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Patent code US9670211

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194743
PNG
(US9670211, 2-11 )
Show SMILES FC1(F)CCC(C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C22H19ClF2N4O/c23-13-1-2-17-16(9-13)27-19(29(17)14-3-5-22(24,25)10-14)12-28-18-11-26-8-4-15(18)21(6-7-21)20(28)30/h1-2,4,8-9,11,14H,3,5-7,10,12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195019
PNG
(US9670211, 10-1 )
Show SMILES Clc1ccc2n(C3CCNCC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H22ClN5O/c23-14-1-2-18-17(11-14)26-20(28(18)15-3-8-24-9-4-15)13-27-19-12-25-10-5-16(19)22(6-7-22)21(27)29/h1-2,5,10-12,15,24H,3-4,6-9,13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194753
PNG
(US9670211, 4-1 )
Show SMILES Clc1ccc2n(C3CS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H17ClN4O3S/c21-12-1-2-16-15(7-12)23-18(25(16)13-10-29(27,28)11-13)9-24-17-8-22-6-3-14(17)20(4-5-20)19(24)26/h1-3,6-8,13H,4-5,9-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194868
PNG
(US9670211, 4-2 )
Show SMILES CC1(C)C(=O)N(Cc2nc3cc(Cl)ccc3n2C2CS(=O)(=O)C2)c2cnccc12
Show InChI InChI=1S/C20H19ClN4O3S/c1-20(2)14-5-6-22-8-17(14)24(19(20)26)9-18-23-15-7-12(21)3-4-16(15)25(18)13-10-29(27,28)11-13/h3-8,13H,9-11H2,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195021
PNG
(US9670211, 11 )
Show SMILES CC(C)C(=O)N1CC[C@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C25H26ClN5O2/c1-15(2)23(32)29-10-6-17(13-29)31-20-4-3-16(26)11-19(20)28-22(31)14-30-21-12-27-9-5-18(21)25(7-8-25)24(30)33/h3-5,9,11-12,15,17H,6-8,10,13-14H2,1-2H3/t17-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195068
PNG
(US9670211, 14-1 )
Show SMILES O[C@H]1C[C@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wU:3.5,1.0,(.71,6.09,;.31,4.61,;1.08,3.27,;-.25,2.5,;-1.02,3.84,;-.65,1.01,;.25,-.23,;1.79,-.23,;2.56,-1.57,;4.1,-1.57,;4.87,-.23,;4.58,-3.03,;5.35,-4.36,;6.12,-3.03,;3.33,-3.94,;3.17,-5.47,;1.76,-6.09,;.52,-5.19,;.68,-3.66,;2.09,-3.03,;-.65,-1.48,;-2.12,-1,;-3.45,-1.77,;-4.78,-1,;-6.12,-1.77,;-4.78,.54,;-3.45,1.31,;-2.12,.54,)|
Show InChI InChI=1S/C21H19ClN4O2/c22-12-1-2-17-16(7-12)24-19(26(17)13-8-14(27)9-13)11-25-18-10-23-6-3-15(18)21(4-5-21)20(25)28/h1-3,6-7,10,13-14,27H,4-5,8-9,11H2/t13-,14+
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194733
PNG
(US9670211, 2-1 )
Show SMILES Clc1ccc2n(C3CC4(C3)CS(=O)(=O)C4)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C23H21ClN4O3S/c24-14-1-2-18-17(7-14)26-20(28(18)15-8-22(9-15)12-32(30,31)13-22)11-27-19-10-25-6-3-16(19)23(4-5-23)21(27)29/h1-3,6-7,10,15H,4-5,8-9,11-13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194738
PNG
(US9670211, 2-6 )
Show SMILES Clc1ccc2n(C3CCOCC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O2/c23-14-1-2-18-17(11-14)25-20(27(18)15-4-9-29-10-5-15)13-26-19-12-24-8-3-16(19)22(6-7-22)21(26)28/h1-3,8,11-12,15H,4-7,9-10,13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194742
