428074, Example 34 | US9527851, 34 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260453
PNG
(US10428074, Example 6 | US9527851, 6 | US9527851, ...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US10428074, Example 147 | US9527851, 147 | US95278...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202291
PNG
(2-hydroxy-1-((3ar,5s,6as)-5-(methyl(7h-pyrrolo[2,3...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OO)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202489
PNG
(US9527851, example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Oc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 5n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202338
PNG
((3ar,5s,6as)-n-(3-(hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES COC(=O)c1nsc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 7n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260479
PNG
(US9527851, 50)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r|
PDB

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n/an/a 7n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260473
PNG
(US10428074, Example 38 | US9527851, 38 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 7n/an/an/an/a7.327



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TM2
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260473
PNG
(US10428074, Example 38 | US9527851, 38 | US9527851...)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r|
PDB

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n/an/a 7n/an/an/an/a7.325



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


US Patent US9527851 (2016)


BindingDB Entry DOI: 10.7270/Q2D21VRM
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 260 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%