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Patent code US9670194

Compile Data Set for Download or QSAR
Found 71 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188124
PNG
(US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189846
PNG
(US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188116
PNG
(US9670194, Ex. 1 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(29-21-19(20(26)27-12-28-21)23-32-31-13(2)35-23)22-30-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,29)/t16-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189408
PNG
(US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189838
PNG
(US9670194, Ex. 57 (S)-2-(1-((6-amino-5-(3-isopropy...)
Show SMILES CC(C)c1noc(n1)-c1c(N)ncnc1N[C@@H](C)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H23ClN8O2/c1-10(2)18-29-21(33-30-18)16-17(24)25-9-26-19(16)27-11(3)20-28-14-6-4-5-13(23)15(14)22(32)31(20)12-7-8-12/h4-6,9-12H,7-8H2,1-3H3,(H3,24,25,26,27)/t11-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189403
PNG
(US9670194, Ex. 37 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C25H24N8O2/c1-4-17(30-22-20(21(26)27-13-28-22)24-29-15(3)32-35-24)23-31-18-12-8-9-14(2)19(18)25(34)33(23)16-10-6-5-7-11-16/h5-13,17H,4H2,1-3H3,(H3,26,27,28,30)/t17-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189845
PNG
(US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188145
PNG
(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189837
PNG
(US9670194, Ex. 56 (S)-2-(1-((6-amino-5-(3-ethyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H23ClN8O2/c1-3-13(27-19-17(18(24)25-10-26-19)21-29-15(4-2)30-33-21)20-28-14-7-5-6-12(23)16(14)22(32)31(20)11-8-9-11/h5-7,10-11,13H,3-4,8-9H2,1-2H3,(H3,24,25,26,27)/t13-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189405
PNG
(US9670194, Ex. 39 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189404
PNG
(US9670194, Ex. 38 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C25H24N8O2/c1-4-17(29-22-20(21(26)27-13-28-22)24-32-31-15(3)35-24)23-30-18-12-8-9-14(2)19(18)25(34)33(23)16-10-6-5-7-11-16/h5-13,17H,4H2,1-3H3,(H3,26,27,28,29)/t17-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189306
PNG
(US9670194, Ex. 34 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C24H20ClFN8O2/c1-3-16(30-21-19(20(27)28-11-29-21)23-33-32-12(2)36-23)22-31-17-9-5-8-15(25)18(17)24(35)34(22)14-7-4-6-13(26)10-14/h4-11,16H,3H2,1-2H3,(H3,27,28,29,30)/t16-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189298
PNG
(US9670194, Ex. 27 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;-.13,-3.52,;-1.04,-4.77,;-2.58,-4.77,;-.13,-6.01,;1.33,-5.54,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,;,6.01,)|
Show InChI InChI=1S/C26H26N8O2/c1-5-17(31-23-21(22(27)28-13-29-23)25-30-16(4)33-36-25)24-32-18-11-8-10-15(3)20(18)26(35)34(24)19-12-7-6-9-14(19)2/h6-13,17H,5H2,1-4H3,(H3,27,28,29,31)/t17-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189832
PNG
(US9670194, Ex. 52 (S)-2-(1-((6-amino-5-(4-methylox...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)co1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H22ClN7O2/c1-3-14(28-19-17(18(24)25-10-26-19)21-27-11(2)9-32-21)20-29-15-6-4-5-13(23)16(15)22(31)30(20)12-7-8-12/h4-6,9-10,12,14H,3,7-8H2,1-2H3,(H3,24,25,26,28)/t14-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189303
PNG
(US9670194, Ex. 31 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;1.33,-5.54,;-.13,-6.01,;-1.04,-4.77,;-2.58,-4.77,;-.13,-3.52,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,;,6.01,)|
Show InChI InChI=1S/C26H26N8O2/c1-5-17(30-23-21(22(27)28-13-29-23)25-33-32-16(4)36-25)24-31-18-11-8-10-15(3)20(18)26(35)34(24)19-12-7-6-9-14(19)2/h6-13,17H,5H2,1-4H3,(H3,27,28,29,30)/t17-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189844
PNG
(US9670194, Ex. 63 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19FN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188473
PNG
(US9670194, Ex. 21 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(C)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H24N8O2/c1-4-14(27-19-17(18(23)24-10-25-19)21-26-12(3)29-32-21)20-28-15-7-5-6-11(2)16(15)22(31)30(20)13-8-9-13/h5-7,10,13-14H,4,8-9H2,1-3H3,(H3,23,24,25,27)/t14-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188332
PNG
(US9670194, Ex. 14 (S)-2-(1-((6-amino-5-(isoxazol-3...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ccon1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H20ClN7O2/c1-2-13(26-19-17(15-8-9-31-28-15)18(23)24-10-25-19)20-27-14-5-3-4-12(22)16(14)21(30)29(20)11-6-7-11/h3-5,8-11,13H,2,6-7H2,1H3,(H3,23,24,25,26)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189840
PNG
(US9670194, Ex. 59 (S)-2-(1-((6-amino-5-(5-isopropy...)