PNG
(US9670211, 2-10 )
Show SMILES Clc1ccc2n(C3CCNC(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H20ClN5O2/c23-13-1-2-17-16(9-13)26-19(28(17)14-3-8-25-20(29)10-14)12-27-18-11-24-7-4-15(18)22(5-6-22)21(27)30/h1-2,4,7,9,11,14H,3,5-6,8,10,12H2,(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194752
PNG
(US9670211, 3-3 )
Show SMILES Clc1ccc2n([C@@H]3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1 |r|
Show InChI InChI=1S/C21H19ClN4O3S/c22-13-1-2-17-16(9-13)24-19(26(17)14-4-8-30(28,29)12-14)11-25-18-10-23-7-3-15(18)21(5-6-21)20(25)27/h1-3,7,9-10,14H,4-6,8,11-12H2/t14-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195002
PNG
(US9670211, 9-1 )
Show SMILES Fc1cc(Cl)cc2nc(CN3C(=O)C4(CC4)c4ccncc34)n([C@H]3CCS(=O)(=O)C3)c12 |r|
Show InChI InChI=1S/C21H18ClFN4O3S/c22-12-7-15(23)19-16(8-12)25-18(27(19)13-2-6-31(29,30)11-13)10-26-17-9-24-5-1-14(17)21(3-4-21)20(26)28/h1,5,7-9,13H,2-4,6,10-11H2/t13-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195076
PNG
(US9670211, 16 )
Show SMILES Clc1ccc2n(C3CNC4(COC4)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C23H22ClN5O2/c24-14-1-2-18-17(7-14)27-20(29(18)15-8-22(26-9-15)12-31-13-22)11-28-19-10-25-6-3-16(19)23(4-5-23)21(28)30/h1-3,6-7,10,15,26H,4-5,8-9,11-13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195078
PNG
(US9670211, 18 )
Show SMILES Clc1ccc2n(C3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C22H20ClN3O3S/c23-15-1-2-19-14(9-15)10-17(26(19)16-4-8-30(28,29)13-16)12-25-20-11-24-7-3-18(20)22(5-6-22)21(25)27/h1-3,7,9-11,16H,4-6,8,12-13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194734
PNG
(US9670211, 2-2 )
Show SMILES Clc1ccc2n(C3CCS(=O)(=O)CC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O3S/c23-14-1-2-18-17(11-14)25-20(27(18)15-4-9-31(29,30)10-5-15)13-26-19-12-24-8-3-16(19)22(6-7-22)21(26)28/h1-3,8,11-12,15H,4-7,9-10,13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194741
PNG
(US9670211, 2-9 )
Show SMILES Clc1ccc2n(C3CCNC3=O)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C21H18ClN5O2/c22-12-1-2-15-14(9-12)25-18(27(15)16-4-8-24-19(16)28)11-26-17-10-23-7-3-13(17)21(5-6-21)20(26)29/h1-3,7,9-10,16H,4-6,8,11H2,(H,24,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194747
PNG
(US9670211, 2-15 )
Show SMILES CC(C)(C)OC(=O)N1CCC(C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C26H28ClN5O3/c1-25(2,3)35-24(34)30-11-7-17(14-30)32-20-5-4-16(27)12-19(20)29-22(32)15-31-21-13-28-10-6-18(21)26(8-9-26)23(31)33/h4-6,10,12-13,17H,7-9,11,14-15H2,1-3H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194750
PNG
(US9670211, 3-1 )
Show SMILES Clc1ccc2n(C3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C21H19ClN4O3S/c22-13-1-2-17-16(9-13)24-19(26(17)14-4-8-30(28,29)12-14)11-25-18-10-23-7-3-15(18)21(5-6-21)20(25)27/h1-3,7,9-10,14H,4-6,8,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194882
PNG
(US9670211, 6 )
Show SMILES Fc1cc(Cl)cc2nc(CN3C(=O)C4(CC4)c4ccncc34)n(C3CS(=O)(=O)C3)c12
Show InChI InChI=1S/C20H16ClFN4O3S/c21-11-5-14(22)18-15(6-11)24-17(26(18)12-9-30(28,29)10-12)8-25-16-7-23-4-1-13(16)20(2-3-20)19(25)27/h1,4-7,12H,2-3,8-10H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195075
PNG
(US9670211, 15 )
Show SMILES Clc1ccc2n(C3CNS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H18ClN5O3S/c21-12-1-2-16-15(7-12)24-18(26(16)13-8-23-30(28,29)11-13)10-25-17-9-22-6-3-14(17)20(4-5-20)19(25)27/h1-3,6-7,9,13,23H,4-5,8,10-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194740
PNG
(US9670211, 2-8 )
Show SMILES OC1CCC(C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C22H21ClN4O2/c23-13-1-4-18-17(9-13)25-20(27(18)14-2-3-15(28)10-14)12-26-19-11-24-8-5-16(19)22(6-7-22)21(26)29/h1,4-5,8-9,11,14-15,28H,2-3,6-7,10,12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194749
PNG
(US9670211, 2-17 )
Show SMILES C[C@]1(O)C[C@@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wU:4.6,1.0,wD:1.1,(1.4,5.69,;.31,4.61,;-.09,6.09,;-1.02,3.84,;-.25,2.5,;1.08,3.27,;-.65,1.01,;.25,-.23,;1.79,-.23,;2.56,-1.57,;4.1,-1.57,;4.87,-.23,;4.58,-3.03,;5.35,-4.36,;6.12,-3.03,;3.33,-3.94,;3.17,-5.47,;1.76,-6.09,;.52,-5.19,;.68,-3.66,;2.09,-3.03,;-.65,-1.48,;-2.12,-1,;-3.45,-1.77,;-4.78,-1,;-6.12,-1.77,;-4.78,.54,;-3.45,1.31,;-2.12,.54,)|
Show InChI InChI=1S/C22H21ClN4O2/c1-21(29)9-14(10-21)27-17-3-2-13(23)8-16(17)25-19(27)12-26-18-11-24-7-4-15(18)22(5-6-22)20(26)28/h2-4,7-8,11,14,29H,5-6,9-10,12H2,1H3/t14-,21-
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194869
PNG
(US9670211, 4-3 )
Show SMILES CCC1(CC)C(=O)N(Cc2nc3cc(Cl)ccc3n2C2CS(=O)(=O)C2)c2cnccc12
Show InChI InChI=1S/C22H23ClN4O3S/c1-3-22(4-2)16-7-8-24-10-19(16)26(21(22)28)11-20-25-17-9-14(23)5-6-18(17)27(20)15-12-31(29,30)13-15/h5-10,15H,3-4,11-13H2,1-2H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194975
PNG
(US9670211, 7-2 )
Show SMILES Clc1ccc2n(C3CNC(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C21H18ClN5O2/c22-12-1-2-16-15(7-12)25-18(27(16)13-8-19(28)24-9-13)11-26-17-10-23-6-3-14(17)21(4-5-21)20(26)29/h1-3,6-7,10,13H,4-5,8-9,11H2,(H,24,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195044
PNG
(US9670211, 12 )
Show SMILES CS(=O)(=O)N1CC(C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C21H20ClN5O3S/c1-31(29,30)25-10-14(11-25)27-17-3-2-13(22)8-16(17)24-19(27)12-26-18-9-23-7-4-15(18)21(5-6-21)20(26)28/h2-4,7-9,14H,5-6,10-12H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195077
PNG
(US9670211, 17 )
Show SMILES Fc1cc(Cl)cc2cc(CN3C(=O)C4(CC4)c4ccncc34)n(C3CCS(=O)(=O)C3)c12
Show InChI InChI=1S/C22H19ClFN3O3S/c23-14-7-13-8-16(27(20(13)18(24)9-14)15-2-6-31(29,30)12-15)11-26-19-10-25-5-1-17(19)22(3-4-22)21(26)28/h1,5,7-10,15H,2-4,6,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194731