Show SMILES CC(C)c1nc(no1)-c1c(N)ncnc1N[C@@H](C)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H23ClN8O2/c1-10(2)21-29-19(30-33-21)16-17(24)25-9-26-18(16)27-11(3)20-28-14-6-4-5-13(23)15(14)22(32)31(20)12-7-8-12/h4-6,9-12H,7-8H2,1-3H3,(H3,24,25,26,27)/t11-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188474
PNG
(US9670194, Ex. 22 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2ccccc2c(=O)n1-c1ccccc1F |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;-.13,-3.52,;-1.04,-4.77,;-2.58,-4.77,;-.13,-6.01,;1.33,-5.54,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,;,6.01,)|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-10-6-4-8-14(17)24(34)33(22)18-11-7-5-9-15(18)25/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188117
PNG
(US9670194, Ex. 2 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(26-18-16(17(23)24-9-25-18)20-29-28-10(2)32-20)19-27-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189408
PNG
(US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1
PDB

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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189843
PNG
(US9670194, Ex. 62 2-((S)-1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@@H]1F |r|
Show InChI InChI=1S/C21H20ClFN8O2/c1-3-12(28-18-16(17(24)25-8-26-18)20-27-9(2)30-33-20)19-29-13-6-4-5-10(22)15(13)21(32)31(19)14-7-11(14)23/h4-6,8,11-12,14H,3,7H2,1-2H3,(H3,24,25,26,28)/t11-,12-,14+/m0/s1
PDB

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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189846
PNG
(US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189842
PNG
(US9670194, Ex. 61 (S)-2-(1-((6-amino-5-(5-ethyl-1,...)
Show SMILES CCc1nc(no1)-c1c(N)ncnc1N[C@@H](C)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-14-28-19(29-32-14)16-17(23)24-9-25-18(16)26-10(2)20-27-13-6-4-5-12(22)15(13)21(31)30(20)11-7-8-11/h4-6,9-11H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t10-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188330
PNG
(US9670194, Ex. 12 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)19-26-10(2)32-29-19)20-28-14-6-4-5-12(22)15(14)21(31)30(20)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188338
PNG
(US9670194, Ex. 20 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H24N8O2/c1-4-14(26-19-17(18(23)24-10-25-19)21-29-28-12(3)32-21)20-27-15-7-5-6-11(2)16(15)22(31)30(20)13-8-9-13/h5-7,10,13-14H,4,8-9H2,1-3H3,(H3,23,24,25,26)/t14-/m0/s1
PDB

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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188475
PNG
(US9670194, Ex. 23 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21FN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM188124
PNG
(US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189305
PNG
(US9670194, Ex. 33 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)18-26-10(2)31-28-18)19-27-13-5-3-4-12(21)14(13)20(30)29(19)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1
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Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189304
PNG
(US9670194, Ex. 32 (S)-2-(1-((6-amino-5-(1-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H22ClN9O/c1-3-16(30-21-19(20(26)27-12-28-21)22-29-13-33(2)32-22)23-31-17-11-7-10-15(25)18(17)24(35)34(23)14-8-5-4-6-9-14/h4-13,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189406
PNG
(US9670194, Ex. 40 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(29-21-19(20(26)27-12-28-21)23-32-31-13(2)35-23)22-30-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,29)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188324
PNG
(US9670194, Ex. 6 2-((S)-1((6-amino-5-((S)-4-methyl...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C1=N[C@@H](C)CO1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r,t:12|
Show InChI InChI=1S/C25H24ClN7O2/c1-3-17(31-22-20(21(27)28-13-29-22)24-30-14(2)12-35-24)23-32-18-11-7-10-16(26)19(18)25(34)33(23)15-8-5-4-6-9-15/h4-11,13-14,17H,3,12H2,1-2H3,(H3,27,28,29,31)/t14-,17-/m0/s1
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n/an/a 99n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189845
PNG
(US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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n/an/a 112n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188145
PNG
(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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n/an/a 113n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189829
PNG
(US9670194, Ex. 51 (S)-2-(1-((6-amino-5-(1-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ccn(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H23ClN8O/c1-3-14(27-20-18(19(24)25-11-26-20)16-9-10-30(2)29-16)21-28-15-6-4-5-13(23)17(15)22(32)31(21)12-7-8-12/h4-6,9-12,14H,3,7-8H2,1-2H3,(H3,24,25,26,27)/t14-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188124
PNG
(US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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n/an/a 142n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189846
PNG
(US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188117
PNG
(US9670194, Ex. 2 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(26-18-16(17(23)24-9-25-18)20-29-28-10(2)32-20)19-27-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t13-/m0/s1
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n/an/a 168n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189833
PNG
(US9670194, Ex. 53 (S)-2-(1-((6-amino-5-(1-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H22ClN9O/c1-3-13(27-18-16(17(23)24-9-25-18)19-26-10-30(2)29-19)20-28-14-6-4-5-12(22)15(14)21(32)31(20)11-7-8-11/h4-6,9-11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188325
PNG
(US9670194, Ex. 7 (S)-2-(1-((6-amino-5-(5-methyloxa...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H22ClN7O2/c1-3-14(28-19-17(18(24)26-10-27-19)21-25-9-11(2)32-21)20-29-15-6-4-5-13(23)16(15)22(31)30(20)12-7-8-12/h4-6,9-10,12,14H,3,7-8H2,1-2H3,(H3,24,26,27,28)/t14-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM188145
PNG
(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189408
PNG
(US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189844
PNG
(US9670194, Ex. 63 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19FN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189295
PNG
(US9670194, Ex. 25 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(F)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21FN8O2/c1-3-13(26-18-16(17(23)24-9-25-18)20-29-28-10(2)32-20)19-27-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189795
PNG
(US9670194, Ex. 44 (S)-2-(1-((6-amino-5-(1-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H20ClN9O/c1-10(26-17-15(16(22)23-8-24-17)18-25-9-29(2)28-18)19-27-13-5-3-4-12(21)14(13)20(31)30(19)11-6-7-11/h3-5,8-11H,6-7H2,1-2H3,(H3,22,23,24,26)/t10-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM188116
PNG
(US9670194, Ex. 1 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(29-21-19(20(26)27-12-28-21)23-32-31-13(2)35-23)22-30-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,29)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM188124
PNG
(US9670194, Ex. 3 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21ClN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189405
PNG
(US9670194, Ex. 39 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189845
PNG
(US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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n/an/a 674n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189405
PNG
(US9670194, Ex. 39 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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n/an/a 893n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189846
PNG
(US9670194, Ex. 65 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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n/an/a 1.01E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189408
PNG
(US9670194, Ex. 41 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)19-26-10(2)28-31-19)18-27-13-5-3-4-12(21)14(13)20(30)29(18)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189844
PNG
(US9670194, Ex. 63 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19FN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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n/an/a 1.32E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM189306
PNG
(US9670194, Ex. 34 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C24H20ClFN8O2/c1-3-16(30-21-19(20(27)28-11-29-21)23-33-32-12(2)36-23)22-31-17-9-5-8-15(25)18(17)24(35)34(22)14-7-4-6-13(26)10-14/h4-11,16H,3H2,1-2H3,(H3,27,28,29,30)/t16-/m0/s1
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n/an/a 1.36E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188329
PNG
(US9670194, Ex. 11 (S)-2-(1-((6-amino-5-(pyridin-2-...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ccccn1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C23H22ClN7O/c1-2-15(29-21-19(20(25)27-12-28-21)16-7-3-4-11-26-16)22-30-17-8-5-6-14(24)18(17)23(32)31(22)13-9-10-13/h3-8,11-13,15H,2,9-10H2,1H3,(H3,25,27,28,29)/t15-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM188145
PNG
(US9670194, Ex. 4 (S)-2-(1-((6-amino-5-(3-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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n/an/a 1.48E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM188117
PNG
(US9670194, Ex. 2 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(26-18-16(17(23)24-9-25-18)20-29-28-10(2)32-20)19-27-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t13-/m0/s1
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n/an/a 1.93E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189296
PNG
(US9670194, Ex. 26 (S)-2-(1-((6-amino-5-(1-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncn(C)n1)c1nc2cccc(F)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H22FN9O/c1-3-13(27-18-16(17(23)24-9-25-18)19-26-10-30(2)29-19)20-28-14-6-4-5-12(22)15(14)21(32)31(20)11-7-8-11/h4-6,9-11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m0/s1