PNG
(US9670211, 1-1 )
Show SMILES CS(=O)(=O)[C@@H]1C[C@@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wD:6.8,4.3,(.31,6.89,;.31,5.35,;-1.23,5.35,;1.85,5.35,;.31,3.81,;1.08,2.48,;-.25,1.71,;-1.02,3.04,;-.65,.22,;.25,-1.03,;1.79,-1.03,;2.56,-2.36,;4.1,-2.36,;4.87,-1.03,;4.58,-3.83,;5.35,-5.16,;6.12,-3.83,;3.33,-4.73,;3.17,-6.26,;1.76,-6.89,;.52,-5.98,;.68,-4.45,;2.09,-3.83,;-.65,-2.27,;-2.12,-1.8,;-3.45,-2.57,;-4.78,-1.8,;-6.12,-2.57,;-4.78,-.26,;-3.45,.51,;-2.12,-.26,)|
Show InChI InChI=1S/C22H21ClN4O3S/c1-31(29,30)15-9-14(10-15)27-18-3-2-13(23)8-17(18)25-20(27)12-26-19-11-24-7-4-16(19)22(5-6-22)21(26)28/h2-4,7-8,11,14-15H,5-6,9-10,12H2,1H3/t14-,15+
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194745
PNG
(US9670211, 2-13 )
Show SMILES Clc1cnc2n(C3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H18ClN5O3S/c21-12-7-15-18(23-8-12)26(13-2-6-30(28,29)11-13)17(24-15)10-25-16-9-22-5-1-14(16)20(3-4-20)19(25)27/h1,5,7-9,13H,2-4,6,10-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194874
PNG
(US9670211, 5 )
Show SMILES Clc1ccc2n(C3CS(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H17ClN4O2S/c21-12-1-2-16-15(7-12)23-18(25(16)13-10-28(27)11-13)9-24-17-8-22-6-3-14(17)20(4-5-20)19(24)26/h1-3,6-8,13H,4-5,9-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195000
PNG
(US9670211, 8-1 )
Show SMILES CN1CC(CC1=O)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C22H20ClN5O2/c1-26-11-14(9-20(26)29)28-17-3-2-13(23)8-16(17)25-19(28)12-27-18-10-24-7-4-15(18)22(5-6-22)21(27)30/h2-4,7-8,10,14H,5-6,9,11-12H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195001
PNG
(US9670211, 8-2 )
Show SMILES CCN1CC(CC1=O)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C23H22ClN5O2/c1-2-27-12-15(10-21(27)30)29-18-4-3-14(24)9-17(18)26-20(29)13-28-19-11-25-8-5-16(19)23(6-7-23)22(28)31/h3-5,8-9,11,15H,2,6-7,10,12-13H2,1H3
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195072
PNG
(US9670211, 14-2 )
Show SMILES O[C@H]1C[C@@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wU:3.5,wD:1.0,(.71,6.09,;.31,4.61,;-1.02,3.84,;-.25,2.5,;1.08,3.27,;-.65,1.01,;.25,-.23,;1.79,-.23,;2.56,-1.57,;4.1,-1.57,;4.87,-.23,;4.58,-3.03,;5.35,-4.36,;6.12,-3.03,;3.33,-3.94,;3.17,-5.47,;1.76,-6.09,;.52,-5.19,;.68,-3.66,;2.09,-3.03,;-.65,-1.48,;-2.12,-1,;-3.45,-1.77,;-4.78,-1,;-6.12,-1.77,;-4.78,.54,;-3.45,1.31,;-2.12,.54,)|
Show InChI InChI=1S/C21H19ClN4O2/c22-12-1-2-17-16(7-12)24-19(26(17)13-8-14(27)9-13)11-25-18-10-23-6-3-15(18)21(4-5-21)20(25)28/h1-3,6-7,10,13-14,27H,4-5,8-9,11H2/t13-,14-
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194735
PNG
(US9670211, 2-3 )
Show SMILES Clc1ccc2n(C3CCCC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H21ClN4O/c23-14-5-6-18-17(11-14)25-20(27(18)15-3-1-2-4-15)13-26-19-12-24-10-7-16(19)22(8-9-22)21(26)28/h5-7,10-12,15H,1-4,8-9,13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195003