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n/an/a 2.29E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188328
PNG
(US9670194, Ex. 10 2-((1S)-1-((6-amino-5-(1-methyl-...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncnn1C)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;1.33,-5.54,;-.13,-6.01,;-1.04,-4.77,;-.13,-3.52,;-.9,-2.19,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,)|
Show InChI InChI=1S/C24H22ClN9O/c1-3-16(31-21-19(20(26)27-12-28-21)23-29-13-30-33(23)2)22-32-17-11-7-10-15(25)18(17)24(35)34(22)14-8-5-4-6-9-14/h4-13,16H,3H2,1-2H3,(H3,26,27,28,31)/t16-/m0/s1
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n/an/a 2.51E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189405
PNG
(US9670194, Ex. 39 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C24H21FN8O2/c1-3-16(30-21-19(20(26)27-12-28-21)23-29-13(2)32-35-23)22-31-17-11-7-10-15(25)18(17)24(34)33(22)14-8-5-4-6-9-14/h4-12,16H,3H2,1-2H3,(H3,26,27,28,30)/t16-/m0/s1
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n/an/a 2.75E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188325
PNG
(US9670194, Ex. 7 (S)-2-(1-((6-amino-5-(5-methyloxa...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C22H22ClN7O2/c1-3-14(28-19-17(18(24)26-10-27-19)21-25-9-11(2)32-21)20-29-15-6-4-5-13(23)16(15)22(31)30(20)12-7-8-12/h4-6,9-10,12,14H,3,7-8H2,1-2H3,(H3,24,26,27,28)/t14-/m0/s1
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n/an/a 2.78E+3n/an/an/an/an/a25



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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188328
PNG
(US9670194, Ex. 10 2-((1S)-1-((6-amino-5-(1-methyl-...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ncnn1C)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;1.33,-5.54,;-.13,-6.01,;-1.04,-4.77,;-.13,-3.52,;-.9,-2.19,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,)|
Show InChI InChI=1S/C24H22ClN9O/c1-3-16(31-21-19(20(26)27-12-28-21)23-29-13-30-33(23)2)22-32-17-11-7-10-15(25)18(17)24(35)34(22)14-8-5-4-6-9-14/h4-13,16H,3H2,1-2H3,(H3,26,27,28,31)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM188337
PNG
(US9670194, Ex. 19 (R)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(27-18-16(17(23)24-9-25-18)20-26-10(2)29-32-20)19-28-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,27)/t13-/m1/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM188117
PNG
(US9670194, Ex. 2 (S)-2-(1-((6-amino-5-(5-methyl-1,...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C21H21ClN8O2/c1-3-13(26-18-16(17(23)24-9-25-18)20-29-28-10(2)32-20)19-27-14-6-4-5-12(22)15(14)21(31)30(19)11-7-8-11/h4-6,9,11,13H,3,7-8H2,1-2H3,(H3,23,24,25,26)/t13-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188324
PNG
(US9670194, Ex. 6 2-((S)-1((6-amino-5-((S)-4-methyl...)
Show SMILES CC[C@H](Nc1ncnc(N)c1C1=N[C@@H](C)CO1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r,t:12|
Show InChI InChI=1S/C25H24ClN7O2/c1-3-17(31-22-20(21(27)28-13-29-22)24-30-14(2)12-35-24)23-32-18-11-7-10-16(26)19(18)25(34)33(23)15-8-5-4-6-9-15/h4-11,13-14,17H,3,12H2,1-2H3,(H3,27,28,29,31)/t14-,17-/m0/s1
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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189844
PNG
(US9670194, Ex. 63 (S)-2-(1-((6-amino-5-(3-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19FN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-29-13(2)31-34-22)21-30-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))		BDBM188329
PNG
(US9670194, Ex. 11 (S)-2-(1-((6-amino-5-(pyridin-2-...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1ccccn1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r|
Show InChI InChI=1S/C23H22ClN7O/c1-2-15(29-21-19(20(25)27-12-28-21)16-7-3-4-11-26-16)22-30-17-8-5-6-14(24)18(17)23(32)31(22)13-9-10-13/h3-8,11-13,15H,2,9-10H2,1H3,(H3,25,27,28,29)/t15-/m0/s1
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US Patent


Assay Description
PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189306
PNG
(US9670194, Ex. 34 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C24H20ClFN8O2/c1-3-16(30-21-19(20(27)28-11-29-21)23-33-32-12(2)36-23)22-31-17-9-5-8-15(25)18(17)24(35)34(22)14-7-4-6-13(26)10-14/h4-11,16H,3H2,1-2H3,(H3,27,28,29,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM189845
PNG
(US9670194, Ex. 64 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C23H19ClN8O2/c1-12(28-20-18(19(25)26-11-27-20)22-31-30-13(2)34-22)21-29-16-10-6-9-15(24)17(16)23(33)32(21)14-7-4-3-5-8-14/h3-12H,1-2H3,(H3,25,26,27,28)/t12-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM189306
PNG
(US9670194, Ex. 34 (S)-2-(1-((6-amino-5-(5-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1 |r|
Show InChI InChI=1S/C24H20ClFN8O2/c1-3-16(30-21-19(20(27)28-11-29-21)23-33-32-12(2)36-23)22-31-17-9-5-8-15(25)18(17)24(35)34(22)14-7-4-6-13(26)10-14/h4-11,16H,3H2,1-2H3,(H3,27,28,29,30)/t16-/m0/s1
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US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%