PNG
(US9670211, 9-2 )
Show SMILES Fc1cc(Cl)cc2nc(CN3C(=O)C4(CC4)c4ccncc34)n([C@@H]3CCS(=O)(=O)C3)c12 |r|
Show InChI InChI=1S/C21H18ClFN4O3S/c22-12-7-15(23)19-16(8-12)25-18(27(19)13-2-6-31(29,30)11-13)10-26-17-9-24-5-1-14(17)21(3-4-21)20(26)28/h1,5,7-9,13H,2-4,6,10-11H2/t13-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195060
PNG
(US9670211, 13 )
Show SMILES CC1(C)[C@@H](CCS1(=O)=O)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r|
Show InChI InChI=1S/C23H23ClN4O3S/c1-22(2)19(6-10-32(22,30)31)28-17-4-3-14(24)11-16(17)26-20(28)13-27-18-12-25-9-5-15(18)23(7-8-23)21(27)29/h3-5,9,11-12,19H,6-8,10,13H2,1-2H3/t19-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194736
PNG
(US9670211, 2-4 )
Show SMILES Clc1ccc2n(C3COC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H17ClN4O2/c21-12-1-2-16-15(7-12)23-18(25(16)13-10-27-11-13)9-24-17-8-22-6-3-14(17)20(4-5-20)19(24)26/h1-3,6-8,13H,4-5,9-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194737
PNG
(US9670211, 2-5 )
Show SMILES FC1(F)CC(C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C21H17ClF2N4O/c22-12-1-2-16-15(7-12)26-18(28(16)13-8-21(23,24)9-13)11-27-17-10-25-6-3-14(17)20(4-5-20)19(27)29/h1-3,6-7,10,13H,4-5,8-9,11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194739
PNG
(US9670211, 2-7 )
Show SMILES OC1CCC(CC1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |(.94,6.53,;.54,5.04,;1.63,3.95,;1.23,2.46,;-.25,2.07,;-1.34,3.16,;-.94,4.64,;-.65,.58,;.25,-.67,;1.79,-.67,;2.56,-2,;4.1,-2,;4.87,-.67,;4.58,-3.47,;5.35,-4.8,;6.12,-3.47,;3.33,-4.37,;3.17,-5.9,;1.76,-6.53,;.52,-5.62,;.68,-4.09,;2.09,-3.47,;-.65,-1.91,;-2.12,-1.44,;-3.45,-2.21,;-4.78,-1.44,;-6.12,-2.21,;-4.78,.1,;-3.45,.87,;-2.12,.1,)|
Show InChI InChI=1S/C23H23ClN4O2/c24-14-1-6-19-18(11-14)26-21(28(19)15-2-4-16(29)5-3-15)13-27-20-12-25-10-7-17(20)23(8-9-23)22(27)30/h1,6-7,10-12,15-16,29H,2-5,8-9,13H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194744
PNG
(US9670211, 2-12 )
Show SMILES OC(=O)[C@H]1CC[C@H](CC1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wD:6.9,3.2,(2.43,6.38,;.94,5.98,;-.15,7.07,;.54,4.5,;-.94,4.1,;-1.34,2.61,;-.25,1.52,;1.23,1.92,;1.63,3.41,;-.65,.03,;.25,-1.21,;1.79,-1.21,;2.56,-2.55,;4.1,-2.55,;4.87,-1.21,;4.58,-4.01,;5.35,-5.34,;6.12,-4.01,;3.33,-4.92,;3.17,-6.45,;1.76,-7.07,;.52,-6.17,;.68,-4.64,;2.09,-4.01,;-.65,-2.46,;-2.12,-1.98,;-3.45,-2.75,;-4.78,-1.98,;-6.12,-2.75,;-4.78,-.44,;-3.45,.33,;-2.12,-.44,)|
Show InChI InChI=1S/C24H23ClN4O3/c25-15-3-6-19-18(11-15)27-21(29(19)16-4-1-14(2-5-16)22(30)31)13-28-20-12-26-10-7-17(20)24(8-9-24)23(28)32/h3,6-7,10-12,14,16H,1-2,4-5,8-9,13H2,(H,30,31)/t14-,16+
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194751
PNG
(US9670211, 3-2 )
Show SMILES Clc1ccc2n([C@H]3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1 |r|
Show InChI InChI=1S/C21H19ClN4O3S/c22-13-1-2-17-16(9-13)24-19(26(17)14-4-8-30(28,29)12-14)11-25-18-10-23-7-3-15(18)21(5-6-21)20(25)27/h1-3,7,9-10,14H,4-6,8,11-12H2/t14-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194950
PNG
(US9670211, 7-1 )
Show SMILES Clc1ccc2n(C3CCC(=O)NC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C22H20ClN5O2/c23-13-1-3-17-16(9-13)26-19(28(17)14-2-4-20(29)25-10-14)12-27-18-11-24-8-5-15(18)22(6-7-22)21(27)30/h1,3,5,8-9,11,14H,2,4,6-7,10,12H2,(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195020
PNG
(US9670211, 10-2 )
Show SMILES Clc1ccc2n(C3CNC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C20H18ClN5O/c21-12-1-2-16-15(7-12)24-18(26(16)13-8-23-9-13)11-25-17-10-22-6-3-14(17)20(4-5-20)19(25)27/h1-3,6-7,10,13,23H,4-5,8-9,11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM195079
PNG
(US9670211, 19 )
Show SMILES Clc1cnc2n(C3CCS(=O)(=O)C3)c(CN3C(=O)C4(CC4)c4ccncc34)cc2c1
Show InChI InChI=1S/C21H19ClN4O3S/c22-14-7-13-8-16(26(19(13)24-9-14)15-2-6-30(28,29)12-15)11-25-18-10-23-5-1-17(18)21(3-4-21)20(25)27/h1,5,7-10,15H,2-4,6,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194732
PNG
(US9670211, 1-2 )
Show SMILES CS(=O)(=O)[C@H]1C[C@@H](C1)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12 |r,wU:4.3,wD:6.8,(.31,6.89,;.31,5.35,;-1.23,5.35,;1.85,5.35,;.31,3.81,;1.08,2.48,;-.25,1.71,;-1.02,3.04,;-.65,.22,;.25,-1.03,;1.79,-1.03,;2.56,-2.36,;4.1,-2.36,;4.87,-1.03,;4.58,-3.83,;5.35,-5.16,;6.12,-3.83,;3.33,-4.73,;3.17,-6.26,;1.76,-6.89,;.52,-5.98,;.68,-4.45,;2.09,-3.83,;-.65,-2.27,;-2.12,-1.8,;-3.45,-2.57,;-4.78,-1.8,;-6.12,-2.57,;-4.78,-.26,;-3.45,.51,;-2.12,-.26,)|
Show InChI InChI=1S/C22H21ClN4O3S/c1-31(29,30)15-9-14(10-15)27-18-3-2-13(23)8-17(18)25-20(27)12-26-19-11-24-7-4-16(19)22(5-6-22)21(26)28/h2-4,7-8,11,14-15H,5-6,9-10,12H2,1H3/t14-,15-
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194746
PNG
(US9670211, 2-14 )
Show SMILES Clc1ccc2n(C3CCOC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1
Show InChI InChI=1S/C21H19ClN4O2/c22-13-1-2-17-16(9-13)24-19(26(17)14-4-8-28-12-14)11-25-18-10-23-7-3-15(18)21(5-6-21)20(25)27/h1-3,7,9-10,14H,4-6,8,11-12H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
Major surface glycoprotein G


(Human respiratory syncytial virus A (strain Long))		BDBM194748
PNG
(US9670211, 2-16 )
Show SMILES OCC(CO)n1c(CN2C(=O)C3(CC3)c3ccncc23)nc2cc(Cl)ccc12
Show InChI InChI=1S/C20H19ClN4O3/c21-12-1-2-16-15(7-12)23-18(25(16)13(10-26)11-27)9-24-17-8-22-6-3-14(17)20(4-5-20)19(24)28/h1-3,6-8,13,26-27H,4-5,9-11H2
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
To measure anti-RSV activity of compounds, 96-well plates are seeded with 6×103 cells per well in Dulbecco's modified Eagle's medium (DMEM) c...

US Patent US9670211 (2017)


BindingDB Entry DOI: 10.7270/Q2C827GQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%